Cintia S De Paiva, M.D., Ph.D.

Professor, Caroline Elles Endowed Professorship

(713) 798-2124

Email

cintiadp@bcm.edu

Positions

Professor, Caroline Elles Endowed Professorship: Ophthalmology-Departmental
Baylor College of Medicine
Houston, TX, United States

Education

MD from State University of Campinas-UNICAMP: 12/1994 - Campinas, Sao Paulo, Brazil; Medicine

Residency at State University of Campinas-UNICAMP: 12/1997 - Campinas, Sao Paulo, Brazil; Ophthalmology

PhD from University of Sao Paulo, Ribeirao Preto: 10/2015 - Ribeirao Preto, Sao Paulo, Brazil

Honors & Awards

Caroline F. Elles Professorship: BCM (04/2023)

Professional Interests

Dry Eye, Ocular Surface Diseases, Animal Models of Sjogren Syndrome, Microbiome, Aging

Professional Statement

Dry eye affects millions of people world-wide. The primary objectives of my research are to investigate the pathogenesis of dry eye-related diseases with the ultimate goal to improve the diagnosis, prognosis, and therapy of dry eye.

Websites

VIICTR Publications List

Selected Publications

Zaheer M, Wang C, Bian F, Yu Z, Hernandez H, de Souza RG, Simmons KT, Schady D, Swennes AG, Pflugfelder SC, Britton RA, de Paiva CS.. " Protective role of commensal bacteria in Sjögren Syndrome. " JJ Autoimmun.. 2018 Sep ; 93 : 45-56.
Pubmed PMID: 29934134.
Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome. " ;
Pubmed PMID: 27087247.
Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn " ;
Pubmed PMID: 28273882.
Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells " ;
Pubmed PMID: 27706128.
Pelegrino FS, Volpe EA, Gandhi NB, Li DQ, Pflugfelder SC, de Paiva CS.. " Deletion of interferon-gamma delays onset and severity of dacryoadenitis in CD25KO mice. " Arthritis Res Ther.. 2012 ; 14 (6) : R234.
Pubmed PMID: 23116218.
Wang C, Zaheer M, Bian F, Quach D, Swennes AG, Britton RA, Pflugfelder SC, de Paiva CS. " Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. " Int J Mol Sci.. 2018 Feb ; 19 (2) : E565.
Pubmed PMID: 29438346.
de Paiva CS, Lindsey JL, Pflugfelder SC. " Assessing the severity of keratitis sicca with videokeratoscopic indices. " Ophthalmology. 2003 Jun ; 110 (6) : 1102-9.
Pubmed PMID: 12799233.
Stern ME, Schaumburg CS, Siemasko KF, Gao J, Wheeler LA, Grupe DA, De Paiva CS, Calder VL, Calonge M, Niederkorn JY, Pflugfelder SC. " Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease. " Invest. Ophthalmol. Vis. Sci.. 2012 ; 53 (4) : 2062-75.
Pubmed PMID: 22395876.
De Paiva CS, Pflugfelder SC, Li DQ. " Cell size correlates with phenotype and proliferative capacity in human corneal epithelial cells. " Stem Cells. 2006 Feb ; 24 (2) : 368-75.
Pubmed PMID: 16123387.
Chen Z, de Paiva CS, Luo L, Kretzer FL, Pflugfelder SC, Li DQ. " Characterization of putative stem cell phenotype in human limbal epithelia. " Stem Cells. 2004 ; 22 (3) : 355-66.
Pubmed PMID: 15153612.
De Paiva CS, Yoon KC, Pangelinan SB, Pham S, Puthenparambil LM, Chuang EY, Farley WJ, Stern ME, Li DQ, Pflugfelder SC. " Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9. " 2009 ; 6 : 31.
Pubmed PMID: 19878594.
