Jacob Mandel, M.D.

Associate Professor

(713) 798-2273

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Email

jacob.mandel@bcm.edu

Positions

Associate Professor: Neurology
Baylor College of Medicine

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

Baylor Neurology (Clinic): Baylor College of Medicine Medical Center
McNair Campus
Houston, TX, 77030
United States
Phone: (713) 798-2273
https://www.bcm.edu/healthcare/care-centers/neurology

Education

Clinical Fellowship at MD Anderson Cancer Center: 06/2014 - Houston, Texas, United States

Residency at Ohio State University Medical Center: 06/2012 - Columbus, Ohio, United States

Internship at Ohio State University Medical Center: 06/2009 - Columbus, Ohio, United States

MD from Rush Medical College: 06/2008 - Chicago, Illinois, United States

BS from University of Illinois-Chicago: 05/2004 - Chicago, Illinois, United States

Certifications

Board Certified in Neurology: #57665 (09/20/2012 - 09/20/2022); American Board of Psychiatry and Neurology

Board Certified in Neuro-Oncology: #NO385-15 (08/31/2015 - 08/31/2025); United Council of Neurologic Subspecialties (UCNS)

Professional Interests

Neuro-oncology
Primary brain tumors
Paraneoplastic syndromes
Leptomeningeal disease
Brain metastasis
Clinical trials for primary brain tumors
Venous thromboembolism in malignant brain tumors

Professional Statement

I am a board certified neuro-oncologist at Baylor College of Medicine responsible for treating patients with brain tumors, brain metastases, and neurologic complications of cancer. I am a co-leader for the Dan L Duncan Cancer center Glioma working group and co-moderator of a biweekly brain tumor board. My research has been accepted for oral presentations at the Society of Neuro-Oncology, the American Academy of Neurology and the European Neurological Society. I have published retrospective studies, topic reviews, case series and reports in several prestigious journals including Neurology, Neuro-Oncology, Journal of Neuro-oncology, Current Oncology Reports, Journal of Neurological Sciences as well as a few book chapters. I am also responsible for the education of heme/onc fellows and neurology residents regarding neuro-oncology at Baylor.

