Kenneth L McClain, M.D., Ph.D.

Professor

(832) 822-4208

Email

kmcclain@bcm.edu

Positions

Professor: Pediatrics-Oncology
Baylor College of Medicine
Houston, TX, US
Currently employed by Baylor College of Medicine, Department of Pediatrics

Medicine: Dan L Duncan Comprehensive Cancer Center
Baylor. College of Medicine
Houston, Texas, United States

Addresses

Office Address (Office): TCH-Clinical Care Center 6701 Fannin St.
Room: TXCL-151010
Houston, TX, 77030
United States
Phone: (832) 822-4208
klmcclai@txch.org

Clinic (Clinic): 6701 Fannin St.
Suite 1400
Houston, TX, 77030
United States
Phone: (832) 822-4866
klmcclai@txch.org

Education

Clinical Fellowship at University Of Minnesota Affiliate Hospitals: 07/1981 - Minneapolis, Minnesota, United States; Pediatric Hematology/Oncology

Post-Doctoral Fellowship at National Institutes Of Health: 06/1979 - Bethesda, Maryland, United States; Molecular Biology

Residency at Johns Hopkins Hospital: 06/1976 - Baltimore, Maryland, United States; Pediatrics

MD from University Of Chicago Hospitals: 06/1973 - Chicago, Illinois, United States; Medicine

PhD from University Of Chicago: 06/1972 - Chicago, Illinois, United States; Pathology/Virology

BA from Augustana College: 06/1967 - Sioux Falls, South Dakota, United States; Chemistry/Biology

Certifications

Medical License: #H-1145 (06/01/2013 - 05/31/2021); State of Texas

Texas Controlled Substances Registration Certificate: #R0064025 (05/03/2014 - 05/31/2015); State of Texas; As of 2017 the Texas Medical Board no longer required a Department of Public Safety controlled substances registration permit. The national DEA certificate is valid

DEA Registration: #AM9026047 (12/10/2019 - 01/31/2023); Drug Enforcement Adm., U.S. Dpt of Justice

Board Certification in Pediatric Hematology/Oncology: #620; American Board of Pediatrics; Re-certification not required per regulations in 1982.

Board Certification in Pediatrics: #23003; American Board of Pediatrics; Board Certification in General Pediatrics

Professional Interests

Histiocytic Diseases
Lymphomas

Professional Statement

My goal is to provide the highest quality of care to my patients by using the most current medical information available and with careful attention to their emotional as well as physical needs. I will always inform the patients and families of critical information so they can better understand how their health problem is being solved.

