Email

kosten@bcm.edu

Positions

Vice-Chair

Psychiatry for Research
Baylor College of Medicine

Director

Division of Alcohol and Addiction Psychiatry
Baylor College of Medicine

Co-Director

Institute for Clinical & Translational Research
Baylor College of Medicine

Professor

Psychiatry
Baylor College of Medicine
Houston, Texas, US

Professor

Neuroscience
Baylor College of Medicine
Houston, Texas, United States

Professor

Pharmacology
Baylor College of Medicine
Houston, Texas, United States

Professor

Immunology and Rheumatology
Baylor College of Medicine
Houston, TX, United States

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Education

MA from Yale University

01/1995 - New Haven, Connecticut, United States

Clinical Fellowship at Yale University School of Medicine

01/1983 - New Haven, Connecticut, United States

M.D. from Cornell University Medical College

01/1977 - New York, NY, United States

BS from Rensselaer Polytechnic Institute

01/1973 - Troy, New York, United States

Residency at Yale University School of Medicine

01/1981 - New Haven, Connecticut, United States

Internship at Greenwich Hospital

01/1978 - Greenwich, Connecticut, United States

Certifications

Psychiatry/Addictions

ABPN

Professional Interests

• Developing medications & vaccines for addictions
• Pharmacology

Websites

Selected Publications

• Malison RT, McCance E, Carpenter LL, Baldwin RM, Seibyl JP, Price LH, Kosten TR, Innis RB. " [123I]beta-CIT SPECT imaging of dopamine transporter availability after mazindol administration in human cocaine addicts. " Psychopharmacology (Berl.). 1998 Jun ; 137 (4) : 321-5.
  Pubmed PMID: 9676890.
• Kosten TR, Rounsaville BJ, Kleber HD. " A 2.5-year follow-up of cocaine use among treated opioid addicts. Have our treatments helped? " Arch. Gen. Psychiatry. 1987 Mar ; 44 (3) : 281-4.
  Pubmed PMID: 3827521.
• Kosten TR, Rounsaville BJ, Kleber HD. " A 2.5 year follow-up of treatment retention and reentry among opioid addicts. " J Subst Abuse Treat. 1986 ; 3 (3) : 181-9.
  Pubmed PMID: 3806731.
• Kosten TR, Rounsaville BJ, Kleber HD. " A 2.5-year follow-up of depression, life crises, and treatment effects on abstinence among opioid addicts. " Arch Gen Psychiatry. 1986 Aug ; 733-8.
  Pubmed PMID: 3729667.
• Rounsaville BJ, Kosten TR, Weissmann MM, Kleber HD. " A 2.5-year follow-up of short-term interpersonal psychotherapy in methadone-maintained opiate addicts. " Compr Psychiatry. ; 27 (3) : 201-10.
  Pubmed PMID: 3709134.
• Avants SK, Margolin A, DePhilippis D, Kosten TR. " A comprehensive pharmacologic-psychosocial treatment program for HIV-seropositive cocaine- and opioid-dependent patients. Preliminary findings. " J Subst Abuse Treat. ; 15 (3) : 261-5.
  Pubmed PMID: 9633038.
• Rounsaville BJ, Kosten TR, Williams JB, Spitzer RL. " A field trial of DSM-III-R psychoactive substance dependence disorders. " Am J Psychiatry. 1987 Mar ; 144 (3) : 351-5.
  Pubmed PMID: 3826436.
• Kosten TR, Steinberg M, Diakogiannis I A. " A cross-over trail of mazindol for cocaine dependence. " Am J Addictions. 1993 ; 161-164.
• Kosten TA, Shen XY, O'Malley PW, Kinsey BM, Lykissa ED, Orson FM, Kosten TR. " A morphine conjugate vaccine attenuates the behavioral effects of morphine in rats. " Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1; 223-9.
  Pubmed PMID: 23739535.
• Margolin A, Kosten TR, Avants SK, Wilkins J, Ling W, Beckson M, Arndt IO, Cornish J, Ascher JA, Li SH. " A multicenter trial of bupropion for cocaine dependence in methadone-maintained patients. " Drug Alcohol Depend. 1995 Dec ; 40 (2) : 125-31.
  Pubmed PMID: 8745134.
• Najavits LM, Kivlahan D, Kosten T. " A national survey of clinicians’ views of evidence-based therapies for PTSD and substance abuse. " 2011 ; 138-147.
• Rosen MI, McMahon TJ, Woods SW, Pearsall HR, Kosten TR. " A pilot study of dextromethorphan in naloxone-precipitated opiate withdrawal. " Eur. J. Pharmacol.. 1996 Jul 4; 307 (3) : 251-7.
  Pubmed PMID: 8836612.
• O'Connor PG, Oliveto AH, Shi JM, Triffleman E, Carroll KM, Kosten TR, Rounsaville BJ. " A pilot study of primary-care-based buprenorphine maintenance for heroin dependence. " Am J Drug Alcohol Abuse. 1996 Nov ; 22 (4) : 523-31.
  Pubmed PMID: 8911590.
• George TP, Vessicchio JC, Termine A, Bregartner TA, Feingold A, Rounsaville BJ, Kosten TR. " A placebo controlled trial of bupropion for smoking cessation in schizophrenia " Biol Psychiatry. 2002 Jul 1; 53-61.
  Pubmed PMID: 12079730.
• Margolin A, Avants SK, DePhilippis D, Kosten TR. " A preliminary investigation of lamotrigine for cocaine abuse in HIV-seropositive patients. " Am J Drug Alcohol Abuse. 1998 Feb ; 24 (1) : 85-101.
  Pubmed PMID: 9513631.
• George TP, Vessicchio JC, Termine A, Jatlow PI, Kosten TR, O'Malley SS. " A preliminary placebo-controlled trial of selegiline hydrochloride for smoking cessation. " Biol. Psychiatry. 2003 Jan 15; 53 (2) : 136-43.
  Pubmed PMID: 12547469.
• Kosten TR, Kreek MJ, Ragunath J, Kleber HD. " A preliminary study of beta endorphin during chronic naltrexone maintenance treatment in ex-opiate addicts. " Life Sci.. 1986 Jul 7; 39 (1) : 55-9.
  Pubmed PMID: 2941636.
• Kosten TR, Schumann B, Wright D, Carney MK, Gawin FH. " A preliminary study of desipramine in the treatment of cocaine abuse in methadone maintenance patients. " J Clin Psychiatry. 1987 Nov ; 48 (11) : 442-4.
  Pubmed PMID: 3680185.
• Frank JB, Kosten TR, Giller EL, Dan E. " A randomized clinical trial of phenelzine and imipramine for posttraumatic stress disorder. " Am J Psychiatry. 1988 Oct ; 145 (10) : 1289-91.
  Pubmed PMID: 3048121.
• Avants SK, Margolin A, Holford TR, Kosten TR. " A randomized controlled trial of auricular acupuncture for cocaine dependence. " Arch. Intern. Med.. ; 160 (15) : 2305-12.
  Pubmed PMID: 10927727.
• O'Connor PG, Oliveto AH, Shi JM, Triffleman EG, Carroll KM, Kosten TR, Rounsaville BJ, Pakes JA, Schottenfeld RS. " A randomized trial of buprenorphine maintenance for heroin dependence in a primary care clinic for substance users versus a methadone clinic. " Am. J. Med.. 1998 Aug ; 105 (2) : 100-5.
  Pubmed PMID: 9727815.
• Kosten TR, McCance E. " A review of pharmacotherapies for substance abuse. " The American Journal on Addictions. 1996 ; 58-59.
• Shen XY, Kosten TA, Lopez AY, Kinsey BM, Kosten TR, Orson FM. " A vaccine against methamphetamine attenuates its behavioral effects in mice. " Drug Alcohol Depend. 2013 Apr 1; 129 (41276) : 41-8.
  Pubmed PMID: 23022610.
• Margolin A, Avants SK, Chang P, Birch S, Kosten TR. " A single-blind investigation of four auricular needle puncture configurations. " Am. J. Chin. Med.. 1995 ; 23 (2) : 105-14.
  Pubmed PMID: 7572770.
• Margolin A, Avants SK, Kosten TR. " Abstinence symptomatology associated with cessation of chronic cocaine abuse among methadone-maintained patients. " Am J Drug Alcohol Abuse. 1996 Aug ; 22 (3) : 377-88.
  Pubmed PMID: 8841686.
• Kosten TR, Gawin FH, Rounsaville BJ, Kleber HD. " Abuse of cocaine with opioids: psychological aspects of treatment. " NIDA Res. Monogr.. 1986 ; 67 : 278-82.
  Pubmed PMID: 3092078.
• Kinsey BM, Kosten TR, Orson FM. " Active immunotherapy for the Treatment of Cocaine Dependence. " 2010 Apr 1; 35 (4) : 301-306.
  Pubmed PMID: 21796226.
• Avants SK, Margolin A, Chang P, Kosten TR, Birch S. " Acupuncture for the treatment of cocaine addiction. Investigation of a needle puncture control. " J Subst Abuse Treat. ; 12 (3) : 195-205.
  Pubmed PMID: 7474027.
• Jacobs S, Mason J, Kosten T, Kasl S, Ostfeld A, Atkins S, Gardner C, Schreiber S. " Acute bereavement, threatened loss, ego defenses and adrenocortical function " Psychother Psychosom. 1985 ; 151-9.
  Pubmed PMID: 3832148.
• Kosten TR. " Addiction as a brain disease. " Am J Psychiatry. 1998 Jun ; 155 (6) : 711-3.
  Pubmed PMID: 9619141.
• Wallace EA, Wisniewski G, Zubal G, vanDyck CH, Pfau SE, Smith EO, Rosen MI, Sullivan MC, Woods SW, Kosten TR. " Acute cocaine effects on absolute cerebral blood flow. " Psychopharmacology (Berl.). 1996 Nov ; 128 (1) : 17-20.
  Pubmed PMID: 8944401.
• Ziedonis D, Richardson T, Lee E, Petrakis I, Kosten T. " Adjunctive desipramine in the treatment of cocaine abusing schizophrenics " Psychopharmacol Bull. 1992 ; 309-14.
  Pubmed PMID: 1480735.
• Kosten TR. " Advances in clinical research on drug addiction: Opioids and cocaine. " Substance Abuse. 1989 ; 35-42.
• Sofuoglu M, Mouratidis M, Yoo S, Kosten T. " Adrenergic blocker carvedilol attenuates the cardiovascular and aversive effects of nicotine in abstinent smokers. " Behav Pharmacol. 2006 Dec 17; 731-5.
  Pubmed PMID: 17110799.
• Ziedonis DM, Kosten TR. " Aggiornamento: Dipendenza da nicotina e schizofrenia. " 1996 ; 44-47.
• Kosten TR. " Advances in pharmacotherapy of stimulant dependence: From alcohol antagonists to Xenova vaccines. " Clinical Neuroscience Research. 2005 ; 169-173.
• Closser MH, Kosten TR. " Alcohol and cocaine abuse. A comparison of epidemiology and clinical characteristics. " Recent Dev Alcohol. 1992 ; 10 : 115-28.
  Pubmed PMID: 1317046.
• Kosten TR, Kosten TA, Rounsaville BJ. " Alcoholism and depressive disorders in opioid addicts and their family members. " Compr Psychiatry. ; 32 (6) : 521-7.
  Pubmed PMID: 1778079.
• 13. Kosten TR, Krystal JH, Giller EL, Frank J, Dan E.. " Alexithymia as a predictor of treatment response in posttraumatic stress disorder. " J Traumatic Stress. 1992 ; 41-51.
• Cui Y, Versace F, Engelmann JM, Minnix JA, Robinson JD, Lam CY, Karam-Hage M, Brown VL, Wetter DW, Dani JA, Kosten TR, Cinciripini PM. " Alpha oscillations in response to affective and cigarette-related stimuli in smokers. " Nicotine Tob. Res.. 2013 May ; 15 (5) : 917-24.
  Pubmed PMID: 23060019.
• Sellers EM, Ciraulo DA, DuPont RL, Griffiths RR, Kosten TR, Romach MK, Woody GE. " Alprazolam and benzodiazepine dependence. " J Clin Psychiatry. 1993 Oct ; 54 : 64-75; discussi.
  Pubmed PMID: 8262891.
• Xiu MH, Chen S, Wang F, Cao LY, Qi LY, Chen da C, Wu GY, Lu L, Kosten TA, Kosten TR, Zhang XY. " Altered interleukin-3 serum levels in drug-naïve and neuroleptic-treated schizophrenic patients. " Schizophr. Res.. 2008 Dec ; 106 (41308) : 369-70.
  Pubmed PMID: 18838250.
• Petrakis IL, Satel SL, Stine S, Kosten TR, Normanworth SN, Charney DS, Krystal JH. " AMPT effects on cue-induced craving for cocaine. " The American Journal of Addictions. 1996 ; 313-320.
• Kosten TA, Kosten TR, Gawin FH, Gordon LT, Hogan I, Kleber HD. " An open trial of sertraline for cocaine abuse. " Am J Addictions. 1992 ; 349-353.
• Spellicy CJ, Kosten TR, Hamon SC, Harding MJ, Nielsen DA. " ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. " Pharmacogenet. Genomics. 2013 Jul ; 23 (7) : 333-40.
  Pubmed PMID: 23635803.
• Kosten TR, Rounsaville BJ, Kleber HD. " Antecedents and consequences of cocaine abuse among opioid addicts. A 2.5-year follow-up. " J. Nerv. Ment. Dis.. 1988 Mar ; 176 (3) : 176-81.
  Pubmed PMID: 3343591.
• Shen X, Orson FM, Kosten TR. " Anti-addiction vaccines. " F1000 Med Rep. 2011 ; 3 : 20.
  Pubmed PMID: 22003367.
• Brimijoin S, Orson F, Kosten TR, Kinsey B, Shen XY, White SJ, Gao Y. " Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice. " Chem. Biol. Interact.. 2013 Mar 25; 203 (1) : 212-6.
  Pubmed PMID: 22960160.
• Leal J, Ziedonis D, Kosten T. " Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence " Drug Alcohol Depend. 1994 Mar ; 31-5.
  Pubmed PMID: 8082553.
• Kinsey BM, Kosten TR, Orson FM. " Anti-cocaine vaccine development. " Expert Rev Vaccines. 2010 Sep ; 9 (9) : 1109-14.
  Pubmed PMID: 20822352.
• Frank JB, Kosten TR, Giller EL. " Antidepressants in the treatment of PTSD. " Am J Psychiatry. 1990 Feb ; 147 (2) : 260.
  Pubmed PMID: 2301678.
• Li CS, Kosten TR, Sinha R. " Antisocial personality and stress-induced brain activation in cocaine-dependent patients. " Neuroreport. 2006 Feb 27; 17 (3) : 243-7.
  Pubmed PMID: 16462591.
• Chen JX, Su YA, Wang SL, Bian QT, Liu YH, Wang N, Yang FD, Haile C, Kosten TR, Zhang XY. " Aripiprazole treatment of risperidone-induced hyperprolactinemia. " J Clin Psychiatry. 2009 Jul ; 70 (7) : 1058-9.
  Pubmed PMID: 19653986.
• Kosten TR, Gottschalk PC, Tucker K, Rinder CS, Dey HM, Rinder HM. " Aspirin or amiloride for cerebral perfusion defects in cocaine dependence. " Drug Alcohol Depend. 2003 Aug 20; 71 (2) : 187-94.
  Pubmed PMID: 12927657.
• Hui L, Zhang X, Yu YQ, Han M, Huang XF, Chen da C, Wang ZR, Du WL, Kou CG, Yu Q, Kosten TR, Zhang XY. " Association between DBH 19bp insertion/deletion polymorphism and cognition in first-episode schizophrenic patients. " Schizophr. Res.. 2013 Jul ; 147 (41308) : 236-40.
  Pubmed PMID: 23707643.
• Sun S, Wang F, Wei J, Cao LY, Wu GY, Lu L, Kosten TA, Kosten TR, Zhang XY. " Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population. " Neurosci. Lett.. 2008 Jul 25; 440 (1) : 35-7.
  Pubmed PMID: 18547720.
• Sun S, Wang F, Wei J, Cao LY, Qi LY, Xiu MH, Chen S, Li XH, Kosten TA, Kosten TR, Zhang XY. " Association between interleukin-6 receptor polymorphism and patients with schizophrenia. " Schizophr. Res.. 2008 Jul ; 102 (41277) : 346-7.
  Pubmed PMID: 18508242.
• Qiu HT, Meng HQ, Song C, Xiu MH, Chen da C, Zhu FY, Wu GY, Kosten TA, Kosten TR, Zhang XY. " Association between monoamine oxidase (MAO)-A gene variants and schizophrenia in a Chinese population. " Brain Res.. 2009 Sep 1; 1287 : 67-73.
  Pubmed PMID: 19573521.
• Cao JX, Hu J, Ye XM, Xia Y, Haile CA, Kosten TR, Zhang XY. " Association between the 5-HTR1B gene polymorphisms and alcohol dependence in a Han Chinese population. " Brain Res.. 2011 Feb 28; 1376 : 41283.
  Pubmed PMID: 21172311.
• Avants SK, Margolin A, McMahon TJ, Kosten TR. " Association between self-report of cognitive impairment, HIV status, and cocaine use in a sample of cocaine-dependent methadone-maintained patients. " Addict Behav. ; 22 (5) : 599-611.