Websites

VIICTR Publications List

Dr. Mandel's Bibliography

Comprehensive list of publications and presentations

Download CV

Selected Publications

de Groot JF, Mandel JJ. " Update on anti-angiogenic treatment for malignant gliomas " Curr Oncol Rep. 2014 Apr 16;
Pubmed PMID: 24510742.
Hamza MA, Mandel JJ, Conrad CA, Gilbert MR, Yung WK, Puduvalli VK, Degroot JF. " Survival outcome of early versus delayed bevacizumab treatment in patients with recurrent glioblastoma " J Neurooncol. 2014 May 7;
Pubmed PMID: 24803001.
Mandel JJ, Olar A, Aldape KD, Tremont-Lukats IW. " Lambrolizumab induced central nervous system (CNS) toxicity " J Neurol Sci. 2014 Jun 20;
Pubmed PMID: 24980937.
Mandel JJ, Yust-Katz S, Cachia D, Wu J, Liu D, de Groot JF, Yung AW, Gilbert MR.. " Leptomeningeal dissemination in glioblastoma; an inspection of risk factors, treatment, and outcomes at a single institution. " J Neurooncol. 2014 Aug 29;
Pubmed PMID: 25168214.
Mandel JJ, Tummala S, Woodman KH, Tremont-Lukats I.. " Delayed imaging abnormalities of neuro-invasive West Nile virus in cancer patients. " J Neurol Sci.. 2015 Mar 15;
Pubmed PMID: 25702151.
Yust-Katz S, Mandel JJ, Wu J, Yuan Y, Webre C, Pawar TA, Lhadha HS, Gilbert MR, Armstrong TS. " Venous thromboembolism (VTE) and glioblastoma. " J Neurooncol.. 2015 Aug ;
Pubmed PMID: 25985958.
Ladha H, Pawar T, Gilbert MR, Mandel J, O-Brien B, Conrad C, Fields M, Hanna T, Loch C, Armstrong TS.. " Wound healing complications in brain tumor patients on Bevacizumab " J Neurooncol.. 2015 Aug 23;
Pubmed PMID: 26298437.
Pacheco JM, Goodman JC, Mandel J.. " Intracranial epithelioid hemangioendothelioma causing subacute loss of vision. " Neurology. 2015 Aug 25;
Pubmed PMID: 26304679.
Cachia D, Kamiya-Matsuoka C, Mandel JJ, Olar A, Cykowski MD, Armstrong TS, Fuller GN, Gilbert MR, De Groot JF.. " Primary and secondary gliosarcomas: clinical, molecular and survival characteristics " J Neurooncol.. 2015 Oct 9;
Pubmed PMID: 26354773.
Mandel JJ, Cachia D, Liu D, Wilson C, Aldape K, Fuller G, de Groot JF.. " Impact of IDH1 mutation status on outcome in clinical trials for recurrent glioblastoma " J Neurooncol. 2016 Jun 7;
Pubmed PMID: 27270908.
Mandel JJ, Goethe EA, Patel AJ, Heck K, Hutton GJ. " Newly diagnosed ganglioglioma in an adult patient with multiple sclerosis. " J Neurol Sci. 2016 Oct 15;
Pubmed PMID: 27653865.
• Beechar VB, Srinivasan VM, Reznik OE, Sen A, Klisch TJ, Ropper AE, Mandel JJ, Heck KA, Seipel TJ, Patel AJ. " Intraventricular Cavernomas of the Third Ventricle: Report of 2 Cases and a Systematic Review of the Literature " World Neurosurg. 2017 Jun 23;
Pubmed PMID: 28648908.
• Cachia D, Elshafeey NA, Kamiya-Matsuoka C, Hatami M, Alfaro-Munoz KD, Mandel JJ, Colen R, DeGroot JF.. " Radiographic patterns of progression with associated outcomes after bevacizumab therapy in glioblastoma patients " J Neurooncol. 2017 Jul 12;
Pubmed PMID: 28702781.
Mandel JJ, Yust-Katz S, Patel AJ, Cachia D, Liu D, Park M, Yuan Y, A Kent T, de Groot JF. " Inability of positive phase II clinical trials of investigational treatments to subsequently predict positive phase III clinical trials in glioblastoma " Neuro Oncol. 2017 Jul 31;