Websites

Texas Children's Histiocytosis Program

Dr. McClain's Research

VIICTR Research Database

Selected Publications

Rogers BB, Browning I, Rosenblatt H, McClain K, Kemp J, Glasser LL, Gresik MV, Sumaya C, Wagner ML, Pollack MS. " A familial lymphoproliferative disorder presenting with primary pulmonary manifestations. " Am. Rev. Respir. Dis.. 1992 Jan ; 145 (1) : 203-8.
Pubmed PMID: 1309966.
McClain KL, Kozinetz CA. " A phase II trial using thalidomide for Langerhans cell histiocytosis. " Pediatr Blood Cancer. 2007 Jan ; 48 (1) : 44-9.
Pubmed PMID: 16333818.
Mahoney DH, McClain KL, Hanson IC, Taylor LD, Steuber CP. " Acquired immune deficiency, myelodysplasia, and acute nonlymphocytic leukemia associated with monosomy 7 and t(3;3) (q21;q26) in a child with Langerhans cell histiocytosis. " Am J Pediatr Hematol Oncol. 1989 ; 11 (2) : 153-7.
Pubmed PMID: 2546462.
McClain K, Wilkowski C. " Activation of endogenous retroviral sequences in human leukemia. " Biochem. Biophys. Res. Commun.. 1985 Dec 31; 133 (3) : 945-50.
Pubmed PMID: 3002378.
Schumacher HR, Desai SN, McClain KL, Domenico DR, Dizikes GJ, Bird ML. " Acute lymphoblastic leukemia-hand mirror variant. Analysis for endogenous retroviral antibodies in bone marrow plasma. " Am. J. Clin. Pathol.. 1989 Apr ; 91 (4) : 410-6.
Pubmed PMID: 2467550.
Murray JC, Kelley PK, McClain KL. " Adenovirus and childhood immune thrombocytopenic purpura. " Am. J. Hematol.. 1994 Sep ; 47 (1) : 65.
Pubmed PMID: 8042623.
Roskrow MA, Rooney CM, Heslop HE, Brenner MK, Krance RA, Gresik MV, McClain K, Aguilar LK, Grilley B, Rob E, Carrum G. " Administration of neomycin resistance gene marked EBV specific cytotoxic T-lymphocytes to patients with relapsed EBV-positive Hodgkin disease. " Hum. Gene Ther.. 1998 May 20; 9 (8) : 1237-50.
Pubmed PMID: 9625264.
Singh A, Prieto VG, Czelusta A, McClain KL, Duvic M. " Adult Langerhans cell histiocytosis limited to the skin. " Dermatology (Basel). 2003 ; 207 (2) : 157-61.
Pubmed PMID: 12920365.
Willman CL, McClain KL. " An update on clonality, cytokines, and viral etiology in Langerhans cell histiocytosis. " Hematol. Oncol. Clin. North Am.. 1998 Apr ; 12 (2) : 407-16.
Pubmed PMID: 9561909.
Jordan MB, McClain KL, Yan X, Hicks J, Jaffe R. " Anti-CD52 antibody, alemtuzumab, binds to Langerhans cells in Langerhans cell histiocytosis. " Pediatr Blood Cancer. 2005 Mar ; 44 (3) : 251-4.
Pubmed PMID: 15390358.
McClain KL. " Are all mutant SNARES equal? " Blood. 2012 Jun 21; 119 (25) : 5944-5.
Pubmed PMID: 22730520.
Pease CL, Horton TM, McClain KL, Kaplan SL. " Aseptic meningitis in a child after systemic treatment with high dose cytarabine. " Pediatr. Infect. Dis. J.. 2001 Jan ; 20 (1) : 87-9.
Pubmed PMID: 11176579.
McClain KL, Leach CT, Jenson HB, Joshi VV, Pollock BH, Parmley RT, DiCarlo FJ, Chadwick EG, Murphy SB. " Association of Epstein-Barr virus with leiomyosarcomas in children with AIDS. " N. Engl. J. Med.. 1995 Jan 5; 332 (1) : 41616.
Pubmed PMID: 7990860.
McClain KL, Natkunam Y, Swerdlow SH. " Atypical cellular disorders. " Hematology Am Soc Hematol Educ Program. 2004 ; 283-96.
Pubmed PMID: 15561688.
Day DL, Shapiro RS, Yueh N, McClain K, Allan BT, Filipovich AH. " B-cell lymphoproliferative disorders in children after bone marrow transplantation: radiologic manifestations. " Radiology. 1987 Mar ; 162 (3) : 807-10.
Pubmed PMID: 3668768.
Murray JC, Gresik MV, Leger F, McClain KL. " B19 parvovirus-induced anemia in a normal child. Initial bone marrow erythroid hyperplasia and response to intravenous immunoglobulin. " Am J Pediatr Hematol Oncol. 1993 Nov ; 15 (4) : 420-3.
Pubmed PMID: 8214365.
Jenson HB, Leach CT, McClain KL, Joshi VV, Pollock BH, Parmley RT, Chadwick EG, Murphy SB. " Benign and malignant smooth muscle tumors containing Epstein-Barr virus in children with AIDS. " Leuk. Lymphoma. 1997 Oct ; 27 (41337) : 303-14.
Pubmed PMID: 9402327.
McClain K, Ramsay NK, Robison L, Sundberg RD, Nesbit M. " Bone marrow involvement in histiocytosis X. " Med. Pediatr. Oncol.. 1983 ; 11 (3) : 167-71.
Pubmed PMID: 6602270.
McClain KL, Joshi VV, Murphy SB. " Cancers in children with HIV infection. " Hematol. Oncol. Clin. North Am.. 1996 Oct ; 10 (5) : 1189-201.
Pubmed PMID: 8880205.