  Pubmed PMID: 9347062.
• Wang F, Fan H, Sun H, Yang F, Luo Y, Liu H, Kosten TR, Lu L, Zhang XY. " Association between TNF-a promoter -308A/G polymorphism and tardive dyskinesiain Chinese Han patients with schizophrenia. " Prog. Neuropsychopharmacol. Biol. Psychiatry. 2012 Apr 27; 37 (1) : 106-10.
  Pubmed PMID: 22227290.
• Li W, Zhou N, Yu Q, Li X, Yu Y, Sun S, Kou C, Chen da C, Xiu MH, Kosten TR, Zhang XY. " Association of BDNF gene polymorphisms with schizophrenia and clinical symptoms in a Chinese population " Am J Med Genet B Neuropsychiatr Genet. 2013 Sep ; 538-45.
  Pubmed PMID: 23832605.
• Zhang XY, Tan YL, Zhou DF, Haile CN, Cao LY, Xu Q, Shen Y, Kosten TA, Kosten TR. " Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population. " J Clin Psychopharmacol. 2007 Jun ; 27 (3) : 246-51.
  Pubmed PMID: 17502770.
• Li WJ, Kou CG, Yu Y, Sun S, Zhang X, Kosten TR, Zhang XY. " Association of Catechol-O-methyltransferase gene polymorphisms with schizophrenia and negative symptoms in a Chinese population. " Am. J. Med. Genet. B Neuropsychiatr. Genet.. 2012 Jun ; 159 (4) : 370-5.
  Pubmed PMID: 22354729.
• Guo S, Chen da F, Zhou DF, Sun HQ, Wu GY, Haile CN, Kosten TA, Kosten TR, Zhang XY. " Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers. " Psychopharmacology (Berl.). 2007 Mar ; 190 (4) : 449-56.
  Pubmed PMID: 17206495.
• Sun H, Guo S, Chen D, Yang F, Zou Y, Di X, Cao Y, Kosten T, Lu L, Zhang XY. " Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy. " 2012 Jun 14;
  Pubmed PMID: 22695756.
• Brown AE, Pavlik VN, Shegog R, Whitney SN, Friedman LC, Romero C, Davis GC, Cech I, Kosten TR, Volk RJ. " Association of spirituality and sobriety during a behavioral spirituality intervention for Twelve Step (TS) recovery. " Am J Drug Alcohol Abuse. 2007 ; 33 (4) : 611-7.
  Pubmed PMID: 17668347.
• Zhang XY, Chen DC, Xiu MH, Hui L, Liu H, Luo X, Zuo L, Zhang H, Kosten TA, Kosten TR. " Association of functional dopamine-beta-hydroxylase (DBH) 19bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers. " Schizophr. Res.. 2012 Aug 4;
  Pubmed PMID: 22871345.
• Liu H, Wang C, Chen PH, Zhang BS, Zheng YL, Zhang CX, Meng HQ, Wang Y, Chen da C, Xiu MH, Kosten TR, Zhang XY. " Association of the manganese superoxide dismutase gene Ala-9Val polymorphism with clinical phenotypes and tardive dyskinesia in schizophrenic patients. " Prog. Neuropsychopharmacol. Biol. Psychiatry. 2010 May 30; 34 (4) : 692-6.
  Pubmed PMID: 20346996.
• Zhou N, Yu Q, Li X, Yu Y, Kou C, Li W, Xu H, Luo X, Zuo L, Kosten TR, Zhang XY. " Association of the dopamine ß-hydroxylase 19?bp insertion/deletion polymorphism with positive symptoms but not tardive dyskinesia in schizophrenia. " Hum Psychopharmacol. 2013 May ; 28 (3) : 230-7.
  Pubmed PMID: 23559427.
• Sofuoglu M, Poling J, Hill K, Kosten T. " Atomoxetine attenuates dextroamphetamine effects in humans. " Am J Drug Alcohol Abuse. 2009 ; 35 (6) : 412-6.
  Pubmed PMID: 20014909.
• Jacobs SC, Kosten TR, Kasl SV, Ostfeld AM, Berkman l, Charpentier P. " Attachment theory and multiple dimensions of grief. " 1988 ; 41-52.
• Krystal JH, McDougle CJ, Kosten TR, Price LH, Aghajanian GK, Charney DS. " Baclofen-assisted detoxification from opiates. A pilot study. " J Subst Abuse Treat. 1992 ; 9 (2) : 139-42.
  Pubmed PMID: 1324986.
• Zhang XY, Zhou DF, Wu GY, Cao LY, Tan YL, Haile CN, Li J, Lu L, Kosten TA, Kosten TR. " BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia. " Neuropsychopharmacology. 2008 Aug ; 33 (9) : 2200-5.
  Pubmed PMID: 17987059.
• Zhang XY, Chen da C, Xiu MH, Luo X, Zuo L, Haile CN, Kosten TA, Kosten TR. " BDNF Val66Met Variant and Smoking in a Chinese Population. " PLoS ONE. 2012 ; 7 (12) : e53295.
  Pubmed PMID: 23285275.
• Oliveto A, Gentry WB, Pruzinsky R, Gonsai K, Kosten TR, Martell B, Poling J. " Behavioral effects of gamma-hydroxybutyrate in humans. " Behav Pharmacol. 2010 Jul ; 21 (4) : 332-42.
  Pubmed PMID: 20526195.
• Hameedi FA, Rosen MI, McCance-Katz EF, McMahon TJ, Price LH, Jatlow PI, Woods SW, Kosten TR. " Behavioral, physiological, and pharmacological interaction of cocaine and disulfiram in humans. " Biol. Psychiatry. 1995 Apr 15; 37 (8) : 560-3.
  Pubmed PMID: 7619981.
• Kosten TR, Fontana A, Sernyak MJ, Rosenheck R. " Benzodiazepine use in posttraumatic stress disorder among veterans with substance abuse. " J. Nerv. Ment. Dis.. 2000 Jul ; 188 (7) : 454-9.
  Pubmed PMID: 10919705.
• Jacobs SC, Mason JW, Kosten TR, Wahby V, Kasl SV, Ostfeld AM. " Bereavement and catecholamines. " J Psychosom Res. 1986 ; 30 (4) : 489-96.
  Pubmed PMID: 3761233.
• Kosten TR, Morgan C, Kreek MJ. " Beta endorphin levels during heroin, methadone, buprenorphine, and naloxone challenges: preliminary findings. " Biol. Psychiatry. 1992 Sep 15; 32 (6) : 523-8.
  Pubmed PMID: 1445968.
• Kosten TR, Kreek MJ, Swift C, Carney MK, Ferdinands L. " Beta endorphin levels in CSF during methadone maintenance. " Life Sci.. 1987 Aug 31; 41 (9) : 1071-6.
  Pubmed PMID: 2956475.
• Kosten TR, Krystal J. " Biological mechanisms in posttraumatic stress disorder. Relevance for substance abuse. " Recent Dev Alcohol. 1988 ;
  Pubmed PMID: 3283864.
• Zhang XY, Zhang WF, Zhou DF, Chen DC, Xiu MH, Wu HR, Haile CN, Kosten TA, Kosten TR. " Brain-Derived Neurotrophic Factor Levels and Its Val66Met Gene Polymorphism Predict Tardive Dyskinesia Treatment Response to Ginkgo Biloba. " 2012 Jun 11;
  Pubmed PMID: 22695185.
• Wang ZR, Zhou DF, Cao LY, Tan YL, Zhang XY, Li J, Lu L, Wu GY, Kosten TA, Kosten TR. " Brain-derived neurotrophic factor polymorphisms and smoking in schizophrenia. " Schizophr. Res.. 2007 Dec ; 97 (41277) : 299-301.
  Pubmed PMID: 17869486.
• Kosten TR, Kleber HD. " Buprenorphine detoxification from opioid dependence: a pilot study. " Life Sci.. 1988 ; 42 (6) : 635-41.
  Pubmed PMID: 3276999.
• Kosten TR, Rosen MI, Schottenfeld R, Ziedonis D. " Buprenorphine for cocaine and opiate dependence. " Psychopharmacol Bull. 1992 ; 28 (1) : 15-9.
  Pubmed PMID: 1609037.
• Rosenheck R, Kosten T. " Buprenorphine for opiate addiction: potential economic impact. " Drug Alcohol Depend. 2001 Aug 1; 63 (3) : 253-62.
  Pubmed PMID: 11418229.
• Kosten TR, Fiellin DA. " Buprenorphine for office-based practice: consensus conference overview. " Am J Addict. 2004 ; 13 : S1-7.
  Pubmed PMID: 15204671.
• Kosten TR. " Buprenorphine for opioid detoxification: A brief review. " Addictive Disorders & Their Treatment. 2003 ;
• Kosten TR, Morgan CJ, Kleber HD. " Buprenorphine treatment of cocaine abuse. " NIDA Res. Monogr.. 1989 ; 95 : 461.
  Pubmed PMID: 2641031.
• Kosten TR, Schottenfeld R, Ziedonis D, Falcioni J. " Buprenorphine versus methadone maintenance for opioid dependence. " J. Nerv. Ment. Dis.. 1993 Jun ; 181 (6) : 358-64.
  Pubmed PMID: 8501457.
• Schottenfeld RS, Pakes JR, Oliveto A, Ziedonis D, Kosten TR. " Buprenorphine vs methadone maintenance treatment for concurrent opioid dependence and cocaine abuse. " Arch. Gen. Psychiatry. 1997 Aug ; 54 (8) : 713-20.
  Pubmed PMID: 9283506.
• Rosen MI, Kosten TR. " Buprenorphine: beyond methadone? " Hosp Community Psychiatry. 1991 Apr ; 42 (4) : 347-9.
  Pubmed PMID: 2050347.
• Schottenfeld RS, Pakes J, Ziedonis D, Kosten TR. " Buprenorphine: dose-related effects on cocaine and opioid use in cocaine-abusing opioid-dependent humans. " Biol. Psychiatry. ; 34 (41276) : 66-74.
  Pubmed PMID: 8373940.
• Rosen MI, Wallace EA, McMahon TJ, Pearsall HR, Woods SW, Price LH, Kosten TR. " Buprenorphine: duration of blockade of effects of intramuscular hydromorphone. " Drug Alcohol Depend. 1994 Apr ; 35 (2) : 141-9.
  Pubmed PMID: 7519977.
• Kosten TR. " Can cocaine craving be a medication development outcome: drug craving and relapse in opioid and cocaine dependence. " Am J Addictions. 1992 ;
• Kosten TR, Domingo CB. " Can you vaccinate against substance abuse? " Expert Opin Biol Ther. 2013 Aug ;
  Pubmed PMID: 23594123.
• D'Souza DC, Kosten TR. " Cannabinoid antagonists: a treatment in search of an illness. " Arch. Gen. Psychiatry. 2001 Apr ; 58 (4) : 330-1.
  Pubmed PMID: 11296092.
• Rosen MI, Pearsall HR, Price LH, McDougle CJ, Woods SW, Kosten TR. " Carbamazepine vs. oxazepam for benzodiazepine detoxification in methadone maintained patients. " Am J Addictions. 1993 ;
• Gottschalk PC, Kosten TR. " Cerebral perfusion defects in combined cocaine and alcohol dependence. " Drug Alcohol Depend. 2002 Sep 1; 68 (1) : 95-104.
  Pubmed PMID: 12167555.
• West JC, Kosten TR, Wilk J, Svikis D, Triffleman E, Rae DS, Narrow WE, Duffy FF, Regier DA. " Challenges in increasing access to buprenorphine treatment for opiate addiction. " Am J Addict. 2004 ; 13 : S8-16.
  Pubmed PMID: 15204672.
• Avants SK, Margolin A, Kosten TR, Singer JL. " Changes concurrent with initiation of abstinence from cocaine abuse. " J Subst Abuse Treat. ; 10 (6) : 577-83.
  Pubmed PMID: 8308943.
• Carroll KM, Kosten TR, Rounsaville BJ. " Choosing a behavioral therapy platform for pharmacotherapy of substance users. " Drug Alcohol Depend. 2004 Aug 16; 75 (2) : 123-34.
  Pubmed PMID: 15276217.
• McCance-Katz EF, Kosten TR, Jatlow P. " Chronic disulfiram treatment effects on intranasal cocaine administration: initial results. " Biol. Psychiatry. 1998 Apr 1; 43 (7) : 540-3.
  Pubmed PMID: 9547934.
• Kosten TR, Kreek MJ, Ragunath J, Kleber HD. " Chronic naltrexone effect on cortisol. " NIDA Res. Monogr.. 1986 ; 67 : 362-5.
  Pubmed PMID: 3092091.
• Zhang XY, Chen da C, Xiu MH, Haile CN, Sun H, Lu L, Kosten TA, Kosten TR. " Cigarette Smoking and Cognitive Function in Chinese Male Schizophrenia: A Case-Control study. " PLoS ONE. 2012 ; 7 (5) : e36563.
  Pubmed PMID: 22570726.
• Zhang XY, Liang J, Chen da C, Xiu MH, He J, Cheng W, Wu Z, Yang FD, Haile CN, Sun H, Lu L, Kosten TA, Kosten TR. " Cigarette smoking in male patients with chronic schizophrenia in a Chinese population: prevalence and relationship to clinical phenotypes. " PLoS ONE. 2012 ; 7 (2) : e30937.
  Pubmed PMID: 22347412.
• Zhang XY, Chen DC, Xiu MH, Haile CN, He SC, Luo X, Zuo L, Rosenheck R, Kosten TA, Kosten TR. " Cigarette smoking, psychopathology and cognitive function in first-episode drug-naive patients with schizophrenia: a case-control study. " Psychol Med. 2013 ;
  Pubmed PMID: 23149169.
• Li SX, Shi J, Epstein DH, Wang X, Zhang XL, Bao YP, Zhang D, Zhang XY, Kosten TR, Lu L. " Circadian alteration in neurobiology during 30 days of abstinence in heroin users. " Biol. Psychiatry. 2009 May 15; 65 (10) : 905-12.
  Pubmed PMID: 19135652.
• Kosten TR. " Client issues in drug abuse treatment: addressing multiple drug abuse. " NIDA Res. Monogr.. 1991 ; 106 : 136-51.
  Pubmed PMID: 1922284.
• Kosten TR. " Clinical and research perspectives on cocaine abuse: the pharmacotherapy of cocaine abuse. " NIDA Res. Monogr.. 1993 ; 135 : 48-56.
  Pubmed PMID: 8289903.
• Li SX, Liu LJ, Jiang WG, Sun LL, Zhou SJ, Le Foll B, Zhang XY, Kosten TR, Lu L. " Circadian alteration in neurobiology during protracted opiate withdrawal in rats. " J. Neurochem.. 2010 Oct ; 115 (2) : 353-62.
  Pubmed PMID: 20738730.
• Poling J, Pruzinsky R, Kosten TR, Gonsai K, Sofuoglu M, Gonzalez G, Oliveto A. " Clinical efficacy of citalopram alone or augmented with bupropion in methadone-stabilized patients. " Am J Addict. ; 16 (3) : 187-94.
  Pubmed PMID: 17612822.
• González G, Desai R, Sofuoglu M, Poling J, Oliveto A, Gonsai K, Kosten TR. " Clinical efficacy of gabapentin versus tiagabine for reducing cocaine use among cocaine dependent methadone-treated patients. " Drug Alcohol Depend. 2007 Feb 23; 87 (1) : 41283.
  Pubmed PMID: 16930857.
• Mancino MJ, McGaugh J, Chopra MP, Guise JB, Cargile C, Williams DK, Thostenson J, Kosten TR, Sanders N, Oliveto A. " Clinical efficacy of sertraline alone and augmented with gabapentin in recently abstinent cocaine-dependent patients with depressive symptoms. " J Clin Psychopharmacol. 2014 Apr ;
  Pubmed PMID: 24525654.
• Zhang XY, Chen da C, Xiu MH, Tan YL, Yang FD, Zhang LY, Zhang LY, Haile CN, Kosten TR. " Clinical symptoms and cognitive impairment associated with male schizophrenia relate to plasma manganese superoxide dismutase activity: A case-control study. " J Psychiatr Res. 2013 Aug ; 47 (8) : 1049-53.
  Pubmed PMID: 23611682.
• Vining E, Kosten TR, Kleber HD. " Clinical utility of rapid clonidine-naltrexone detoxification for opioid abusers. " Br J Addict. 1988 May ; 83 (5) : 567-75.
  Pubmed PMID: 3382815.
• Kosten TR, Gawin FH, Rounsaville BJ, Kleber HD. " Cocaine abuse among opioid addicts: demographic and diagnostic factors in treatment. " Am J Drug Alcohol Abuse. 1986 ; 12 (41276) : 41290.
  Pubmed PMID: 3788892.
• McCance EF, Price LH, Kosten TR, Jatlow PI. " Cocaethylene: pharmacology, physiology and behavioral effects in humans. " J. Pharmacol. Exp. Ther.. 1995 Jul ; 274 (1) : 215-23.
  Pubmed PMID: 7616402.
• Kleber HD, Riordan CE, Rounsaville B, Kosten T, Charney D, Gaspari J, Hogan I, O'Connor C. " Clonidine in outpatient detoxification from methadone maintenance " Arch Gen Psychiatry. 1985 Apr ;
  Pubmed PMID: 3977557.
• Kleber HD, Topazian M, Gaspari J, Riordan CE, Kosten T. " Clonidine and naltrexone in the outpatient treatment of heroin withdrawal. " Am J Drug Alcohol Abuse. 1987 ;
  Pubmed PMID: 3687878.
• Kosten TA, Kosten TR. " Cocaine abuse and opioid withdrawal. " Lancet. 1989 Jul 15; 2 (8655) : 165-6.
  Pubmed PMID: 2567937.
• Avants SK, Margolin A, Kosten TR. " Cocaine abuse in methadone maintenance programs: integrating pharmacotherapy with psychosocial interventions. " J Psychoactive Drugs. ; 26 (2) : 137-46.
  Pubmed PMID: 7931858.
• Stine SM, Satel S, Kosten TR. " Cocaine precipitation of patient identified opiate withdrawal. " Am J Addictions. 1993 ;
