Mediators of Interferon-Dependent HSC Proliferation and Differentiation
We conducted transcriptional profiling of HSCs from naïve and infected animals to identify molecular mediators of the HSC immune response. Currently we are characterizing candidate genes from that screen for their role in HSC quiescence and differentiation.
Investigating Effects of Antibiotic Treatment on Primitive Hematopoiesis
We are utilizing a mouse model of long-term antibiotic therapy to investigate how changes in microbiome and basal inflammatory tone affect hematopoiesis.
Role of Dnmt3a in Hematopoietic Stem Cell Responses to Infection
The epigenetic modifier Dnmt3a appears to be required for HSC differentiation upon inflammatory stress. Dampened responses to inflammatory stress give Dnmt3a-loss of function HSCs a selection advantage during chronic infection. We are investigating how epigenetic regulation participates in stress hematopoiesis and trained immunity.