De Paiva CS, Pflugfelder SC. " Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation. " Am. J. Ophthalmol.. 2004 Jan ; 137 (1) : 109-15.
Pubmed PMID: 14700652.
De Paiva CS, Corrales RM, Villarreal AL, Farley WJ, Li DQ, Stern ME, Pflugfelder SC. " Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. " Exp. Eye Res.. 2006 Sep ; 83 (3) : 526-35.
Pubmed PMID: 16643899.
Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, Stern ME, Pflugfelder SC. " Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice. " J. Autoimmun.. 2008 Jun ; 30 (4) : 212-21.
Pubmed PMID: 17988834.
Beardsley RM, De Paiva CS, Power DF, Pflugfelder SC. " Desiccating stress decreases apical corneal epithelial cell size--modulation by the metalloproteinase inhibitor doxycycline. " Cornea. 2008 Sep ; 27 (8) : 935-40.
Pubmed PMID: 18724157.
Zhang X, Chen W, De Paiva CS, Volpe EA, Gandhi NB, Farley WJ, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC. " Desiccating Stress Induces CD4(+) T-Cell-Mediated Sjögren's Syndrome-Like Corneal Epithelial Apoptosis via Activation of the Extrinsic Apoptotic Pathway by Interferon-?. " Am. J. Pathol.. 2011 Oct ; 179 (4) : 1807-14.
Pubmed PMID: 21843497.
Niederkorn JY, Stern ME, Pflugfelder SC, De Paiva CS, Corrales RM, Gao J, Siemasko K. " Desiccating stress induces T cell-mediated Sjögren's Syndrome-like lacrimal keratoconjunctivitis. " J. Immunol.. 2006 Apr 1; 176 (7) : 3950-7.
Pubmed PMID: 16547229.
Zheng X, de Paiva CS, Li DQ, Farley WJ, Pflugfelder SC. " Desiccating Stress Promotion of Th17 Differentiation by Ocular Surface Tissues through a Dendritic Cell-Mediated Pathway. " Invest. Ophthalmol. Vis. Sci.. 2010 Jun ; 51 (6) : 3083-91.
Pubmed PMID: 20130281.
Corrales RM, Stern ME, De Paiva CS, Welch J, Li DQ, Pflugfelder SC. " Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. " Invest. Ophthalmol. Vis. Sci.. 2006 Aug ; 47 (8) : 3293-302.
Pubmed PMID: 16877394.
De Paiva CS, Volpe EA, Gandhi NB, Zhang X, Zheng X, Pitcher JD, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Flavell RA, Pflugfelder SC. " Disruption of TGF-ß Signaling Improves Ocular Surface Epithelial Disease in Experimental Autoimmune Keratoconjunctivitis Sicca. " PLoS ONE. 2011 ; 6 (12) : e29017.
Pubmed PMID: 22194977.
De Paiva CS, Villarreal AL, Corrales RM, Rahman HT, Chang VY, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Pflugfelder SC. " Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. " Invest. Ophthalmol. Vis. Sci.. 2007 Jun ; 48 (6) : 2553-60.
Pubmed PMID: 17525184.
Pflugfelder SC, De Paiva CS, Villarreal AL, Stern ME. " Effects of sequential artificial tear and cyclosporine emulsion therapy on conjunctival goblet cell density and transforming growth factor-beta2 production. " Cornea. 2008 Jan ; 27 (1) : 64-9.
Pubmed PMID: 18245969.
Kim HH, De Paiva CS, Yen MT. " Effects of upper eyelid blepharoplasty on ocular surface sensation and tear production. " Can. J. Ophthalmol.. 2007 Oct ; 42 (5) : 739-42.
Pubmed PMID: 17823642.
Corrales RM, de Paiva CS, Li DQ, Farley WJ, Henriksson JT, Bergmanson JP, Pflugfelder SC. " Entrapment of conjunctival goblet cells by desiccation-induced cornification. " Invest. Ophthalmol. Vis. Sci.. 2011 ; 52 (6) : 3492-9.