• Kosten TA, Kosten TR, Rounsaville BJ. " Cocaine symptoms are predicted by familial psychopathology. " NIDA Res. Monogr.. 1990 ; 105 : 603-4.
  Pubmed PMID: 1876139.
• Oliveto AH, Kosten TR, Schottenfeld RS, Ziedonis D, Falcioni J. " Cocaine use in buprenorphine vs. methadone maintained cocaine users. " Am J Addictions. 1994 ;
• Martell BA, Orson FM, Poling J, Mitchell E, Rossen RD, Gardner T, Kosten TR. " Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial. " Arch. Gen. Psychiatry. 2009 Oct ; 66 (10) : 1116-23.
  Pubmed PMID: 19805702.
• Sofuoglu M, Poling J, Gonzalez G, Gonsai K, Kosten T. " Cocaine withdrawal symptoms predict medication response in cocaine users. " Am J Drug Alcohol Abuse. 2006 ; 32 (4) : 617-27.
  Pubmed PMID: 17127550.
• Rosen MI, Kosten T. " Cocaine-associated panic attacks in methadone-maintained patients. " Am J Drug Alcohol Abuse. 1992 ;
  Pubmed PMID: 1314016.
• Gottschalk C, Beauvais J, Hart R, Kosten T. " Cognitive function and cerebral perfusion during cocaine abstinence. " Am J Psychiatry. 2001 Apr ;
  Pubmed PMID: 11282686.
• Zhang XY, Chen da C, Xiu MH, Yang FD, Tan Y, Luo X, Zuo L, Kosten TA, Kosten TR. " Cognitive function, plasma MnSOD activity, and MnSOD Ala-9Val polymorphism in patients with schizophrenia and normal controls. " Schizophr Bull. 2014 May ;
  Pubmed PMID: 23588476.
• Zhang XY, Chen da C, Xiu MH, Haile CN, Luo X, Xu K, Zhang HP, Zuo L, Zhang Z, Zhang X, Kosten TA, Kosten TR. " Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls. " Hum. Genet.. 2012 Jul ; 131 (7) : 1187-95.
  Pubmed PMID: 22362486.
• Gonzalez G, Oliveto A, Kosten TR. " Combating opiate dependence: a comparison among the available pharmacological options. " Expert Opin Pharmacother. 2004 Apr ; 5 (4) : 713-25.
  Pubmed PMID: 15102558.
• Kosten TR. " Combining family therapy with pharmacotherapy in opioid addicts: Use of naltrexone. " International Journal of Family Psychiatry. 1986 ;
• Carroll ME, Zlebnik NE, Anker JJ, Kosten TR, Orson FM, Shen X, Kinsey B, Parks RJ, Gao Y, Brimijoin S. " Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion. " PLoS One. 2012 ;
  Pubmed PMID: 22912888.
• Kosten TR. " Commentary: Commitment for substance abuse- Current judicial interventions. " The Journal of the American Academy of Psychi. 2002 ;
• Kosten TR, Price LH. " Commentary on: Phenomenology and sequelae of MDMA use.. " J Nervous Mental Dis. 1992 ;
• Gonzalez G, Feingold A, Oliveto A, Gonsai K, Kosten TR. " Comorbid major depressive disorder as a prognostic factor in cocaine-abusing buprenorphine-maintained patients treated with desipramine and contingency management. " Am J Drug Alcohol Abuse. 2003 Aug ; 29 (3) : 497-514.
  Pubmed PMID: 14510037.
• Kosten TR, Rounsaville BJ, Kleber HD. " Comparison of clinician ratings to self reports of withdrawal during clonidine detoxification of opiate addicts. " Am J Drug Alcohol Abuse. 1985 ; 11 (41276) : 41284.
  Pubmed PMID: 3904410.
• Kosten TR, Jalali B, Kleber HD. " Complementary marital roles of male heroin addicts: evolution and intervention tactics. " Am J Drug Alcohol Abuse. ; 9 (2) : 155-69.
  Pubmed PMID: 7171079.
• McCance-Katz EF, Price LH, McDougle CJ, Kosten TR, Black JE, Jatlow PI. " Concurrent cocaine-ethanol ingestion in humans: pharmacology, physiology, behavior, and the role of cocaethylene. " Psychopharmacology (Berl.). 1993 ; 111 (1) : 39-46.
  Pubmed PMID: 7870932.
• McCance-Katz EF, Kosten TR, Jatlow P. " Concurrent use of cocaine and alcohol is more potent and potentially more toxic than use of either alone--a multiple-dose study. " Biol. Psychiatry. 1998 Aug 15; 44 (4) : 250-9.
  Pubmed PMID: 9715356.
• Kosten TR, Rounsaville BJ, Kleber HD. " Concurrent validity of the addiction severity index. " J. Nerv. Ment. Dis.. 1983 Oct ; 171 (10) : 606-10.
  Pubmed PMID: 6619823.
• Fiellin DA, Kleber H, Trumble-Hejduk JG, McLellan AT, Kosten TR. " Consensus statement on office-based treatment of opioid dependence using buprenorphine. " J Subst Abuse Treat. 2004 Sep ; 27 (2) : 153-9.
  Pubmed PMID: 15450648.
• Petry NM, Petrakis I, Trevisan L, Wiredu G, Boutros NN, Martin B, Kosten TR. " Contingency management interventions: from research to practice. " Am J Psychiatry. 2001 May ; 158 (5) : 694-702.
  Pubmed PMID: 11329388.
• Fiellin DA, Rosenheck RA, Kosten TR. " Coordination of medical care and opioid dependence treatment in primary care: a case report. " Subst Abus. 2003 Mar ;
  Pubmed PMID: 12652094.
• Boutros NN, Lisanby SH, McClain-Furmanski D, Oliwa G, Gooding D, Kosten TR. " Cortical excitability in cocaine-dependent patients: a replication and extension of TMS findings. " J Psychiatr Res. 2005 May ; 39 (3) : 295-302.
  Pubmed PMID: 15725428.
• Kosten TR, Kreek MJ, Ragunath J, Kleber HD. " Cortisol levels during chronic naltrexone maintenance treatment in ex-opiate addicts. " Biol. Psychiatry. 1986 Feb ; 21 (2) : 217-20.
  Pubmed PMID: 3947698.
• Margolin A, Avants SK, Kosten TR. " Cue-elicited cocaine craving and autogenic relaxation. Association with treatment outcome. " J Subst Abuse Treat. ; 11 (6) : 549-52.
  Pubmed PMID: 7884838.
• Kosten TR, Scanley BE, Tucker KA, Oliveto A, Prince C, Sinha R, Potenza MN, Skudlarski P, Wexler BE. " Cue-induced brain activity changes and relapse in cocaine-dependent patients. " Neuropsychopharmacology. 2006 Mar ; 31 (3) : 644-50.
  Pubmed PMID: 16123763.
• Kosten TR, Scanley BE, Tucker K, Oliveto A, Prince C, Sinha R, Potenza MN, Skudlarski P, Wexler BE. " Cue-induced brain activity changes and treatment outcome in depressed cocaine dependent patients. " Neuropsychopharmacology. 2006 ;
• Gottschalk PC, Jacobsen LK, Kosten TR. " Current concepts in pharmacotherapy of substance abuse. " Curr Psychiatry Rep. 1999 Dec ; 1 (2) : 172-8.
  Pubmed PMID: 11122921.
• Gottchalk PCH, Jacobsen LK, Kosten TR. " Current concepts in pharmacotherapy of substance abuse-the dawn of a new era. " Current Psychiatry Reports. 1999 ;
• Kosten TR, O’Connor PG. " Current concepts-management of drug withdrawal. " New England Journal of Medicine. 2003 ;
• Kosten TR. " Current pharmacotherapies for opioid dependence " Psychopharmacol Bull. 1990 ;
  Pubmed PMID: 2196628.
• Oliveto A, Benios T, Gonsai K, Feingold A, Poling J, Kosten TR. " D-cycloserine-Naloxone interactions in opioid-dependent humans under a novel-response naloxone discrimination procedure. " Exp Clin Psychopharmacol. 2003 Aug ; 11 (3) : 237-46.
  Pubmed PMID: 12940503.
• Avants SK, Margolin A, Sindelar JL, Rounsaville BJ, Schottenfeld R, Stine S, Cooney NL, Rosenheck RA, Li SH, Kosten TR. " Day treatment versus enhanced standard methadone services for opioid-dependent patients: a comparison of clinical efficacy and cost. " Am J Psychiatry. 1999 Jan ;
  Pubmed PMID: 9892294.
• Kosten TR, Domingo CB, Hamon SC, Nielsen DA. " DBH gene as predictor of response in a cocaine vaccine clinical trial. " Neurosci. Lett.. 2013 Apr 29; 541 : 29-33.
  Pubmed PMID: 23458673.
• Silverman DG, Kosten TR, Jatlow PI, Gutter V, Fleming J, O'Connor TZ, Byck R. " Decreased digital flow persists after the abatement of cocaine-induced hemodynamic stimulation. " Anesth. Analg.. 1997 Jan ; 84 (1) : 46-50.
  Pubmed PMID: 8988997.
• Chen da C, Wang J, Wang B, Yang SC, Zhang CX, Zheng YL, Li YL, Wang N, Yang KB, Xiu MH, Kosten TR, Zhang XY. " Decreased levels of serum brain-derived neurotrophic factor in drug-naïve first-episode schizophrenia: relationship to clinical phenotypes. " Psychopharmacology (Berl.). 2009 Dec ; 207 (3) : 375-80.
  Pubmed PMID: 19787338.
• Yang YQ, Sun S, Yu YQ, Li WJ, Zhang X, Xiu MH, Chen da C, Yang FD, Liu H, Li C, Kosten TR, Zhang XY. " Decreased serum brain-derived neurotrophic factor levels in schizophrenic patients with tardive dyskinesia. " Neurosci. Lett.. 2011 Sep 8; 502 (1) : 37-40.
  Pubmed PMID: 21798311.
• Xiu MH, Hui L, Dang YF, Hou TD, Zhang CX, Zheng YL, Chen da C, Kosten TR, Zhang XY. " Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics. " Prog. Neuropsychopharmacol. Biol. Psychiatry. 2009 Nov 13; 33 (8) : 1508-12.
  Pubmed PMID: 19720106.
• Kosten TR, Markou A, Koob GF. " Depression and stimulant dependence: neurobiology and pharmacotherapy. " J. Nerv. Ment. Dis.. 1998 Dec ; 186 (12) : 737-45.
  Pubmed PMID: 9865811.
• Kosten T, Falcioni J, Oliveto A, Feingold A. " Depression predicts higher rates of heroin use on desipramine with buprenorphine than with methadone. " Am J Addict. 2004 Mar ;
  Pubmed PMID: 15204669.
• Ziedonis DM, Kosten TR. " Depression as a prognostic factor for pharmacological treatment of cocaine dependence. " Psychopharmacol Bull. 1991 ; 27 (3) : 337-43.
  Pubmed PMID: 1775608.
• Kosten TR, Morgan C, Kosten TA. " Depressive symptoms during buprenorphine treatment of opioid abusers. " J Subst Abuse Treat. 1990 ; 7 (1) : 51-4.
  Pubmed PMID: 2313769.
• Jacobs S, Kosten TR. " Depressive syndromes during acute bereavement: Indications for professional intervention. " Yale Psychiatric Quarterly. 1983 ;
• Satel SL, Kosten TR. " Designing drug efficacy trials in the treatment of cocaine abuse. " J Nerv Ment Dis. 1991 Feb ;
  Pubmed PMID: 1990076.
• Kosten TR, Gawin FH, Morgan C, Nelson JC, Jatlow P. " Desipramine and its 2-hydroxy metabolite in patients taking or not taking methadone. " Am J Psychiatry. 1990 Oct ; 147 (10) : 1379-80.
  Pubmed PMID: 2400009.
• Kosten T, Oliveto A, Feingold A, Poling J, Sevarino K, McCance-Katz E, Stine S, Gonzalez G, Gonsai K. " Desipramine and contingency management for cocaine and opiate dependence in buprenorphine maintained patients " Drug Alcohol Depend. 2003 Jun ;
  Pubmed PMID: 12757969.
• Gawin FH, Kleber HD, Byck R, Rounsaville BJ, Kosten TR, Jatlow PI, Morgan C. " Desipramine facilitation of initial cocaine abstinence. " Arch. Gen. Psychiatry. 1989 Feb ; 46 (2) : 117-21.
  Pubmed PMID: 2492422.
• Oliveto AH, Feingold A, Schottenfeld R, Jatlow P, Kosten TR. " Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone. " Arch. Gen. Psychiatry. 1999 Sep ; 56 (9) : 812-20.
  Pubmed PMID: 12884887.
• Kosten T, Sofuoglu M, Poling J, Gonsai K, Oliveto A. " Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response. " Am J Addict. ; 14 (1) : 41503.
  Pubmed PMID: 15804873.
• Oliveto A, Kosten TR, Schottenfeld R, Falcioni J, Ziedonis D. " Desipramine, amantadine, or fluoxetine in buprenorphine-maintained cocaine users. " J Subst Abuse Treat. ; 12 (6) : 423-8.
  Pubmed PMID: 8749726.
• Han M, Huang XF, Chen da C, Xiu M, Kosten TR, Zhang XY. " Diabetes and cognitive deficits in chronic schizophrenia: a case-control study " PLoS One. 2013 Jun ;
  Pubmed PMID: 23840437.
• Kosten TR. " Diagnosing depression with the DST and TRH in cocaine and opioid abusers. " J Subst Abuse Treat. 1986 ; 3 (1) : 47-9.
  Pubmed PMID: 3090273.
• Avants SK, Margolin A, Kosten TR, Cooney NL. " Differences between responders and nonresponders to cocaine cues in the laboratory. " Addict Behav. ; 20 (2) : 215-24.
  Pubmed PMID: 7484315.
• Cui Y, Robinson JD, Versace F, Lam CY, Minnix JA, Karam-Hage M, Dani JA, Kosten TR, Wetter DW, Brown VL, Cinciripini PM. " Differential cigarette-related startle cue reactivity among light, moderate, and heavy smokers. " Addict Behav. 2012 Aug ; 37 (8) : 885-9.
  Pubmed PMID: 22571920.
• Kosten TR, Kleber HD. " Differential diagnosis of psychiatric comorbidity in substance abusers. " J Subst Abuse Treat. 1988 ; 5 (4) : 201-6.
  Pubmed PMID: 3216436.
• Oliveto AH, Rosen MI, Woods SW, Kosten TR. " Discriminative stimulus, self-reported and cardiovascular effects of orally administered cocaine in humans. " J Pharmacol Exp Ther. 1995 Jan ;
  Pubmed PMID: 7815337.
• Zhang XY, Tan YL, Zhou DF, Cao LY, Wu GY, Haile CN, Kosten TA, Kosten TR. " Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenic patients with tardive dyskinesia. " J Clin Psychiatry. 2007 May ; 68 (5) : 754-60.
  Pubmed PMID: 17503985.
• McCance-Katz EF, Kosten TR, Jatlow P. " Disulfiram effects on acute cocaine administration. " Drug Alcohol Depend. 1998 Sep 1; 52 (1) : 27-39.
  Pubmed PMID: 9788003.
• Sofuoglu M, Poling J, Waters A, Sewell A, Hill K, Kosten T. " Disulfiram enhances subjective effects of dextroamphetamine in humans. " Pharmacol Biochem Behav. 2008 Sep ;
  Pubmed PMID: 18474395.
• Haile CN, During MJ, Jatlow PI, Kosten TR, Kosten TA. " Disulfiram facilitates the development and expression of locomotor sensitization to cocaine in rats. " Biol. Psychiatry. 2003 Nov 1; 54 (9) : 915-21.
  Pubmed PMID: 14573319.
• George TP, Chawarski MC, Pakes J, Carroll KM, Kosten TR, Schottenfeld RS. " Disulfiram versus placebo for cocaine dependence in buprenorphine-maintained subjects: a preliminary trial. " Biol. Psychiatry. 2000 Jun 15; 47 (12) : 1080-6.
  Pubmed PMID: 10862808.
• Ren ZY, Zhang XL, Liu Y, Zhao LY, Shi J, Bao Y, Zhang XY, Kosten TR, Lu L. " Diurnal variation in cue-induced responses among protracted abstinent heroin users. " Pharmacol. Biochem. Behav.. 2009 Jan ; 91 (3) : 468-72.
  Pubmed PMID: 18809427.
• McDougle CJ, Price LH, Palumbo JM, Kosten TR, Heninger GR, Kleber HD. " Dopaminergic responsivity during cocaine abstinence: a pilot study. " Psychiatry Res. 1992 Jul ; 43 (1) : 77-85.
  Pubmed PMID: 1359594.
• Gawin FH, Morgan C, Kosten TR, Kleber HD. " Double-blind evaluation of the effect of acute amantadine on cocaine craving. " Psychopharmacology (Berl.). 1989 ; 97 (3) : 402-3.
  Pubmed PMID: 2497490.
• Singh RA, Kosten TA, Kinsey BM, Shen X, Lopez AY, Kosten TR, Orson FM. " Dose-dependent changes in the locomotor responses to methamphetamine in BALB/c mice: low doses induce hypolocomotion. " Pharmacol Biochem Behav. 2012 Dec ;
  Pubmed PMID: 23010423.
• Hameedi FA, Woods SW, Rosen MI, Pearsall HR, Kosten TR. " Dose dependent effects of yohimbine on methadone maintained patients. " Am J Drug Alcohol Abuse. 1997 May ; 23 (2) : 327-33.
  Pubmed PMID: 9143642.
