Positions
- Professor
-
Medicine-Gastroenterology
Baylor College of Medicine
Houston, TX US
Addresses
- Veterans Affairs Medical Centr (Office)
-
Room: VAMC-3A-320
Houston, TX 77030
United States
Education
- Advanced Training from Baylor College Of Medicine Affiliate Hospitals
- 01/1966 - Houston, TX United States
- M.D. from Baylor College Of Medicine
- 01/1966 - Houston, TX United States
- B.S. from University Of Notre Dame
- 01/1962 - Notre Dame, IN United States
Certifications
- American Board of Internal Medicine
- Subspecialty Board - Gastroenterology
Honors & Awards
- M.D. Degree Conferred with Honors
- Alpha Omega Alpha
- 1976
- Henry Baker Lecture, American College of Gastroenterology
- 1983
- President, American College of Gastroenterology
- 1990-1991
Professional Interests
- Interaction of infectious agents and the gastrointestinal tract
- Gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs)
- Acid peptic diseases
- Helicobacter pylori
- Viral gastroenteritis
Websites
Selected Publications
- Opekun AR, Klein PD, Graham DY "[13C]Aminopyrine breath test detects altered liver metabolism caused by low-dose oral contraceptives.." Dig. Dis. Sci.. 1995 Nov;40(11):2417-22. Pubmed PMID: 7587824
- Bjorkman DJ, Moore JG, Klein PD, Graham DY "13C-bicarbonate breath test as a measure of gastric emptying.." Am. J. Gastroenterol.. 1991 Jul;86(7):821-3. Pubmed PMID: 2058621
- Yamaoka Y, Kwon DH, Graham DY "A M(r) 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori.." Proc. Natl. Acad. Sci. U.S.A.. 2000 Jun 20;97(13):7533-8. Pubmed PMID: 10852959
- Saeed ZA, Michaletz PA, Feiner SD, Woods KL, Graham DY "A new endoscopic method for managing food impaction in the esophagus.." Endoscopy. 1990 Sep;22(5):226-8. Pubmed PMID: 2242743
- El-Zimaity HM, Ota H, Scott S, Killen DE, Graham DY "A new triple stain for Helicobacter pylori suitable for the autostainer: carbol fuchsin/Alcian blue/hematoxylin-eosin.." Arch. Pathol. Lab. Med.. 1998 Aug;122(8):732-6. Pubmed PMID: 9701336
- Nurgalieva ZZ, Graham DY, Dahlstrom KR, Wei Q, Sturgis EM "A pilot study of Helicobacter pylori infection and risk of laryngopharyngeal cancer.." Head Neck. 2005 Jan;27(1):22-7. Pubmed PMID: 15459921
- Smith EM, Estes MK, Graham DY, Gerba CP "A plaque assay for the simian rotavirus SAII.." J. Gen. Virol.. 1979 Jun;43(3):513-9. Pubmed PMID: 225432
- Malaty HM, Abudayyeh S, Graham DY, Gilger MA, Rabeneck L, O'Malley K "A prospective study for the association of Helicobacter pylori infection to a multidimensional measure for recurrent abdominal pain in children.." Helicobacter. 2006 Aug;11(4):250-7. Pubmed PMID: 16882328
- Anand BS, Saeed ZA, Michaletz PA, Winchester CB, Doherty MA, Liem JH, Graham DY "A randomized comparison of dilatation alone versus dilatation plus laser in patients receiving chemotherapy and external beam radiation for esophageal carcinoma.." Dig. Dis. Sci.. 1998 Oct;43(10):2255-60. Pubmed PMID: 9790462
- Graham DY "A reliable cure for Helicobacter pylori infection?." Gut. 1995 Jul;37(1):154-6. Pubmed PMID: 7672669
- el-Zimaity HM, Wu J, Akamatsu T, Graham DY "A reliable method for the simultaneous identification of H pylori and gastric metaplasia in the duodenum.." J. Clin. Pathol.. 1999 Dec;52(12):914-6. Pubmed PMID: 10711255