Pubmed PMID: 29016865.
Nascimento FA, Kan P, Sharp L, Mandel JJ. " Spinal Dural Arteriovenous Fistula and Concomitant Intramedullary Spinal Lesion " Can J Neurol Sci.. 2017 Dec 18;
Pubmed PMID: 29251587.
Wagner KM, Mandel JJ, Goodman JC, Gopinath S, Patel AJ.. " Intracranial Erdheim-Chester Disease mimicking parafalcine meningioma: report of two cases and review of the literature. " World Neurosurg. 2017 Nov 27;
Pubmed PMID: 29191545.
Fellner A, Makranz C, Lotem M, Bokstein F, Taliansky A, Rosenberg S, Blumenthal DT, Mandel J, Fichman S, Kogan E, Steiner I, Siegal T, Lossos A, Yust-Katz S. " Neurologic complications of immune checkpoint inhibitors " J Neurooncol. 2018 Jan 13;
Pubmed PMID: 29332184.
Mandel JJ, Youssef M, Ludmir E, Yust-Katz S, Patel AJ, De Groot JF. " Highlighting the need for reliable clinical trials in glioblastoma " Expert Rev Anticancer Ther.. 2018 Jul 12;
Pubmed PMID: 29973092.
Ludmir EB, Mandel JJ, McAleer MF, de Groot J. " Disparities along the glioblastoma clinical trials landscape. " Neuro Oncol. 2018 Nov 26;
Pubmed PMID: 30476295.
Mandel JJ, Youssef M, Nam J, Patel AJ, Jalali A, Ludmir EB, Liu D, Wu J, Armstrong G, Huse J, Bondy M, de Groot JF.. " Effect of health disparities on overall survival of patients with glioblastoma. " J Neurooncol. 2019 Jan 22;
Pubmed PMID: 30671709.
Bayley V JC, Goethe EA, Srinivasan VM, Klisch TK, Mandel JJ, Patel AJ. " Newly-diagnosed Optic Pathway Glioma During Pregnancy: A Case Report. " World Neurosurg. 2019 Mar 13;
Pubmed PMID: 30878749.
• Ludmir EB, Mainwaring W, Lin TA, Miller AB, Jethanandani A, Espinoza AF, Mandel JJ, Lin SH, Smith BD, Smith GL, VanderWalde NA, Minsky BD, Koong AC, Stinchcombe TE, Jagsi R, Gomez DR, Thomas CR, Fuller CD. " Factors Associated With Age Disparities Among Cancer Clinical Trial Participants " JAMA Oncology. 2019 Jun 3;
Pubmed PMID: 31158272.
Goethe, E. A.,Youssef, M.,Patel, A. J.,Jalali, A.,Goodman, J. C, Mandel, JJ. " Recurrent Papillary Glioneuronal Tumor " World Neurosurg. 2019 May 13;
Pubmed PMID: 31078809.
Youssef M, Ludmir EB, Mandel JJ, Patel AJ, Jalali A, Treiber J, Wu J, McAleer MF, de Groot JF. " Treatment Strategies for Glioblastoma in Older Patients: Age Is Just a Number. " J Neurooncol. 2019 Oct 13;
Pubmed PMID: 31643011.
Ludmir, E. B., Subbiah, I. M., Mainwaring, W., Miller, A. B., Lin, T. A., Jethanandani, A., Espinoza, A. F., Mandel, JJ., Fang, P., Smith, B. D., et al.. " Decreasing incidence of upper age restriction enrollment criteria among cancer clinical trials " Journal of geriatric oncology. 2019 Nov 8;
Pubmed PMID: 31711757.
Prablek, M., Srinivasan, V. M., Srivatsan, A., Holdener, S., Oneissi, M., Heck, K. A., Jalali, A., Mandel, J, Viswanathan, A., & Patel, A. J.. " Gastrointestinal stromal tumor with intracranial metastasis: case presentation and systematic review of literature " BMC cancer. 2019 Nov 15;
Pubmed PMID: 31730471.
Patel, R. R., Verma, V., Miller, A. B., Lin, T. A., Jethanandani, A., Espinoza, A. F., Mainwaring, W., Augustyn, A., Fuller, C. D., Sulman, E. P., Yeboa, D. N., Chung, C. C., McAleer, M. F., et al.. " Exclusion of patients with brain metastases from cancer clinical trials " Neuro-oncology. 2020 Apr 15;