• Stitzer ML, Polk T, Bowles S, Kosten T. " Drug users' adherence to a 6-month vaccination protocol: effects of motivational incentives. " Drug Alcohol Depend. 2010 Feb 1; 107 (1) : 76-9.
  Pubmed PMID: 19828264.
• Kosten TR, Rounsaville BJ, Kleber HD. " DSM-III personality disorders in opiate addicts. " Compr Psychiatry. ; 23 (6) : 572-81.
  Pubmed PMID: 7160176.
• Gardner T, Kosten T. " Dual dependency on cocaine and alcohol in opiate addicts: treatment options. " J Clin Psychiatry. 2007 ;
  Pubmed PMID: 17685754.
• Stine SM, Krystal JH, Petrakis IL, Jatlow PI, Heninger GR, Kosten TR, Charney DS. " Effect of alpha-methyl-para-tyrosine on response to cocaine challenge. " Biol. Psychiatry. 1997 Aug 1; 42 (3) : 181-90.
  Pubmed PMID: 9232210.
• Rosen MI, McMahon TJ, Hameedi FA, Pearsall HR, Woods SW, Kreek MJ, Kosten TR. " Effect of clonidine pretreatment on naloxone-precipitated opiate withdrawal. " J. Pharmacol. Exp. Ther.. 1996 Mar ; 276 (3) : 1128-35.
  Pubmed PMID: 8786543.
• Rosen MI, Pearsall HR, McDougle CJ, Price LH, Woods SW, Kosten TR. " Effects of acute buprenorphine on responses to intranasal cocaine: a pilot study " Am J Drug Alcohol Abuse. 1993 ;
  Pubmed PMID: 8273766.
• Oliveto AH, Farren C, Kosten TR. " Effect of LAAM dose on opiate use in opioid-dependent patients. A pilot study. " Am J Addict. 1998 ; 7 (4) : 272-82.
  Pubmed PMID: 9809131.
• McCance-Katz EF, Rainey PM, Friedland G, Kosten TR, Jatlow P. " Effect of opioid dependence pharmacotherapies on zidovudine disposition. " Am J Addict. 2001 ; 10 (4) : 296-307.
  Pubmed PMID: 11783744.
• Shi J, Jun W, Zhao LY, Xue YX, Zhang XY, Kosten TR, Lu L. " Effect of rapamycin on cue-induced drug craving in abstinent heroin addicts. " Eur. J. Pharmacol.. 2009 Aug 1; 615 (41277) : 108-12.
  Pubmed PMID: 19470385.
• Gao Y, Geng L, Orson F, Kinsey B, Kosten TR, Shen X, Brimijoin S. " Effects of anti-cocaine vaccine and viral gene transfer of cocaine hydrolase in mice on cocaine toxicity including motor strength and liver damage. " Chem. Biol. Interact.. 2013 Mar 25; 203 (1) : 208-11.
  Pubmed PMID: 22935511.
• Oliveto A, McCance-Katz FE, Singha A, Petrakis I, Hameedi F, Kosten TR. " Effects of cocaine prior to and during bupropion maintenance in cocaine-abusing volunteers. " Drug Alcohol Depend. 2001 Jul 1; 63 (2) : 155-67.
  Pubmed PMID: 11376920.
• Oliveto AH, McCance-Katz E, Singha A, Hameedi F, Kosten TR. " Effects of d-amphetamine and caffeine in humans under a cocaine discrimination procedure. " Behav Pharmacol. 1998 May ; 9 (3) : 207-17.
  Pubmed PMID: 9832935.
• Rosen MI, Pearsall HR, Woods SW, Kosten TR. " Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients. " J Subst Abuse Treat. ; 14 (2) : 149-54.
  Pubmed PMID: 9258859.
• Sinha R, Kimmerling A, Doebrick C, Kosten TR. " Effects of lofexidine on stress-induced and cue-induced opioid craving and opioid abstinence rates: preliminary findings. " Psychopharmacology (Berl.). 2007 Mar ; 190 (4) : 569-74.
  Pubmed PMID: 17136399.
• Winther LC, Saleem R, McCance-Katz EF, Rosen MI, Hameedi FA, Pearsall HR, Jatlow PI, Kosten TR, Woods SW. " Effects of lamotrigine on behavioral and cardiovascular responses to cocaine in human subjects. " Am J Drug Alcohol Abuse. 2000 Feb ;
  Pubmed PMID: 10718163.
• Sofuoglu M, Singha A, Kosten TR, McCance-Katz FE, Petrakis I, Oliveto A. " Effects of naltrexone and isradipine, alone or in combination, on cocaine responses in humans. " Pharmacol. Biochem. Behav.. 2003 Jul ; 75 (4) : 801-8.
  Pubmed PMID: 12957222.
• Sofuoglu M, Mitchell E, Kosten TR. " Effects of progesterone treatment on cocaine responses in male and female cocaine users. " Pharmacol. Biochem. Behav.. 2004 Aug ; 78 (4) : 699-705.
  Pubmed PMID: 15301924.
• Kosten TR, Rayford BS. " Effects of ethnicity on low-dose opiate stabilization. " J Subst Abuse Treat. ; 12 (2) : 111-6.
  Pubmed PMID: 7623388.
• Kosten T, Poling J, Oliveto A. " Effects of reducing contingency management values on heroin and cocaine use for buprenorphine- and desipramine-treated patients. " Addiction. 2003 May ;
  Pubmed PMID: 12751984.
• Zhang XY, Zhou DF, Shen YC, Zhang PY, Zhang WF, Liang J, Chen da C, Xiu MH, Kosten TA, Kosten TR. " Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia. " Neuropharmacology. 2012 Apr ; 62 (41400) : 1928-34.
  Pubmed PMID: 22227558.
• Margolin A, Chang P, Avants SK, Kosten TR. " Effects of sham and real auricular needling: implications for trials of acupuncture for cocaine addiction. " Am. J. Chin. Med.. 1993 ; 21 (2) : 103-11.
  Pubmed PMID: 8237887.
• George TP, Vessicchio JC, Termine A, Sahady DM, Head CA, Pepper WT, Kosten TR, Wexler BE. " Effects of smoking abstinence on visuospatial working memory function in schizophrenia. " Neuropsychopharmacology. 2002 Jan ; 26 (1) : 75-85.
  Pubmed PMID: 11751034.
• Sofuoglu M, Mouratidis M, Yoo S, Culligan K, Kosten T. " Effects of tiagabine in combination with intravenous nicotine in overnight abstinent smokers. " Psychopharmacology (Berl.). 2005 Sep ; 181 (3) : 504-10.
  Pubmed PMID: 15983800.
• Sofuoglu M, Poling J, Mouratidis M, Kosten T. " Effects of topiramate in combination with intravenous nicotine in overnight abstinent smokers. " Psychopharmacology (Berl.). 2006 Mar ; 184 (41337) : 645-51.
  Pubmed PMID: 16432681.
• Oliveto A, Poling J, Sevarino KA, Gonsai KR, McCance-Katz EF, Stine SM, Kosten TR. " Efficacy of dose and contingency management procedures in LAAM-maintained cocaine-dependent patients. " Drug Alcohol Depend. 2005 Aug 1; 79 (2) : 157-65.
  Pubmed PMID: 16002025.
• Castells X, Kosten TR, Capellà D, Vidal X, Colom J, Casas M. " Efficacy of opiate maintenance therapy and adjunctive interventions for opioid dependence with comorbid cocaine use disorders: a systematic review and meta-analysis of controlled clinical trials. " Am J Drug Alcohol Abuse. 2009 ; 35 (5) : 339-49.
  Pubmed PMID: 20180662.
• Jacobsen LK, Staley JK, Malison RT, Zoghbi SS, Seibyl JP, Kosten TR, Innis RB. " Elevated central serotonin transporter binding availability in acutely abstinent cocaine-dependent patients. " Am J Psychiatry. 2000 Jul ; 157 (7) : 1134-40.
  Pubmed PMID: 10873923.
• Xiu MH, Chen DC, Wang D, Zhang K, Dong A, Tang W, Zhang F, Liu LJ, Liu JH, Liu HB, Yang FD, Kosten TR, Zhang XY. " Elevated interleukin-18 serum levels in chronic schizophrenia: Association with psychopathology. " 2012 May 28;
  Pubmed PMID: 22647522.
• Wu Z, Zhang XY, Wang H, Tang W, Xia Y, Zhang F, Liu J, Fu Y, Hu J, Chen Y, Liu L, Chen da C, Xiu MH, Kosten TR, He J. " Elevated plasma superoxide dismutase in first-episode and drug naive patients with schizophrenia: inverse association with positive symptoms. " Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jan ;
  Pubmed PMID: 21896300.
• Chen da C, Qi LY, Xiu MH, Cao LY, Wang F, Chen S, Wu GY, Kosten TA, Kosten TR, Zhang XY. " Elevated serum levels of tumor necrosis factor-alpha in clozapine-associated obesity in chronic schizophrenia. " Schizophr. Res.. 2008 Dec ; 106 (41308) : 367-8.
  Pubmed PMID: 18835132.
• Malison RT, Best SE, van Dyck CH, McCance EF, Wallace EA, Laruelle M, Baldwin RM, Seibyl JP, Price LH, Kosten TR, Innis RB. " Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT. " Am J Psychiatry. 1998 Jun ; 155 (6) : 832-4.
  Pubmed PMID: 9619159.
• Mason JW, Giller EL, Kosten TR, Harkness L. " Elevation of urinary norepinephrine/cortisol ratio in posttraumatic stress disorder. " J. Nerv. Ment. Dis.. 1988 Aug ; 176 (8) : 498-502.
  Pubmed PMID: 3404142.
• Sofuoglu M, Kosten TR. " Emerging pharmacological strategies in the fight against cocaine addiction. " Expert Opin Emerg Drugs. 2006 Mar ; 11 (1) : 91-8.
  Pubmed PMID: 16503828.
• Sun HQ, Chen HM, Yang FD, Lu L, Kosten TR. " Epidemiological trends and the advances of treatments of amphetamine-type stimulants (ATS) in China. " Am J Addict. 2014 May ;
  Pubmed PMID: 24724890.
• Nielsen DA, Utrankar A, Reyes JA, Simons DD, Kosten TR. " Epigenetics of drug abuse: predisposition or response. " Pharmacogenomics. 2012 Jul ; 13 (10) : 1149-60.
  Pubmed PMID: 22909205.
• Kosten TR, Rounsaville BJ, Kleber HD. " Ethnic and gender differences among opiate addicts. " Int J Addict. 1985 Aug ; 20 (8) : 1143-62.
  Pubmed PMID: 4077316.
• Malison RT, Best SE, Wallace EA, McCance E, Laruelle M, Zoghbi SS, Baldwin RM, Seibyl JS, Hoffer PB, Price LH. " Euphorigenic doses of cocaine reduce [123I]beta-CIT SPECT measures of dopamine transporter availability in human cocaine addicts. " Psychopharmacology. 1995 Dec ;
  Pubmed PMID: 8657833.
• Kosten TR, Gawin FH, Morgan C, Nelson JC, Jatlow P. " Evidence for altered desipramine disposition in methadone-maintained patients treated for cocaine abuse. " Am J Drug Alcohol Abuse. 1990 ; 16 (41337) : 329-36.
  Pubmed PMID: 2288330.
• Lingford-Hughes AR, Welch S, Nutt DJ; British Association for Psychopharmacology. " Evidence-based guidelines for the pharmacological management of substance misuse, addiction and comorbidity: recommendations from the British Association for Psychopharmacology. " J Psychopharmacol. 2004 Sep ;
  Pubmed PMID: 15358975.
• An HM, Tan YL, Shi J, Wang ZR, Li J, Wang YC, Kosten TR, Zhou DF, Yang FD, Zhang XY. " Extract of Ginkgo biloba is equivalent to vitamin E in attenuating and preventing vacuous chewing movements in a rat model of tardive dyskinesia. " Behav Pharmacol. 2013 Aug ;
  Pubmed PMID: 23994817.
• Browndyke JN, Tucker KA, Woods SP, Beauvals J, Cohen RA, Gottschalk PC, Kosten TR. " Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers. " J Neuroimaging. 2004 Apr ;
  Pubmed PMID: 23994817.
• Sun HQ, Guo S, Chen DF, Jiang ZN, Liu Y, Di XL, Yang FD, Zhang XY, Kosten TR, Lu L. " Family support and employment as predictors of smoking cessation success: a randomized, double-blind, placebo-controlled trial of nicotine sublingual tablets in Chinese smokers. " Am J Drug Alcohol Abuse. 2009 ; 35 (3) : 183-8.
  Pubmed PMID: 19462302.
• Kosten TR, Jalali B, Hogan I, Kleber HD. " Family denial as a prognostic factor in opiate addict treatment outcome. " J. Nerv. Ment. Dis.. 1983 Oct ; 171 (10) : 611-6.
  Pubmed PMID: 6619824.
• Petrakis I, Carroll KM, Nich C, Gordon L, Kosten T, Rounsaville B. " Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts. " Drug Alcohol Depend. 1998 May ;
  Pubmed PMID: 9649975.
• Kosten TR. " For Council on Addictions of American Psychiatry Association. Policy—statement on methadone maintenance treatment.. " Am J Psychiatry. 1994 ;
• Wu JQ, Kosten TR, Zhang XY. " Free radicals, antioxidant defense systems, and schizophrenia " Prog Neuropsychopharmacol Biol Psychiatry. 2013 Oct ;
  Pubmed PMID: 23470289.
• Kosten TA, Gawin FH, Kosten TR, Rounsaville BJ. " Gender differences in cocaine use and treatment response. " J Subst Abuse Treat. ; 10 (1) : 63-6.
  Pubmed PMID: 8450576.
• Han M, Huang XF, Chen DC, Xiu MH, Hui L, Liu H, Kosten TR, Zhang XY. " Gender differences in cognitive function of patients with chronic schizophrenia. " Prog. Neuropsychopharmacol. Biol. Psychiatry. 2012 Jul 20;
  Pubmed PMID: 22820676.
• Kosten TR. " Future of anti-addiction vaccines. " Stud Health Technol Inform. 2005 ; 118 : 177-85.
  Pubmed PMID: 16301778.
• He J, Xie Y, Tao J, Su H, Wu W, Zou S, Zhang J, Zhang J, Zhang H, Yang X, Guo J, Tang W, Zhang F, Liu J, Liu L, Chen Y, Wen N, Kosten TR, Zhang XY. " Gender differences in socio-demographic and clinical characteristics of methamphetamine inpatients in a Chinese population. " Drug Alcohol Depend. 2013 Jun 1; 130 (41277) : 94-100.
  Pubmed PMID: 23149112.
• Zhang XY, Chen da C, Xiu MH, Yang FD, Haile CN, Kosten TA, Kosten TR. " Gender differences in never-medicated first-episode schizophrenia and medicated chronic schizophrenia patients. " J Clin Psychiatry. 2012 Aug ; 73 (7) : 1025-33.
  Pubmed PMID: 22901352.
• Kosten TR, Kosten TA, McDougle CJ, Hameedi FA, McCance EF, Rosen MI, Oliveto AH, Price LH. " Gender differences in response to intranasal cocaine administration to humans. " Biol. Psychiatry. 1996 Jan 15; 39 (2) : 147-8.
  Pubmed PMID: 8717615.
• Chen da C, Zhou MA, Zhou DH, Xiu MH, Wu GY, Kosten TR, Zhang XY. " Gender differences in the prevalence of diabetes mellitus in chronic hospitalized patients with schizophrenia on long-term antipsychotics. " Psychiatry Res. 2011 Apr 30; 186 (41308) : 451-3.
  Pubmed PMID: 20797801.
• Zhang XY, Chen da C, Qi LY, Wang F, Xiu MH, Chen S, Wu GY, Kosten TA, Kosten TR. " Gender differences in the prevalence, risk and clinical correlates of tardive dyskinesia in Chinese schizophrenia. " Psychopharmacology (Berl.). 2009 Sep ; 205 (4) : 647-54.
  Pubmed PMID: 19529921.
• Haile CN, Kosten TR, Kosten TA. " Genetics of dopamine and its contribution to cocaine addiction. " Behav. Genet.. 2007 Jan ; 37 (1) : 119-45.
  Pubmed PMID: 17063402.
• Kosten TR, Rounsaville BJ, Kosten TA, Merikangas K. " Gender differences in the specificity of alcoholism transmission among the relatives of opioid addicts. " J. Nerv. Ment. Dis.. 1991 Jul ; 179 (7) : 392-400.
  Pubmed PMID: 1869867.
• Tucker KA, Browndyke JN, Gottschalk PC, Cofrancesco AT, Kosten TR. " Gender-specific vulnerability for rCBF abnormalities among cocaine abusers. " Neuroreport. 2004 Apr 9; 15 (5) : 797-801.
  Pubmed PMID: 15073517.
• McCance-Katz EF, Hart CL, Boyarsky B, Kosten T, Jatlow P. " Gender effects following repeated administration of cocaine and alcohol in humans " Subst Use Misuse. 2005 ;
  Pubmed PMID: 15830733.
• McCance-Katz EF, Kosten TA, Kosten TR. " Going from the bedside back to the bench with ecopipam: a new strategy for cocaine pharmacotherapy development. " Psychopharmacology (Berl.). 2001 Jun ; 155 (4) : 327-9.
  Pubmed PMID: 11441421.
• Manji H, Chen G, Potter W, Kosten TR. " Guanine nucleotide binding proteins in opioid-dependent patients. " Biol. Psychiatry. 1997 Jan 15; 41 (2) : 130-4.
