Email

zhaow@bcm.edu

Positions

Associate Professor

Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology
Baylor College of Medicine
Houston, Texas, United States

Co-Director

CryoEM Core (Advanced Technology Core)
Baylor College of Medicine
houston, Texas, United States

member

Dan L Duncan Comprehensive Cancer Center

Associate Professor

Department of Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas, United States

Adjunct Assistant Professor

Materials Science and NanoEngineering
Rice University
Houston, Texas, United States

Adjunct Assistant professor

Department of Molecular and Cellular Oncology, Division of Basic Science,
The University of Texas MD Anderson Cancer Center
Houston, Texas, United States

Addresses

One Baylor Plaza (Office)

N410.07
HOUSTON, TX, 77030
United States
Phone: (713) 798-3086
zhaow@bcm.edu

Education

PhD from Peking University

Beijing, China

MS from Wuhan Univerisity

Wuhan, Hubei, China

BS from Wuhan University

Wuhan, Hubei, China

Professional Interests

• Cryo-electron Microscopy and Tomography
• Antibiotic Resistance and Drug Efflux Pumps
• Nuclear Receptor
• Membrane Proteins/Ion Channel

Websites

Selected Publications

• Zhang K, Wang Z, Fan GZ, Wang J, Gao S, Li Y, Sun L, Yin CC, Liu WJ. " Two polar residues within C-terminal domain of M1 are critical for the formation of influenza A Virions " Cell Microbiol.. 2015 Nov ;
  Pubmed PMID: 25939747.
• Du D, Voss J, Wang Z, Chiu W, Luisi BF.. " The pseudo-atomic structure of an RND-type tripartite multidrug efflux pump " Biol Chem.. 2015 Sep ;
  Pubmed PMID: 25803077.
• Hu H*, Wang Z*, Wei R*, Fan G, Wang Q, Zhang K, Yin CC.. " The molecular architecture of dihydropyrindine receptor/L-type Ca2+ channel complex. " Sci Rep.. 2015 Feb ;
  Pubmed PMID: 25667046.
• Du D, Wang Z, James NR, Voss JE, Klimont E, Ohene-Agyei T, Venter H, Chiu W, Luisi BF.. " Structure of the AcrAB-TolC multidrug efflux pump. " Nature. 2014 May ;
  Pubmed PMID: 24747401.
• Yi P*, Wang Z*, Feng Q, Pintilie GD, Foulds CE, Lanz RB, Ludtke SJ, Schmid MF, Chiu W, O'Malley BW. " Structure of a biologically active estrogen receptor-coactivator complex on DNA " Mol Cell.. 2015 Mar ;
  Pubmed PMID: 25728767.
• Shi X, Wang Z, Yan L, Ezemaduka AN, Fan G, Wang R, Fu X, Yin C, Chang Z.. " Small heat shock protein AgsA forms dynamic fibrils. " FEBS Lett.. 2011 Nov ;
  Pubmed PMID: 22001209.
• Fan G, Baker ML, Wang Z, Baker MR, Sinyagovskiy PA, Chiu W, Ludtke SJ, Serysheva II.. " Gating machinery of InsP3R channels revealed by electron cryomicroscopy " Nature. 2015 Nov ;
  Pubmed PMID: 26458101.
• Zhang K, Wang Z, Liu X, Yin C, Basit Z, Xia B, Liu W.. " Dissection of influenza A virus M1 protein: pH-dependent oligomerization of N-terminal domain and dimerization of C-terminal domain. " PLoS One.. 2012 Jul ;
  Pubmed PMID: 22655068.
• Ni P, Wang Z, Ma X, Das NC, Sokol P, Chiu W, Dragnea B, Hagan M, Kao CC.. " An examination of the electrostatic interactions between the N-terminal tail of the Brome Mosaic Virus coat protein and encapsidated RNAs " J Mol Biol.. 2012 Jun ;
  Pubmed PMID: 22472420.
• Wang Z, Hryc CF, Bammes B, Afonine PV, Jakana J, Chen DH, Liu X, Baker ML, Kao C, Ludtke SJ, Schmid MF, Adams PD, Chiu W.. " An atomic model of brome mosaic virus using direct electron detection and real-space optimization. " Nat Commun.. 2014 Sep ;
  Pubmed PMID: 25185801.