- Saeed ZA, Winchester CB, Michaletz PA, Woods KL, Graham DY "A scoring system to predict rebleeding after endoscopic therapy of nonvariceal upper gastrointestinal hemorrhage, with a comparison of heat probe and ethanol injection.." Am. J. Gastroenterol.. 1993 Nov;88(11):1842-9. Pubmed PMID: 8237930
- Evans DJ, Evans DG, Graham DY, Klein PD "A sensitive and specific serologic test for detection of Campylobacter pylori infection.." Gastroenterology. 1989 Apr;96(4):1004-8. Pubmed PMID: 2925047
- Ramirez FC, Clarridge JE, Heiser MC, Michaletz PA, Schwartz JT, Saeed ZA, Graham DY "A study of the frequency of recovery of unexpected Giardia lamblia and Cryptosporidium from duodenal aspirates taken during routine upper endoscopy.." Am. J. Gastroenterol.. 1993 Apr;88(4):552-4. Pubmed PMID: 8470636
- Graham DY, Opekun A, Lew GM, Evans DJ, Klein PD, Evans DG "Ablation of exaggerated meal-stimulated gastrin release in duodenal ulcer patients after clearance of Helicobacter (Campylobacter) pylori infection.." Am. J. Gastroenterol.. 1990 Apr;85(4):394-8. Pubmed PMID: 2327380
- Graham DY, Klein PD "Accurate diagnosis of Helicobacter pylori. 13C-urea breath test.." Gastroenterol. Clin. North Am.. 2000 Dec;29(4):885-93, x. Pubmed PMID: 11190073
- Peterson WL, Barnett CC, Evans DJ, Feldman M, Carmody T, Richardson C, Walsh J, Graham DY "Acid secretion and serum gastrin in normal subjects and patients with duodenal ulcer: the role of Helicobacter pylori.." Am. J. Gastroenterol.. 1993 Dec;88(12):2038-43. Pubmed PMID: 8249971
- Kumagai T, Malaty HM, Graham DY, Hosogaya S, Misawa K, Furihata K, Ota H, Sei C, Tanaka E, Akamatsu T, Shimizu T, Kiyosawa K, Katsuyama T "Acquisition versus loss of Helicobacter pylori infection in Japan: results from an 8-year birth cohort study.." J. Infect. Dis.. 1998 Sep;178(3):717-21. Pubmed PMID: 9728540
- Graham DY, Davis RE "Acute upper-gastrointestinal hemorrhage. New observations on an old problem.." Am J Dig Dis. 1978 Jan;23(1):76-84. Pubmed PMID: 304304
- Ramirez FC, Osato MS, Graham DY, Woods KL "Addition of gentamicin to endoscopic retrograde cholangiopancreatography (ERCP) contrast medium towards reducing the frequency of septic complications of ERCP.." J Dig Dis. 2010 Aug;11(4):237-43. Pubmed PMID: 20649737
- Evans DG, Evans DJ, Graham DY "Adherence and internalization of Helicobacter pylori by HEp-2 cells.." Gastroenterology. 1992 May;102(5):1557-67. Pubmed PMID: 1568565
- Genta RM, Gürer IE, Graham DY, Krishnan B, Segura AM, Gutierrez O, Kim JG, Burchette JL "Adherence of Helicobacter pylori to areas of incomplete intestinal metaplasia in the gastric mucosa.." Gastroenterology. 1996 Nov;111(5):1206-11. Pubmed PMID: 8898634
- Adler-Storthz K, Dreesman GR, Graham DY, Evans DG "Biotin-avidin amplified ELISA for quantitation of human IgA.." J Immunoassay. 1985;6(41276):67-77. Pubmed PMID: 3894425
- Mason BB, Graham DY, Estes MK "Biochemical mapping of the simian rotavirus SA11 genome.." J. Virol.. 1983 May;46(2):413-23. Pubmed PMID: 6302311
- Horiuchi A, Nakayama Y, Kajiyama M, Kato N, Kamijima T, Graham DY, Tanaka N "Biliary stenting in the management of large or multiple common bile duct stones.." Gastrointest. Endosc.. 2010 Jun;71(7):1200-1203.e2. Pubmed PMID: 20400079
- Graham DY "Bile acid therapy for Helicobacter pylori.." Aliment. Pharmacol. Ther.. 1992 Oct;6(5):653. Pubmed PMID: 1294096