  Pubmed PMID: 9018382.
• Margolin A, Avants SK, Malison RT, Kosten TR. " High-and low-dose mazindol for cocaine dependence in methadone-maintained patients: A preliminary evaluation. " Substance Abuse. 1997 ;
• Meandzija B, O'Connor PG, Fitzgerald B, Rounsaville BJ, Kosten TR. " HIV infection and cocaine use in methadone maintained and untreated intravenous drug users. " Drug Alcohol Depend. 1994 Oct ; 36 (2) : 109-13.
  Pubmed PMID: 7851277.
• Oliveto AH, Rosen MI, Kosten TA, Hameedi FA, Woods SW, Kosten TR. " Hydromorphone-naloxone combinations in opioid-dependent humans under a naloxone novel-response discrimination procedure. " Exp Clin Psychopharmacol. 1998 May ; 6 (2) : 169-78.
  Pubmed PMID: 9608349.
• Gardner TJ, Kosten TR. " Human laboratory and neuroimaging studies in substance use disorders: developing new treatment approaches. " Am J Drug Alcohol Abuse. 2007 ; 33 (6) : 765-7.
  Pubmed PMID: 17994472.
• 66. O’Connor PG, Meandzija B, Poling J, Kosten TR, Fitzgerald B, Rounsaville BJ. " HIV vaccine preparedness trials in injection-drug users: Are we prepared?. " Substance Abuse. 1995 ;
• Kosten TR, Rosen M, Bond J, Settles M, Roberts JS, Shields J, Jack L, Fox B. " Human therapeutic cocaine vaccine: safety and immunogenicity. " Vaccine. 2002 Jan 15; 20 (41463) : 1196-204.
  Pubmed PMID: 11803082.
• Kosten TR. " Images in psychiatry. Marie Nyswander, 1919-1986. " Am J Psychiatry. 1998 Dec ; 155 (12) : 1766.
  Pubmed PMID: 9842790.
• Kosten TR. " Images in Psychiatry: Abraham Winkler, MD: 1910-1981. " American Journal of Psychiatry. 1998 ;
• Shen X, Kosten TR. " Immunotherapy for drug abuse. " CNS Neurol Disord Drug Targets. 2011 Dec 1; 10 (8) : 876-9.
  Pubmed PMID: 22229313.
• Kosten T, Owens SM. " Immunotherapy for the treatment of drug abuse. " Pharmacol. Ther.. 2005 Oct ; 108 (1) : 76-85.
  Pubmed PMID: 16023218.
• Najavits LM, Norman SB, Kivlahan D, Kosten TR. " Improving PTSD/Substance Abuse Treatment in the VA: A Survey of Providers. " Am J Addict. 2010 May ; 19 (3) : 257-63.
  Pubmed PMID: 20525033.
• Carroll KM, Chang G, Behr H, Clinton B, Kosten TR. " Improving treatment outcome in pregnant methadone maintained women; Results from a randomized clinical trial. " Am J Addictions. 1995 ;
• Chang G, Carroll KM, Behr HM, Kosten TR. " Improving treatment outcome in pregnant opiate-dependent women. " J Subst Abuse Treat. 1992 ; 9 (4) : 327-30.
  Pubmed PMID: 1479630.
• Zhang XY, Xiu MH, Chen da C, Zhu FY, Wu GY, Haile CN, Lu L, Kosten TA, Kosten TR. " Increased S100B serum levels in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements. " J Psychiatr Res. 2010 May ; 44 (7) : 429-33.
  Pubmed PMID: 19932492.
• Zhang XY, Xiu MH, Song C, Chen da C, Wu GY, Haile CN, Kosten TA, Kosten TR. " Increased serum S100B in never-medicated and medicated schizophrenic patients. " J Psychiatr Res. 2010 Dec ;
  Pubmed PMID: 20510426.
• Singha AK, McCance-Katz EF, Heck SA, Kosten TR, Oliveto A. " Individual differences in humans responding under a cocaine discrimination procedure: discriminators versus nondiscriminators. " Exp Clin Psychopharmacol. 1999 Nov ; 7 (4) : 391-8.
  Pubmed PMID: 10609974.
• Qi LY, Xiu MH, Chen da C, Wang F, Kosten TA, Kosten TR, Zhang XY. " Increased serum S100B levels in chronic schizophrenic patients on long-term clozapine or typical antipsychotics. " Neurosci. Lett.. 2009 Sep 22; 462 (2) : 113-7.
  Pubmed PMID: 19539717.
• Avants SK, Margolin A, Kosten TR. " Influence of treatment readiness on outcomes of two pharmacotherapy trials for cocaine abuse among methadone-maintained patients. " Psychology Addictive Behaviors. 1996 ;
• Kosten TR, Rounsaville BJ, Foley SH. " Inpatient vs. outpatient cocaine abuse treatments. " NIDA Res. Monogr.. 1989 ; 95 : 312-3.
  Pubmed PMID: 2640976.
• Rosenheck R, Harkness L, Johnson B, Sweeney C, Buck N, Deegan D, Kosten T. " Intensive community-focused treatment of veterans with dual diagnoses. " Am J Psychiatry. 1998 Oct ;
  Pubmed PMID: 9766776.
• Kosten TR, Woods SW, Rosen MI, Pearsall HR. " Interactions of cocaine with nimodipine: a brief report. " Am J Addict. 1999 ; 8 (1) : 77-81.
  Pubmed PMID: 10189518.
• Zhang XY, Tang W, Xiu MH, Chen da C, Yang FD, Tan YL, Wang ZR, Zhang F, Liu J, Liu L, Chen Y, Wen N, Kosten TR. " Interleukin 18 and cognitive impairment in first episode and drug naïve schizophrenia versus healthy controls. " Brain Behav. Immun.. 2013 Aug ; 32 : 105-11.
  Pubmed PMID: 23499732.
• 72. Kosten T, Gawin FH, Silverman DG, Fleming J, Compton M, Jatlow P, Byck R. " Intravenous cocaine challenges during desipramine maintenance " Neuropsychopharmacology. 1992 Nov ;
  Pubmed PMID: 1388643.
• Oliveto A, Poling J, Kosten TR, Gonsai K. " Isradipine and dextromethorphan in methadone-maintained humans under a naloxone discrimination procedure. " Eur. J. Pharmacol.. 2004 May 3; 491 (41308) : 157-68.
  Pubmed PMID: 15140632.
• Kosten T, Silverman DG, Fleming J, Kosten TA, Gawin FH, Compton M, Jatlow P, Byck R. " Intravenous cocaine challenges during naltrexone maintenance: a preliminary study. " Biol Psychiatry. 1992 Sep ;
  Pubmed PMID: 1445971.
• Gottschalk PC, Kosten TR. " Isradipine enhancement of cerebral blood flow in abstinent cocaine abusers with and without chronic perfusion deficits. " Am J Addict. 2002 ; 11 (3) : 200-8.
  Pubmed PMID: 12202012.
• Kosten TR, Oliveto A, Sevarino KA, Gonsai K, Feingold A. " Ketoconazole increases cocaine and opioid use in methadone maintained patients. " Drug Alcohol Depend. 2002 Apr 1; 66 (2) : 173-80.
  Pubmed PMID: 11906804.
• Li W, Wei J, Zhou DF, Tan YL, Cao YL, Zhang XY, Wu G, Kosten TA, Kosten TR. " Lack of association between the BDNF C270T polymorphism and schizophrenia in a Chinese Han population. " Schizophr. Res.. 2007 Dec ; 97 (41277) : 297-8.
  Pubmed PMID: 17669628.
• Rounsaville BJ, Kosten TR, Kleber HD. " Long-term changes in current psychiatric diagnoses of treated opiate addicts. " Compr Psychiatry. ; 27 (5) : 480-98.
  Pubmed PMID: 3757496.
• Zhang XY, Cao LY, Song C, Wu GY, Chen da C, Qi LY, Wang F, Xiu MH, Chen S, Zhang Y, Lu L, Kosten TA, Kosten TR. " Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics. " Psychopharmacology (Berl.). 2008 Dec ; 201 (3) : 383-9.
  Pubmed PMID: 18719893.
• Zhang XY, Liang J, Chen DC, Xiu MH, De Yang F, Kosten TA, Kosten TR. " Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia. " 2012 Jan 26;
  Pubmed PMID: 22274000.
• Zhen YF, Zhang J, Liu XY, Fang H, Tian LB, Zhou DH, Kosten TR, Zhang XY. " Low BDNF is associated with cognitive deficits in patients with type 2 diabetes. " Psychopharmacology (Berl.). 2013 May ; 227 (1) : 93-100.
  Pubmed PMID: 23263460.
• Liu H, Kang Y, Liang J, Li C, Xiu M, Chen D, Yang F, Wang F, Wu G, Haile CN, Kosten TA, Kosten TR, Zhang XY. " Lower serum interleukin-2 levels in schizophrenic patients with tardive dyskinesia. " 2012 Mar 12;
  Pubmed PMID: 22417931.
• Kosten TR. " Mandatory drug testing needs controlled evaluation. " Am J Bioeth. 2004 ; 4 (1) : 32.
  Pubmed PMID: 15035939.
• Kosten TR, O'Connor PG. " Management of drug and alcohol withdrawal. " N. Engl. J. Med.. 2003 May 1; 348 (18) : 1786-95.
  Pubmed PMID: 12724485.
• Margolin A, Avants SK, Kosten TR. " Mazindol for relapse prevention to cocaine abuse in methadone-maintained patients. " Am J Drug Alcohol Abuse. 1995 Nov ; 21 (4) : 469-81.
  Pubmed PMID: 8561098.
• Stine SM, Krystal JH, Kosten TR, Charney DS. " Mazindol treatment for cocaine dependence. " Drug Alcohol Depend. 1995 Oct ; 39 (3) : 245-52.
  Pubmed PMID: 8556974.
• Diakogiannis IA, Steinberg M, Kosten TR. " Mazindol treatment of cocaine abuse. A double-blind investigation. " NIDA Res. Monogr.. 1990 ; 105 : 514.
  Pubmed PMID: 1876105.
• Reid MC, Tinetti ME, O'Connor PG, Kosten TR, Concato J. " Measuring alcohol consumption among older adults: a comparison of available methods. " Am J Addict. ; 12 (3) : 211-9.
  Pubmed PMID: 12851017.
• Kosten TR. " Medications development and the war on drugs: victims of the Gulf war? " Biol. Psychiatry. 1991 Mar 15; 29 (6) : 521-3.
  Pubmed PMID: 2054428.
• Stine SM, Grillon CG, Morgan CA, Kosten TR, Charney DS, Krystal JH. " Methadone patients exhibit increased startle and cortisol response after intravenous yohimbine. " Psychopharmacology (Berl.). 2001 Mar ; 154 (3) : 274-81.
  Pubmed PMID: 11351934.
• Streltzer J, Kosten TR. " Methadone maintenance therapy and chronic pain. " JAMA. 2003 Nov ;
  Pubmed PMID: 14612466.
• Stine SM, Kosten TR. " Methadone dose in the treatment of opiate dependence. " Medscape Mental Health. 1997 ;
• Schottenfeld RS, Chawarski MC, Pakes JR, Pantalon MV, Carroll KM, Kosten TR. " Methadone versus buprenorphine with contingency management or performance feedback for cocaine and opioid dependence. " Am J Psychiatry. 2005 Feb ; 162 (2) : 340-9.
  Pubmed PMID: 15677600.
• Nielsen DA, Harding MJ, Hamon SC, Huang W, Kosten TR. " Modifying the role of serotonergic 5-HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study. " Genes Brain Behav. 2012 Aug ;
  Pubmed PMID: 22925276.
• Margolin A, Avants SK, Rounsaville B, Kosten TR, Schottenfeld RS. " Motivational factors in cocaine pharmacotherapy trials with methadone-maintained patients: problems and paradoxes. " J Psychoactive Drugs. ; 29 (2) : 205-12.
  Pubmed PMID: 9250948.
• Kosten TR, Rounsaville BJ, Kleber HD. " Multidimensionality and prediction of treatment outcome in opioid addicts: 2.5-year follow-up. " Compr Psychiatry. ; 28 (1) : 41346.
  Pubmed PMID: 3802797.
• Jacobsen LK, Kosten TR. " Naloxone challenge as a biological predictor of treatment outcome in opiate addicts. " Am J Drug Alcohol Abuse. 1989 ; 15 (4) : 355-66.
  Pubmed PMID: 2596440.
• Mason JW, Kosten TR, Giller EL. " Multidimensional hormonal discrimination of paranoid schizophrenic from bipolar manic patients. " Biol. Psychiatry. 1991 Mar 1; 29 (5) : 457-66.
  Pubmed PMID: 2018819.
• Kleber HD, Kosten TR. " Naltrexone induction: psychologic and pharmacologic strategies " J Clin Psychiatry. 1984 Sep ;
  Pubmed PMID: 6469934.
• Krupitsky E, Zvartau E, Blokhina E, Verbitskaya E, Tsoy M, Wahlgren V, Burakov A, Masalov D, Romanova TN, Palatkin V, Tyurina A, Yaroslavtseva T, Sinha R, Kosten TR. " Naltrexone with or without guanfacine for preventing relapse to opiate addiction in St.-Petersburg, Russia " Drug Alcohol Depend. 2013 Oct ;
  Pubmed PMID: 23683793.
• Sevarino KA, Oliveto A, Kosten TR. " Neurobiological adaptations to psychostimulants and opiates as a basis of treatment development. " Ann. N. Y. Acad. Sci.. 2000 ; 909 : 51-87.
  Pubmed PMID: 10911924.
• Markou A, Kosten TR, Koob GF. " Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. " Neuropsychopharmacology. 1998 Mar ; 18 (3) : 135-74.
  Pubmed PMID: 9471114.
• Krystal J, Kosten TR, Perry B, Southwick S, Mason JW, Giller EL. " Neurobiological aspects of post traumatic stress disorder: Review of clinical and pre-clinical studies.. " Behavior Therapy. 1989 ;
• Sinha R, Lacadie C, Skudlarski P, Fulbright RK, Rounsaville BJ, Kosten TR, Wexler BE. " Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study. " Psychopharmacology (Berl.). 2005 Dec ; 183 (2) : 171-80.
  Pubmed PMID: 16163517.
• Kosten TR. " Neurobiology of abused drugs. Opioids and stimulants. " J. Nerv. Ment. Dis.. 1990 Apr ; 178 (4) : 217-27.
  Pubmed PMID: 2156952.
• Kosten TR, Margolin A. " New developments in opioid abuse treatment. " Annals Clinical Psychiatry. 1990 ;
• Sernyak MJ, Kosten TR, Fontana A, Rosenheck R. " Neuroleptic use in the treatment of Post-Traumatic Stress Disorder. " Psychiatr Q. 2001 ; 72 (3) : 197-213.
  Pubmed PMID: 11467155.
• Kosten TR, Gardner TJ. " New hot topics sections: 1. China's new march forward in addiction treatment: methadone for the masses. 2. Issues in formulating DSM V. " Am J Drug Alcohol Abuse. 2008 ; 34 (2) : 123-6.
  Pubmed PMID: 18293228.
• Kosten TR, Kosten TA. " New medication strategies for comorbid substance use and bipolar affective disorders. " Biol. Psychiatry. 2004 Nov 15; 56 (10) : 771-7.
  Pubmed PMID: 15556122.
• Zhang XY, Tan YL, Zhou DF, Haile CN, Wu GY, Cao LY, Kosten TA, Kosten TR. " Nicotine dependence, symptoms and oxidative stress in male patients with schizophrenia. " Neuropsychopharmacology. 2007 Sep ; 32 (9) : 2020-4.
  Pubmed PMID: 17228336.
• Ziedonis DM, Kosten TR, Glazer WM, Frances RJ. " Nicotine dependence and schizophrenia. " Hosp Community Psychiatry. 1994 Mar ; 45 (3) : 204-6.
  Pubmed PMID: 7910577.
• Zhang XY, Xiu MH, Chen da C, Yang FD, Wu GY, Lu L, Kosten TA, Kosten TR. " Nicotine dependence and serum BDNF levels in male patients with schizophrenia " Psychopharmacology (Berl).. 2010 Oct ;
  Pubmed PMID: 20661552.
• George TP, Ziedonis DM, Feingold A, Pepper WT, Satterburg CA, Winkel J, Rounsaville BJ, Kosten TR. " Nicotine transdermal patch and atypical antipsychotic medications for smoking cessation in schizophrenia. " Am J Psychiatry. 2000 Nov ; 157 (11) : 1835-42.
  Pubmed PMID: 11058482.
• Zhang X, Guan SL, Wang ZQ, You Y, Sun SL, Hui L, Miao LN, Yu Y, Kosten TR, Zhang XY. " No association between the type 2 diabetes mellitus susceptibility gene, SLC30A8 and schizophrenia in a Chinese population. " Hum Psychopharmacol. 2012 Jul ; 27 (4) : 392-6.
  Pubmed PMID: 22778022.
• Kleber HD, Kosten TR, Gaspari J, Topazian M. " Nontolerance to the opioid antagonism of naltrexone. " Biol. Psychiatry. 1985 Jan ; 20 (1) : 66-72.
  Pubmed PMID: 2981129.
• Newton TF, De La Garza R, Brown G, Kosten TR, Mahoney JJ, Haile CN. " Noradrenergic a(1) Receptor Antagonist Treatment Attenuates Positive Subjective Effects of Cocaine in Humans: A Randomized Trial. " PLoS ONE. 2012 ; 7 (2) : e30854.
  Pubmed PMID: 22319592.