• Hryc CF, Chen DH, Afonine PV, Jakana J, Wang Z, Haase-Pettingell C, Jiang W, Adams PD, King JA, Schmid MF, Chiu W. " Accurate model annotation of a near-atomic resolution cryo-EM map " Proc Natl Acad Sci U S A. 2017 Mar ;
  Pubmed PMID: 28270620.
• Zhang K*, Ezemaduka AN*, Wang Z*, Hu H, Shi X, Liu C, Lu X, Fu X, Chang Z, Yin CC.. " A novel mechanism for small heat shock proteins to function as molecular chaperones. " Sci Rep.. 2015 Mar ;
  Pubmed PMID: 25744691.
• Dilip Kumar, Xinzhe Yu, Sue E Crawford, Rodolfo Moreno, Joanita Jakana, Banumathi Sankaran, Ramakrishnan Anish, Soni Kaundal, Liya Hu, Mary K Estes, Zhao Wang, BV Venkataram Prasad. " 2.7 Å cryo-EM structure of rotavirus core protein VP3, a unique capping machine with a helicase activity " Science Advances. 2020 Apr 1;
  Pubmed PMID: 32494598.
• Xinzhe Yu, Ping Yi, Ross A Hamilton, Hong Shen, Muyuan Chen, Charles E Foulds, Michael A Mancini, Steven J Ludtke, Zhao Wang, Bert W O’Malley. " Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes " Molecular Cell. 2020 Jul 14;
  Pubmed PMID: 32668201.
• Hanzhi Zhang, Yaping Pan, Liya Hu, M Ashley Hudson, Katrina S Hofstetter, Zhichun Xu, Mingqiang Rong, Zhao Wang, BV Venkataram Prasad, Steve W Lockless, Wah Chiu, Ming Zhou. " TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential " Nature communications. 2020 Jan 28;
  Pubmed PMID: 31992706.
• Muyuan Chen, James M Bell, Xiaodong Shi, Stella Y Sun, Zhao Wang, Steven J Ludtke. " A complete data processing workflow for cryo-ET and subtomogram averaging " Nature methods. 2019 Oct 14;
  Pubmed PMID: 31611690.
• Ran Meng, Mengqiu Jiang, Zhicheng Cui, Jeng-Yih Chang, Kailu Yang, Joanita Jakana, Xinzhe Yu, Zhao Wang, Bo Hu, Junjie Zhang. " Structural basis for the adsorption of a single-stranded RNA bacteriophage " Nature communications. 2019 Jul 16;
  Pubmed PMID: 31311931.
• Xiaodong Shi, Muyuan Chen, Zhili Yu, James M Bell, Hans Wang, Isaac Forrester, Heather Villarreal, Joanita Jakana, Dijun Du, Ben F Luisi, Steven J Ludtke, Zhao Wang. " In situ structure and assembly of the multidrug efflux pump AcrAB-TolC " Nature communications. 2019 Jun 14;
  Pubmed PMID: 31201302.
• Qingqing Xie, Zhao Wang, Fengyun Ni, Xiaorui Chen, Jianpeng Ma, Nita Patel, Hanxin Lu, Ye Liu, Jing-Hui Tian, David Flyer, Michael J Massare, Larry Ellingsworth, Gregory Glenn, Gale Smith, Qinghua Wang. " Structure basis of neutralization by a novel site II/IV antibody against respiratory syncytial virus fusion protein " PloS one. 2019 Feb 7;
  Pubmed PMID: 30730999.
• Timothy L Dosey, Zhao Wang, Guizhen Fan, Zhixian Zhang, Irina I Serysheva, Wah Chiu, Theodore G Wensel. " Structures of TRPV2 in distinct conformations provide insight into role of the pore turret " Nature structural & molecular biology. 2019 Jan ;
  Pubmed PMID: 30598551.
• Guizhen Fan, Mariah R Baker, Zhao Wang, Alexander B Seryshev, Steven J Ludtke, Matthew L Baker, Irina I Serysheva. " Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating " Cell research. 2018 Dec ;
  Pubmed PMID: 30470765.
• Ping Yi, Zhao Wang, Qin Feng, Chao-Kai Chou, Grigore D Pintilie, Hong Shen, Charles E Foulds, Guizhen Fan, Irina Serysheva, Steven J Ludtke, Michael F Schmid, Mien-Chie Hung, Wah Chiu, Bert W O’Malley. " Structural and functional impacts of ER coactivator sequential recruitment " Molecular cell. 2017 Sep 17;
  Pubmed PMID: 28844863.
• Zhao Wang, Guizhen Fan, Corey F Hryc, James N Blaza, Irina I Serysheva, Michael F Schmid, Wah Chiu, Ben F Luisi, Dijun Du. " An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump " Elife. 2017 Mar 19;