Allen CE, Li L, Peters TL, Leung HC, Yu A, Man TK, Gurusiddappa S, Phillips MT, Hicks MJ, Gaikwad A, Merad M, McClain KL. " Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells. " J. Immunol.. 2010 Apr 15; 184 (8) : 4557-67.
Pubmed PMID: 20220088.
Grois N, Fahrner B, Arceci RJ, Henter JI, McClain K, Lassmann H, Nanduri V, Prosch H, Prayer D. " Central nervous system disease in Langerhans cell histiocytosis. " J. Pediatr.. 2010 Jun ; 156 (6) : 873-81, 881.e1.
Pubmed PMID: 20434166.
Jenson HB, Montalvo EA, McClain KL, Ench Y, Heard P, Christy BA, Dewalt-Hagan PJ, Moyer MP. " Characterization of natural Epstein-Barr virus infection and replication in smooth muscle cells from a leiomyosarcoma. " J. Med. Virol.. 1999 Jan ; 57 (1) : 36-46.
Pubmed PMID: 9890420.
Murray JC, Kelley PK, Hogrefe WR, McClain KL. " Childhood idiopathic thrombocytopenic purpura: association with human parvovirus B19 infection. " Am J Pediatr Hematol Oncol. 1994 Nov ; 16 (4) : 314-9.
Pubmed PMID: 7978048.
McClain K, Estrov Z, Chen H, Mahoney DH. " Chronic neutropenia of childhood: frequent association with parvovirus infection and correlations with bone marrow culture studies. " Br. J. Haematol.. 1993 Sep ; 85 (1) : 57-62.
Pubmed PMID: 8251410.
McClain KL. " Chronic, episodic thrombocytopenia. A case report with long-term observation. " Clin Pediatr (Phila). 1990 Mar ; 29 (3) : 179-81.
Pubmed PMID: 2306904.
Hanson CA, Frizzera G, Patton DF, Peterson BA, McClain KL, Gajl-Peczalska KJ, Kersey JH. " Clonal rearrangement for immunoglobulin and T-cell receptor genes in systemic Castleman's disease. Association with Epstein-Barr virus. " Am. J. Pathol.. 1988 Apr ; 131 (1) : 84-91.
Pubmed PMID: 2833104.
Phillips M, Allen C, Gerson P, McClain K. " Comparison of FDG-PET scans to conventional radiography and bone scans in management of Langerhans cell histiocytosis. " Pediatr Blood Cancer. 2009 Jan ; 52 (1) : 97-101.
Pubmed PMID: 18951435.
Eckschlager T, McClain K. " Comparison of fluorescent in situ hybridization (FISH) and the polymerase chain reaction (PCR) for detection of residual neuroblastoma cells. " Neoplasma. 1996 ; 43 (5) : 301-3.
Pubmed PMID: 8996548.
Vogel H, Kornman M, Ledet SC, Rajagopalan L, Taber L, McClain K. " Congenital parvovirus infection. " Pediatr Pathol Lab Med. ; 17 (6) : 903-12.
Pubmed PMID: 9353830.
Franz MJ, Splett PL, Monk A, Barry B, McClain K, Weaver T, Upham P, Bergenstal R, Mazze RS. " Cost-effectiveness of medical nutrition therapy provided by dietitians for persons with non-insulin-dependent diabetes mellitus. " J Am Diet Assoc. 1995 Sep ; 95 (9) : 1018-24.
Pubmed PMID: 7657903.
Venkataraman G, McClain KL, Pittaluga S, Rao VK, Jaffe ES. " Development of disseminated histiocytic sarcoma in a patient with autoimmune lymphoproliferative syndrome and associated Rosai-Dorfman disease. " Am. J. Surg. Pathol.. 2010 Apr ; 34 (4) : 589-94.
Pubmed PMID: 20216376.
Abla O, Weitzman S, Minkov M, McClain KL, Visser J, Filipovich A, Grois N. " Diabetes insipidus in Langerhans cell histiocytosis: When is treatment indicated? " Pediatr Blood Cancer. 2009 May ; 52 (5) : 555-6.
Pubmed PMID: 19142995.
Fung EB, Harmatz PR, Milet M, Balasa V, Ballas SK, Casella JF, Hilliard L, Kutlar A, McClain KL, Olivieri NF, Porter JB, Vichinsky EP. " Disparity in the management of iron overload between patients with sickle cell disease and thalassemia who received transfusions. " Transfusion. 2008 Sep ; 48 (9) : 1971-80.
Pubmed PMID: 18513257.
Fusner JE, McClain KL. " Disseminated lymphonodular cryptococcosis treated with 5-fluorocytosine. " J. Pediatr.. 1979 Apr ; 94 (4) : 599-601.
Pubmed PMID: 430297.
Mustafa MM, McClain KL. " Diverse hematologic effects of parvovirus B19 infection. " Pediatr. Clin. North Am.. 1996 Jun ; 43 (3) : 809-21.
Pubmed PMID: 8649911.
Wu WS, McClain KL. " DNA polymorphisms and mutations of the tumor necrosis factor-alpha (TNF-alpha) promoter in Langerhans cell histiocytosis (LCH). " J. Interferon Cytokine Res.. 1997 Oct ; 17 (10) : 631-5.
Pubmed PMID: 9355965.
McClain KL. " Drug therapy for the treatment of Langerhans cell histiocytosis. " Expert Opin Pharmacother. 2005 Nov ; 6 (14) : 2435-41.
Pubmed PMID: 16259575.