• McDougle CJ, Black JE, Malison RT, Zimmermann RC, Kosten TR, Heninger GR, Price LH. " Noradrenergic dysregulation during discontinuation of cocaine use in addicts. " Arch. Gen. Psychiatry. 1994 Sep ; 51 (9) : 713-9.
  Pubmed PMID: 8080348.
• Sofuoglu M, Kosten TR. " Novel approaches to the treatment of cocaine addiction. " CNS Drugs. 2005 ; 19 (1) : 13-25.
  Pubmed PMID: 15651902.
• Krystal JH, Woods SW, Kosten TR, Rosen MI, Seibyl JP, van Dyck CC, Price LH, Zubal IG, Hoffer PB, Charney DS. " Opiate dependence and withdrawal: preliminary assessment using single photon emission computerized tomography (SPECT). " Am J Drug Alcohol Abuse. 1995 Feb ; 21 (1) : 47-63.
  Pubmed PMID: 7762544.
• Fiellin DA, Rosenheck RA, Kosten TR. " Office-based treatment for opioid dependence: reaching new patient populations. " Am J Psychiatry. 2001 Aug ; 158 (8) : 1200-4.
  Pubmed PMID: 11481150.
• Shorter D, Kosten TR. " Novel pharmacotherapeutic treatments for cocaine addiction. " 2011 Nov 3; 9 (1) : 119.
  Pubmed PMID: 22047090.
• Best SE, Oliveto AH, Kosten TR. " Opioid addiction: Recent advances in detoxification and maintenance therapy. " CNS Drugs. 1996 ;
• Kosten TR, Krystal JH, Charney DS, Price LH, Morgan CH, Kleber HD. " Opioid antagonist challenges in buprenorphine maintained patients. " Drug Alcohol Depend. 1990 Feb ; 25 (1) : 73-8.
  Pubmed PMID: 2323312.
• Margolin A, Avants SK, Kosten TR. " Pemoline for the treatment of cocaine dependence in methadone-maintained patients. " J Psychoactive Drugs. ; 28 (3) : 301-4.
  Pubmed PMID: 8895115.
• Stotts AL, Dodrill CL, Kosten TR. " Opioid dependence treatment: options in pharmacotherapy. " Expert Opin Pharmacother. 2009 Aug ; 10 (11) : 1727-40.
  Pubmed PMID: 19538000.
• Potenza MN, Kosten TR, Rounsaville BJ. " Pathological gambling. " JAMA. 2001 Jul ;
• Kosten TR, Rounsaville BJ, Kleber HD. " Parental alcoholism in opioid addicts. " J. Nerv. Ment. Dis.. 1985 Aug ; 173 (8) : 461-9.
  Pubmed PMID: 4020363.
• Sigmon SC, Bisaga A, Nunes EV, O'Connor PG, Kosten T, Woody G. " Opioid detoxification and naltrexone induction strategies: recommendations for clinical practice. " Am J Drug Alcohol Abuse. 2012 May ; 38 (3) : 187-99.
  Pubmed PMID: 22404717.
• Kosten TR, Novak P, Kleber HD. " Perceived marital and family environment of opiate addicts. " Am J Drug Alcohol Abuse. 1984 ; 10 (4) : 491-501.
  Pubmed PMID: 6534181.
• Rosen MI, Bridge TP, O’Malley SS, Pearsall HR, Maritini B, O’Connor PG, Brett-Smith H, Thomas HM, van Dyke CH, Woods SW, Kosten TR.. " Peptide T treatment of cognitive impairment in HIV positive intravenous drug users. " Am J Addictions. 1992 ;
• Lane SD, Moeller FG, Steinberg JL, Buzby M, Kosten TR. " Performance of cocaine dependent individuals and controls on a response inhibition task with varying levels of difficulty. " Am J Drug Alcohol Abuse. 2007 ; 33 (5) : 717-26.
  Pubmed PMID: 17891664.
• McIntosh BJ, Zhang XY, Kosten T, Tan SP, Xiu MH, Rakofsky J, Harvey PD. " Performance-based assessment of functional skills in severe mental illness: Results of a large-scale study in China. " J Psychiatr Res. 2011 Aug ; 45 (8) : 1089-94.
  Pubmed PMID: 21300378.
• Tucker KA, Potenza MN, Beauvais JE, Browndyke JN, Gottschalk PC, Kosten TR. " Perfusion abnormalities and decision making in cocaine dependence " Biol Psychiatry. 2004 Oct ;
  Pubmed PMID: 15450790.
• Kosten TA, Kosten TR, Rounsaville BJ. " Personality disorders in opiate addicts show prognostic specificity. " J Subst Abuse Treat. 1989 ; 6 (3) : 163-8.
  Pubmed PMID: 2795705.
• Kosten TR, Wu G, Huang W, Harding MJ, Hamon SC, Lappalainen J, Nielsen DA. " Pharmacogenetic Randomized Trial for Cocaine Abuse: Disulfiram and Dopamine ß-Hydroxylase. " Biol. Psychiatry. 2012 Aug 17;
  Pubmed PMID: 22906516.
• Shorter D, Nielsen DA, Huang W, Harding MJ, Hamon SC, Kosten TR.. " Pharmacogenetic randomized trial for cocaine abuse: disulfiram and α1A-adrenoceptor gene variation " Eur Neuropsychopharmacol. 2013 Nov ;
  Pubmed PMID: 23849431.
• Haile CN, Kosten TA, Kosten TR. " Pharmacogenetic treatments for drug addiction: alcohol and opiates. " Am J Drug Alcohol Abuse. 2008 ; 34 (4) : 355-81.
  Pubmed PMID: 18584566.
• Kosten TR. " Pharmacological approaches to cocaine dependence. " Clin Neuropharmacol. 1992 ; 15 : 70A-71A.
  Pubmed PMID: 1498999.
• Haile CN, Kosten TR, Kosten TA. " Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine. " Am J Drug Alcohol Abuse. 2009 ; 35 (3) : 161-77.
  Pubmed PMID: 19462300.
• Sofuoglu M, Kosten TR. " Pharmacologic management of relapse prevention in addictive disorders. " Psychiatr. Clin. North Am.. 2004 Dec ; 27 (4) : 627-48.
  Pubmed PMID: 15550284.
• Kosten TA, Kosten TR. " Pharmacological blocking agents for treating substance abuse. " J. Nerv. Ment. Dis.. 1991 Oct ; 179 (10) : 583-92.
  Pubmed PMID: 1919542.
• Kosten TR. " Pharmacotherapeutic interventions for cocaine abuse. Matching patients to treatments. " J. Nerv. Ment. Dis.. 1989 Jul ; 177 (7) : 379-89.
  Pubmed PMID: 2664072.
• Verrico CD, Haile CN, Newton TF, Kosten TR, De La Garza R. " Pharmacotherapeutics for substance-use disorders: a focus on dopaminergic medications " Expert Opin Investig Drugs. 2013 Dec ;
  Pubmed PMID: 24033127.
• Gardner TJ, Kosten TR. " Pharmacotherapeutic environments for substance use disorders. " Am J Drug Alcohol Abuse. 2007 ; 33 (5) : 627-9.
  Pubmed PMID: 17891655.
• Kosten TR. " Pharmacotherapy for addictions: partnering with contingency management. " Am J Drug Alcohol Abuse. 2007 ; 33 (3) : 341-2.
  Pubmed PMID: 17613962.
• Kosten TR, Morgan CM, Falcione J, Schottenfeld RS. " Pharmacotherapy for cocaine-abusing methadone-maintained patients using amantadine or desipramine. " Arch. Gen. Psychiatry. 1992 Nov ; 49 (11) : 894-8.
  Pubmed PMID: 1444728.
• Kosten TR, Frank JB, Dan E, McDougle CJ, Giller EL. " Pharmacotherapy for posttraumatic stress disorder using phenelzine or imipramine. " J. Nerv. Ment. Dis.. 1991 Jun ; 179 (6) : 366-70.
  Pubmed PMID: 2051152.
• Warner EA, Kosten TR, O'Connor PG. " Pharmacotherapy for opioid and cocaine abuse. " Med. Clin. North Am.. 1997 Jul ; 81 (4) : 909-25.
  Pubmed PMID: 9222260.
• Haile CN, Kosten TR. " Pharmacotherapy for stimulant-related disorders. " Curr Psychiatry Rep. 2013 Nov ;
  Pubmed PMID: 24142188.
• McCance-Katz E, Sevarino K, Gottschalk PC, Kosten T. " Pharmacotherapy of stimulant dependence: one of Japan's greatest public health challenges. " Nihon Shinkei Seishin Yakurigaku Zasshi. 1999 Oct ;
  Pubmed PMID: 10637824.
• Ziedonis DM, Kosten TR. " Pharmacotherapy improves treatment outcome in depressed cocaine addicts. " J Psychoactive Drugs. ; 23 (4) : 417-25.
  Pubmed PMID: 1813613.
• Kosten TR. " Pharmacotherapy of cerebral ischemia in cocaine dependence. " Drug Alcohol Depend. 1998 Jan 1; 49 (2) : 133-44.
  Pubmed PMID: 9543650.
• Kosten TR, Morgan C, Kleber HD. " Phase II clinical trials of buprenorphine: detoxification and induction onto naltrexone. " NIDA Res. Monogr.. 1992 ; 121 : 101-19.
  Pubmed PMID: 1406906.
• Kosten TR, Astrachan BM. " Planning for crisis on a psychiatric research ward: a task analysis. " Compr Psychiatry. 1981 May ;
  Pubmed PMID: 7238004.
• Bowers MB, Malison RT, Seibyl JP, Kosten TR. " Plasma homovanillic acid and the dopamine transporter during cocaine withdrawal. " Biol. Psychiatry. 1998 Feb 15; 43 (4) : 278-81.
  Pubmed PMID: 9513737.
• Zhang XY, Chen DC, Xiu MH, Tang W, Zhang F, Liu L, Chen Y, Liu J, Yao JK, Kosten TA, Kosten TR. " Plasma total antioxidant status and cognitive impairments in schizophrenia. " 2012 May 1;
  Pubmed PMID: 22555016.
• Kosten TR, Tucker K, Gottschalk PC, Rinder CS, Rinder HM. " Platelet abnormalities associated with cerebral perfusion defects in cocaine dependence. " Biol. Psychiatry. 2004 Jan 1; 55 (1) : 91-7.
  Pubmed PMID: 14706430.
• Rinder HM, Ault KA, Jatlow PI, Kosten TR, Smith BR. " Platelet alpha-granule release in cocaine users. " Circulation. 1994 Sep ; 90 (3) : 1162-7.
  Pubmed PMID: 7522132.
• Jacobsen LK, Staley JK, Zoghbi SS, Seibyl JP, Kosten TR, Innis RB, Gelernter J. " Prediction of dopamine transporter binding availability by genotype: a preliminary report. " Am J Psychiatry. 2000 Oct ; 157 (10) : 1700-3.
  Pubmed PMID: 11007732.
• Sofuoglu M, Gonzalez G, Poling J, Kosten TR. " Prediction of treatment outcome by baseline urine cocaine results and self-reported cocaine use for cocaine and opioid dependence. " Am J Drug Alcohol Abuse. 2003 ; 29 (4) : 713-27.
  Pubmed PMID: 14713135.
• Kosten TR, Rounsaville BJ, Kleber HD. " Predictors of 2.5-year outcome in opioid addicts: pretreatment source of income. " Am J Drug Alcohol Abuse. 1987 ; 13 (41276) : 19-32.
  Pubmed PMID: 3687883.
• Dodrill CL, Helmer DA, Kosten TR. " Prescription pain medication dependence. " Am J Psychiatry. 2011 May ; 168 (5) : 466-71.
  Pubmed PMID: 21536702.
• Mooney ME, Poling J, Gonzalez G, Gonsai K, Kosten T, Sofuoglu M. " Preliminary study of buprenorphine and bupropion for opioid-dependent smokers. " Am J Addict. ; 17 (4) : 287-92.
  Pubmed PMID: 18612883.
• O'Brien CP, Charney DS, Lewis L, Cornish JW, Post RM, Woody GE, Zubieta JK, Anthony JC, Blaine JD, Bowden CL, Calabrese JR, Carroll K, Kosten T, Rounsaville B, Childress AR, Oslin DW, Pettinati HM, Davis MA, Demartino R, Drake RE, Fleming MF, Fricks L, Gl. " Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to action. " Biol. Psychiatry. 2004 Nov 15; 56 (10) : 703-13.
  Pubmed PMID: 15556110.
• Zhang XY, Al Jurdi RK, Zoghbi AW, Chen da C, Xiu MH, Tan YL, Yang FD, Kosten TR. " Prevalence, demographic and clinical correlates of suicide attempts in Chinese medicated chronic inpatients with schizophrenia " J Psychiatr Res. 2013 Oct ;
  Pubmed PMID: 23791457.
• Ramakrishnan M, Alves De Melo F, Kinsey BM, Ladbury JE, Kosten TR, Orson FM. " Probing cocaine-antibody interactions in buffer and human serum. " PLoS ONE. 2012 ; 7 (7) : e40518.
  Pubmed PMID: 22859949.
• Sofuoglu M, Poling J, Gonzalez G, Gonsai K, Oliveto A, Kosten TR. " Progesterone effects on cocaine use in male cocaine users maintained on methadone: a randomized, double-blind, pilot study. " Exp Clin Psychopharmacol. 2007 Oct ; 15 (5) : 453-60.
  Pubmed PMID: 17924779.
• Schottenfeld RS, Pakes JR, Kosten TR. " Prognostic factors in Buprenorphine- versus methadone-maintained patients. " J. Nerv. Ment. Dis.. 1998 Jan ; 186 (1) : 35-43.
  Pubmed PMID: 9457145.
• Rounsaville BJ, Kosten TR, Weissman MM, Kleber HD. " Prognostic significance of psychopathology in treated opiate addicts. A 2.5-year follow-up study. " Arch. Gen. Psychiatry. 1986 Aug ; 43 (8) : 739-45.
  Pubmed PMID: 3729668.
• Rounsaville BJ, Kosten TR, Weissman MM, Prusoff B, Pauls D, Anton SF, Merikangas K. " Psychiatric disorders in relatives of probands with opiate addiction. " Arch. Gen. Psychiatry. 1991 Jan ; 48 (1) : 33-42.
  Pubmed PMID: 1984760.
• Kosten TR, Jacobs S, Mason J, Wahby V, Atkins S. " Psychological correlates of growth hormone response to stress. " Psychosom Med.. 1984 Jan ;
  Pubmed PMID: 6701254.
• Brimijoin S, Shen X, Orson F, Kosten T. " Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuse. " Expert Rev Vaccines. 2013 Mar ; 12 (3) : 323-32.
  Pubmed PMID: 23496671.
• Jacobsen LK, Giedd JN, Kreek MJ, Gottschalk C, Kosten TR. " Quantitative medial temporal lobe brain morphology and hypothalamic-pituitary-adrenal axis function in cocaine dependence: a preliminary report. " Drug Alcohol Depend. 2001 Mar 1; 62 (1) : 49-56.
  Pubmed PMID: 11173167.
• Kosten TR, Rounsaville BJ. " Psychopathology in opioid addicts. " Psychiatr. Clin. North Am.. 1986 Sep ; 9 (3) : 515-32.
  Pubmed PMID: 3774603.
• Jacobsen LK, Giedd JN, Gottschalk C, Kosten TR, Krystal JH. " Quantitative morphology of the caudate and putamen in patients with cocaine dependence. " Am J Psychiatry. 2001 Mar ; 158 (3) : 486-9.
  Pubmed PMID: 11229995.
• Schottenfeld RS, Chawarski MC, Cubells JF, George TP, Lappalainen J, Kosten TR. " Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment " Drug Alcohol Depend. 2014 Mar ;
  Pubmed PMID: 24462581.
• Oliveto A, Poling J, Mancino MJ, Feldman Z, Cubells JF, Pruzinsky R, Gonsai K, Cargile C, Sofuoglu M, Chopra MP, Gonzalez-Haddad G, Carroll KM, Kosten TR. " Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients. " Drug Alcohol Depend. 2011 Jan ;
  Pubmed PMID: 20828943.
• Kosten TR, Kleber HD. " Rapid death during cocaine abuse: a variant of the neuroleptic malignant syndrome? " Am J Drug Alcohol Abuse. 1988 ; 14 (3) : 335-46.
  Pubmed PMID: 3055940.
• O'Connor PG, Kosten TR. " Rapid and ultrarapid opioid detoxification techniques. " JAMA. 1998 Jan 21; 279 (3) : 229-34.
  Pubmed PMID: 9438745.
• Kosten TR, Krystal JH, Charney DS, Price LH, Morgan CH, Kleber HD. " Rapid detoxification from opioid dependence. " Am J Psychiatry. 1989 Oct ; 146 (10) : 1349.
  Pubmed PMID: 2675644.
• Li XF, Zheng YL, Xiu MH, Chen da C, Kosten TR, Zhang XY. " Reduced plasma total antioxidant status in first-episode drug-naive patients with schizophrenia. " Prog. Neuropsychopharmacol. Biol. Psychiatry. 2011 Jun 1; 35 (4) : 1064-7.
  Pubmed PMID: 21392552.
• Chen da C, Xiu MH, Liu H, Zhang BS, Wang Y, Kosten TR, Zhang XY. " Reduced status of plasma total antioxidant capacity in schizophrenia with tardive dyskinesia. " J Psychiatr Res. 2010 Nov ; 44 (15) : 1111-2.
  Pubmed PMID: 20398909.
• Stine SM, Kosten TR. " Reduction of opiate withdrawal-like symptoms by cocaine abuse during methadone and buprenorphine maintenance. " Am J Drug Alcohol Abuse. 1994 Nov ; 20 (4) : 445-58.
  Pubmed PMID: 7832179.
• Kosten TR, Rounsaville BJ, Kleber HD. " Relationship of depression to psychosocial stressors in heroin addicts. " J. Nerv. Ment. Dis.. 1983 Feb ; 171 (2) : 97-104.
  Pubmed PMID: 6822825.
• Kosten TR, Cheeves C, Palumbo J, Seibyl JP, Price LH, Woods SW. " Regional cerebral blood flow during acute and chronic abstinence from combined cocaine-alcohol abuse. " Drug Alcohol Depend. 1998 May 1; 50 (3) : 187-95.
