Genetic Disorders of Obesity Program
Project Dates: April 2021 - Present
This project is to understand the characteristics of children with early-onset obesity who are evaluated in the GDOP clinic. The aim is to use this information to determine better strategies for identifying children who would benefit from genetic testing, how children respond to therapies, and how to better support parents. This project also includes collecting samples from children and their parents for genetic analysis by future studies.
Central Vitamin D in Weight and Glucose Regulation
Project Dates: February 2013 - Present
This project is funded by the United States Department of Agriculture (cooperative agreement 6250-51000-053, PI Bier; Project 3092-51000-065-02S) and was previously funded by the American Diabetes Association (1-17-JDF-037; PI Sisley). This project investigates the role of the vitamin D receptor in the brain on body weight and blood glucose regulation. The study uses genetic mouse models as well as investigations of the interaction of diet with vitamin D receptor action in the brain.
Posters and Presentations
- Vitamin D Deficiency Screening and Monitoring in Pediatric Patients
- Expression of Vitamin D Receptor Pathway Genes in Subcutaneous Adipose Tissue of Obese Individuals
- Vitamin D Enhances Insulin Sensitivity in Neurons
- Vitamin D Antagonizes Effects of High-fat Diet on Brain Transcriptome
- Vitamin D Receptor in the Paraventricular Nucleus of the Hypothalamus is Necessary for Beneficial Effects of 1,25D3 on Peripheral Glucose Levels
Studies
- RM-493-034: A Study of Setmelanotide In Patients With Specific Gene Defects In The Melanocortin-4 Receptor Pathway (H-50539)
- Phase 1 Clinical Trial for Childhood Obesity Treatment with Tirzepatide! (H-53214)
- Refining Metrics Of Food Behavior In Smith-Magenis Syndrome (H-51761)
- Genetic Disorders of Obesity Program Database (H-44596)
- Characterization and Analysis of Human Brown Adipose Tissue (H-44643)
- Study of Setmelanotide In Patients With Specific Gene Defects In The Melanocortin-4 Receptor Pathway (H-51805)