Lee DA, Tatevian N, Herring RA, McClain KL. " EBV+ lymphoproliferative disease following prolonged chemotherapy for refractory LCH. " Pediatr Blood Cancer. 2008 Mar ; 50 (3) : 728-30.
Pubmed PMID: 17243127.
Franz MJ, Monk A, Barry B, McClain K, Weaver T, Cooper N, Upham P, Bergenstal R, Mazze RS. " Effectiveness of medical nutrition therapy provided by dietitians in the management of non-insulin-dependent diabetes mellitus: a randomized, controlled clinical trial. " J Am Diet Assoc. 1995 Sep ; 95 (9) : 1009-17.
Pubmed PMID: 7657902.
Stine KC, Saylors RL, Saccente S, McClain KL, Becton DL. " Efficacy of continuous infusion 2-CDA (cladribine) in pediatric patients with Langerhans cell histiocytosis. " Pediatr Blood Cancer. 2004 Jul ; 43 (1) : 81-4.
Pubmed PMID: 15170896.
McClain K, Kirsten WH. " Electrophoretic analysis of the RNA from a mouse leukemia virus. " Cancer Res.. 1972 Jul ; 32 (7) : 1470-5.
Pubmed PMID: 4337831.
Hanto DW, Gajl-Peczalska KJ, Frizzera G, Arthur DC, Balfour HH, McClain K, Simmons RL, Najarian JS. " Epstein-Barr virus (EBV) induced polyclonal and monoclonal B-cell lymphoproliferative diseases occurring after renal transplantation. Clinical, pathologic, and virologic findings and implications for therapy. " Ann. Surg.. 1983 Sep ; 198 (3) : 356-69.
Pubmed PMID: 6311121.
McClain KL. " Epstein-Barr virus and HIV-AIDS-associated diseases. " Biomed. Pharmacother.. 2001 Sep ; 55 (7) : 348-52.
Pubmed PMID: 11669495.
Shapiro RS, McClain K, Frizzera G, Gajl-Peczalska KJ, Kersey JH, Blazar BR, Arthur DC, Patton DF, Greenberg JS, Burke B. " Epstein-Barr virus associated B cell lymphoproliferative disorders following bone marrow transplantation. " Blood. 1988 May ; 71 (5) : 1234-43.
Pubmed PMID: 2833957.
McClain K. " Epstein-Barr virus DNA in lymphocytes of patients with the virus-associated hemophagocytic syndrome. " Am J Pediatr Hematol Oncol. 1986 ; 8 (2) : 121-7.
Pubmed PMID: 3017142.
McClain K, Estrov Z, Raju U, Kelley PK, Aggarwal BB. " Epstein-Barr Virus EBNA-2 gene expression enhances lymphotoxin production by B lymphocytes. " Methods. 1997 Jan ; 11 (1) : 83-7.
Pubmed PMID: 8990093.
Patton DF, Wilkowski CW, Hanson CA, Shapiro R, Gajl-Peczalska KJ, Filipovich AH, McClain KL. " Epstein-Barr virus--determined clonality in posttransplant lymphoproliferative disease. " Transplantation. 1990 Jun ; 49 (6) : 1080-4.
Pubmed PMID: 2163133.
Patton DF, Wilkowski C, Hanson CA, Kersey JH, Bostrom B, McClain KL. " Epstein-Barr-virus-related post-bone-marrow-transplant lymphoproliferative disease: association with cytomegalovirus infection and Down syndrome donor marrow. " Am J Pediatr Hematol Oncol. 1989 ; 11 (4) : 429-32.
Pubmed PMID: 2559622.
Allen CE, McClain KL. " Erdheim-Chester: beyond the lesion. " Blood. 2011 Mar 10; 117 (10) : 2745-6.
Pubmed PMID: 21393495.
Jenson HB, McClain KL, Leach CT, Deng JH, Gao SJ. " Evaluation of human herpesvirus type 8 infection in childhood langerhans cell histiocytosis. " Am. J. Hematol.. 2000 Aug ; 64 (4) : 237-41.
Pubmed PMID: 10911374.
McClain KL. " Expression of oncogenes in human leukemias. " Cancer Res.. 1984 Nov ; 44 (11) : 5382-9.
Pubmed PMID: 6593118.
McClain KL, Cai YH, Hicks J, Peterson LE, Yan XT, Che S, Ginsberg SD. " Expression profiling using human tissues in combination with RNA amplification and microarray analysis: assessment of Langerhans cell histiocytosis. " Amino Acids. 2005 May ; 28 (3) : 279-90.
Pubmed PMID: 15791395.
Horwitz CA, McClain K, Henle W, Henle G, Anderson SJ. " Fatal illness in a 2-week-old infant: diagnosis by detection of Epstein-Barr virus genomes from a lymph node biopsy. " J. Pediatr.. 1983 Nov ; 103 (5) : 752-5.
Pubmed PMID: 6313890.
Kelly C, Salvi S, McClain K, Hayani A. " Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia. " Pediatr Blood Cancer. 2011 Apr ; 56 (4) : 658-60.
Pubmed PMID: 21298755.
Bird JA, McClain KL, Rosenblatt HM, Abramson SL, Hanson IC. " Hemophagocytic lymphohistiocytosis in a patient with x-linked lymphoproliferative disease. " Allergy Asthma Proc. ; 30 (4) : 458-62.
Pubmed PMID: 19772767.
Niece JA, Rogers ZR, Ahmad N, Langevin AM, McClain KL. " Hemophagocytic lymphohistiocytosis in Texas: observations on ethnicity and race. " Pediatr Blood Cancer. 2010 Mar ; 54 (3) : 424-8.
Pubmed PMID: 19953651.
