Positions

Professor
Biochemistry and Molecular Biology
Baylor College of Medicine
Houston, TX, US
Primary Appointment
Charles C. Bell Professor
Biochemistry and Molecular Biology
Baylor College of Medicine
Director
CryoEM Core
Baylor College of Medicine
Co-Director
Center for Computational and Integrative Biomedical Research (CIBR)
Baylor College of Medicine
Houston, Texas, United States
Member
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine

Education

PhD from Rice University
Physics
MA from Rice University
Physics
BS from Caltech
Physics

Honors & Awards

Burton Medal
HAMBP (Houston Area Molecular Biophysics Program) Fellow
NRSA (Institutional) Fellow
NRSA (Individual) Fellow

Professional Interests

  • Cryo-electron Microscopy and Tomography
  • Quantitative Image Processing Algorithm Development
  • Structural Biology and Macromolecular Assemblies
  • Membranes and Membrane Proteins
  • Protein Structure-Function and Protein Folding
  • Antibiotic Resistance

Professional Statement

My group focuses on CryoEM/CryoET and quantitative image processing, applying these techniques to a wide range of biological systems ranging from individual macromolecules to whole cells. For the last 20 years my group has been developing the EMAN software suite for both high resolution single particle analysis as well as in-situ and in-vitro tomography. This software has been used on a large fraction of the structures in the EMDatabank, and with over 30,000 downloads is one of the most widely used in the field. In addition to developing new image processing methods such as deep learning applications and bispectral analysis, my group engages in a wide range of biological projects, from the high resolution structure and dynamics of individual molecules to the study of functioning macromolecular assemblies within the cell. Over the last 3-5 years, cryoEM has experienced a renaissance, largely due to the development of revolutionary direct detector technology, making this field directly competitive with X-ray crystallography for high resolution structural analysis, and providing many unique capabilities, such as in-situ structural biology. This is an exciting time for the cryoEM field, with many opportunities to substantially advance our fundamental understanding of biomolecular interactions.

Selected Publications

Memberships

Biophysical Society
Microscopy Society of America