Email

jtang1@bcm.edu

Positions

Associate Professor

Pediatrics - Neurology
Baylor College of Medicine
Houston, Texas, USA

Director

In Vivo Neurophysiology Core
Jan and Dan Duncan Neurological Research Institute
Houston, Texas, USA

Addresses

Jan and Dan Duncan Neurological Research Institute (Office)

1250 Moursund St., Suite 1025
Houston, TX, 77030
United States
Phone: (832) 824-8866
Fax: (832) 825-1271
jtang1@bcm.edu

Jan and Dan Duncan Neurological Research Institute (Lab)

1250 Moursund St., Suite 1025
Houston, TX, 77030
United States
Phone: (832) 824-8866
Fax: (832) 825-1271
jtang1@bcm.edu

Education

PhD from East China Normal University

07/1997 - Shanghai, China

BSc from Southwest University

07/1984 - Chongqing, China

Postdoctoral Fellowship at University Of Hamburg

08/2000 - Hamburg, Germany

Postdoctoral Fellowship at Max Planck Institute Of Psychiatry

01/2002 - Munich, Germany

Websites

Selected Publications

• Wu Chen, Zhao-Lin Cai, Eugene S Chao, Hongmei Chen, Colleen M Longley, Shuang Hao, Hsiao-Tuan Chao, Joo Hyun Kim, Jessica E Messier, Huda Y Zoghbi, Jianrong Tang, John W Swann, Mingshan Xue. " Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy " eLIFE. 2020 Feb ;
  Pubmed PMID: 32073399.
• Thomas K Creson, Camilo Rojas, Ernie Hwaun, Thomas Vaissiere, Murat Kilinc, Andres Jimenez-Gomez, Jimmy Lloyd Holder Jr, Jianrong Tang, Laura L Colgin, Courtney A Miller, Gavin Rumbaugh. " Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior " eLIFE. 2019 Apr ;
  Pubmed PMID: 31025938.
• Amy E Pohodich, Hari Yalamanchili, Ayush T Raman, Ying-Wooi Wan, Michael Gundry, Shuang Hao, Haijing Jin, Jianrong Tang, Zhandong Liu, Huda Y Zoghbi. " Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity " eLIFE. 2018 Mar ;
  Pubmed PMID: 29570050.
• James P. Orengo, Meike E. van der Heijden, Shuang Hao, Jianrong Tang, Harry T. Orr, Huda Y. Zoghbi. " Motor neuron degeneration correlates with respiratory dysfunction in SCA1 " Dis Model Mech. 2018 Feb ;
  Pubmed PMID: 29419414.
• Vincenzo A. Gennarino, Elizabeth E. Palmer, Laura M. McDonell, Li Wang, Carolyn J. Adamski, Amanda Koire, Lauren See, Christian P. Schaaf, Shuang Hao, Olivier Lichtarge, Jianrong Tang, Kym M. Boycott, J. Lloyd Holder, Jr., Huda Y. Zoghbi. " A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures " Cell. 2018 Feb ;
  Pubmed PMID: 29474920.
• Yeh SY, Huang WH, Wang W, Ward CS, Chao ES, Wu Z, Tang B, Tang J, Sun JJ, Esther van der Heijden M, Gray PA, Xue M, Ray RS, Ren D, Zoghbi HY. " Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn " Neuron. 2017 Apr 19; 94 (2) : 294-303.
  Pubmed PMID: 28392070.
• Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, Botas J, Zoghbi HY. " Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. " Neuron. 2016 Oct 19; 92 (2) : 407-418.
  Pubmed PMID: 27720485.
• Lu H, Ash RT, He L, Kee SE, Wang W, Yu D, Hao S, Meng X, Ure K, Ito-Ishida A, Tang B, Sun Y, Ji D, Tang J, Arenkiel BR, Smirnakis SM, Zoghbi HY. " Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model " Neuron. 2016 Aug 17; 91 (4) : 739-747.
  Pubmed PMID: 27499081.