Rooms L, Fitzgerald N, McClain KL. " Hemophagocytic lymphohistiocytosis masquerading as child abuse: presentation of three cases and review of central nervous system findings in hemophagocytic lymphohistiocytosis. " Pediatrics. 2003 May ; 111 (5) : e636-40.
Pubmed PMID: 12728123.
Palazzi DL, McClain KL, Kaplan SL. " Hemophagocytic syndrome after Kawasaki disease. " Pediatr. Infect. Dis. J.. 2003 Jul ; 22 (7) : 663-6.
Pubmed PMID: 12886898.
Palazzi DL, McClain KL, Kaplan SL. " Hemophagocytic syndrome in children: an important diagnostic consideration in fever of unknown origin. " Clin. Infect. Dis.. 2003 Feb 1; 36 (3) : 306-12.
Pubmed PMID: 12539072.
Estrov Z, Talpaz M, Kantarjian HM, Zipf TF, McClain KL, Kurzrock R. " Heterogeneity in lineage derivation of Philadelphia-positive acute lymphoblastic leukemia expressing p190BCR-ABL or p210BCR-ABL: determination by analysis of individual colonies with the polymerase chain reaction. " Cancer Res.. 1993 Jul 15; 53 (14) : 3289-93.
Pubmed PMID: 8324740.
Allen CE, Yu X, Kozinetz CA, McClain KL. " Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis. " Pediatr Blood Cancer. 2008 Jun ; 50 (6) : 1227-35.
Pubmed PMID: 18085676.
Filipovich A, McClain K, Grom A. " Histiocytic disorders: recent insights into pathophysiology and practical guidelines. " Biol. Blood Marrow Transplant.. 2010 Jan ; 16 (1) : S82-9.
Pubmed PMID: 19932759.
Kavan P, Smelhaus V, Stary J, McClain K, Koutecky J. " History of pediatric hematology-oncology in the Czech Republic. " Pediatr Hematol Oncol. ; 14 (4) : 307-13.
Pubmed PMID: 9211535.
Henter JI, Horne A, Aricó M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J, Janka G. " HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. " Pediatr Blood Cancer. 2007 Feb ; 48 (2) : 124-31.
Pubmed PMID: 16937360.
Chintagumpala MM, Mahoney DH, McClain K, Dreyer ZE, Fishman MA, Carrol CL, Steuber CP. " Hodgkin's disease associated with central pontine myelinolysis. " Med. Pediatr. Oncol.. 1993 ; 21 (4) : 311-4.
Pubmed PMID: 7682285.
Jordan MB, Allen CE, Weitzman S, Filipovich AH, McClain KL. " How I treat hemophagocytic lymphohistiocytosis. " Blood. 2011 Oct 13; 118 (15) : 4041-52.
Pubmed PMID: 21828139.
Leach CT, Pollock BH, McClain KL, Parmley RT, Murphy SB, Jenson HB. " Human herpesvirus 6 and cytomegalovirus infections in children with human immunodeficiency virus infection and cancer. " Pediatr. Infect. Dis. J.. 2002 Feb ; 21 (2) : 125-32.
Pubmed PMID: 11840079.
Leach CT, Frantz C, Head DR, Gao SJ, McClain KL, Cohen M, Campbell AB, Pollock BH, Murphy SB, Jenson HB. " Human herpesvirus-8 (HHV-8) associated with small non-cleaved cell lymphoma in a child with AIDS. " Am. J. Hematol.. 1999 Mar ; 60 (3) : 215-21.
Pubmed PMID: 10072113.
McClain KL. " Immunodeficiency states and related malignancies. " Cancer Treat. Res.. 1997 ; 92 : 39-61.
Pubmed PMID: 9494757.
Winter H, Hu HM, McClain K, Urba WJ, Fox BA. " Immunotherapy of melanoma: a dichotomy in the requirement for IFN-gamma in vaccine-induced antitumor immunity versus adoptive immunotherapy. " J. Immunol.. 2001 Jun 15; 166 (12) : 7370-80.
Pubmed PMID: 11390488.
Steiner QG, Otten LA, Hicks MJ, Kaya G, Grosjean F, Saeuberli E, Lavanchy C, Beermann F, McClain KL, Acha-Orbea H. " In vivo transformation of mouse conventional CD8alpha+ dendritic cells leads to progressive multisystem histiocytosis. " Blood. 2008 Feb 15; 111 (4) : 2073-82.
Pubmed PMID: 18029555.
Weiss NS, Katz JA, Frankel LS, Lloyd LE, McClain KL, Torges K, Thomas PJ, Bleyer WA. " Incidence of childhood and adolescent cancer in Texas. " Tex Med. 1996 Jul ; 92 (7) : 54-60.
Pubmed PMID: 8763250.
Rolland A, Guyon L, Gill M, Cai YH, Banchereau J, McClain K, Palucka AK. " Increased blood myeloid dendritic cells and dendritic cell-poietins in Langerhans cell histiocytosis. " J. Immunol.. 2005 Mar 1; 174 (5) : 3067-71.
Pubmed PMID: 15728521.
Dreyer ZE, Dowell BL, Chen H, Hawkins E, McClain KL. " Infection-associated hemophagocytic syndrome. Evidence for Epstein-Barr virus gene expression. " Am J Pediatr Hematol Oncol. 1991 ; 13 (4) : 476-81.
Pubmed PMID: 1696073.
Allen CE, McClain KL. " Interleukin-17A is not expressed by CD207(+) cells in Langerhans cell histiocytosis lesions. " Nat. Med.. 2009 May ; 15 (5) : 483-4; author r.
Pubmed PMID: 19424201.