Pubmed PMID: 31900480.
de Groot, J., Penas-Prado, M., Alfaro-Munoz, K., Hunter, K., Pei, B. L., O'Brien, B., Weathers, S. P., Loghin, M., Kamiya Matsouka, C., Yung, W., Mandel, J., Wu, J., Yuan, Y., Zhou, S., Fuller, G. N., Huse, J., Rao, G., et al.. " Window-of-opportunity clinical trial of pembrolizumab in patients with recurrent glioblastoma reveals predominance of immune-suppressive macrophages " Neuro-oncology. 2020 Apr 15;
Pubmed PMID: 31755915.
Nam JY, Gilbert A, Cachia D, Mandel J, Fuller GN, Penas-Prado M, de Groot J, Kamiya-Matsuoka C.. " Pineal parenchymal tumor of intermediate differentiation: a single-institution experience " Neurooncol Pract. 2020 May 12;
Pubmed PMID: 33312675.
Torrealba-Acosta G., Mandel J.. " Hyperostosis frontalis interna diagnosed after a provoked seizure " BMJ Case Rep. 2020 Jul ;
Pubmed PMID: 32611657.
Gopakumar S, Daou M, Gadot R, Ropper AE, Mandel J. " Spinal meningioma in a patient with multiple sclerosis " Surg Neurol Int. 2020 Jul 18;
Pubmed PMID: 32754367.
Ben-Zion Berliner M, Katz LH, Derazne E, Levine H, Keinan-Boker L, Benouaich-Amiel A, Gal O, Kanner AA, Laviv Y, Honig A, Siegal T, Mandel J, Twig G, Yust-Katz S. " Height as a risk factor in meningioma: a study of 2 million Israeli adolescents " BMC Cancer. 2020 Aug 20;
Pubmed PMID: 32819306.
Gal O, Dudnik E, Rotem O, Finkel I, Peretz I, Zer A, Mandel J, Amiel A, Siegal T, Bar J, Lobachov A, Yust S. " Tyrosine Kinase Inhibitors as a Treatment of Symptomatic CNS Metastases in Oncogene-Driven NSCLC " J Oncol.. 2020 Sep 3;
Pubmed PMID: 32963526.
Soomro Z, Youssef M, Yust-Katz S, Jalali A, Patel AJ, Mandel J.. " Paraneoplastic syndromes in small cell lung cancer " J Thorac Dis. 2020 Oct 12;
Pubmed PMID: 33209464.
Gopakumar S, Srinivasan VM, Hadley CC, Anand A, Daou M, Karas PJ, Mandel J, Gopinath SP, Patel AJ. " Intracranial Solitary Fibrous Tumor of the Skull Base: Two Cases and Systematic Review of the Literature. " World Neurosurg. 2021 Feb 17;
Pubmed PMID: 33609763.
Benouaich-Amiel A, Khasminsky V, Gal O, Weiss T, Fichman S, Kanner AA, Berkowitz S, Laviv Y, Mandel J, Dudnik E, Siegal T, Yust-Katz S.. " Multicentric non-enhancing lesions in glioblastoma: A retrospective study " J Clin Neurosci. 2021 Jan 3;
Pubmed PMID: 33581785.
Jackson HN, Hadley CC, Khan AB, Gadot R, Bayley JC 5th, Shetty A, Mandel J, Jalali A, Gallagher KK, Sweeney AD, Harmanci AO, Harmanci AS, Klisch T, Gopinath SP, Rao G, Yoshor D, Patel AJ.. " Racial and Socioeconomic Disparities in Patients With Meningioma: A Retrospective Cohort Study " Neurosurgery. 2022 Jan ;
Pubmed PMID: 34982878.
Mandel JJ, Youssef M, Yust-Katz S, Patel AJ, Jalali A, Li Z, Wu J, Ludmir EB, de Groot JF. IDH mutation status and the development of venous thromboembolism in astrocytoma patients.. " IDH mutation status and the development of venous thromboembolism in astrocytoma patients. " J Neurol Sci.. 2021 Aug ;
Pubmed PMID: 34146775.
