Lisa White, Ph.D.

Associate Professor

(713) 798-7607

Email

lisaw@bcm.edu

Positions

Associate Professor: Molecular and Human Genetics
Baylor College of Medicine
Houston, TX, US

Associate Professor: Molecular & Cellular Biology
Baylor College of Medicine

Director: Genomic & RNA Profiling Core
Baylor College of Medicine

Director: Integrated Genomics Core
Baylor College of Medicine
Diabetes Research Center

Director - Genomic Profiling Shared Resource: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Co-Director: Functional Genomics and Microbiome Core
Texas Medical Center Digestive Disease Center

Director, Genomic and RNA Profiling Shared Resource: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

BCM-MD Anderson Hall (Office): Room: BCMA-333e
Houston, TX, 77030
United States

Education

BA from Baylor University: 01/1989 - Waco, TX, United States

PhD from University Of Houston: 01/1994 - Houston, TX, United States

Post-Doctoral Fellowship at University Of Maryland At College Park: 01/1998 - College Park, MD, United States

Professional Interests

Genomic and RNA profiling utilizing cutting edge whole genome/transcriptome technologies to understand cancer and metastases

Professional Statement

I am interested in genomic profiling technologies and how these technologies can be used to answer questions in cancer, especially the changes that occur at the genomic, transcriptomic, and regulatory levels. For example, utilizing high throughput sequencing platforms we can assay the entire genome with applications like mRNA-seq, smallRNA-seq, ChIP-seq, whole genome sequencing, etc. I am particularly interested in genomic changes that result in progression to metastasis in cancer models. These changes can be chromosomal (copy number gains and losses) that affect coding genes and, importantly, non-coding RNAs or microRNAs.

As Director of the Genomic & RNA Profiling Core at BCM, I support high throughput genomic and RNA profiling technologies for members of the BCM community and throughout the Texas Medical Center. We collaborate with users from the Dan L Duncan Cancer Center, The BCM Diabetes Research Center, The Intellectual and Developmental Disabilities Research Center, and the Texas Medical Center Digestive Disease Center.

Websites

VIICTR Publications List

Genomic and RNA Profiling Core

Genomic & RNA Profiling Core Facility

Selected Publications

Ku BJ, Kim TH, Lee JH, Buras ED, White LD, Stevens RD, Ilkayeva OR, Bain JR, Newgard CB, Demayo FJ, Jeong JW. " Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile Acid synthesis. " PLoS ONE. 2012 ; 7 (8) : e42915.
Pubmed PMID: 22912762.
Li J, Harris RA, Cheung SW, Coarfa C, Jeong M, Goodell MA, White LD, Patel A, Kang SH, Shaw C, Chinault AC, Gambin T, Gambin A, Lupski JR, Milosavljevic A. " Genomic hypomethylation in the human germline associates with selective structural mutability in the human genome. " PLoS Genet.. 2012 May ; 8 (5) : e1002692.
Pubmed PMID: 22615578.
Homan EP, Rauch F, Grafe I, Lietman C, Doll JA, Dawson B, Bertin T, Napierala D, Morello R, Gibbs R, White L, Miki R, Cohn DH, Crawford S, Travers R, Glorieux FH, Lee B. " Mutations in SERPINF1 cause osteogenesis imperfecta type VI. " J. Bone Miner. Res.. 2011 Dec ; 26 (12) : 2798-803.
Pubmed PMID: 21826736.
Mullany LK, Fan HY, Liu Z, White LD, Marshall A, Gunaratne P, Anderson ML, Creighton CJ, Xin L, Deavers M, Wong KK, Richards JS. " Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo. " Oncogene. 2011 Aug 11; 30 (32) : 3522-36.
Pubmed PMID: 21423204.
Franco HL, Lee KY, Rubel CA, Creighton CJ, White LD, Broaddus RR, Lewis MT, Lydon JP, Jeong JW, DeMayo FJ. " Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse. " Biol. Reprod.. 2010 May ; 82 (5) : 991-9.
Pubmed PMID: 20130264.
Franco HL, Lee KY, Broaddus RR, White LD, Lanske B, Lydon JP, Jeong JW, DeMayo FJ. " Ablation of Indian hedgehog in the murine uterus results in decreased cell cycle progression, aberrant epidermal growth factor signaling, and increased estrogen signaling. " Biol. Reprod.. 2010 Apr ; 82 (4) : 783-90.
Pubmed PMID: 20056671.
Oshima J, Magner DB, Lee JA, Breman AM, Schmitt ES, White LD, Crowe CA, Merrill M, Jayakar P, Rajadhyaksha A, Eng CM, del Gaudio D. " Regional genomic instability predisposes to complex dystrophin gene rearrangements. " Hum. Genet.. 2009 Sep ; 126 (3) : 411-23.
Pubmed PMID: 19449031.
Jeong JW, Lee HS, Lee KY, White LD, Broaddus RR, Zhang YW, Vande Woude GF, Giudice LC, Young SL, Lessey BA, Tsai SY, Lydon JP, DeMayo FJ. " Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. " Proc. Natl. Acad. Sci. U.S.A.. 2009 May 26; 106 (21) : 8677-82.
Pubmed PMID: 19439667.
Van den Veyver IB, Patel A, Shaw CA, Pursley AN, Kang SH, Simovich MJ, Ward PA, Darilek S, Johnson A, Neill SE, Bi W, White LD, Eng CM, Lupski JR, Cheung SW, Beaudet AL. " Clinical use of array comparative genomic hybridization (aCGH) for prenatal diagnosis in 300 cases. " Prenat. Diagn.. 2009 Jan ; 29 (1) : 29-39.
Pubmed PMID: 19012303.
Bi W, Breman AM, Venable SF, Eng PA, Sahoo T, Lu XY, Patel A, Beaudet AL, Cheung SW, White LD. " Rapid prenatal diagnosis using uncultured amniocytes and oligonucleotide array CGH. " Prenat. Diagn.. 2008 Oct ; 28 (10) : 943-9.
Pubmed PMID: 18792925.