Shah MD, McClain KL. " Intracranial plasma cell granuloma: case report and treatment of recurrence with methotrexate and 6-mercaptopurine. " J. Pediatr. Hematol. Oncol.. 2005 Nov ; 27 (11) : 599-603.
Pubmed PMID: 16282891.
Aricò M, Girschikofsky M, Généreau T, Klersy C, McClain K, Grois N, Emile JF, Lukina E, De Juli E, Danesino C. " Langerhans cell histiocytosis in adults. Report from the International Registry of the Histiocyte Society. " Eur. J. Cancer. 2003 Nov ; 39 (16) : 2341-8.
Pubmed PMID: 14556926.
McClain KL, Laud P, Wu WS, Pollack MS. " Langerhans cell histiocytosis patients have HLA Cw7 and DR4 types associated with specific clinical presentations and no increased frequency in polymorphisms of the tumor necrosis factor alpha promoter. " Med. Pediatr. Oncol.. 2003 Dec ; 41 (6) : 502-7.
Pubmed PMID: 14595706.
Allen CE, McClain KL. " Langerhans cell histiocytosis: a review of past, current and future therapies. " Drugs Today. 2007 Sep ; 43 (9) : 627-43.
Pubmed PMID: 17940639.
McClain K, Jin H, Gresik V, Favara B. " Langerhans cell histiocytosis: lack of a viral etiology. " Am. J. Hematol.. 1994 Sep ; 47 (1) : 16-20.
Pubmed PMID: 8042610.
Willman CL, Busque L, Griffith BB, Favara BE, McClain KL, Duncan MH, Gilliland DG. " Langerhans'-cell histiocytosis (histiocytosis X)--a clonal proliferative disease. " N. Engl. J. Med.. 1994 Jul 21; 331 (3) : 154-60.
Pubmed PMID: 8008029.
Rubin CM, Arthur DC, Meyers G, McClain KL, Kim TH, Woods WG. " Leukemia cutis treated with total skin irradiation. " Cancer. 1985 Jun 1; 55 (11) : 2649-52.
Pubmed PMID: 3888368.
Girschikofsky M, Arico M, Castillo D, Chu A, Doberauer C, Fichter J, Haroche J, Kaltsas GA, Makras P, Marzano AV, de Menthon M, Micke O, Passoni E, Seegenschmiedt HM, Tazi A, McClain KL. " Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net. " Orphanet J Rare Dis. 2013 ; 8 : 72.
Pubmed PMID: 23672541.
Roberts WM, Estrov Z, Ouspenskaia MV, Johnston DA, McClain KL, Zipf TF. " Measurement of residual leukemia during remission in childhood acute lymphoblastic leukemia. " N. Engl. J. Med.. 1997 Jan 30; 336 (5) : 317-23.
Pubmed PMID: 9011783.
Cabalo E, Wilkinson R, Lu NT, Shimizu S, Melish M, McClain KL, Jenson HB, Shiramizu B. " Molecular analysis and pathology of a second pediatric HIV-associated Burkitt lymphoma. " Pediatr Pathol Mol Med. ; 21 (6) : 525-30.
Pubmed PMID: 12537769.
McClain KL, Leach CT, Jenson HB, Joshi VV, Pollock BH, Hutchison RE, Murphy SB. " Molecular and virologic characteristics of lymphoid malignancies in children with AIDS. " J. Acquir. Immune Defic. Syndr.. 2000 Feb 1; 23 (2) : 152-9.
Pubmed PMID: 10737430.
McClain K, Kirsten WH. " Mouse leukemia virus growth in mouse cells contaminated with Mycoplasma. " Cancer Res.. 1974 Feb ; 34 (2) : 281-5.
Pubmed PMID: 6267781.
Loeffel S, Chang CH, Heyn R, Harada S, Lipscomb H, Sinangil F, Volsky DJ, McClain K, Ochs H, Purtilo DT. " Necrotizing lymphoid vasculitis in X-linked lymphoproliferative syndrome. " Arch. Pathol. Lab. Med.. 1985 Jun ; 109 (6) : 546-50.
Pubmed PMID: 2986573.
McClain KL, Gonzalez JM, Jonkers R, De Juli E, Egeler M. " Need for a cooperative study: Pulmonary Langerhans cell histiocytosis and its management in adults. " Med. Pediatr. Oncol.. 2002 Jul ; 39 (1) : 35-9.
Pubmed PMID: 12116077.
Peters TL, McClain KL, Allen CE. " Neither IL-17A mRNA Nor IL-17A Protein Are Detectable in Langerhans Cell Histiocytosis Lesions. " Mol. Ther.. 2011 Aug ; 19 (8) : 1433-9.
Pubmed PMID: 21654633.
Allen CE, Flores R, Rauch R, Dauser R, Murray JC, Puccetti D, Hsu DA, Sondel P, Hetherington M, Goldman S, McClain KL. " Neurodegenerative central nervous system Langerhans cell histiocytosis and coincident hydrocephalus treated with vincristine/cytosine arabinoside. " Pediatr Blood Cancer. 2010 Mar ; 54 (3) : 416-23.
Pubmed PMID: 19908293.
Bender AP, Robison LL, Kashmiri SV, McClain KL, Woods WG, Smithson WA, Heyn R, Finlay J, Schuman LM, Renier C. " No involvement of bovine leukemia virus in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma. " Cancer Res.. 1988 May 15; 48 (10) : 2919-22.
Pubmed PMID: 2834051.
Cantu MA, Lupo PJ, Bilgi M, Hicks MJ, Allen CE, McClain KL. " Optimal therapy for adults with langerhans cell histiocytosis bone lesions. " PLoS ONE. 2012 ; 7 (8) : e43257.
