Hua-Sheng Chiu, Ph.D.
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Hua-Sheng Chiu, Ph.D.
Assistant Professor
Positions
- Assistant Professor
-
Pediatrics-Oncology
Texas Children's Hospital, Baylor College of Medicine
Houston, Texas United States
Addresses
- Texas Children's Hospital - Feigin Center (Office)
-
1102 Bates Avenue
Room: TXFC-C1220.10
Houston, TX 77030
United States
Education
- PhD from Columbia University in the City of New York
- 12/2013 - New York, New York United States
- Department of Biomedical Informatics - Bioinformatics track
- MPH from Columbia University in the City of New York
- 06/2012 - New York, New York United States
- Department of Biomedical Informatics - Bioinformatics track
- MA from Columbia University in the City of New York
- 10/2011 - New York, New York United States
- Department of Biomedical Informatics - Bioinformatics track
Honors & Awards
- Young Investigator Travel Fellowship Award
- Symposia on Cancer Research: Genomic Medicine (10/2013)
- Travel Fellowship Award
- The RNA Society (05/2015)
- Honorary Member
- The Phi Tau Phi Scholastic Honor Society
- Cancers 2020 Outstanding Reviewer Awards
- MDPI (Multidisciplinary Digital Publishing Institute) (01/2020 - 12/2020)
- Editorial Review Board
- SAGE Journals: Technology in Cancer Research & Treatment (TCRT) (12/2021)
- Editorial Review Board
- MDPI Journals: Cancers (06/2020)
- Editorial Review Board
- MDPI Journals: Microorganisms (12/2020)
- Editorial Review Board
- MDPI Journals: Non-Coding RNA (01/2021)
- Graduate Student Fellowship
- Columbia University in the City of New York (09/2009 - 08/2010)
- Best Master’s Thesis Award
- Taiwan Association for Artificial Intelligence
- Studying Abroad Scholarship
- Ministry of Education, Taiwan (09/2009 - 08/2011)
- Undergraduate Graduation with Distinction (1%)
- National Central University
Professional Interests
- MicroRNA
- Long noncoding RNA
- Competing endogenous RNA (ceRNA)
- Computational systems biology of cancer
- Integrative genomics
- Machine learning
- Data science
Websites
Prediction of ceRNA interactions
Simultaneous prediction of miRNA-targets and ceRNAs
Prediction of regulation by lncRNA including decoy, cofactor, guide, and switch
Professional Development
- Keystone Symposia: MicroRNAs and Noncoding RNAs in Cancer
- Conference (Participant, 2015)
- RNA 2015
- Conference (Participant, 2015)
- Cell Symposia: Regulatory RNAs
- Conference (Presenter, 2011)
- Symposia on Cancer Research: ncRNA in Disease and Cancer
- Conference (Participant, 2014)
- American Society of Human Genetics
- Conference (Participant, 2013)
- Symposia on Cancer Research: Genomic Medicine
- Conference (Participant, 2013)
- Boston Taiwanese Biotechnology Symposium
- Conference (Presenter, 2013)
- Cold Spring Harbor Laboratory Meeting on Systems Biology: Networks
- Conference (Participant, 2013)
- The Cancer Genome Atlas (TCGA) 1st Annual Scientific Symposium
- Conference (Participant, 2011)
- International Conference on Research in Computational Molecular Biology (RECOMB)
- Conference (Participant, 2004)
- RECOMB Satellite Joint Conference on Systems Biology and Regulatory Genomics
- Conference (Participant, 2010)
- IEEE International Conference on Bioinformatics and Bioengineering (BIBE)
- Conference (Participant, 2009)
- Asia Pacific Bioinformatics Conference
- Conference (Participant, 2006)
Selected Publications
- Chiu HS *, Somvanshi S *, et al "Pan-cancer analysis of lncRNA regulation supports their targeting of cancer genes in each tumor context." Cell Reports. 2018 Apr 3;23(1):297-312. Pubmed PMID: 29617668
- Chiu HS *, Llobet-Navas D *, et al "Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks." Genome Research. 2015 Feb 10;25(2):257-67. Pubmed PMID: 25378249
- Sumazin P *, Yang X *, Chiu HS *, et al "An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma." Cell. 2011 Oct 14;147(2):370-381. Pubmed PMID: 22000015
- Chiu HS et al "High-throughput validation of ceRNA regulatory networks." BMC Genomics. 2017 May 30;18(1):418. Pubmed PMID: 28558729
- Lo A, Chiu HS, et al "Enhanced membrane protein topology prediction using a hierarchical classification method and a new scoring function." Journal of Proteome Research. 2007 Dec 15;7(2):487-96. Pubmed PMID: 18081245
- Su EC, Chiu HS, et al "Protein subcellular localization prediction based on compartment-specific features and structure conservation." BMC Bioinformatics. 2007 Sep 8;8(330) Pubmed PMID: 17825110
- Chang JM, Su EC, Lo A, Chiu HS, et al "PSLDoc: Protein subcellular localization prediction based on gapped‐dipeptides and probabilistic latent semantic analysis." Proteins: Structure, Function, and Bioinfo. 2008 Aug;72(2):693-710. Pubmed PMID: 18260102
- Campbell JD, Yau C, Bowlby R, ..., Chiu HS, ..., Pickering CR, Chen Z, and Waes CV "Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas." Cell Reports. 2018 Apr 3;23(1):194-212. Pubmed PMID: 29617660
- Berger AC, Korkut A, Kanchi RS, ..., Chiu HS, ..., Mills GB, Levine DA, and Akbani R "A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers." Cancer Cell. 2018 Apr 2; Pubmed PMID: 29622464
- Chiu HS *, Martínez MR *, et al "The number of titrated microRNA species dictates ceRNA regulation." Nucleic Acids Res. 2018 May 18;46(9):4354–4369. Pubmed PMID: 29684207
- Ustianenko D *, Chiu HS *, Treiber T *, et al "LIN28 selectively modulates a subclass of let-7 microRNAs." Mol Cell. 2018 Jul 19;71(2):271–283.e5. Pubmed PMID: 30029005
- Lorenzi L *, Chiu HS *, Avila Cobos F, Gross S, Volders PJ, Cannoodt R, Nuytens J, Vanderheyden K, Anckaert J, Lefever S, ..., Wilkins MR, Unnikrishnan A, De Preter K, Kjems J, Koster J, Schroth GP, Vandesompele J, Sumazin P, Mestdagh P "The RNA Atlas expands the catalog of human non-coding RNAs." Nat Biotechnol. 2021 Nov 9;39(11):1453–1465. Pubmed PMID: 34140680
Memberships
- The RNA Society
- Member (01/2015 - 12/2015)
- The American Society of Human Genetics (ASHG)
- Member (10/2013 - 10/2014)
- American Association for the Advancement of Science (AAAS)
- Member (02/2012 - 01/2014)
- Taiwan Association for Artificial Intelligence (TAAI)
- The Lifetime Membership (09/2004)
Skills
- Programming language: C/C++, MATLAB, R
- Molecular Biology: Cell Culture, Western Blot, qRT-PCR, Proliferation Assay, Migration Assay
- Analysis of large-scale data, e.g., RNA-Seq or small RNA-Seq
Languages
Chinese (Mandarin), Chinese (Min)
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