Cristian Coarfa, Ph.D.

Associate Professor

Email

coarfa@bcm.edu

Positions

Associate Professor: Mol & Cell Biology-Mol.Regulation
Baylor College of Medicine
Houston, TX, US

Associate Professor: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Associate Professor: Center for Precision Environmental Health
BAYLOR COLLEGE OF MEDICINE
Houston, Texas, United States

Education

PhD from Rice University: Houston, TX, United States; Computer Science

MS from Rice University: Houston, TX, United States; Computer Science

Professional Statement

Our research focuses on achieving biological insight via integrative analysis, interpretation, and visualization of large scale multi-omics datasets, and enabling of scientific advancements via collaborative tools and computing platforms. Our lab has extensive experience with analysis of RNA-Seq coding and non-coding transcriptomics, Small RNA-Seq, Whole-Genome Bisulfite-Seq, MS-based Metabolomics and Lipidomics, MS Proteomics, and RPPA Proteomics. We have developed methods for integration of genetic and epigenetic variation, reference pipelines for epigenetic assays, and bioinformatic tools for high-throughput reads mapping and structural variants detection. Our current focus is on tool development for metabolomics and transcriptomics integration, and mining of large transcriptomic and epigenomic data collections.

Websites

VIICTR Publications List

Selected Publications

Coarfa C, Yu F, Miller CA, Chen Z, Harris RA, Milosavljevic A. " Pash 3.0: A versatile software package for read mapping and integrative analysis of genomic and epigenomic variation using massively parallel DNA sequencing. " BMC Bioinformatics. 2010 ; 11 : 572.
Pubmed PMID: 21092284.
Van Baak TE, Coarfa C, et al, Waterland RA.. " Epigenetic supersimilarity of monozygotic twin pairs " Genome Biology. 2018 Jan 9; 19
Pubmed PMID: 29310692.
Mindikoglu AL, Opekun AR, Putluri N, Coarfa C. " Unique metabolomic signature associated with hepatorenal dysfunction and mortality in cirrhosis " Transl Res. 2018 May ;
Pubmed PMID: 29291380.
Abbas HA, Bui NHB, Rajapakshe K, Wong J, Gunaratne P, Tsai KY, Coarfa C, Flores ER. " Distinct TP63 Isoform-Driven Transcriptional Signatures Predict Tumor Progression and Clinical Outcomes " Cancer Research. 2018 Jan ;
Pubmed PMID: 29180475.
Coarfa C, Couroucli X, Moorthy B, Lingappan K. " Sexual dimorphism of the pulmonary transcriptome in neonatal hyperoxic lung injury: identification of angiogenesis as a key pathway " Am J Physiol Lung Cell Mol Physiol. 2017 Dec ;
Pubmed PMID: 28818871.
von Rundstedt FC, Rajapakshe K, Lerner SP, Coarfa C, Putluri N.. " Integrative Pathway Analysis of Metabolic Signature in Bladder Cancer: A Linkage to The Cancer Genome Atlas Project and Prediction of Survival " J Urology. 2016 Jun ;
Pubmed PMID: 26802582.