Pubmed PMID: 22916233.
Rathore N, Eissa HM, Margolin JF, Liu H, Wu MF, Horton T, Kamdar K, Dreyer Z, Steuber P, Rabin KR, Redell M, Allen CE, McClain KL, Guillerman RP, Bollard CM. " Pediatric Hodgkin Lymphoma: Are We Over-scanning Our Patients? " Pediatr Hematol Oncol. 2012 Aug ; 29 (5) : 415-23.
Pubmed PMID: 22632168.
Haupt R, Nanduri V, Calevo MG, Bernstrand C, Braier JL, Broadbent V, Rey G, McClain KL, Janka-Schaub G, Egeler RM. " Permanent consequences in Langerhans cell histiocytosis patients: a pilot study from the Histiocyte Society-Late Effects Study Group. " Pediatr Blood Cancer. 2004 May ; 42 (5) : 438-44.
Pubmed PMID: 15049016.
Estrov Z, Ouspenskaia MV, Felix EA, McClain KL, Lee MS, Harris D, Pinkel DP, Zipf TF. " Persistence of self-renewing leukemia cell progenitors during remission in children with B-precursor acute lymphoblastic leukemia. " Leukemia. 1994 Jan ; 8 (1) : 46-52.
Pubmed PMID: 8289497.
Furman WL, Strother D, McClain K, Bell B, Leventhal B, Pratt CB. " Phase I clinical trial of recombinant human tumor necrosis factor in children with refractory solid tumors: a Pediatric Oncology Group study. " J. Clin. Oncol.. 1993 Nov ; 11 (11) : 2205-10.
Pubmed PMID: 8229135.
Wright-Browne V, McClain KL, Talpaz M, Ordonez N, Estrov Z. " Physiology and pathophysiology of dendritic cells. " Hum. Pathol.. 1997 May ; 28 (5) : 563-79.
Pubmed PMID: 9158705.
O'Brien MM, Lee-Kim Y, George TI, McClain KL, Twist CJ, Jeng M. " Precursor B-cell acute lymphoblastic leukemia presenting with hemophagocytic lymphohistiocytosis. " Pediatr Blood Cancer. 2008 Feb ; 50 (2) : 381-3.
Pubmed PMID: 16856156.
Hayani A, Venger BH, Rouah E, Laurent JP, Mahoney DH, McClain KL. " Primary leptomeningeal B-cell lymphoma in a 8-year-old child. " Cancer. 1990 Oct 15; 66 (8) : 1856-60.
Pubmed PMID: 2170000.
Murray JC, Stein F, McGlothlin JC, McClain KL. " Prolongation of the prothrombin time after organophosphate poisoning. " Pediatr Emerg Care. 1994 Oct ; 10 (5) : 289-90.
Pubmed PMID: 7845858.
Lin TF, Ferlic-Stark LL, Allen CE, Kozinetz CA, McClain KL. " Rate of decline of ferritin in patients with hemophagocytic lymphohistiocytosis as a prognostic variable for mortality. " Pediatr Blood Cancer. 2011 Jan ; 56 (1) : 154-5.
Pubmed PMID: 20842751.
Minkov M, Steiner M, Pötschger U, Aricò M, Braier J, Donadieu J, Grois N, Henter JI, Janka G, McClain K, Weitzman S, Windebank K, Ladisch S, Gadner H. " Reactivations in multisystem Langerhans cell histiocytosis: data of the international LCH registry. " J. Pediatr.. 2008 Nov ; 153 (5) : 700-5, 705.e1-2.
Pubmed PMID: 18589441.
Murray JC, Paul ME, Rosenblatt HM, McClain KL. " Recurrent human parvovirus B19-induced anemia: initial manifestation of humoral immunodeficiency. " J. Pediatr. Hematol. Oncol.. 1996 Feb ; 18 (1) : 97-8.
Pubmed PMID: 8556382.
Kelley PK, McClain KL. " Respiratory contamination of polymerase chain reactions by human herpesvirus 6. " Am. J. Hematol.. 1994 Dec ; 47 (4) : 325-7.
Pubmed PMID: 7977307.
Pollock BH, Jenson HB, Leach CT, McClain KL, Hutchison RE, Garzarella L, Joshi VV, Parmley RT, Murphy SB. " Risk factors for pediatric human immunodeficiency virus-related malignancy. " JAMA. 2003 May 14; 289 (18) : 2393-9.
Pubmed PMID: 12746363.
Mahoney DH, Schreuders LC, Gresik MV, McClain KL. " Role of staging bone marrow examination in children with Hodgkin disease. " Med. Pediatr. Oncol.. 1998 Mar ; 30 (3) : 175-7.
Pubmed PMID: 9434827.
Leonard AS, Alyono D, Fischel RJ, Nesbit ME, Nguyen DH, McClain KL. " Role of the surgeon in the treatment of children's cancer. " Surg. Clin. North Am.. 1985 Dec ; 65 (6) : 1387-422.
Pubmed PMID: 3000008.
Marsh RA, Allen CE, McClain KL, Weinstein JL, Kanter J, Skiles J, Lee ND, Khan SP, Lawrence J, Mo JQ, Bleesing JJ, Filipovich AH, Jordan MB. " Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab. " Pediatr Blood Cancer. 2013 Jan ; 60 (1) : 101-9.
Pubmed PMID: 22522603.
Thompson PA, Allen CE, Horton T, Jones JY, Vinks AA, McClain KL. " Severe neurologic side effects in patients being treated for hemophagocytic lymphohistiocytosis. " Pediatr Blood Cancer. 2009 May ; 52 (5) : 621-5.
Pubmed PMID: 19137570.