• Meng X, Wang W, Lu H, He LJ, Chen W, Chao ES, Fiorotto ML, Tang B, Herrera JA, Seymour ML, Neul JL, Pereira FA, Tang J, Xue M, Zoghbi HY.. " Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders. " eLIFE. 2016 Jun 21; e14199.
  Pubmed PMID: 27328325.
• Ure K, Lu H, Wang W, Ito-Ishida A, Wu Z, He LJ, Sztainberg Y, Chen W, Tang J, Zoghbi HY.. " Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome. " eLIFE. 2016 Jun 21; e14198.
  Pubmed PMID: 27328321.
• Sztainberg Y, Chen HM, Swann JW, Hao S, Tang B, Wu Z, Tang J, Wan YW, Liu Z, Rigo F, Zoghbi HY. " Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides " Nature. 2015 Dec 3; 528 (7580) : 123-126.
  Pubmed PMID: 26605526.
• Hao S, Tang B, Wu Z, Ure K, Sun Y, Tao H, Gao Y, Patel AJ, Curry DJ, Samaco RC, Zoghbi HY, Tang J. " Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice " Nature. 2015 Oct 15; 526 (7573) : 430-434.
  Pubmed PMID: 26469053.
• Jenson D, Yang K, Acevedo-Rodriguez A, Levine A, Broussard JI, Tang J, Dani JA. " Dopamine and norepinephrine receptors participate in methylphenidate enhancement of in vivo hippocampal synaptic plasticity. " Neuropharmacology. 2015 Mar ; 90 : 23-32.
  Pubmed PMID: 25445492.
• Han K, Holder JL, Schaaf CP, Lu H, Chen H, Kang H, Tang J, Wu Z, Hao S, Cheung SW, Yu P, Sun H, Breman AM, Patel A, Lu HC, Zoghbi HY. " SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties " Nature. 2013 Nov 7; 503 (7474) : 72-77.
  Pubmed PMID: 24153177.
• Zhang TA, Tang J, Pidoplichko VI, Dani JA. " Addictive nicotine alters local circuit inhibition during the induction of in vivo hippocampal synaptic potentiation. " J. Neurosci.. 2010 May 5; 30 (18) : 6443-53.
  Pubmed PMID: 20445070.
• Tang J, Dani JA. " Dopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine. " Neuron. 2009 Sep 10; 63 (5) : 673-82.
  Pubmed PMID: 19755109.
• Kamprath K, Marsicano G, Tang J, Monory K, Bisogno T, Di Marzo V, Lutz B, Wotjak CT. " Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes. " J. Neurosci.. 2006 Jun 21; 26 (25) : 6677-86.
  Pubmed PMID: 16793875.
• Wu LJ, Toyoda H, Zhao MG, Lee YS, Tang J, Ko SW, Jia YH, Shum FW, Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson YP, Kaang BK, Zhuo M. " Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. " J. Neurosci.. 2005 Nov 30; 25 (48) : 11107-16.
  Pubmed PMID: 16319310.
• Wanisch K, Tang J, Mederer A, Wotjak CT. " Trace fear conditioning depends on NMDA receptor activation and protein synthesis within the dorsal hippocampus of mice. " Behav. Brain Res.. 2005 Feb 10; 157 (1) : 63-9.
  Pubmed PMID: 15617772.
• Tang J, Ko S, Ding HK, Qiu CS, Calejesan AA, Zhuo M. " Pavlovian fear memory induced by activation in the anterior cingulate cortex. " Mol Pain. 2005 ; 1 : 6.
  Pubmed PMID: 15813993.
• Wei F, Xia XM, Tang J, Ao H, Ko S, Liauw J, Qiu CS, Zhuo M. " Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral response: a microelectroporation study in adult rodents " J Neurosci. 2003 Sep 10; 23 (23) : 8402-8409.
  Pubmed PMID: 12968002.
• Tang J, Wagner S, Schachner M, Dityatev A, Wotjak CT. " Potentiation of amygdaloid and hippocampal auditory-evoked potentials in a discriminatory fear-conditioning task in mice as a function of tone pattern and context. " Eur. J. Neurosci.. 2003 Aug ; 18 (3) : 639-50.
  Pubmed PMID: 12911760.