Pubmed PMID: 21421863.
Pflugfelder SC, de Paiva CS, Li DQ, Stern ME. " Epithelial-immune cell interaction in dry eye. " Cornea. 2008 Sep ; 27 : S9-11.
Pubmed PMID: 18813079.
De Paiva CS, Pangelinan SB, Chang E, Yoon KC, Farley WJ, Li DQ, Pflugfelder SC. " Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress. " Arch. Ophthalmol.. 2009 Dec ; 127 (12) : 1625-31.
Pubmed PMID: 20008718.
Zheng X, De Paiva CS, Rao K, Li DQ, Farley WJ, Stern M, Pflugfelder SC. " Evaluation of the Transforming Growth Factor-beta Activity in Normal and Dry Eye Human Tears by CCL-185 Cell Bioassay. " Cornea. 2010 Sep ; 29 (9) : 1048-54.
Pubmed PMID: 20539212.
Tong L, Corrales RM, Chen Z, Villarreal AL, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC. " Expression and regulation of cornified envelope proteins in human corneal epithelium. " Invest. Ophthalmol. Vis. Sci.. 2006 May ; 47 (5) : 1938-46.
Pubmed PMID: 16639001.
Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, Pflugfelder SC. " Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. " Invest. Ophthalmol. Vis. Sci.. 2007 Jun ; 48 (6) : 2561-9.
Pubmed PMID: 17525185.
Alex A, Edwards A, Hays JD, Kerkstra M, Shih A, de Paiva CS, Pflugfelder SC. " Factors predicting the ocular surface response to desiccating environmental stress. " Invest. Ophthalmol. Vis. Sci.. 2013 ; 54 (5) : 3325-32.
Pubmed PMID: 23572103.
Qi H, Shine HD, Li DQ, de Paiva CS, Farley WJ, Jones DB, Pflugfelder SC. " Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs. " Exp. Eye Res.. 2008 Dec ; 87 (6) : 580-6.
Pubmed PMID: 18938159.
Rocha EM, Pelegrino FS, de Paiva CS, Vigorito AC, de Souza CA. " GVHD dry eyes treated with autologous serum tears. " Bone Marrow Transplant.. 2000 May ; 25 (10) : 1101-3.
Pubmed PMID: 10828873.
Alberto-Rincon Mdo C, de Paiva CS, Abrahamsohn PA, Zorn TM. " Histochemical demonstration of phospholipid containing choline in the cytoplasm of murine decidual cells. " Acta Anat (Basel). 1994 ; 150 (2) : 119-26.
Pubmed PMID: 7526589.
De Paiva CS, Raince JK, McClellan AJ, Shanmugam KP, Pangelinan SB, Volpe EA, Corrales RM, Farley WJ, Corry DB, Li DQ, Pflugfelder SC. " Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13. " Mucosal Immunol. 2011 Jul ; 4 (4) : 397-408.
Pubmed PMID: 21178983.
De Paiva CS, Chotikavanich S, Pangelinan SB, Pitcher JD, Fang B, Zheng X, Ma P, Farley WJ, Siemasko KF, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. " IL-17 disrupts corneal barrier following desiccating stress. " 2009 May ; 2 (3) : 243-53.
Pubmed PMID: 19242409.
Zheng X, Bian F, Ma P, De Paiva CS, Stern M, Pflugfelder SC, Li DQ. " Induction of Th17 differentiation by corneal epithelial-derived cytokines. " J. Cell. Physiol.. 2010 Jan ; 222 (1) : 95-102.
Pubmed PMID: 19746420.
De Paiva CS, Harris LD, Pflugfelder SC. " Keratoconus-like topographic changes in keratoconjunctivitis sicca. " Cornea. 2003 Jan ; 22 (1) : 22-4.
Pubmed PMID: 12502943.