Tschernichovsky R, Katz LH, Derazne E, Berliner MB, Simchoni M, Levine H, Keinan-Boker L, Benouaich-Amiel A, Kanner AA, Laviv Y, Honig A, Dudnik E, Siegal T, Mandel J, Twig G, Yust-Katz S.. " Height in adolescence as a risk factor for glioma subtypes: a nationwide retrospective cohort study of 2.2 million subject " NEURO-ONCOLOGY. 2021 Aug ;
Pubmed PMID: 33631004.
Sapienza LG, Ludwig MS, Mandel JJ, Nguyen DH, Echeverria AE. " Could patients benefit from whole-brain radiotherapy with unilateral hippocampus sparing " Rep Pract Oncol Radiother.. 2021 Jun ;
Pubmed PMID: 34277100.
Alkabie S, Castrodad-Molina R, Heck KA, Mandel J, Hutton GJ. " The concurrence of multiple sclerosis and glioblastoma " Mult Scler Relat Disord.. 2021 May ;
Pubmed PMID: 33711579.
Flores A, Gadot R, Noorbhai I, Hall H, Heck KA, Raper DMS, Xu D, Karas P, Mandel JJ, Ropper AE.”. " S-100-negative, GNA11 mutation-positive intramedullary meningeal melanocytoma of the thoracic spine: A radiographic challenge and histologic anomaly " Surg Neurol Int.. 2021 Jun ;
Pubmed PMID: 34345456.
41. Snyder R, Lee S, Heck K, Mandel JJ, Patel AJ, Jalali A.. " Hemorrhagic cavum vergae colloid cyst: A presentation of anterograde amnesia without hydrocephalus " Surg Neurol Int.. 2022 Apr 15;
Pubmed PMID: 35509582.
42. McDonald MF, Rao G, Mandel JJ.. " Hypertrophic Olivary Degeneration Postoperatively Following Pilocytic Astrocytoma Resection " World Neurosurg. 2022 Jun 16;
Pubmed PMID: 35718276.
40. Strowd RE, Dunbar EM, Gan HK, Kurz S, Jordan JT, Mandel JJ, Mohile NA, Nevel KS, Taylor JW, Ullrich NJ, Welch MR, Wasilewski A, Mrugala MM. " Practical guidance for telemedicine use in neuro-oncology " Neurooncol Pract. 2022 Jan 17;
Pubmed PMID: 35371525.
43. Woodford R, Prather L, Helfer C, Davey L, Penas-Prado M, Armstrong T, Tucker K, Aldape K, Gilbert M, Clark C, Thavaneswaran S, Wang D, Mandel J, Kasherman L. " Malignant melanocytic schwannian tumor and leptomeningeal disease: A case series with a focus on management. " J Neurol Sci. 2022 May 16;
Pubmed PMID: 35635863.
44. Ehrlich AM, Larkin MB, English CW, Shetty A, Gupta M, Nouri SH, Lu HC, Mandel JJ, Patel AJ.. " Protracted course of chemical meningitis following posterior fossa epidermoid cyst excision - A case report " Surg Neurol Int.. 2022 Nov 18;
Pubmed PMID: 36447893.
Reddy S, Flores A, Lee S, Shetty A, Shah D, Heck KA, Jalali A, Mandel JJ, Patel AJ. " EWSR1-PATZ1 Fusion Gene in Ependymoma: A Report of Two Adult Cases and Systematic Review of Literature. " JCO Precis Oncol.. 2022 Dec 6;
Pubmed PMID: 36480780.
46. McDonald MF, Athukuri P, Anand A, Gopakumar S, Jalali A, Patel AJ, Rao G, Goodman JC, Lu HC, Mandel JJ.. " Varied histomorphology and clinical outcomes of FGFR3-TACC3 fusion gliomas " Neurosurg Focus. 2022 Dec ;
Pubmed PMID: 36455273.
Pati S, Baid U, Edwards B, et al.. " Federated learning enables big data for rare cancer boundary detection. " Nat Commun.. 2022 Dec 5;
Pubmed PMID: 36470898.
48. Dodoo GN, De B, Lee SS, Abi Jaoude J, Vauthey JN, Tzeng CD, Tran Cao HS, Katlowitz KA, Mandel JJ, Beckham TH, Minsky BD, Smith GL, Holliday EB, Koong AC, Das P, Taniguchi CM, Javle M, Koay EJ, Ludmir EB. " Brain Metastases from Biliary Tract Cancer: Case Series and Clinicogenomic Analysis " Oncologist. 2023 Jan 28;