- Graham DY "Benefits from elimination of Helicobacter pylori infection include major reduction in the incidence of peptic ulcer disease, gastric cancer, and primary gastric lymphoma.." Prev Med. 1994 Sep;23(5):712-6. Pubmed PMID: 7845945
- Graham DY "Bisphosphonate gastrointestinal damage: perspective and research needs.." Pharmacoepidemiol Drug Saf. 2000 Sep;9(5):377-81. Pubmed PMID: 19025843
- Lanza FL, Graham DY "Bougienage is effective therapy for most benign esophageal strictures.." JAMA. 1978 Sep 1;240(9):844-7. Pubmed PMID: 671729
- Kudo M, Gutierrez O, El-Zimaity HM, Cardona H, Nurgalieva ZZ, Wu J, Graham DY "CagA in Barrett's oesophagus in Colombia, a country with a high prevalence of gastric cancer.." J. Clin. Pathol.. 2005 Mar;58(3):259-62. Pubmed PMID: 15735156
- Yamaoka Y, Graham DY "CagA status and gastric cancer unreliable serological tests produce unreliable data.." Gastroenterology. 1999 Sep;117(3):745. Pubmed PMID: 10490363
- Ito K, Yamaoka Y, Ota H, El-Zimaity H, Graham DY "Adherence, internalization, and persistence of Helicobacter pylori in hepatocytes.." Dig. Dis. Sci.. 2008 Sep;53(9):2541-9. Pubmed PMID: 18320323
- Evans DG, Graham DY, Evans DJ "Administration of purified colonization factor antigens (CFA/I, CFA/II) of enterotoxigenic Escherichia coli to volunteers. Response to challenge with virulent enterotoxigenic Escherichia coli.." Gastroenterology. 1984 Oct;87(4):934-40. Pubmed PMID: 6381216
- Graham DY, Lu H, Yamaoka Y "African, Asian or Indian enigma, the East Asian Helicobacter pylori: facts or medical myths.." J Dig Dis. 2009 May;10(2):77-84. Pubmed PMID: 19426388
- Malaty HM, El-Kasabany A, Graham DY, Miller CC, Reddy SG, Srinivasan SR, Yamaoka Y, Berenson GS "Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood.." Lancet. 2002 Mar 16;359(9310):931-5. Pubmed PMID: 11918912
- Graham DY "Alcohol and alcoholism: acute and chronic sequelae.." Tex Med. 1975 Feb;71(2):71-6. Pubmed PMID: 1089327
- Smith JE, Graham DY "Alcohol hepatitis therapy.." Gastroenterology. 1982 Jan;82(1):163-4. Pubmed PMID: 7053330
- Graham DY, Malaty HM "Alendronate and naproxen are synergistic for development of gastric ulcers.." Arch. Intern. Med.. 2001 Jan 8;161(1):107-10. Pubmed PMID: 11146706
- Graham DY, Malaty HM "Alendronate gastric ulcers.." Aliment. Pharmacol. Ther.. 1999 Apr;13(4):515-9. Pubmed PMID: 10215737
- Ramirez FC, Lee K, Graham DY "All lactase preparations are not the same: results of a prospective, randomized, placebo-controlled trial.." Am. J. Gastroenterol.. 1994 Apr;89(4):566-70. Pubmed PMID: 8147360
- Miehlke S, Kibler K, Kim JG, Figura N, Small SM, Graham DY, Go MF "Allelic variation in the cagA gene of Helicobacter pylori obtained from Korea compared to the United States.." Am. J. Gastroenterol.. 1996 Jul;91(7):1322-5. Pubmed PMID: 8677987
- Dore MP, Osato MS, Realdi G, Mura I, Graham DY, Sepulveda AR "Amoxycillin tolerance in Helicobacter pylori.." J. Antimicrob. Chemother.. 1999 Jan;43(1):47-54. Pubmed PMID: 10381100
- Graham DY "An alternate explanation of the effect of citric acid on proton pump inhibitor-associated false negative urea breath tests.." Am. J. Gastroenterol.. 2001 Oct;96(10):3037-9. Pubmed PMID: 11693351
