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Katy Patras Lab

Publications

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Patras KA, Coady A, Babu P, Shing SR, Ha AD, Rooholfada E, Brandt SL, Geriak M, Gallo RL, Nizet Host Cathelicidin Exacerbates Group B Streptococcus Urinary Tract Infection. V.mSphere. 2020 Apr 22;5(2):e00932-19. doi: 10.1128/mSphere.00932-19.PMID: 32321824.

Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. Global chemical effects of the microbiome include new bile-acid conjugations. Nature. 2020 Mar;579(7797):123-129. doi: 10.1038/s41586-020-2047-9. Epub 2020 Feb 26.PMID: 32103176.

Shing SR, Ramos AR, Patras KA, Riestra AM, McCabe S, Nizet V, Coady A. The Fungal Pathogen Candida albicans Promotes Bladder Colonization of Group B Streptococcus. Front Cell Infect Microbiol. 2020 Jan 10;9:437. doi: 10.3389/fcimb.2019.00437. eCollection 2019.PMID: 31998657 

Burcham LR, Spencer BL, Keeler LR, Runft DL, Patras KA, Neely MN, Doran KS. Determinants of Group B streptococcal virulence potential amongst vaginal clinical isolates from pregnant women. PLoS One. 2019 Dec 18;14(12):e0226699. doi: 10.1371/journal.pone.0226699. eCollection 2019.PMID: 31851721.

Spencer BL, Deng L, Patras KA, Burcham ZM, Sanches GF, Nagao PE, Doran KS. Cas9 Contributes to Group B Streptococcal Colonization and Disease. Front Microbiol. 2019 Aug 21;10:1930. doi: 10.3389/fmicb.2019.01930. eCollection 2019.PMID: 31497003.

Patras KA, Ha AD, Rooholfada E, Olson J, Ramachandra Rao SP, Lin AE, Nizet V. Augmentation of Urinary Lactoferrin Enhances Host Innate Immune Clearance of Uropathogenic Escherichia coli. J Innate Immun. 2019;11(6):481-495. doi: 10.1159/000499342. Epub 2019 May 3.PMID: 31055580 

Meier A, Chien J, Hobohm L, Patras KA, Nizet V, Corriden R. Inhibition of Human Neutrophil Extracellular Trap (NET) Production by Propofol and Lipid Emulsion. Front Pharmacol. 2019 Apr 5;10:323. doi: 10.3389/fphar.2019.00323. PMID: 31024300; PMCID: PMC6460395.

Vrbanac A, Riestra AM, Coady A, Knight R, Nizet V, Patras KA. The murine vaginal microbiota and its perturbation by the human pathogen group B Streptococcus. BMC Microbiol. 2018 Nov 26;18(1):197. doi: 10.1186/s12866-018-1341-2. PMID: 30477439; PMCID: PMC6260558.

Riestra AM, Valderrama JA, Patras KA, Booth SD, Quek XY, Tsai CM, Nizet V. Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages. J Innate Immun. 2019;11(1):86-98. doi: 10.1159/000493585. Epub 2018 Nov 2. PMID: 30391945; PMCID: PMC6296884.

Coady A, Ramos AR, Olson J, Nizet V, Patras KA. Tamm-Horsfall Protein Protects the Urinary Tract against Candida albicans. Infect Immun. 2018 Nov 20;86(12):e00451-18. doi: 10.1128/IAI.00451-18. PMID: 30297523; PMCID: PMC6246913.

Patras KA, Nizet V. Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches. Front Pediatr. 2018 Feb 22;6:27. doi: 10.3389/fped.2018.00027. PMID: 29520354; PMCID: PMC5827363.

Patras KA, Coady A, Olson J, Ali SR, RamachandraRao SP, Kumar S, Varki A, Nizet V. Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract. Immunol Cell Biol. 2017 Nov;95(10):960-965. doi: 10.1038/icb.2017.63. Epub 2017 Aug 22. PMID: 28829050; PMCID: PMC5698129.

Patras KA, Doran KS. A Murine Model of Group B Streptococcus Vaginal Colonization. J Vis Exp. 2016 Nov 16;(117):54708. doi: 10.3791/54708. PMID: 27911391; PMCID: PMC5226234.

Mu R, Cutting AS, Del Rosario Y, Villarino N, Stewart L, Weston TA, Patras KA, Doran KS. Identification of CiaR Regulated Genes That Promote Group B Streptococcal Virulence and Interaction with Brain Endothelial Cells. PLoS One. 2016 Apr 21;11(4):e0153891. doi: 10.1371/journal.pone.0153891. PMID: 27100296; PMCID: PMC4839699.

Patras KA, Wescombe PA, Rösler B, Hale JD, Tagg JR, Doran KS. Streptococcus salivarius K12 Limits Group B Streptococcus Vaginal Colonization. Infect Immun. 2015 Sep;83(9):3438-44. doi: 10.1128/IAI.00409-15. Epub 2015 Jun 15. PMID: 26077762; PMCID: PMC4534663.

Patras KA, Rösler B, Thoman ML, Doran KS. Characterization of host immunity during persistent vaginal colonization by Group B Streptococcus. Mucosal Immunol. 2015 Nov;8(6):1339-48. doi: 10.1038/mi.2015.23. Epub 2015 Apr 8. PMID: 25850655; PMCID: PMC4598252.

Faralla C, Metruccio MM, De Chiara M, Mu R, Patras KA, Muzzi A, Grandi G, Margarit I, Doran KS, Janulczyk R. Analysis of two-component systems in group B Streptococcus shows that RgfAC and the novel FspSR modulate virulence and bacterial fitness. mBio. 2014 May 20;5(3):e00870-14. doi: 10.1128/mBio.00870-14. PMID: 24846378; PMCID: PMC4030450.

Wang NY, Patras KA, Seo HS, Cavaco CK, Rösler B, Neely MN, Sullam PM, Doran KS. Group B streptococcal serine-rich repeat proteins promote interaction with fibrinogen and vaginal colonization. J Infect Dis. 2014 Sep 15;210(6):982-91. doi: 10.1093/infdis/jiu151. Epub 2014 Mar 11. PMID: 24620021; PMCID: PMC4192050.

Cavaco CK, Patras KA, Zlamal JE, Thoman ML, Morgan EL, Sanderson SD, Doran KS. A novel C5a-derived immunobiotic peptide reduces Streptococcus agalactiae colonization through targeted bacterial killing. Antimicrob Agents Chemother. 2013 Nov;57(11):5492-9. doi: 10.1128/AAC.01590-13. Epub 2013 Aug 26. PMID: 23979760; PMCID: PMC3811312.

Patras KA, Wang NY, Fletcher EM, Cavaco CK, Jimenez A, Garg M, Fierer J, Sheen TR, Rajagopal L, Doran KS. Group B Streptococcus CovR regulation modulates host immune signalling pathways to promote vaginal colonization. Cell Microbiol. 2013 Jul;15(7):1154-67. doi: 10.1111/cmi.12105. Epub 2013 Jan 30. PMID: 23298320; PMCID: PMC3657335.