Pubmed PMID: 36715178.
McDonald MF, Prather LL, Helfer CR, Ludmir EB, Echeverria AE, Yust-Katz S, Patel AJ, Deneen B, Rao G, Jalali A, Dhar SU, Amos CI, Mandel JJ.. " Prevalence of pathogenic germline variants in adult-type diffuse glioma. " Neurooncol Pract. 2023 Jun 21;
Pubmed PMID: 37720399.
Mandel JJ, de Groot JF.. " External Control Arms and Data Analysis Methods in Nonrandomized Trial of Patients With Glioblastoma " JAMA Oncol. 2023 Jul 1;
Pubmed PMID: 37200018.
Rampalli, Ihika BS‡,*; English, Collin William BS‡,*; Lazaro, Tyler MD‡; Lovin, Benjamin Daniel MD§; Lee, Sungho MD, PhD‡,**; Huang, Andrew Tsao MD§; Jalali, Ali MD, PhD‡; Gallagher, Kathleen Kelly MD§; Mandel, Jacob J. MD. " Case Report: Contralateral Progression of a Vestibular Schwannoma After Resection in a Patient with Neurofibromatosis Type 2. " Neurosurgery Practice. 2024 Mar ;
Pubmed PMID: 39957857.
52. Harmanci AS, Boudreau B, Lau S, Hosseingholi Nouri S, Mandel JJ, Lu HC, Harmanci AO, Klisch TJ, Levine JM, Patel AJ. " Aggressive human MenG C meningiomas have a molecular counterpart in canine. Acta Neuropathol " Acta Neuropathol. 2024 Feb 20;
Pubmed PMID: 38376654.
Rogers JL, Mandel J, Ozer BH, Lee EQ, Ranjan S, Lukas RV, Raygada M, Salacz ME, Smith-Cohn MA, Snyder J, Soldatos A, Theeler BJ, Widemann BC, Camphausen KA, Heiss JD, Armstrong TS, Gilbert MR, Penas-Prado M. " Virtual multi-institutional tumor board: a strategy for personalized diagnoses and management of rare CNS tumors. " J Neurooncol. 2024 May ;
Pubmed PMID: 38427131.
El-Dana F, Aldape K, Abdullaev Z, Sheth SA, Mandel J, Lu HC. " Low-grade glial/glioneuronal tumor with YAP1::FAM118B fusion: A novel molecular finding. " . J Neuropathol Exp Neurol. 2024 Sep ;
Pubmed PMID: 39301650.
55. Chen JW, Giridharan N, Kavoussi AA, Van Arsdale D, Hosseingholi Nouri S, Nitturi V, Trudeau T, Mandel JJ, Lu HC, Patel AJ. " Isolated calvarial lesion as the initial presentation of metastatic hepatocellular carcinoma: A case report and review of the literature " Surg Neurol Int. 2025 Jan ;
Pubmed PMID: 39926447.
McDonald MF, Gopakumar S, Juratli TA, Eyüpoglu IY, Rao G, Mandel JJ, Jalali A.. " Discontiguous recurrences of IDH-wildtype glioblastoma share a common origin with the initial tumor and are frequently hypermutated " Acta Neuropathol Commun. 2025 Jan 16;
Pubmed PMID: 39926447.
Gibbs DL, Cioffi G, Aguilar B, Waite KA, Pan E, Mandel J, Umemura Y, Luo J, Rubin JB, Pot D, et al. " Robust Cluster Prediction Across Data Types Validates Association of Sex and Therapy Response in GBM " Cancers. 2025 ;
Pubmed PMID: 39941811.
Zenk M, Baid U, Pati S, Mandel J, et al, Bakas S. " Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge " Nat Commun.. 2025 Jul 8;
Pubmed PMID: 40628696.
Gigi E, Mandel JJ, Shental N, Shai A, Yust-Katz S, Straussman R. " Characterization of the tumor microbiome of brain metastases and glioblastoma reveals tumor-type-specific and location-specific microbial signatures " Nat Cancer. 2025 Nov 6;
Pubmed PMID: 41238775.

Memberships

American Academy of Neurology

Society of Neuro-oncology

American Society of Clinical Oncology