- Graham DY, Breiter JR, Ciociola AA, Sykes DL, McSorley DJ "An alternative non-macrolide, non-imidazole treatment regimen for curing Helicobacter pylori and duodenal ulcers: ranitidine bismuth citrate plus amoxicillin. The RBC H. pylori Study Group.." Helicobacter. 1998 Jun;3(2):125-31. Pubmed PMID: 9631312
- Lanza F, Schwartz H, Sahba B, Malaty HM, Musliner T, Reyes R, Quan H, Graham DY "An endoscopic comparison of the effects of alendronate and risedronate on upper gastrointestinal mucosae.." Am. J. Gastroenterol.. 2000 Nov;95(11):3112-7. Pubmed PMID: 11095326
- Graham DY "An enteric-coated pancreatic enzyme preparation that works.." Dig. Dis. Sci.. 1979 Dec;24(12):906-9. Pubmed PMID: 510089
- Saeed ZA, Ramirez FC, Hepps KS, Cole RA, Schneider FE, Ferro PS, Graham DY "An objective end point for dilation improves outcome of peptic esophageal strictures: a prospective randomized trial.." Gastrointest. Endosc.. 1997 May;45(5):354-9. Pubmed PMID: 9165314
- Kwon DH, El-Zaatari FA, Kato M, Osato MS, Reddy R, Yamaoka Y, Graham DY "Analysis of rdxA and involvement of additional genes encoding NAD(P)H flavin oxidoreductase (FrxA) and ferredoxin-like protein (FdxB) in metronidazole resistance of Helicobacter pylori.." Antimicrob. Agents Chemother.. 2000 Aug;44(8):2133-42. Pubmed PMID: 10898687
- Fisher RG, Schwartz JT, Graham DY "Angiotherapy with Mallory-Weiss tear.." AJR Am J Roentgenol. 1980 Apr;134(4):679-84. Pubmed PMID: 6767351
- Bardhan KD, Hunter JO, Miller JP, Thomson AB, Graham DY, Russell RI, Sontag S, Hines C, Martin T, Gaussen L "Antacid maintenance therapy in the prevention of duodenal ulcer relapse.." Gut. 1988 Dec;29(12):1748-54. Pubmed PMID: 3065157
- Simon LS, Weaver AL, Graham DY, Kivitz AJ, Lipsky PE, Hubbard RC, Isakson PC, Verburg KM, Yu SS, Zhao WW, Geis GS "Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial.." JAMA. 1999 Nov 24;282(20):1921-8. Pubmed PMID: 10580457
- Hultén K, Almashhrawi A, El-Zaatari FA, Graham DY "Antibacterial therapy for Crohn's disease: a review emphasizing therapy directed against mycobacteria.." Dig. Dis. Sci.. 2000 Mar;45(3):445-56. Pubmed PMID: 10749316
- Graham DY "Antibiotic resistance in Helicobacter pylori: implications for therapy.." Gastroenterology. 1998 Nov;115(5):1272-7. Pubmed PMID: 9797384
- Steinbach G, Ford R, Glober G, Sample D, Hagemeister FB, Lynch PM, McLaughlin PW, Rodriguez MA, Romaguera JE, Sarris AH, Younes A, Luthra R, Manning JT, Johnson CM, Lahoti S, Shen Y, Lee JE, Winn RJ, Genta RM, Graham DY, Cabanillas FF "Antibiotic treatment of gastric lymphoma of mucosa-associated lymphoid tissue. An uncontrolled trial.." Ann. Intern. Med.. 1999 Jul 20;131(2):88-95. Pubmed PMID: 10419446
- Graham DY, Qureshi WA "Antibiotic-resistant H. pylori infection and its treatment.." Curr. Pharm. Des.. 2000 Oct;6(15):1537-44. Pubmed PMID: 10974150
- Chamberlin W, Hulten K, Graham DY "Antibiotics as primary therapy for Crohn's disease.." Drugs Today. 2000 Oct;36(10):667-78. Pubmed PMID: 12847571
- Yamaoka Y, Kodama T, Kashima K, Graham DY "Antibody against Helicobacter pylori CagA and VacA and the risk for gastric cancer.." J. Clin. Pathol.. 1999 Mar;52(3):215-8. Pubmed PMID: 10450182
- Ajami NJ, Barry MA, Carrillo B, Muhaxhiri Z, Neill FH, Prasad BV, Opekun AR, Gilger MA, Graham DY, Atmar RL, Estes MK "Antibody Responses to Norovirus Genogroup GI.1 and GII.4 Proteases in Volunteers Administered Norwalk Virus.." Clin. Vaccine Immunol.. 2012 Dec;19(12):1980-3. Pubmed PMID: 23035177