Pelegrino FS, Pflugfelder SC, De Paiva CS. " Low humidity environmental challenge causes barrier disruption and cornification of the mouse corneal epithelium via a c-jun N-terminal kinase 2 (JNK2) pathway. " Exp. Eye Res.. 2012 Jan ; 94 (1) : 150-6.
Pubmed PMID: 22166618.
Pflugfelder SC, Farley W, Luo L, Chen LZ, de Paiva CS, Olmos LC, Li DQ, Fini ME. " Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. " Am. J. Pathol.. 2005 Jan ; 166 (1) : 61-71.
Pubmed PMID: 15632000.
Schaumburg CS, Siemasko KF, De Paiva CS, Wheeler LA, Niederkorn JY, Pflugfelder SC, Stern ME. " Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. " J. Immunol.. 2011 Oct 1; 187 (7) : 3653-62.
Pubmed PMID: 21880984.
Li DQ, Chen Z, Song XJ, de Paiva CS, Kim HS, Pflugfelder SC. " Partial enrichment of a population of human limbal epithelial cells with putative stem cell properties based on collagen type IV adhesiveness. " Exp. Eye Res.. 2005 Apr ; 80 (4) : 581-90.
Pubmed PMID: 15781286.
Qi H, Chuang EY, Yoon KC, de Paiva CS, Shine HD, Jones DB, Pflugfelder SC, Li DQ. " Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions. " Mol. Vis.. 2007 ; 13 : 1934-41.
Pubmed PMID: 17982417.
Pitcher JD, De Paiva CS, Pelegrino FS, McClellan AJ, Raince JK, Pangelinan SB, Rahimy E, Farley WJ, Stern ME, Li DQ, Pflugfelder SC. " Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland. " Invest. Ophthalmol. Vis. Sci.. 2011 ; 52 (6) : 3221-7.
Pubmed PMID: 21273534.
Kim HS, Jun Song X, de Paiva CS, Chen Z, Pflugfelder SC, Li DQ. " Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures. " Exp. Eye Res.. 2004 Jul ; 79 (1) : 41-9.
Pubmed PMID: 15183099.
Chotikavanich S, de Paiva CS, Li de Q, Chen JJ, Bian F, Farley WJ, Pflugfelder SC. " Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. " Invest. Ophthalmol. Vis. Sci.. 2009 Jul ; 50 (7) : 3203-9.
Pubmed PMID: 19255163.
de Paiva CS, Schwartz CE, Gjörstrup P, Pflugfelder SC. " Resolvin E1 (RX-10001) Reduces Corneal Epithelial Barrier Disruption and Protects Against Goblet Cell Loss in a Murine Model of Dry Eye. " Cornea. 2012 Nov ; 31 (11) : 1299-303.
Pubmed PMID: 22257864.
Li DQ, Zhang L, Pflugfelder SC, De Paiva CS, Zhang X, Zhao G, Zheng X, Su Z, Qu Y. " Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. " J. Allergy Clin. Immunol.. 2011 Dec ; 128 (6) : 1318-1325.e2.
Pubmed PMID: 21820713.
Yeh S, de Paiva CS, Hwang CS, Trinca K, Lingappan A, Rafati JK, Farley WJ, Li DQ, Pflugfelder SC. " Spontaneous T cell mediated keratoconjunctivitis in Aire-deficient mice. " Br J Ophthalmol. 2009 Sep ; 93 (9) : 1260-4.
Pubmed PMID: 19429577.
Pflugfelder SC, de Paiva CS, Tong L, Luo L, Stern ME, Li DQ. " Stress-activated protein kinase signaling pathways in dry eye and ocular surface disease. " Ocul Surf. 2005 Oct ; 3 (4) : S154-7.
Pubmed PMID: 17216108.
de Paiva CS, Pflugfelder SC. " Tear clearance implications for ocular surface health. " Exp. Eye Res.. 2004 Mar ; 78 (3) : 395-7.
Pubmed PMID: 15106918.
Lam H, Bleiden L, de Paiva CS, Farley W, Stern ME, Pflugfelder SC. " Tear cytokine profiles in dysfunctional tear syndrome. " Am. J. Ophthalmol.. 2009 Feb ; 147 (2) : 198-205. e1.
Pubmed PMID: 18992869.
