Positions

Professor
Biochemistry and Molecular Biology
Baylor College of Medicine
Houston, Texas, United States
Ruth McLean Bowman Bowers Professorship in Biochemistry
Biochemistry and Molecular Biology
Baylor College of Medicine
Houston, Texas, United States
Member
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Education

Postdoctoral Fellowship at The Rockefeller University
Mechanisms of the N-type inactivation gating and of ion permeation in potassium ion channels by X-ray crystallography and electrophysiology
PhD from State University Of New York At Buffalo
Mechanism of ligand recognition and channel gating in acetylcholine receptor channels by single-channel recordings and kinetic analyses

Honors & Awards

Pew Scholar in Biomedical Science
Alfred P. Sloan Fellow
Basil O’Connor Starter Scholar Award
Irma Hirschl Award

Professional Interests

  • Membrane Transport Proteins and Membrane Embedded Enzymes
  • Neuroscience
  • Metabolism
  • Enzymology
  • Structural Biology
  • Biomembranes
  • Cancer Biology
  • Chemical Biology
  • Drug Discovery and Medicinal Chemistry

Professional Statement

Membrane transport proteins are transporters and channels that mediate the transmembrane flow of nutrients such as amino acids, sugars, nucleotides and ions. Membrane transport proteins are essential for maintaining cellular functions, and mutations in these proteins cause genetic diseases in humans. Dr. Zhou’s lab applies structural, functional and computational methods to understand basic chemical and physical principles in membrane transport proteins: How substrates are recognized; what structural changes are required for substrate translocation; and how the electrochemical gradient of one substrate drives the concentrative uptake of another substrate.

Selected Publications

Memberships

Biophysical Society
Protein Society