Petersen JM, Tubbs RR, Savage RA, Calabrese LC, Proffitt MR, Manolova Y, Manolov G, Shumaker A, Tatsumi E, McClain K. " Small noncleaved B cell Burkitt-like lymphoma with chromosome t(8;14) translocation and Epstein-Barr virus nuclear-associated antigen in a homosexual man with acquired immune deficiency syndrome. " Am. J. Med.. 1985 Jan ; 78 (1) : 141-8.
Pubmed PMID: 2981469.
McClain K, Warkentin P, Kay N. " Spontaneous remission of Burkitt's lymphoma associated with herpes zoster infection. " Am J Pediatr Hematol Oncol. 1985 ; 7 (1) : 41531.
Pubmed PMID: 3876039.
Grishaber JE, McClain KL, Mahoney DH, Fernbach DJ. " Successful outcome of severe aplastic anemia following Epstein-Barr virus infection. " Am. J. Hematol.. 1988 Aug ; 28 (4) : 273-5.
Pubmed PMID: 2843043.
Rubin CM, Burke BA, McKenna RW, McClain KL, White JG, Nesbit ME, Filipovich AH. " The accelerated phase of Chediak-Higashi syndrome. An expression of the virus-associated hemophagocytic syndrome? " Cancer. 1985 Aug 1; 56 (3) : 524-30.
Pubmed PMID: 2988747.
Morad AB, McClain KL, Ogden AK. " The role of tranexamic acid in the treatment of giant hemangiomas in newborns. " Am J Pediatr Hematol Oncol. 1993 Nov ; 15 (4) : 383-5.
Pubmed PMID: 7605400.
Joshi VV, Gagnon GA, Chadwick EG, Berard CW, McClain KL, Leach CT, Jenson HB, Murphy SB. " The spectrum of mucosa-associated lymphoid tissue lesions in pediatric patients infected with HIV: A clinicopathologic study of six cases. " Am. J. Clin. Pathol.. 1997 May ; 107 (5) : 592-600.
Pubmed PMID: 9128273.
Gadner H, Minkov M, Grois N, Pötschger U, Thiem E, Aricò M, Astigarraga I, Braier J, Donadieu J, Henter JI, Janka-Schaub G, McClain KL, Weitzman S, Windebank K, Ladisch S. " Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis. " Blood. 2013 Jun 20; 121 (25) : 5006-14.
Pubmed PMID: 23589673.
Kavan P, Kabicková E, Gajdos P, Koutecký J, Smelhaus V, Stanková J, McClain KL. " Treatment of children and adolescents with non-Hodgkin's lymphoma (results based on the NHL Berlin-Frankfurt-Münster 90 protocols). " Cas. Lek. Cesk.. 1999 Jan 18; 138 (2) : 40-6.
Pubmed PMID: 10376402.
Kavan P, Kabickova E, Koutecky J, McClain K, Gajdos P, Kodet R, Slavik Z, Tousovska K. " Treatment of Hodgkin's disease in children with VAMP (vinblastine, adriamycin, methotrexate, prednisone) and VEPA (vinblastine, etoposide, prednisone, adriamycin). " Pediatr Hematol Oncol. ; 16 (2) : 141-8.
Pubmed PMID: 10100274.
Kavan P, Kabickova E, Gajdos P, Koutecky J, Kodet R, McClain KL. " Treatment of pediatric B-cell non-Hodgkin's lymphomas at the Motol Hospital in Prague, Czech Republic: results based on the NHL BFM 90 protocols. " Pediatr Hematol Oncol. ; 16 (3) : 201-12.
Pubmed PMID: 10326218.
Chadwick EG, Connor EJ, Hanson IC, Joshi VV, Abu-Farsakh H, Yogev R, McSherry G, McClain K, Murphy SB. " Tumors of smooth-muscle origin in HIV-infected children. " JAMA. 1990 Jun 20; 263 (23) : 3182-4.
Pubmed PMID: 2348529.
Murray JC, McClain KL, Wearden ME. " Using granulocyte colony-stimulating factor for neutropenia during neonatal sepsis. " Arch Pediatr Adolesc Med. 1994 Jul ; 148 (7) : 764-6.
Pubmed PMID: 7517276.
Ford R, McClain K, Cunningham BA. " Veno-occlusive disease following marrow transplantation. " Nurs. Clin. North Am.. 1983 Sep ; 18 (3) : 563-8.
Pubmed PMID: 6351022.
McClain K, Gehrz R, Grierson H, Purtilo D, Filipovich A. " Virus-associated histiocytic proliferations in children. Frequent association with Epstein-Barr virus and congenital or acquired immunodeficiencies. " Am J Pediatr Hematol Oncol. 1988 ; 10 (3) : 196-205.
Pubmed PMID: 2845831.
McClain K, Weiss RA. " Viruses and Langerhans cell histiocytosis: is there a link? " Br. J. Cancer Suppl.. 1994 Sep ; 23 : S34-6.
Pubmed PMID: 8075003.

Memberships

American Society for Hematology: Member

American Society for Pediatric Hematology/Oncology: Member

Histiocyte Society: Past President

Texas Medical Association: Member

Society for Pediatric Research: Member

Children's Oncology Group: Member

Dan L Duncan Comprehensive Cancer Center: Member (05/2015)

Funding

Redefining Langerhans Cell Histiocytosis as a Myeloid Dysplasia and Identifying Biomarkers for Early Detection and Risk Assessment #RO1 CA154489-01): $1,950,000.00 (04/01/2011 - 03/31/2016); Grant funding from NIH

Languages

Spanish