  Pubmed PMID: 9649971.
• Kosten TR, Rounsaville BJ, Kleber HD. " Relationship of depression to clonidine detoxification of opiate addicts. " Compr Psychiatry. ; 25 (5) : 503-8.
  Pubmed PMID: 6488761.
• Kosten TR, Jalali B, Steidl JH, Kleber HD. " Relationship of marital structure and interactions to opiate abuse relapse. " Am J Drug Alcohol Abuse. 1987 ; 13 (4) : 387-99.
  Pubmed PMID: 3687898.
• Rosen MI, McMahon TJ, Margolin A, Gill TS, Woods SW, Pearsall HR, Kreek MJ, Kosten TR. " Reliability of sequential naloxone challenge tests. " Am J Drug Alcohol Abuse. 1995 Nov ; 21 (4) : 453-67.
  Pubmed PMID: 8561097.
• Wisner KL, Conley RR, Taylor SF, Kosten T, Rapaport MH, Brown LS. " Researcher experiences with IRBs: a survey of members of the American College of Neuropsychopharmacology. " IRB. ; 33 (5) : 14-20.
  Pubmed PMID: 22043746.
• Sofuoglu M, Waters AJ, Mooney M, Kosten T. " Riluzole and D-amphetamine interactions in humans " Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan ;
  Pubmed PMID: 17714844.
• Poling J, Kosten TR. " Risperidone for substance dependent psychotic patients. " 2005 ;
• Kosten TR, Kleber HD, Morgan C. " Role of opioid antagonists in treating intravenous cocaine abuse. " Life Sci.. 1989 ; 44 (13) : 887-92.
  Pubmed PMID: 2927249.
• Boutros NN, Gelernter J, Gooding DC, Cubells J, Young A, Krystal JH, Kosten T. " Sensory gating and psychosis vulnerability in cocaine-dependent individuals: preliminary data. " Biol. Psychiatry. 2002 Apr 15; 51 (8) : 683-6.
  Pubmed PMID: 11955469.
• Hirunsatit R, Ilomäki R, Malison R, Räsänen P, Ilomäki E, Kranzler HR, Kosten T, Sughondhabirom A, Thavichachart N, Tangwongchai S, Listman J, Mutirangura A, Gelernter J, Lappalainen J. " Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research " BMC Genet. 2007 Oct ;
  Pubmed PMID: 17941974.
• Aronson SC, Black JE, McDougle CJ, Scanley BE, Jatlow P, Kosten TR, Heninger GR, Price LH. " Serotonergic mechanisms of cocaine effects in humans. " Psychopharmacology (Berl.). 1995 May ; 119 (2) : 179-85.
  Pubmed PMID: 7659765.
• Graham DP, Helmer DA, Harding MJ, Kosten TR, Petersen NJ, Nielsen DA. " Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans. " J Psychiatr Res. 2013 Jun ; 47 (6) : 835-42.
  Pubmed PMID: 23478049.
• Oliveto A, Poling J, Mancino MJ, Williams DK, Thostenson J, Pruzinsky R, Gonsai K, Sofuoglu M, Gonzalez G, Tripathi S, Kosten TR. " Sertraline delays relapse in recently abstinent cocaine-dependent patients with depressive symptoms. " Addiction. 2012 Jan ; 107 (1) : 131-41.
  Pubmed PMID: 21707811.
• Zhang XY, Tan YL, Zhou DF, Cao LY, Wu GY, Xu Q, Shen Y, Haile CN, Kosten TA, Kosten TR. " Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics. " J Psychiatr Res. 2007 Dec ; 41 (12) : 997-1004.
  Pubmed PMID: 17095017.
• Wahby V, Ibrahim G, Friedenthal S, Giller E, Kosten T, Mason J. " Serum concentrations of circulating thyroid hormones in a group of depressed men " Neuropsychobiology. 1989 ;
  Pubmed PMID: 2639287.
• Li SX, Li J, Epstein DH, Zhang XY, Kosten TR, Lu L. " Serum cortisol secretion during heroin abstinence is elevated only nocturnally. " Am J Drug Alcohol Abuse. 2008 ; 34 (3) : 321-8.
  Pubmed PMID: 18428074.
• Mason JW, Giller EL, Kosten TR. " Serum testosterone differences between patients with schizophrenia and those with affective disorder. " Biol. Psychiatry. 1988 Feb 15; 23 (4) : 357-66.
  Pubmed PMID: 3342266.
• Mason JW, Giller El, Kosten TR, Wahby VS. " Serum testosterone levels in post traumatic stress disorder inpatients. " J Traumatic Stress. 1990 ;
• Southwick S, Mason JW, Giller EL, Kosten TR. " Serum thyroxine change and clinical recovery in psychiatric inpatients. " Biol. Psychiatry. 1989 Jan ; 25 (1) : 67-74.
  Pubmed PMID: 2912510.
• Zhang XY, Zhang RL, Pan M, Chen da C, Xiu MH, Kosten TR. " Sex difference in the prevalence of smoking in Chinese schizophrenia. " J Psychiatr Res. 2010 Oct ; 44 (14) : 986-8.
  Pubmed PMID: 20334878.
• Mason JW, Kennedy JL, Kosten TR, Giller EL. " Serum thyroxine levels in schizophrenic and affective disorder diagnostic subgroups. " J. Nerv. Ment. Dis.. 1989 Jun ; 177 (6) : 351-8.
  Pubmed PMID: 2723624.
• Yang FD, Wang XQ, Liu XP, Zhao KX, Fu WH, Hao XR, Zhang XL, Huang GS, Qu SC, Bai JS, Huang XF, Kosten TR, Zhang XY. " Sex difference in QTc prolongation in chronic institutionalized patients with schizophrenia on long-term treatment with typical and atypical antipsychotics. " Psychopharmacology (Berl.). 2011 Jul ; 216 (1) : 41533.
  Pubmed PMID: 21301815.
• Kosten TA, Jacobsen LK, Kosten TR. " Severity of precipitated opiate withdrawal predicts drug dependence by DSM-III-R criteria. " Am J Drug Alcohol Abuse. 1989 ; 15 (3) : 237-50.
  Pubmed PMID: 2763981.
• Li CS, Kosten TR, Sinha R. " Sex differences in brain activation during stress imagery in abstinent cocaine users: a functional magnetic resonance imaging study. " Biol. Psychiatry. 2005 Mar 1; 57 (5) : 487-94.
  Pubmed PMID: 15737663.
• Singha AK, McCance-Katz EF, Petrakis I, Kosten TR, Oliveto A. " Sex differences in self-reported and physiological response to oral cocaine and placebo in humans. " Am J Drug Alcohol Abuse. 2000 Nov ; 26 (4) : 643-57.
  Pubmed PMID: 11097197.
• Li YQ, Wang XY, Zhai HF, Zhang XY, Kosten T, Lu L. " Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats. " Behav Brain Res. 2008 Jan ;
  Pubmed PMID: 17765982.
• Zhang XY, Liu L, Liu S, Hong X, Chen da C, Xiu MH, Yang FD, Zhang Z, Zhang X, Kosten TA, Kosten TR. " Short-term tropisetron treatment and cognitive and p50 auditory gating deficits in schizophrenia. " Am J Psychiatry. 2012 Sep 1; 169 (9) : 974-81.
  Pubmed PMID: 22952075.
• Poling J, Oliveto A, Petry N, Sofuoglu M, Gonsai K, Gonzalez G, Martell B, Kosten TR. " Six-month trial of bupropion with contingency management for cocaine dependence in a methadone-maintained population. " Arch. Gen. Psychiatry. 2006 Feb ; 63 (2) : 219-28.
  Pubmed PMID: 16461866.
• 102. Kosten TR, Gawin FH, Kosten TA, Morgan C, Rounsaville BJ, Schottenfeld RS, Kleber HD. " Six month follow-up of short term pharmacotherapy for cocaine dependence. " Am J Addictions. 1992 ;
• Farren CK, Hameedi FA, Rosen MA, Woods S, Jatlow P, Kosten TR. " Significant interaction between clozapine and cocaine in cocaine addicts. " Drug Alcohol Depend. 2000 May 1; 59 (2) : 153-63.
  Pubmed PMID: 10891628.
• Satel SL, Kosten TR, Schuckit MA, Fischman MW. " Should protracted withdrawal from drugs be included in DSM-IV? " Am J Psychiatry. 1993 May ; 150 (5) : 695-704.
  Pubmed PMID: 8097618.
• Zhang XY, Yu YQ, Sun S, Zhang X, Li W, Xiu MH, Chen da C, Yang FD, Zhu F, Kosten TA, Kosten TR. " Smoking and tardive dyskinesia in male patients with chronic schizophrenia. " Prog. Neuropsychopharmacol. Biol. Psychiatry. 2011 Aug 15; 35 (7) : 1765-9.
  Pubmed PMID: 21723906.
• Kosten TR, Rounsaville BJ. " Source of income as a predictor in opioid addicts: 2.5 year follow-up. " NIDA Res. Monogr.. 1987 ; 76 : 196-9.
  Pubmed PMID: 3125447.
• Zhang XY, Li CB, Li M, Zheng YL, Zhang CX, Yan QZ, Liu WZ, Kang YM, Wang F, Chen da C, Xiu MH, Kosten TR. " Smoking initiation and schizophrenia: a replication study in a Chinese Han population. " Schizophr. Res.. 2010 Jun ; 119 (41277) : 110-4.
  Pubmed PMID: 20022218.
• Zhang XY, Chen da C, Tan YL, Xiu MH, Cui J, Hui L, De Yang F, Kosten TR. " Socio-demographic and clinical characteristics of heavy and non-heavy smokers among schizophrenia inpatients in a Chinese Han population " Psychopharmacology (Berl). 2014 Jan ;
  Pubmed PMID: 23963531.
• van Dyck CH, Rosen MI, Thomas HM, McMahon TJ, Wallace EA, O'Connor PG, Sullivan M, Krystal JH, Hoffer PB, Woods SW. " SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine. " Psychiatry Res.. 1994 Dec ;
  Pubmed PMID: 7701033.
• Woods SW, O'Malley SS, Martini BL, McDougle CJ, Price LH, Krystal JH, Hoffer PB, Kosten TR. " SPECT regional cerebral blood flow and neuropsychological testing in non-demented HIV-positive drug abusers: preliminary results. " Prog. Neuropsychopharmacol. Biol. Psychiatry. 1991 ; 15 (5) : 649-62.
  Pubmed PMID: 1956993.
• Brown AE, Tonigan JS, Pavlik VN, Kosten TR, Volk RJ. " Spirituality and Confidence to Resist Substance Use Among Celebrate Recovery Participants. " J Relig Health. 2011 Jan 19;
  Pubmed PMID: 21246280.
• Orson FM, Rossen RD, Shen X, Lopez AY, Wu Y, Kosten TR. " Spontaneous Development of IgM Anti-Cocaine Antibodies in Habitual Cocaine Users: Effect on IgG Antibody Responses to a Cocaine Cholera Toxin B Conjugate Vaccine. " Am J Addict. 2013 Mar ; 22 (2) : 169-74.
  Pubmed PMID: 23414504.
• Zhao LY, Shi J, Zhang XL, Epstein DH, Zhang XY, Liu Y, Kosten TR, Lu L. " Stress enhances retrieval of drug-related memories in abstinent heroin addicts. " Neuropsychopharmacology. 2010 Feb ; 35 (3) : 720-6.
  Pubmed PMID: 19890257.
• Lago JA, Kosten TR. " Stimulant withdrawal. " Addiction. 1994 Nov ; 89 (11) : 1477-81.
  Pubmed PMID: 7841859.
• Kosten TR. " Stress and addiction. " Am J Psychiatry. 2011 Jun ; 168 (6) : 566-8.
  Pubmed PMID: 21642477.
• Kosten TR, Kleber HD. " Strategies to improve compliance with narcotic antagonists. " Am J Drug Alcohol Abuse. 1984 ; 10 (2) : 249-66.
  Pubmed PMID: 6475891.
• Lu L, Wang X, Kosten TR. " Stereotactic neurosurgical treatment of drug addiction. " Am J Drug Alcohol Abuse. 2009 ; 35 (6) : 391-3.
  Pubmed PMID: 20014906.
• Kosten TR, Ziedonis DM. " Substance abuse and schizophrenia: editors' introduction. " Schizophr Bull. 1997 ; 23 (2) : 181-6.
  Pubmed PMID: 9165628.
• Jacobsen LK, Southwick SM, Kosten TR. " Substance use disorders in patients with posttraumatic stress disorder: a review of the literature. " Am J Psychiatry. 2001 Aug ; 158 (8) : 1184-90.
  Pubmed PMID: 11481147.
• Orson FM, Kinsey BM, Singh RA, Wu Y, Gardner T, Kosten TR. " Substance abuse vaccines. " Ann. N. Y. Acad. Sci.. 2008 Oct ; 1141 : 257-69.
  Pubmed PMID: 18991962.
• Zhang XY, Zhou DF, Qi LY, Chen S, Cao LY, Chen da C, Xiu MH, Wang F, Wu GY, Lu L, Kosten TA, Kosten TR. " Superoxide dismutase and cytokines in chronic patients with schizophrenia: association with psychopathology and response to antipsychotics. " Psychopharmacology (Berl.). 2009 May ; 204 (1) : 177-84.
  Pubmed PMID: 19139851.
• Calhoun P, Najavits LM, Kosten T, Kivlahan D. " Substance Use in OIF/OEF Veterans. " VA Health Services Research & Development For. 2007 ;
• Kosten TR, Rounsaville BJ, Babor TF, Spitzer RL, Williams JB. " Substance-use disorders in DSM-III-R. Evidence for the dependence syndrome across different psychoactive substances. " Br J Psychiatry. 1987 Dec ; 151 : 834-43.
  Pubmed PMID: 2901887.
• Kosten TR, Rounsaville BJ. " Suicidality among opioid addicts: 2.5 year follow-up. " Am J Drug Alcohol Abuse. 1988 ; 14 (3) : 357-69.
  Pubmed PMID: 3189257.
• Rounsaville BJ, Kosten T, Kleber H. " Success and failure at outpatient opioid detoxification. Evaluating the process of clonidine- and methadone-assisted withdrawal. " J Nerv Ment Dis.. 1985 ;
  Pubmed PMID: 3881558.
• Kosten TR, Mason JW, Giller EL, Ostroff RB, Harkness L. " Sustained urinary norepinephrine and epinephrine elevation in post-traumatic stress disorder. " Psychoneuroendocrinology. 1987 ; 12 (1) : 13-20.
  Pubmed PMID: 3588809.
• van Dyck CH, McMahon TJ, Rosen MI, O'Malley SS, O'Connor PG, Lin CH, Pearsall HR, Woods SW, Kosten TR. " Sustained-release methylphenidate for cognitive impairment in HIV-1-infected drug abusers: a pilot study. " J Neuropsychiatry Clin Neurosci. 1997 ; 9 (1) : 29-36.
  Pubmed PMID: 9017526.
• Martell BA, O'Connor PG, Kerns RD, Becker WC, Morales KH, Kosten TR, Fiellin DA. " Systematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addiction. " Ann. Intern. Med.. 2007 Jan 16; 146 (2) : 116-27.
  Pubmed PMID: 17227935.
• Anton RF, Litten RZ, Falk DE, Palumbo JM, Bartus RT, Robinson RL, Kranzler HR, Kosten TR, Meyer RE, O'Brien CP, Mann K, Meulien D. " The Alcohol Clinical Trials Initiative (ACTIVE): Purpose and Goals for Assessing Important and Salient Issues for Medications Development in Alcohol Use Disorders. " 2011 Sep 7;
  Pubmed PMID: 21900883.
• Rounsaville BJ, Kosten TR, Kleber HD. " The antecedents and benefits of achieving abstinence in opioid addicts: a 2.5-year follow-up study. " Am J Drug Alcohol Abuse. 1987 ; 13 (3) : 213-29.
  Pubmed PMID: 3687888.
• Wang F, Xiu MH, Zhou DF, Cao LY, Wu GY, Kosten TA, Kosten TR, Zhang XY. " The CCR5 32-bp deletion allele is rare in a Chinese population. " Schizophr. Res.. 2008 Apr ; 101 (41277) : 341-3.
  Pubmed PMID: 18295459.
• Gao Y, Orson FM, Kinsey B, Kosten T, Brimijoin S. " The concept of pharmacologic cocaine interception as a treatment for drug abuse. " Chem. Biol. Interact.. 2010 Sep 6; 187 (41277) : 421-4.
  Pubmed PMID: 20219449.
• Kosten TR, Rounsaville BJ, Babor TF, Spitzer RL, Williams JB. " The dependence syndrome across different psychoactive substances: revised DSM-III. " NIDA Res. Monogr.. 1987 ; 76 : 255-8.
  Pubmed PMID: 3125454.
• Kosten TA, Kosten TR. " The dependence syndrome concept as applied to alcohol and other substances of abuse. " Recent Dev Alcohol. 1990 ; 8 : 47-68.
  Pubmed PMID: 2185524.
• Kosten TR, Wahby V, Giller E, Mason J. " The dexamethasone suppression test and thyrotropin-releasing hormone stimulation test in posttraumatic stress disorder. " Biol. Psychiatry. 1990 Oct 15; 28 (8) : 657-64.
  Pubmed PMID: 2122916.
• Kosten TR, Jacobs S, Mason JW. " The dexamethasone suppression test during bereavement " J Nerv Ment Dis.. 1984 Jun ;
  Pubmed PMID: 6544808.
• Abi-Saab D, Beauvais J, Mehm J, Brody M, Gottschalk C, Kosten TR. " The effect of alcohol on the neuropsychological functioning of recently abstinent cocaine-dependent subjects. " Am J Addict. ; 14 (2) : 166-78.
