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Nicolas Young Lab

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2019

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June 4, 2019 - Nick Young receives an American Society of Mass Spectrometry Research Award.

June 4, 2019 - Nick Young organizes the American Society for Mass Spectrometry Workshop on Top-Down Proteomics at the 67th ASMS Conference on Mass Spectrometry and Allied Topics in Atlanta, Ga.

June 1-7, 2019 - The Young Lab attends the 67th ASMS Conference on Mass Spectrometry and Allied Topics, Atlanta, Ga.

June 1, 2019 - New Publication: "One-Pot Quantitative Top- and Middle-Down Analysis of GluC-Digested Histone H4" Holt MV, Wang T, Young, NL*, J. Am. Soc. Mass Spectrom. (2019) PMID: 31147891

May 10, 2019 - Karl Poncha joins the Young lab.

Apr. 9, 2019 - Nick Young gives the Biochemistry Department Seminar at the University of North Carolina, Chapel Hill, N.C.

Mar. 27, 2019 - Matt Holt receives permission to write his dissertation.

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2018

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Nov. 2-6, 2018 - Nick Young organizes the 34th Asilomar Conference on Mass Spectrometry, "Quantitative Analysis of Posttranslational Modifications by Mass Spectrometry" in Asilomar, Calif.

Oct. 25, 2018 - Nick Young gives a talk at the Federation of Analytical Chemistry and Spectroscopy Societies, Atlanta, Ga.

Sep. 10, 2018 New Publication: "Control of Hexamerization, Assembly, and Excluded Strand Specificity for the Sulfolobus solfataricus MCM Helicase," Graham BW, Bougoulias ME, Dodge KL, Thaxton CT, Olaso D, Tao Y, Young NL, Marshall AG, Trakselis MA. Biochemistry 2018 Sep 10. PMID: 30199238

Aug. 7, 2018 - New Publication: “Early Butyrate Induced Acetylation of Histone H4 is Proteoform Specific and Linked to Methylation State,” Wang T, Holt MV, Young, NL. Epigenetics. 2018 Aug 7:1-17. PMID: 29940793.

July 31, 2018 - Karl Poncha joins the lab as a rotation student. Welcome, Karl!

June 7, 2018 - New Publication: "The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance," Wang T, Holt MV, and Young NL. Epigenetics & Chromatin 2018 11:29.

June 7, 2018 - Matt Holt and Tao Wang Present Posters at the 66th ASMS Conference on Mass Spectrometry and Allied Topics in San Diego, Calif. “Quantitative Top Down Mass Spectrometry of Histone H4 Proteoforms Reveals the Immediate-Early Response Dynamics of Methyltransferase SUV4-20 Inhibition” and "Quantitative Top Down Proteomics of Histone H4"

June 6, 2018 - Nikit Venishetty wins an American Society of Mass Spectrometry Undergraduate Travel Award.

June 6, 2018 - Nick Young organizes the American Society of Mass Spectrometry Workshop on Top-Down Proteomics at the 66th ASMS Conference on Mass Spectrometry and Allied Topics in San Diego, Calif.

June 5, 2018 - Nikit Venishetty gives a talk on our work at the 66th ASMS Conference on Mass Spectrometry and Allied Topics in San Diego, Calif.: "Quantitative Top Down Proteomic Determination of Proteoform-Level Substrate Specificity of the Acetyltransferase P300 and Underlying Mechanisms of Specificity"

June 4, 2018 - Nick Young gives a talk on our work at the 66th ASMS Conference on Mass Spectrometry and Allied Topics in San Diego, Calif.: "False Quantitative Discovery Rate (FQDR): A Tunable Metric that Enables Quantitative Top Down Proteomics via Empirical False Discovery"

May 2018 - Angel Garces is admitted to graduate school at MD Anderson Cancer Center. Congratulations!

April 17, 2018 - New Publication: "Middle‐Down Characterization of the Cell Cycle Dependence of Histone H4 Posttranslational Modifications and Proteoforms," Jiang T, Hoover ME, Holt MV, Freitas MA, Marshall AG, Young NL. Proteomics. 2018 Jun;18(11):e1700442.