De Paiva CS, Chen Z, Koch DD, Hamill MB, Manuel FK, Hassan SS, Wilhelmus KR, Pflugfelder SC. " The incidence and risk factors for developing dry eye after myopic LASIK. " Am. J. Ophthalmol.. 2006 Mar ; 141 (3) : 438-45.
Pubmed PMID: 16490488.
Tong L, Chen Z, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC. " Transglutaminase participates in UVB-induced cell death pathways in human corneal epithelial cells. " Invest. Ophthalmol. Vis. Sci.. 2006 Oct ; 47 (10) : 4295-301.
Pubmed PMID: 17003418.
Zheng X, Ma P, de Paiva CS, Cunningham MA, Hwang CS, Pflugfelder SC, Li DQ. " TSLP and Downstream Molecules in Experimental Mouse Allergic Conjunctivitis. " Invest. Ophthalmol. Vis. Sci.. 2010 Jun ; 51 (6) : 3076-82.
Pubmed PMID: 20107175.
77. Moore QL, De Paiva CS, Pflugfelder SC. " Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model " Am J Ophthalmol. 2015 Jul ; 160 (1) : 135-142.
Pubmed PMID: 26348638.
De Paiva CS, Corrales RM, Villarreal AL, Farley W, Li DQ, Stern ME, Pflugfelder SC. " Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. " Invest. Ophthalmol. Vis. Sci.. 2006 Jul ; 47 (7) : 2847-56.
Pubmed PMID: 16799024.
Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren's syndrome. " ;
Pubmed PMID: 25889094.
De Paiva CS, Hwang CS, Pitcher JD, Pangelinan SB, Rahimy E, Chen W, Yoon KC, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. " Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. " Rheumatology (Oxford). 2010 Feb ; 49 (2) : 246-58.
Pubmed PMID: 20007286.
75. You IC, Bian F, Volpe EA, de Paiva CS, Pflugfelder SC. " Age-related conjunctival disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sjögren Syndrome develops independent of lacrimal dysfunction. " Invest Ophthalmol Vis Sci. 2015 Mar ;
Pubmed PMID: 25758816.
de Paiva CS, Chen Z, Corrales RM, Pflugfelder SC, Li DQ. " ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells. " Stem Cells. 2005 ; 23 (1) : 63-73.
Pubmed PMID: 15625123.
Ahmad S, Kolli S, Li DQ, de Paiva CS, Pryzborski S, Dimmick I, Armstrong L, Figueiredo FC, Lako M. " A putative role for RHAMM/HMMR as a negative marker of stem cell-containing population of human limbal epithelial cells. " Stem Cells. 2008 Jun ; 26 (6) : 1609-19.
Pubmed PMID: 18356573.
Deng R, Su Z, Lu F, Zhang L, Lin J, Zhang X, de Paiva CS, Pflugfelder SC, Li DQ.. " A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells " Exp Eye Res. 2014;. 2014 ; 120 (118) : 26. 29.
Pubmed PMID: 24486456.
Lin J, Yoon KC, Zhang L, Su Z, Lu R, Ma P, De Paiva CS, Pflugfelder SC, Li DQ. " A native-like corneal construct using donor corneal stroma for tissue engineering. " PLoS ONE. 2012 ; 7 (11) : e49571.
Pubmed PMID: 23166715.
Pflugfelder SC, Maskin SL, Anderson B, Chodosh J, Holland EJ, De Paiva CS, Bartels SP, Micuda T, Proskin HM, Vogel R. " A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance. " Am. J. Ophthalmol.. 2004 Sep ; 138 (3) : 444-57.
Pubmed PMID: 15364229.
Desiccating Stress-Induced Chemokine Expression in the Epithelium Is Dependent on Upregulation of NKG2D/RAE-1 and Release of IFN-γ in Experimental Dry Eye. " J Immunol. 2014 Nov 15;. ; 193 (10) : 5264-72..
Pubmed PMID: 25288568.
Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas. " ;
80. Coursey TG, Henriksson JT, Marcano DC, Shin CS, Isenhart LC, Ahmad F, De Paiva CS, Pflugfelder SC, Acharya G. " Dexamethasone nanowafer as an effective therapy for dry eye disease " J Control Release. 2015 ;
Pubmed PMID: 26184051.
Effects of dry eye therapies on environmentally induced ocular surface disease " ;
Pubmed PMID: 25868759.
IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells " ;
Pubmed PMID: 26132778.
Zhang X, Chen W, De Paiva CS, Corrales RM, Volpe EA, McClellan AJ, Farley WJ, Li DQ, Pflugfelder SC. " Interferon-{gamma} Exacerbates Dry Eye-Induced Apoptosis in Conjunctiva through Dual Apoptotic Pathways. " Invest. Ophthalmol. Vis. Sci.. 2011 Sep ; 52 (9) : 6279-85.
Pubmed PMID: 21474767.
Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease. " Arch Immunol Ther Exp (Warsz). 2015 Mar 13.. 2015 Mar ;
Pubmed PMID: 25772203.
Coursey TG, de Paiva CS. " Managing Sjögren's Syndrome and non-Sjögren Syndrome dry eye with anti-inflammatory therapy. " Clin Ophthalmol.. 2014 ;
Pubmed PMID: 25120351.
Zhang X, Volpe EA, Gandhi NB, Schaumburg CS, Siemasko KF, Pangelinan SB, Kelly SD, Hayday AC, Li DQ, Stern ME, Niederkorn JY, Pflugfelder SC, De Paiva CS. " NK cells promote th-17 mediated corneal barrier disruption in dry eye. " PLoS ONE. 2012 ; 7 (5) : e36822.
Pubmed PMID: 22590618.
de Paiva CS, Rocha EM. " Sjögren syndrome: what and where are we looking for? " Curr Opin Ophthalmol.. 2015 ;
Pubmed PMID: 26367089.
Rahimy E, Pitcher JD, Pangelinan SB, Chen W, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC, De Paiva CS. " Spontaneous Autoimmune Dacryoadenitis in Aged CD25KO Mice. " Am. J. Pathol.. 2010 Aug ; 177 (2) : 744-53.
Pubmed PMID: 20566743.
Suhalim JL, Parfitt GJ, Xie Y, de Paiva CS, Pflugfelder SC, Shah TN, Potma EO, Brown DJ, Jester JV.. " Effect of desiccating stress on mouse meibomian gland function. " Ocul Surf.. 2014 ; 12 (1) : 59-68.
Pubmed PMID: 24439047.
McClellan AJ, Volpe EA, Zhang X, Darlington GJ, Li DQ, Pflugfelder SC, de Paiva CS.. " Ocular Surface Disease and Dacryoadenitis in Aging C57BL/6 Mice. " Am J Pathol.. 2014 ; 184 (3) : 631-43.
Pubmed PMID: 24389165.
Zhang X, de Paiva CS, Su Z, Volpe EA, Li DQ, Pflugfelder SC.. " Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye. " Exp Eye Res.. 2014 ; 118 : 117-24.
Pubmed PMID: 24315969.
Coursey TG, Gandhi NB, Volpe EA, Pflugfelder SC, de Paiva CS.. " Chemokine Receptors CCR6 and CXCR3 Are Necessary for CD4(+) T Cell Mediated Ocular Surface Disease in Experimental Dry Eye Disease.. " PLoS One. 2013;. ; 8 (11) : e78508.
Zhang X, Schaumburg CS, Coursey TG, Siemasko KF, Volpe EA, Gandhi NB, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC, de Paiva CS.. " CD8+ cells regulate the T helper-17 response in an experimental murine model of Sjögren syndrome. " Mucosal Immunol.. 2014 ; 7 (2) : 417-27.
Pubmed PMID: 24022789.
Pflugfelder SC, Corrales RM, de Paiva CS.. " T helper Cytokines in Dry Eye Disease " Exp Eye Res.. 2013 ; 117 : 118-25.
Pubmed PMID: 24012834.