  Pubmed PMID: 16019965.
• Hui L, Zhang X, Huang XF, Han M, Fernandez F, Yu Y, Sun S, Li W, Chen da C, Xiu MH, Kosten TR, Zhang XY. " The dopamine b-hydroxylase 19 bp insertion/deletion polymorphism was associated with first-episode but not medicated chronic schizophrenia. " J Psychiatr Res. 2012 Jun ; 46 (6) : 733-7.
  Pubmed PMID: 22445279.
• Rosen MI, Pearsall HR, Woods SW, Kosten TR. " The effect of gamma-hydroxybutyric acid on naloxone-precipitated opiate withdrawal. " Neuropsychopharmacology. 1996 Mar ; 14 (3) : 187-93.
  Pubmed PMID: 8866702.
• Rosen MI, Pearsall HR, Kosten TR. " The effect of lamotrigine on naloxone-precipitated opiate withdrawal. " Drug Alcohol Depend. 1998 Oct 1; 52 (2) : 173-6.
  Pubmed PMID: 9800147.
• Stine SM, Freeman M, Burns B, Charney DS, Kosten TR. " The effect of methadone dose on cocaine abuse in a methadone program. " Am J Addictions. 1992 ;
• Kosten TR, Hogan I, Jalali B, Steidl J, Kleber HD. " The effect of multiple family therapy on addict family functioning: a pilot study. " Adv Alcohol Subst Abuse. 1986 ; 5 (3) : 51-62.
  Pubmed PMID: 3728193.
• Rosen MI, Kosten TR, Kreek MJ. " The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers. " Biol. Psychiatry. 1999 Jun 15; 45 (12) : 1636-45.
  Pubmed PMID: 10376126.
• Orson FM, Wang R, Brimijoin S, Kinsey BM, Singh RA, Ramakrishnan M, Wang HY, Kosten TR. " The future potential for cocaine vaccines. " Expert Opin Biol Ther. 2014 ;
  Pubmed PMID: 24835496.
• Orson FM, Kinsey BM, Singh RA, Wu Y, Gardner T, Kosten TR. " The future of vaccines in the management of addictive disorders. " Curr Psychiatry Rep. 2007 Oct ; 9 (5) : 381-7.
  Pubmed PMID: 17915077.
• Haile CN, De La Garza R, Mahoney JJ, Nielsen DA, Kosten TR, Newton TF. " The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial. " PLoS ONE. 2012 ; 7 (11) : e47702.
  Pubmed PMID: 23144826.
• Liu S, Green CE, Lane SD, Kosten TR, Moeller FG, Nielsen DA, Schmitz JM. " The influence of dopamine β-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study " Pharmacogenet Genomics. 2014 Jul ;
  Pubmed PMID: 24809448.
• 112. Sun H, Wang F, Fan H, Yan Q, Cui K, Yuan W, Zhao F, Zhao L, Yuan J, Yang F, Kosten TR, Zhang XY. " The interaction of polymorphisms of IL10 and DBH was associated with general symptoms of PANSS with TD in Chinese Han schizophrenic patients " PLoS One. 2013 Aug ;
  Pubmed PMID: 23951054.
• Kosten TR, Gorelick DA. " The Lexington narcotic farm. " Am J Psychiatry. 2002 Jan ; 159 (1) : 22.
  Pubmed PMID: 11772684.
• Jacobs SC, Kasl SV, Ostfeld AM, Berkman L, Kosten TR, Charpentier P. " The measurement of grief: bereaved versus non-bereaved " Hosp J.. 1986 ;
  Pubmed PMID: 3647919.
• Spellicy CJ, Kosten TR, Hamon SC, Harding MJ, Nielsen DA. " The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency. " Front Psychiatry. 2012 ; 3 : 109.
  Pubmed PMID: 23335901.
• Kosten TR, George TP. " The neurobiology of opioid dependence: implications for treatment. " 2002 Jul ; 1 (1) : 13-20.
  Pubmed PMID: 18567959.
• Zhang XY, Chen da C, Xiu MH, Wang F, Qi LY, Sun HQ, Chen S, He SC, Wu GY, Haile CN, Kosten TA, Lu L, Kosten TR. " The novel oxidative stress marker thioredoxin is increased in first-episode schizophrenic patients. " Schizophr. Res.. 2009 Sep ; 113 (41308) : 151-7.
  Pubmed PMID: 19540723.
• Kosten TA, Bianchi MS, Kosten TR. " The predictive validity of the dependence syndrome in opiate abusers. " Am J Drug Alcohol Abuse. 1992 ; 18 (2) : 145-56.
  Pubmed PMID: 1562012.
• Kosten TR, George TP, Kosten TA. " The potential of dopamine agonists in drug addiction. " Expert Opin Investig Drugs. 2002 Apr ; 11 (4) : 491-9.
  Pubmed PMID: 11922858.
• Rao S, Ziedonis DM, Kosten TR. " The pharmacotherapy of cocaine dependence. " Psychiatric Annals. 1995 ;
• Haile CN, Kosten TR. " The potential of pharmacogenomics to treat drug addiction. " Pharmacogenomics. 2009 Dec ; 10 (12) : 1883-6.
  Pubmed PMID: 19958085.
• Zhang R, Hao W, Pan M, Wang C, Zhang X, Chen DC, Xiu MH, De Yang F, Kosten TR, Zhang XY. " The prevalence and clinical-demographic correlates of diabetes mellitus in chronic schizophrenic patients receiving clozapine. " Hum Psychopharmacol. 2011 Aug 8;
  Pubmed PMID: 21826737.
• Kosten TR. " The pharmacotherapy of relapse prevention using anticonvulsants. " Am J Addict. 1998 ; 7 (3) : 205-9.
  Pubmed PMID: 9702288.
• Kosten TR, Rounsaville BJ, Merikangas KR, Prusoff BA, Kleber HD. " The relationship of the Maudsley Personality Inventory to depression in addicts. " Compr Psychiatry. ; 24 (6) : 535-42.
  Pubmed PMID: 6653096.
• McCance EF, Kosten TR. " The role of the human laboratory in drug abuse research. Psychiatric Annals. " Psychiatric Annals. 1995 ;
• Zhang X, Hui L, Liu Y, Wang ZQ, You Y, Miao LN, Sun SL, Guan SL, Xiang Y, Kosten TR, Zhang XY. " The type 2 diabetes mellitus susceptibility gene IGF2BP2 is associated with schizophrenia in a Han Chinese population. " J Clin Psychiatry. 2013 Apr ; 74 (4) : e287-92.
  Pubmed PMID: 23656854.
• Mason JW, Kosten TR, Southwick SM, Giller EL.. " The use of hormonal profile strategies in post-traumatic stress disorder. " J Applied Social Psychology. 1990 ;
• Kosten TR, Bryant K, Rounsaville BJ. " The SCID: a clinical instrument for assessing psychiatric disorders. " NIDA Res. Monogr.. 1990 ; 105 : 213-9.
  Pubmed PMID: 1876002.
• Zhou DH, Yan QZ, Yan XM, Li CB, Fang H, Zheng YL, Zhang CX, Yao HJ, Chen da C, Xiu MH, Kosten TR, Zhang XY. " The study of BDNF Val66Met polymorphism in Chinese schizophrenic patients. " Prog. Neuropsychopharmacol. Biol. Psychiatry. 2010 Aug 16; 34 (6) : 930-3.
  Pubmed PMID: 20420877.
• Rohrbaugh RM, Felker B, Kosten T. " The VA psychiatry-primary care education initiative. " Acad Psychiatry. 2009 Jan ;
  Pubmed PMID: 19349441.
• Wang Y, Wang JD, Wu HR, Zhang BS, Fang H, Ma QM, Liu H, Chen da C, Xiu MH, Hail CN, Kosten TR, Zhang XY. " The Val66Met polymorphism of the brain-derived neurotrophic factor gene is not associated with risk for schizophrenia and tardive dyskinesia in Han Chinese population. " Schizophr. Res.. 2010 Jul ; 120 (41277) : 240-2.
  Pubmed PMID: 20395113.
• Nielsen DA, Hamon SC, Kosten TR. " The κ-opioid receptor gene as a predictor of response in a cocaine vaccine clinical trial " Psychiatr Genet. 2013 Dec ;
  Pubmed PMID: 23995774.
• Gardner TJ, Kosten TR. " Therapeutic options and challenges for substances of abuse. " 2007 ; 9 (4) : 431-45.
  Pubmed PMID: 18286802.
• Haney M, Kosten TR. " Therapeutic vaccines for substance dependence. " Expert Rev Vaccines. 2004 Feb ; 3 (1) : 41586.
  Pubmed PMID: 14761239.
• Kosten TR, Biegel D. " Therapeutic vaccines for substance dependence. " Expert Rev Vaccines. 2002 Oct ; 1 (3) : 363-71.
  Pubmed PMID: 12901575.
• Zhang XY, Chen da C, Xiu MH, Yang FD, Tan YL, He S, Kosten TA, Kosten TR. " Thioredoxin, a novel oxidative stress marker and cognitive performance in chronic and medicated schizophrenia versus healthy controls. " Schizophr. Res.. 2013 Feb ; 143 (41308) : 301-6.
  Pubmed PMID: 23238053.
• O'Connor PG, Carroll KM, Shi JM, Schottenfeld RS, Kosten TR, Rounsaville BJ. " Three methods of opioid detoxification in a primary care setting. A randomized trial. " Ann. Intern. Med.. 1997 Oct 1; 127 (7) : 526-30.
  Pubmed PMID: 9313020.
• Schottenfeld RS, Pakes J, O'Connor P, Chawarski M, Oliveto A, Kosten TR. " Thrice-weekly versus daily buprenorphine maintenance. " Biol. Psychiatry. 2000 Jun 15; 47 (12) : 1072-9.
  Pubmed PMID: 10862807.
• Sofuoglu M, Poling J, Mitchell E, Kosten TR. " Tiagabine affects the subjective responses to cocaine in humans. " Pharmacol. Biochem. Behav.. 2005 Nov ; 82 (3) : 569-73.
  Pubmed PMID: 16332385.
• Gonzalez G, Sevarino K, Sofuoglu M, Poling J, Oliveto A, Gonsai K, George TP, Kosten TR. " Tiagabine increases cocaine-free urines in cocaine-dependent methadone-treated patients: results of a randomized pilot study. " Addiction. 2003 Nov ; 98 (11) : 1625-32.
  Pubmed PMID: 14616189.
• Shi J, Li SX, Zhang XL, Wang X, Le Foll B, Zhang XY, Kosten TR, Lu L. " Time-Dependent Neuroendocrine Alterations and Drug Craving during the First Month of Abstinence in Heroin Addicts. " Am J Drug Alcohol Abuse. 2009 ; 35 (5) : 267-72.
  Pubmed PMID: 19591065.
• Lu L, Liu Y, Zhu W, Shi J, Liu Y, Ling W, Kosten TR. " Traditional medicine in the treatment of drug addiction. " Am J Drug Alcohol Abuse. 2009 ; 35 (1) : 41285.
  Pubmed PMID: 19152199.
• Rounsaville BJ, Kosten TR. " Treatment for opioid dependence: quality and access. " JAMA. 2000 Mar ;
  Pubmed PMID: 10714736.
• Kosten TR, Kleber HD, Morgan C. " Treatment of cocaine abuse with buprenorphine " Biol Psychiatry. 1989 Oct ;
  Pubmed PMID: 2790101.
• Nigam R, Schottenfeld R, Kosten TR. " Treatment of dual diagnosis patients: a relapse prevention group approach. " J Subst Abuse Treat. 1992 ; 9 (4) : 305-9.
  Pubmed PMID: 1362227.
• Kosten TR, Rosen MI, McMahon TL, Bridge TP, O'Malley SS, Pearsall R, O'Connor PG. " Treatment of early AIDS dementia in intravenous drug users: high versus low dose peptide T. " Am J Drug Alcohol Abuse. 1997 Nov ; 23 (4) : 543-53.
  Pubmed PMID: 9366972.
• Gonzalez G, Oliveto A, Kosten TR. " Treatment of heroin (diamorphine) addiction: current approaches and future prospects. " Drugs. 2002 ; 62 (9) : 1331-43.
  Pubmed PMID: 12076182.
• Kosten TR, Morgan C, Kleber HD. " Treatment of heroin addicts using buprenorphine. " Am J Drug Alcohol Abuse. 1991 Jun ; 17 (2) : 119-28.
  Pubmed PMID: 1862786.
• Treatment of patients with substance use disorders, second edition. American Psychiatic Association. " Am J Addictions. 2006 Oct ;
  Pubmed PMID: 16981488.
• Kleber HD, Weiss RD, Anton RF, George TP, Greenfield SF, Kosten TR, O'Brien CP, Rounsaville BJ, Strain EC, Ziedonis DM, Hennessy G, Connery HS, McIntyre JS, Charles SC, Anzia DJ, Cook IA, Finnerty MT, Johnson BR, Nininger JE, Summergrad P, Woods SM, Yager. " Treatment of patients with substance use disorders, second edition. American Psychiatric Association. " Am J Psychiatry. 2007 Apr ; 164 (4) : 5-123.
  Pubmed PMID: 17569411.
• Kosten TR, Forrest JN. " Treatment of severe lithium-induced polyuria with amiloride. " Am J Psychiatry. 1986 Dec ; 143 (12) : 1563-8.
  Pubmed PMID: 3538913.
• Poling J, Kosten TR, Sofuoglu M. " Treatment outcome predictors for cocaine dependence. " Am J Drug Alcohol Abuse. 2007 ; 33 (2) : 191-206.
  Pubmed PMID: 17497542.
• Satel SL, Krystal JH, Delgado PL, Kosten TR, Charney DS. " Tryptophan depletion and attenuation of cue-induced craving for cocaine. " Am J Psychiatry. 1995 May ; 152 (5) : 778-83.
  Pubmed PMID: 7726319.
• Kosten TR, McCance E. " Una revision de tratamientos farmacologicos para el abuso de substancias. " Revista de Toxicomanias. 1997 ;
• Kosten TR. " Update on addiction medicine in the State of Connecticut. " Connecticut Medicine. 1999 ;
• Jacobs SC, Mason J, Kosten TR, Kasl SV, Ostfeld AM, Wahby V. " Urinary free cortisol and separation anxiety early in the course of bereavement and threatened loss. " Biol. Psychiatry. 1987 Feb ; 22 (2) : 148-52.
  Pubmed PMID: 3814667.
• Mason JW, Giller EL, Kosten TR, Ostroff RB, Podd L. " Urinary free-cortisol levels in posttraumatic stress disorder patients. " J. Nerv. Ment. Dis.. 1986 Mar ; 174 (3) : 145-9.
  Pubmed PMID: 3950596.
• Druss BG, Rohrbaugh R, Kosten T, Hoff R, Rosenheck RA. " Use of alternative medicine in major depression " Psychiatr Serv.. 1998 Nov ;
  Pubmed PMID: 9826237.
• Stine SM, Kosten TR. " Use of drug combinations in treatment of opioid withdrawal. " J Clin Psychopharmacol. 1992 Jun ; 12 (3) : 203-9.
  Pubmed PMID: 1629388.
• Jacobs S, Mason J, Kosten T, Brown S, Ostfeld A. " Urinary-free cortisol excretion in relation to age in acutely stressed persons with depressive symptoms " Psychosom Med. 1984 May ;
  Pubmed PMID: 6739681.
• Kosten TR, Domingo CB, Shorter D, Orson F, Green C, Somoza E, Sekerka R, Levin FR, Mariani JJ, Stitzer M, Tompkins DA, Rotrosen J, Thakkar V, Smoak B, Kampman K. " Vaccine for cocaine dependence: a randomized double-blind placebo-controlled efficacy trial. " Drug Alcohol Depend. 2014 Jul ;
  Pubmed PMID: 24793366.
• Feingold A, Oliveto A, Schottenfeld R, Kosten TR. " Utility of crossover designs in clinical trials: efficacy of desipramine vs. placebo in opioid-dependent cocaine abusers. " Am J Addict. 2002 ; 11 (2) : 111-23.
  Pubmed PMID: 12028741.
• Martell BA, Mitchell E, Poling J, Gonsai K, Kosten TR. " Vaccine pharmacotherapy for the treatment of cocaine dependence. " Biol. Psychiatry. 2005 Jul 15; 58 (2) : 158-64.
  Pubmed PMID: 16038686.
• Shen XY, Orson FM, Kosten TR. " Vaccines Against Drug Abuse. " Clin. Pharmacol. Ther.. 2011 Nov 30;
  Pubmed PMID: 22130115.
• Kosten T, Domingo C, Orson F, Kinsey B. " Vaccines against stimulants: cocaine and MA " Br J Clin Pharmacol.. 2014 Feb ;
  Pubmed PMID: 23509915.
• Orson FM, Kinsey BM, Singh RA, Wu Y, Kosten TR. " Vaccines for cocaine abuse. " 2009 Apr ; 5 (4) : 194-9.
  Pubmed PMID: 19276665.
• Shorter D, Kosten TR. " Vaccines in the Treatment of Substance Abuse " Focus (Am Psychiatr Publ).. 2011 Dec ;
  Pubmed PMID: 23472050.
• Kosten TR. " What are America's opportunities for harm reduction strategies in opiate dependence? " Am J Addict. ; 14 (4) : 307-10.
  Pubmed PMID: 16188710.
• Stine SM, Southwick SM, Petrakis IL, Kosten TR, Charney DS, Krystal JH. " Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients. " Biol. Psychiatry. 2002 Apr 15; 51 (8) : 642-51.
  Pubmed PMID: 11955464.
• Avants SK, Margolin A, Kosten TR, Rounsaville BJ, Schottenfeld RS. " When is less treatment better? The role of social anxiety in matching methadone patients to psychosocial treatments. " J Consult Clin Psychol. 1998 Dec ; 66 (6) : 924-31.
  Pubmed PMID: 9874905.

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