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Positions
- Professor
- Molec. Physiology/ Martin
- Baylor College of Medicine
- Houston, TX, US
- Vivian L. Smith Chair in Regenerative Medicine
- Baylor College of Medicine
- Houston, Texas, United States
Education
- Post-Doctoral Fellowship at University Of Texas MD Anderson Cancer Center
- Ph.D. from University Of Texas Health Science Center
- MD from University Of Texas Medical School At Houston
- BS from Fordham University
Professional Interests
- Cell and Developmental Biology
- Molecular Biology and Genetics
- Human Disease
- Cardiovascular Sciences
Professional Statement
We are interested in understanding how developmental pathways are connected to adult tissue regeneration. We are investigating the Hippo, Wnt, and Bmp-signaling pathways for developmental and regenerative capabilities
Selected Publications
- Morikawa, Y., Heallen, T., Leach, J., Xiao, Y., and Martin, J.F.. "Dystrophin glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation." Nature. 2017;547(7662):227-231.
- Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Baruch-Umansky K, Yifa O, Kain D, Rajchman D, Leach J, Bassat DR, Udi Y, Sarig R, Sagi I, Martin JF, Bursac N, Cohen S and Tzahor E.. "The extracellular matrix protein Agrin promotes heart regeneration in mice." Nature. 2017;547(7662):179-184. Pubmed PMID: 28581497
- Tao G, Kahr PC, Morikawa Y, Zhang M, Rahmani M, Heallen TR, Li L, Sun Z, Olson EN, Amendt BA and Martin JF.. "Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury." Nature. 2016;534(7605):119-23. Pubmed PMID: 27251288
- Morikawa Y, Zhang M, Heallen T, Leach J, Tao G, Xiao Y, Bai Y, Li W, Willerson JT and Martin JF.. "Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice." Sci Signal. 2015;8(375):ra41. Pubmed PMID: 25943351
- Wang, J., Bai, Y., Li, N., Ye, W., Zhang, M., Greene, S.B., Tao, Y., Chen, Y., Wehrens, X.H., and Martin, J.F.. "Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation." Proc Natl Acad Sci U S A. 2014;111:9181-9186. Pubmed PMID: 24927531
- Jun Wang, Yan Bai, Hong Li, Stephanie Greene, Elzbieta Klysik, Wei Yu, Robert J. Schwartz, Trevor J. Williams and James F. Martin.. "MicroRNA-17-92, a direct Ap-2α transcriptional target, modulates T-box factor activity in orofacial clefting." Plos Genetics. 2013;9(9):e1003785. Pubmed PMID: 24068957
- Bonilla-Claudio M, Wang J, Bai Y, Klysik E, Selever J, Martin JF. "Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development.." Development. 2012 February;139(4):709-19. Pubmed PMID: 22219353
- Heallen T, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, Martin JF. "Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size.." Science. 2011 April 22;332(6028):458-61. Pubmed PMID: 21512031
- Wang J, Klysik E, Sood S, Johnson RL, Wehrens XH, Martin JF. "Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification.." Proc. Natl. Acad. Sci. U.S.A.. 2010 May 25;107(21):9753-8. Pubmed PMID: 20457925
- Wang J, Greene SB, Bonilla-Claudio M, Tao Y, Zhang J, Bai Y, Huang Z, Black BL, Wang F, Martin JF. "Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism.." Dev. Cell. 2010 December 14;19(6):903-12. Pubmed PMID: 21145505