Gandhi NB, Su Z, Zhang X, Volpe EA, Pelegrino FS, Rahman SA, Li DQ, Pflugfelder SC, de Paiva CS.. " Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress. " J Leukoc Biol.. 2013 ; 94 (6) : 1293-301.
Pubmed PMID: 23983225.
Alex A, Edwards A, Hays JD, Kerkstra M, Shih A, de Paiva CS, Pflugfelder SC.. " Factors predicting the ocular surface response to desiccating environmental stress. " Invest Ophthalmol Vis Sci.. 2013 ; 54 (5) : 3325-82.
Pubmed PMID: 23572103.
Su Z, Lin J, Lu F, Zhang X, Zhang L, Gandhi NB, de Paiva CS, Pflugfelder SC, Li DQ.. " Potential autocrine regulation of interleukin-33/ST2 signaling of dendritic cells in allergic inflammation. " Mucosal Immunol.. 2013 ; 6 (5) : 921-30.
Pubmed PMID: 23299617.
Lin J, Yoon KC, Zhang L, Su Z, Lu R, Ma P, de Paiva CS, Pflugfelder SC, Li DQ.. " A native-like corneal construct using donor corneal stroma for tissue engineering. " PLoS One. 2012 ; 7 (11) : e49571.
Pubmed PMID: 23166715.
Henriksson JT, de Paiva CS, Farley W, Pflugfelder SC, Burns AR, Bergmanson JP.. " Morphologic Alterations of the Palpebral Conjunctival Epithelium in a Dry Eye Model Cornea. " Cornea. 2013 ; 32 (4) : 483-90.
Pubmed PMID: 23146932.
Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye. " ;
Pubmed PMID: 27327581.
Effects of Aging in Dry Eye " ;
Pubmed PMID: 28282314.
Interferon-γ-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome " ;
Pubmed PMID: 27085137.
Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model " ;
Pubmed PMID: 27136463.
Aqueous Tear Deficiency Increases Conjunctival Interferon-γ (IFN-γ) Expression and Goblet Cell Loss " ;
Pubmed PMID: 26618646.
Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye " ;
Pubmed PMID: 26772899.
Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye " ;
Pubmed PMID: 28238526.
MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions " ;
Pubmed PMID: 26923552.
Sjögren syndrome: what and where are we looking for? " ;
Pubmed PMID: 26367089.
Severity of Sjögren's Syndrome Keratoconjunctivitis Sicca Increases with Increased Percentage of Conjunctival Antigen-Presenting Cells. " ;
Pubmed PMID: 30223431.
Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast. " ;
Pubmed PMID: 29958030.
Interferon-gamma deficiency protects against aging-related goblet cell loss " ;
Pubmed PMID: 27623073.
Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. " ;
Pubmed PMID: 30010888.
Highlights from the 21st International Ocular Surface Society meeting. " ;
Pubmed PMID: 30130576.

Funding

Investigating the anti-inflammatory mechanisms of calorie restriction in the aged lacrimal gland #R01EY035333: (06/01/2024 - 02/28/2029); Grant funding from NIH-NEI

Pathobiology of autoimmune Meibomian gland dysfunctionron-gamma and cathepsin S in age-related dry eye #5R21EY036677-02: (08/01/2024 - 07/31/2027); Grant funding from NIH/NEI

Multi-method investigation and characterization of the ocular microbiome #U24EY035067: (07/01/2023 - 06/30/2027); Grant funding from NIH/NEI

Effects of cornea epithelial barrier disruption on the cornea trigeminal neural circuit #U01EY034692: (09/30/2022 - 10/31/2026); Grant funding from NIH/NEI