- Nakata S, Estes MK, Graham DY, Loosle R, Tao H, Wang SH, Saif LJ, Melnick JL "Antigenic characterization and ELISA detection of adult diarrhea rotaviruses.." J. Infect. Dis.. 1986 Sep;154(3):448-55. Pubmed PMID: 3016112
- Hachem CY, Clarridge JE, Reddy R, Flamm R, Evans DG, Tanaka SK, Graham DY "Antimicrobial susceptibility testing of Helicobacter pylori. Comparison of E-test, broth microdilution, and disk diffusion for ampicillin, clarithromycin, and metronidazole.." Diagn. Microbiol. Infect. Dis.. 1996 Jan;24(1):37-41. Pubmed PMID: 8988762
- Opekun AR, Graham DY "Antimony electrodes for in vivo pH monitoring.." Dig. Dis. Sci.. 1991 Aug;36(8):1180-1. Pubmed PMID: 1864216
- Opekun AR, Smith JL, Graham DY "Antimony electrodes. Mucosal potential differences and buffer composition adversely affect pH measurements in the stomach.." Dig. Dis. Sci.. 1990 Aug;35(8):950-5. Pubmed PMID: 2384040
- Graham DY, Lew GM, Lechago J "Antral G-cell and D-cell numbers in Helicobacter pylori infection: effect of H. pylori eradication.." Gastroenterology. 1993 Jun;104(6):1655-60. Pubmed PMID: 8500723
- Julapalli VR, Graham DY "Appropriate use of intravenous proton pump inhibitors in the management of bleeding peptic ulcer.." Dig. Dis. Sci.. 2005 Jul;50(7):1185-93. Pubmed PMID: 16047458
- Malaty HM, Graham DY, Isaksson I, Engstrand L, Pedersen NL "Are genetic influences on peptic ulcer dependent or independent of genetic influences for Helicobacter pylori infection?." Arch. Intern. Med.. 2000 Jan 10;160(1):105-9. Pubmed PMID: 10632311
- Graham DY, Malaty HM, Go MF "Are there susceptible hosts to Helicobacter pylori infection?." Scand. J. Gastroenterol. Suppl.. 1994;205:41435. Pubmed PMID: 7863244
- Graham DY, Smith JL "Aspirin and the stomach.." Ann. Intern. Med.. 1986 Mar;104(3):390-8. Pubmed PMID: 3511824
- Asaka M, Kato M, Kudo M, Katagiri M, Nishikawa K, Koshiyama H, Takeda H, Yoshida J, Graham DY "Atrophic changes of gastric mucosa are caused by Helicobacter pylori infection rather than aging: studies in asymptomatic Japanese adults.." Helicobacter. 1996 Mar;1(1):52-6. Pubmed PMID: 9398913
- Asaka M, Sugiyama T, Nobuta A, Kato M, Takeda H, Graham DY "Atrophic gastritis and intestinal metaplasia in Japan: results of a large multicenter study.." Helicobacter. 2001 Dec;6(4):294-9. Pubmed PMID: 11843961
- Ricuarte O, Gutierrez O, Cardona H, Kim JG, Graham DY, El-Zimaity HM "Atrophic gastritis in young children and adolescents.." J. Clin. Pathol.. 2005 Nov;58(11):1189-93. Pubmed PMID: 16254110
Memberships
- American Association for the Advancement of Science
- Fellow
- American College of Gastroenterology
- Master
- American College of Physicians
- Fellow
- American Gastroenterological Association
- American Society of Gastrointestinal Endoscopy
- American Society of Microbiology
- Houston Gastroenterological Society
- Hong Kong Society of Gastroenterology
- Fellow, Honorary
- Infectious Diseases Society of America
- Fellow
- Japanese Research Society for Helicobacter pylori Related Gastroduodenal Diseases
- Japanese Gastroenterology Society
- Honorary
- Texas Society for Gastroenterology and Endoscopy
- The Herb Fred Medical Society
- World Innovation Foundation
- Fellow
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