• Tang J, Wotjak CT, Wagner S, Williams G, Melitta Schachner M, Dityatev A. " Potentiated amygdaloid auditory-evoked potentials and freezing behavior after fear conditioning in mice " Brain Res. 2001 ; 919 : 232-241.
  Pubmed PMID: 11701135.
• Marsicano G, Wotjak CT, Azad SC, Bisogno T, Rammes G, Cascio MG, Hermann H, Tang J, Hofmann C, Zieglgänsberger W, Di Marzo V, Lutz B. " The endogenous cannabinoid system controls extinction of aversive memories. " Nature. 2002 Aug 1; 418 (6897) : 530-4.
  Pubmed PMID: 12152079.
• Alcott CE, Yalamanchili HK, Ji P, van der Heijden ME, Saltzman A, Elrod N, Lin A, Leng, Bhatt B, Hao S, Wang Q, Saliba A, Tang J, Malovannaya A, Wagner EJ, Liu Z, Zoghbi HY. " Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation " eLIFE. 2020 Apr ; 9 : 50895.
  Pubmed PMID: 32319885.
• Shao Y, Sztainberg Y, Wang Q, Bajikar SS, Trostle AJ, Wan YW, Jafar-Nejad P, Rigo F, Liu Z, Tang J, Zoghbi HY.. " Antisense oligonucleotide therapy in a humanized mouse model of MECP2 duplication syndrome " Sci Transl Med. 2021 Mar 3; 13 (583) : aaz7785.
  Pubmed PMID: 33658357.
• Shuang Hao, Qi Wang, Bin Tang, Zhenyu Wu, Tingting Yang, Jianrong Tang. " CDKL5 deficiency augments inhibitory input into the dentate gyrus that can be reversed by deep brain stimulation " J Neurosci. 2021 Oct 27; 41 (43) : 9031-46.
  Pubmed PMID: 34544833.
• Lingjie He, Matthew S Caudill, Junzhan Jing, Wei Wang, Yaling Sun, Jianrong Tang, Xiaolong Jiang, Huda Y Zoghbi. " A weakened recurrent circuit in the hippocampus of Rett syndrome mice disrupts long-term memory representations " Neuron. 2022 May 18; 110 (10) : 1689-1699.
  Pubmed PMID: 35290792.
• Qi Wang, Nicola de Prisco, Jianrong Tang, Vincenzo A Gennarino. " Protocol for recording epileptiform discharges of EEG and behavioral seizures in freely moving mice " STAR Protoc. 2022 Mar 14; 3 (2) : 101245.
  Pubmed PMID: 35310070.
• Qi Wang, Bin Tang, Jianrong Tang. " Protocol for deep brain stimulation in the fimbria-fornix of freely moving mice " STAR Protoc. 2021 Dec 21; 3 (1) : 101054.
  Pubmed PMID: 35005636.

Show 26 more publications

Projects

In vivo analysis of neural network activities in mouse models of neurological disorders

Jan and Dan Duncan Neurological Research Institute (07/2010 - present)

Houston, Texas

Memberships

Society for Neuroscience

Regular member (01/2002)

Molecular and Cellular Cognition Society

Regular member (01/2002)

Funding

Deep brain stimulation in Rett syndrome mice: cognitive benefits and their mechanisms
#R56NS100738

$213,040.00   (04/01/2017 - 03/31/2018)

Grant funding from NIH

Deep brain stimulation in Rett syndrome mice: cognitive benefits and their mechanisms
#R01NS100738

$886,193.00   (04/01/2018 - 03/31/2022)

Grant funding from NIH

Studies of forniceal deep brain stimulation and hippocampal memory in CDKL5 mice
#CDKL5–16–108–01

$150,000.00   (05/01/2016 - 04/30/2017)

Grant funding from LouLou Foundation

Studying the effects and mechanisms of deep brain stimulation in Rett syndrome mice
#2R01NS100738-A1

$1,198,743.00   (09/23/2022 - 07/31/2027)

Grant funding from NIH

Skills

system neuroscience

cognitive neuroscience

in vivo neurophysiology

mouse behavior

deep brain stimulation