Choel Kim, Ph.D., M.S.

Associate Professor

(713) 798-8411

Email

ckim@bcm.edu

Positions

Associate Professor: Pharmacology and Chemical Biology
Baylor College of Medicine
Houston, TX, US

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Education

Postdoctoral Fellowship at University Of California, San Diego: 01/2008 - La Jolla, California, United States; Biology

PhD from University Of California, San Diego: 01/2002 - La Jolla, CA, United States; Chemistry

BS from University Of California, San Diego: 06/1996 - La Jolla, California, United States; Biology

Professional Interests

Protein Kinase Structure Function, Signal Transduction

Websites

VIICTR Publications List

Kim Lab Website

Selected Publications

Choel Kim, Cecilia Y. Cheng, Adrian S. Saldanha, Susan S. Taylor. " PKA-I Holoenzyme Structure: Dynamic Conformational Change of RI Reveals Mechanism for cAMP-dependent Activation. " Cell. 2007 ; 130 : 1032-1043.
Francis S. Kinderman*, Choel Kim*, Sventja von Daake, Bao Q. Pham, Glen Spraggon, Patricia A. Jennings, and Susan S. Taylor. " A Dynamic Mechanism for AKAP Binding to RII Isoforms of cAMP-Dependent Protein Kinase. " Molecular Cell. 2006 ; 24 : 397-408.
Choel Kim, Nguyen-Huu Xuong, and Susan S. Taylor. " Crystal Structure of a Complex between the Catalytic and Regulatory (RI) Subunits of PKA. " Science. 2005 ; 307 : 690-696.
Simon H. Brown, Choel Kim, Susan S. Taylor. " Crystal Structure of Protein Kinase A bound to Type II Regulatory Subunit Mimics a Transition State. " J.Mol.Biol. 2009 ; 393 (5) : 1070-82.
Justin Gullingsrud, Choel Kim, Susan S. Taylor and J. Andrew McCammon. " Dynamic Binding of PKA Regulatory subunit (RI). " Structure. 2006 ; 14 : 141-149.
Ganapathy N. Sarma, Francis S. Kinderman, Choel Kim, Sventja von Daake, Lirong Chen, Bi-Cheng Wang and Susan S. Taylor. " Structure of D-AKAP2:PKA RI Complex: Insights into AKAP Specificity and Selectivity. " Structure. 2009 ; 18 (2) : 155-166.
GY Huang, JJ Kim, AS Reger, R Lorenz, EW Moon, C Zhao, DE Casteel, D Bertinetti, B Vanschouwen, R Selvaratnam, JW Pflugrath, B Sankaran, G Melacini, FW Herberg and C Kim. " Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG I.. " Structure. 2014 ; 22 (1) : 116-124.
GY Huang, OO Gerlits, MP Blakeley, B Sankaran, AY Kovalevsky and C Kim. " Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: insights for cGMP-dependent protein kinase agonist design.. " Biochemistry. 2014 ; 53 (43) : 6725-6727.
DC Guo, E Regalado, DE Casteel, JJ Kim, S Dyack, SG Horne, G Chang, G Jondeau, C Boileau, JS Coselli, Z Li, SM Leal, J Shendure, MJ Rieder, MJ Bamshad, DA Nickerson, C Kim and DM Milewicz. " Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections.. " 2013 ; 93 (2) : 398-404.
James C. Campbell, Philipp Henning, Eugen Franz, Banumathi Sankaran, Friedrich W. Herberg, and Choel Kim. " Structural Basis of Analog Specificity in PKG I and II " ACS Chem. Biol.. 2017 ; 2388–2398.
Pubmed PMID: 28793191.
James C. Campbell, Jeong Joo Kim, Kevin Y. Li, Gilbert Y. Huang, Albert S. Reger, Shinya Matsuda, Banumathi Sankaran, Todd M. Link, Keizo Yuasa, John E. Ladbury, Darren E. Casteel and Choel Kim. " Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II " JBC. 2016 Mar 11; 291 (11) : 5623-33.
Pubmed PMID: 26769964.
Jeong Joo Kim , Christian Flueck , Eugen Franz, Eduardo Sanabria-Figueroa, Eloise Thompson, Robin Lorenz, Daniela Bertinetti, David A. Baker, Friedrich W. Herberg, Choel Kim. " Crystal structures of the carboxyl cGMP binding domain of the Plasmodium falciparum cGMP-dependent protein kinase reveal a novel capping triad crucial for merozoite egress " PLOS Patho. 2015 Feb 3;
Pubmed PMID: 25646845.
Jeong Joo Kim , Robin Lorenz , Stefan T. Arold , Albert S. Reger7 , Banumathi Sankaran , Darren E. Casteel , Friedrich W. Herberg , Choel Kim. " Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation " Structure. 2016 Apr 7; 24 (5) : 710-720.
Pubmed PMID: 27066748.