Email

Positions

Associate Professor

Center for Gene Therapy
Baylor College of Medicine
Houston, TX, US

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

TX Childs Feigin Ctr (Lab)

Room: TXFC-1770
Houston, TX, 77030
United States

TX Childs Feigin Ctr (Office)

Room: TXFC-1770
Houston, TX, 77030
United States

Professional Interests

• The application of helper-dependent adenoviral vectors (HDAds) to cancer immunotherapy
• Combinatorial cancer immunotherapy with gene therapy and cell therapy
• Evaluation of cancer immunotherapy in humanized mouse model
• Evaluation tumor immune microenvironment in pre-clinical and clinical samples
• In vivo CAR-T cell generation using adenoviral vector

Websites

Selected Publications

• Rosewell Shaw A, Porter CE, Watanabe N, Tanoue K, Sikora A, Gottschalk S, Brenner MK, Suzuki M. " Adenovirotherapy Delivering Cytokine and Checkpoint Inhibitor Augments CAR T Cells against Metastatic Head and Neck Cancer " Molecular Therapy. 2017 ;
  Pubmed PMID: 28974431.
• Tanoue K, Rosewell Shaw A, Watanabe N, Porter C, Rana B, Gottschalk S, Brenner M, Suzuki M. " Armed Oncolytic Adenovirus-Expressing PD-L1 Mini-Body Enhances Antitumor Effects of Chimeric Antigen Receptor T Cells in Solid Tumors " Cancer Research. 2017 ;
  Pubmed PMID: 28235763.
• Rosewell Shaw A, Suzuki M. " Oncolytic Viruses Partner With T-Cell Therapy for Solid Tumor Treatment " ;
  Pubmed PMID: 30298067.
• Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors " 2021 ;
  Pubmed PMID: 33742099.
• Oncolytic Adenovirus Armed with BiTE, Cytokine, and Checkpoint Inhibitor Enables CAR T Cells to Control the Growth of Heterogeneous Tumors " 2020 ;
  Pubmed PMID: 32145203.
• Ultralow-dose binary oncolytic/helper-dependent adenovirus promotes antitumor activity in preclinical and clinical studies " 2023 ;
  Pubmed PMID: 36989357.

Projects

Combination immunotherapy with oncolytic adeno-immunotherapy and CAR cell therapy for solid tumor treatment

In vivo CAR-T cell generation using adenoviral vector