  Pubmed PMID: 28355133.
• In situ structure of the AcrAB-TolC efflux pump at subnanometer resolution " 2021 Sep ;
• Steroid receptor-coregulator transcriptional complexes: new insights from CryoEM " Essays in Biochemistry. 2021 Jun ;
• The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1 " Journal of Biological Chemistry. 2021 Jan ;
• Zhili Yu, Yaoming Wu, Muyuan Chen, Tong Huo, Wei Zheng, Steven J. Ludtke, Xiaodong Shi, Zhao Wang. " Membrane translocation process revealed by in situ structures of type II secretion system secretins " 2023 Jul ;
  Pubmed PMID: 37419909.
• Xinzhe Yu, Ping Yi, Anil K Panigrahi, Lance Edward V Lumahan, John P Lydon, David M Lonard, Steven J Ludtke, Zhao Wang, Bert W O’Malley. " Spatial definition of the human progesterone receptor-B transcriptional complex " 2022 Nov ;
  Pubmed PMID: 36325049.
• Yuewei Wang, Tong Huo, Yu-Jung Tseng, Lan Dang, Zhili Yu, Wenjuan Yu, Zachary Foulks, Rebecca L Murdaugh, Steven J Ludtke, Daisuke Nakada, Zhao Wang. " Using Cryo-ET to distinguish platelets during pre-acute myeloid leukemia from steady state hematopoiesis " 2022 Jan ;
  Pubmed PMID: 35058565.
• Xinzhe Yu, Ping Yi, Anil K Panigrahi, Lance Edward V Lumahan, John P Lydon, David M Lonard, Steven J Ludtke, Zhao Wang, Bert W O’Malley. " Spatial definition of the human progesterone receptor-B transcriptional complex " 2022 ;
  Pubmed PMID: 36325049.
• Tong Huo, Wei Zheng, Zhili Yu, Yaoming Wu, Qiuyu Ren, Junli Cao, Zhao Wang, Xiaodong Shi. " The assembly and efflux processes revealed by in situ structures of the ABC-type tripartite pump MacAB-TolC " 2024 ;
  Pubmed PMID: 40461577.
• Hongjiang Wu, Liang Sun, Tong Huo, Theodore G Wensel, Frank T Horrigan, Zhao Wang. " The identification of XPR1 as a voltage- and phosphate-activated phosphate-permeable ion channel " 2025 ;
  Pubmed PMID: 40374661.
• Xuqian Tan, Ethan Boniuk, Anisha Abraham, Xueting Zhou, Zhili Yu, Steven J Ludtke, Zhao Wang. " TomoScore: A Neural Network Approach for Quality Assessment of Cellular cryo-ET " 2025 ;
  Pubmed PMID: 40343344.
• Felipe-Andrés Piedra, Miguel A Salazar, Sara Abouelniaj, Raayed Rahman, Justin C Clark, Yimo Han, Zhao Wang, Anthony Maresso. " Eco-microbiology: discovering biochemical enhancers of PET biodegradation by Piscinibacter sakaiensis " 2025 ;
  Pubmed PMID: 39992123.
• Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy " 2025 ;
  Pubmed PMID: 39761077.
• ZNF397 deficiency triggers TET2-driven lineage plasticity and AR-targeted therapy resistance in prostate cancer " 2024 ;
  Pubmed PMID: 38591846.

Show 32 more publications

Memberships

Biophysical Society

(01/2013)

American Endocrine Society

(01/2017)

Funding

Sex Hormone Receptor Components and the Cell Genome
#5 R01 HD07857

Grant funding from NIH-NICHD

O'Malley (PI), Co-Investigator

Determining Chemical Interactions Mediating Biological Complex Formation by Cryo-EM
#Q-1967-20180324

Grant funding from Welch Foundation

PI

Molecular mechanism of Androgen Receptor mediated transcription
#R01GM143380

Grant funding from NIH-NIGMS

Wang(PI)

Investigation of the Cellular and Molecular Mechanisms of Thrombocyte Integrin Signaling
#R01HL162842

Grant funding from NILBI

Molecular Assembly of Bacterial Tripartite Multidrug Efflux Pumps
#1R01AI179879

(05/01/2024 - 04/30/2029)

Grant funding from NIAID