Positions

Associate Professor
Pediatrics
Nutrition
Baylor College of Medicine
Houston, Texas, United States
Secondary Associate Professor
Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas, United States

Education

Fellowship at University Of Texas Southwestern Medical School
PhD from University of Alberta
MSc from Tongji Medical University
MD from Tongji Medial University

Professional Interests

  • CNS control of body weight, glucose and blood pressure

Professional Statement

The goal of my research is to identify the novel neural circuits, neurotransmitters and intra-neuronal signals that are critical for coordinated control of body weight, feeding behavior, glucose balance and blood pressure. The critical approach that makes the cornerstone of my laboratory efforts is targeted gene manipulation in mice. We use the Cre-loxP and/or Flpe-frt strategy to achieve tissue or cell-specific gene deletion or re-activation in functional animals. This genetic approach is supplemented by optogenetics, neuroanatomy, electrophysiology, systemic physiology, biochemistry, molecular biology and cell-based techniques.

Ongoing projects in the laboratory include:

(1) Sex differences in central control of body weight and glucose balance.

(2) External and intrinsic signals regulating activities of melanocortin neurons in the context obesity and diabetes.

(3) The 5-HT neural circuits and feeding behaviors.

(4) Brain estrogenic actions and blood pressure.

Selected Publications

Funding

Brain steroid receptor coactivators and energy homeostasis
- #P01 DK113954
Grant funding from NIH
Neurobiology for the sex differences in energy balance
- #R01 DK117281
Grant funding from NIH
Hypothalamic Grb10 and body weight
- #R01 DK115761
Grant funding from NIH