Positions

Professor
University of Washington
Adjunct Professor
Baylor College of Medicine

Education

Post-Doctoral Fellowship at University of California, Los Angeles
PhD from Shanghai Institute of Biochemistry and Cellular Biology, Chinese Academy of Sciences
BS from Nanjing University

Professional Interests

  • Prostate stem cells, development and carcinogenesis.

Professional Statement

My lab is interested in using the prostate as a tissue model to study the molecular and cellular mechanisms that regulate development, tissue homeostasis and carcinogenesis. Currently, there are two major research focuses in the lab. The first research focus is to characterize the prostate epithelial lineage hierarchy. We seek to investigate how individual prostate epithelial lineages are maintained in adults by prostate stem cells or progenitors, and to identify master regulators that control adult prostate homeostasis. The second focus of the lab is to investigate the molecular and cellular basis of aggressive prostate cancer. We are interested in determining the function of disease-associated genes in prostate cancer initiation and progression, and characterizing the identity of the cells of origin for prostate cancer. The major approaches that we utilize are cell culture-based prostate stem cell assays, genetically engineered mouse models, and a prostate regeneration method.

I have relocated my laboratory to the University of Washington at Seattle since August 1, 2018. https://www.washington.edu/urology/people/li-xin-ph-d/.

Selected Publications

Memberships

American Association of Cancer Research
Society of Basic Urological Research
International Society for Stem Cell Research

Funding

The prostate epithelial cell lineage hierarchy
- #R01DK092202
Grant funding from NIH/NIDDK
The Notch signaling in prostate homeostasis and carcinogenesis
- #R01CA190378
Grant funding from NIH/NCI