Email

yustein@bcm.edu

Positions

Associate Professor

Pediatrics, Hematology-Oncology
Baylor College of Medicine
Houston, TX, US

Co-Associate Director of Education

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Director, Faris D. Virani Ewing Sarcoma Center

Texas Children's Cancer Center

Addresses

Texas Children's Clinical Care Center (Clinic)

1102 Bates St., 10th Floor
C1025.07
Houston, TX, 77030
United States
Phone: (832) 824-4601
yustein@bcm.edu
http://txch.org/doctors/dr-jason-yustein/

Education

BA from University of Virginia

05/1994 - Charlottesville, Virginia, United States

MD-PhD from Case Western Reserve University School of Medicine

05/2002 - Cleveland, OH

Fellowship at Johns Hopkins University Hospital

07/2008 - Baltimore, MD

Pediatric Hematology and Oncology

Residency at Johns Hopkins University Hospital

07/2005 - Baltimore, MD

Pediatrics

Internship at Johns Hopkins University Hospital

07/2003 - Baltimore, MD

Pediatrics

Certifications

Pediatric Hematology and Oncology

(06/01/2009 - 06/30/2019)

American Board of Pediatrics

Professional Interests

• Investigations into the Molecular Pathogenesis of Pediatric Sarcomas; sarcoma metastasis; cancer therapeutics

Websites

Selected Publications

• Zeller KI, Zhao X, Lee CW, Chiu KP, Yao F, Yustein JT, Ooi HS, Orlov YL, Shahab A, Yong HC, Fu Y, Weng Z, Kuznetsov VA, Sung WK, Ruan Y, Dang CV, Wei CL. " Global mapping of c-Myc binding sites and target gene networks in human B cells. " Proc. Natl. Acad. Sci. U.S.A.. 2006 Nov 21; 103 (47) : 17834-9.
  Pubmed PMID: 17093053.
• Awad O, Yustein JT, Shah P, Gul N, Katuri V, O'Neill A, Kong Y, Brown ML, Toretsky JA, Loeb DM. " High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition. " PLoS ONE. 2010 ; 5 (11) : e13943.
  Pubmed PMID: 21085683.
• Yustein JT, Liu YC, Gao P, Jie C, Le A, Vuica-Ross M, Chng WJ, Eberhart CG, Bergsagel PL, Dang CV. " Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. " Proc. Natl. Acad. Sci. U.S.A.. 2010 Feb 23; 107 (8) : 3534-9.
  Pubmed PMID: 20133585.
• Li F, Wang Y, Zeller KI, Potter JJ, Wonsey DR, O'Donnell KA, Kim JW, Yustein JT, Lee LA, Dang CV. " Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. " Mol. Cell. Biol.. 2005 Jul ; 25 (14) : 6225-34.
  Pubmed PMID: 15988031.
• Gwack Y, Nakamura H, Lee SH, Souvlis J, Yustein JT, Gygi S, Kung HJ, Jung JU. " Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication. " Mol. Cell. Biol.. 2003 Nov ; 23 (22) : 8282-94.
  Pubmed PMID: 14585985.
• Ruan MZ, Erez A, Guse K, Dawson B, Bertin T, Chen Y, Jiang MM, Yustein J, Gannon F, Lee BH. " Proteoglycan 4 expression protects against the development of osteoarthritis. " Sci Transl Med. 2013 Mar 13; 5 (176) : 176ra34.
  Pubmed PMID: 23486780.
• Dang CV, Kim JW, Gao P, Yustein J. " The interplay between MYC and HIF in cancer. " Nat. Rev. Cancer. 2008 Jan ; 8 (1) : 51-6.
  Pubmed PMID: 18046334.
• Yustein JT, Dang CV. " Biology and treatment of Burkitt's lymphoma. " Curr. Opin. Hematol.. 2007 Jul ; 14 (4) : 375-81.
  Pubmed PMID: 17534164.
• Wu G, Yustein JT, McCall MN, Zilliox M, Irizarry RA, Zeller K, Dang CV, Ji H. " ChIP-PED enhances the analysis of ChIP-seq and ChIP-chip data. " Bioinformatics. 2013 May 1; 29 (9) : 1182-9.
  Pubmed PMID: 23457041.
• Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ. " Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38. " Oncogene. 2003 Sep 18; 22 (40) : 6129-41.
  Pubmed PMID: 13679851.
• Yustein JT, Li D, Robinson D, Kung HJ. " KFC, a Ste20-like kinase with mitogenic potential and capability to activate the SAPK/JNK pathway. " Oncogene. 2000 Feb 3; 19 (5) : 710-8.
  Pubmed PMID: 10698516.
• Ke S, Wang W, Qiu X, Zhang F, Yustein JT, Cameron AG, Zhang S, Yu D, Zou C, Gao X, Lin J, Yallampalli S, Li M. " Multiple target-specific molecular agents for detection and image analysis of breast cancer characteristics in mice. " Curr. Mol. Med.. 2013 Mar 1; 13 (3) : 446-58.
  Pubmed PMID: 23331017.
• Robinson D, Chen HC, Li D, Yustein JT, He F, Lin WC, Hayman MJ, Kung HJ. " Tyrosine kinase expression profiles of chicken erythro-progenitor cells and oncogene-transformed erythroblasts. " J. Biomed. Sci.. 1998 ; 5 (2) : 93-100.
  Pubmed PMID: 9662068.
• Shapiro MC, Tang T, Dasgupta A, Kurenbekova L, Shuck R, Gaber MW, Yustein JT. " In Vitro and In Vivo Characterization of a Preclinical Irradiation-Adapted Model for Ewing Sarcoma. " Int J Radiat Oncol Biol Phys. 2018 May 1; 101
• Dasgupta A, Trucco M, Rainusso N, Bernardi RJ, Shuck R, Kurenbekova L, Loeb DM, Yustein JT. " Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties.. " Oncotarget. 2017 Aug 24; 8
• Satterfield L, Shuck R, Kurenbekova L, Allen-Rhoades W, Edwards D, Huang S, Rajapakshe K, Coarfa C, Donehower LA, Yustein JT. " miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma. " Int J Cancer. 2017 Nov 15; 141
• Zhao S, Kurenbekova L, Gao Y, Roos A, Creighton CJ, Rao P, Hicks J, Man TK, Lau C, Brown AM, Jones SN, Lazar AJ, Ingram D, Lev D, Donehower LA, Yustein JT.. " NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma.. " Oncogene. 2015 Sep 24; 34

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