Feb. 14, 2018 - New Publication: "How Many Human Proteoforms are There?”, Nat Chem Biol. 2018 Feb 14;14(3):206-214 PMID: 29443976.

Feb. 10-14, 2018 - The Young Lab attends Keystone Conference on Cancer Epigenetics: New Mechanisms, New Therapies in Breckenridge, Colo. Many collaborations emerge from this conference with several labs across the U.S.

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2017

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Nov. 2017 - Tao Wang attends the American Society for Mass Spectrometry Fall Workshop on Top-Down Proteomics in Boston, MA.

Nov. 2017 - Tao Wang wins an American Society for Mass Spectrometry Postdoctoral Travel Award.

Oct. 20, 2017 - Matt Holt wins the Joshi Award for the best talk (1st Prize), Baylor College of Medicine, Verna and Marrs McLean Department of Biochemistry & Molecular Biology and Department of Pharmacology Research Conference, League City, TX (Oct 19-20, 2017)

Aug. 10, 2017 - New Publication: "Mapping the contact surfaces in the Lamin A:AIMP3 complex by hydrogen/deuterium exchange FT-ICR mass spectrometry." Tao Y, Fang P, Kim S, Guo M, Young NL, Marshall AG. PLoS One. 2017 Aug 10;12(8):e0181869. https://doi.org/10.1371/journal.pone.0181869

August 2017 - Nikit Venishetty joins the lab as an undergraduate researcher.

July 15, 2017 - Nick Young gives a talk at the 14th Uppsala Conference (UppCon) on Electron Capture and Transfer Dissociation Mass Spectrometry, Cornell University, Ithaca, NY "Electron Transfer Dissociation-Enabled Top Down Proteomics for the Study of Proteoform Temporal Dynamics"

June 2017 - Angel Garces joins the lab as a summer SMART student. He continues on as an undergraduate researcher for the school year.

May 30, 2017 - Nick Young presents a talk at the Annual Stone Symposium, Baylor University, Waco, TX “Quantitative Top Down Proteomics Reveals Time-Resolved Proteoform Dynamics"

March 22, 2017 -Nick Young gives a talk at US HUPO 2017: Precision Proteomics for Discovery and Health, San Diego, CA “Immediate-Early Proteoform Dynamics in Response to Epigenetic Inhibitors”

Feb. 27, 2017 - New Publication: “Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cells”, Fan Y, Guo YR, Yuan W, Zhou Y, Holt MV, Wang T, Demeler B, Young NL, Zhong W, Tao YT https://doi.org/10.1371/journal.ppat.1006231

Feb. 4, 2017 - New Publication: "Recent Advances in Understanding Histone Modification Events", Holt MV, Wang T, Young NL https://link.springer.com/article/10.1007/s40610-017-0050-1

Jan. 2017 - New Publication: "Ultrahigh Resolution FT-ICR MS and MS/MS for Peptide de Novo Amino Acid Sequencing for a Seven-Protein Mixture by Paired Single-Residue Transposed Lys-N and Lys-C Digestion", Guan X, Brownstein NC, Young NL, Marshall AG https://doi.org/10.1002/rcm.7783

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2016

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Aug. 15, 2016 – Dr. Tao Wang joins the laboratory as a postdoctoral associate. He recently received his Ph.D. from Colorado State University with Karolin Lugar. Welcome, Tao!

July 18, 2016 - New Publication: "Label-Free Relative Quantitation of Isobaric and Isomeric Human Histone H2A and H2B Variants by Fourier Transform Ion Cyclotron Resonance Top-Down MS/MS.”, Dang X, Singh A, Spetman BD, Nolan KD, Isaacs JS, Dennis JH, Dalton S, Marshall AG, Young NL https://pubs.acs.org/doi/10.1021/acs.jproteome.6b00414

July 10, 2016 – Matt Holt joins the laboratory. Welcome, Matt!

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