Positions

Associate Professor
Molecular and Human Genetics
Baylor College of Medicine
Houston, Texas, United States
Associate Professor
Molecular Physiology & Biophysics
Baylor College of Medicine
Houston, Texas, United States
Faculty Member
Computational and Integrative Biomedical Research Center
Baylor College of Medicine
Houston, Texas, United States
Faculty Member
Program in Structural & Computational Biology and Molecular Biophysics
Baylor College of Medicine
Houston, Texas, United States
Faculty Senator
Baylor College of Medicine
Houston, Texas, United States
Member
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Education

BS from Texas A&M University
PhD from Baylor College Of Medicine
Post-Doctoral Fellowship at The Rockefeller University

Professional Interests

  • Functional genomics, bioinformatics, metabolomics and human genetics of mitochondrial and metabolic disease.

Professional Statement

Personalized genomics to identify genes causing Mitochondrial Disease

Mitochondrial disease has an incidence of 1/5000 and can affect every organ system. Childhood-onset mitochondrial disease most often results from recessive mutations in the nuclear genome; however, the vast majority of cases remain without a molecular diagnosis and no effective treatments thus underscoring the critical need to identify the genetic aberrations driving these disorders. We are leveraging a personalized functional genomics approach combining genome-wide sequencing, mitochondrial functional profiling in patient cells, and functional genomics to identify validated novel mitochondrial disease genes. This project will significantly advance the diagnosis and treatment of mitochondrial disease, as well as provide new insights into the mechanisms underlying the pathology of mitochondrial respiratory chain disorders and commonly occurring conditions associated with mitochondrial dysfunction such as cancer, diabetes and neurodegeneration.

Selected Publications

Memberships

American Society of Human Genetics