Integrative Functional Genomics Laboratory

Journal articles authored and co-authored by members of the Integrative Functional Genomics Laboratory are listed here in reverse chronological order and grouped by published year. Click on the Expand plus symbol or Collapse minus symbol symbol to expand/collapse the list of journal publications by year, respectively.

Click on the PubMed link for details of that publication.

The cite count designates the number of times the publication has been cited by other papers indexed in Scopus. To access cite count information powered by Scopus, you must have a valid Texas Medical Center Resource Access Account. Need to register for access or forget password? Click here.

Sort By:    Year Published    Cite Count

2024

Collapse All | Expand All

Journal Articles Published in 2024 (n = 1)

Cite Count

PubMed

Reference

0     

Smith HS, Robinson JO, Levchenko A, Pereira S, Pascual B, Bradbury K, et al. Research participants' perspectives on precision diagnostics for Alzheimer's disease. J Alzheimers Dis. 2024;97(3):1261-74. PMID: 38250770.

2023

Collapse All | Expand All

Journal Articles Published in 2023 (n = 4)

Cite Count

PubMed

Reference

0     

Li J, Amoh BK, McCormick E, Tarkunde A, Zhu KF, Perez A, et al. Integration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson's disease genes. Hum Mol Genet. 2023;32(4):685-95. PMID: 36173927.

0     

Wu T, Deger JM, Ye H, Guo C, Dhindsa J, Pekarek BT, et al. Tau polarizes an aging transcriptional signature to excitatory neurons and glia. elife. 2023;12:. PMID: 37219079.

0     

Ye H, Robak LA, Yu M, Cykowski M, Shulman JM. Genetics and pathogenesis of Parkinson's syndrome. Annu Rev Pathol. 2023;18:95-121. PMID: 36100231.

0     

Yu M, Ye H, De-Paula RB, Mangleburg CG, Wu T, Lee TV, et al. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. PLoS Genet. 2023;19(5):e1010760. PMID: 37200393.

2022

Collapse All | Expand All

Journal Articles Published in 2022 (n = 5)

Cite Count

PubMed

Reference

0     

Hill EJ, Robak LA, Al-Ouran R, Deger J, Fong JC, Vandeventer PJ, et al. Genome sequencing in the Parkinson disease clinic. Neurol Genet. 2022;8(4):e200002. PMID: 35747619.

0     

Hodge BA, Meyerhof GT, Katewa SD, Lian T, Lau C, Bar S, et al. Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster. Nat Commun. 2022;13(1):3156. PMID: 35672419.

0     

Lagisetty Y, Bourquard T, Al-Ramahi I, Mangleburg CG, Mota S, Soleimani S, et al. Identification of risk genes for Alzheimer's disease by gene embedding. Cell Genom. 2022;2(9):. PMID: 36268052.

0     

Yang SA, Salazar JL, Li-Kroeger D, Yamamoto S. Functional studies of genetic variants associated with human diseases in Notch signaling-related genes using Drosophila. Methods Mol Biol. 2022;2472:235-76. PMID: 35674905.

0     

Ye F, Funk Q, Rockers E, Shulman JM, Masdeu JC, Pascual B, et al. In Alzheimer-prone brain regions, metabolism and risk-gene expression are strongly correlated. Brain Commun. 2022;4(5):. PMID: 36092303.

<2021

Collapse All | Expand All

Journal Articles Published in <2021 (n = 121)

Cite Count

PubMed

Reference

0     

Abreha MH, Ojelade S, Dammer EB, McEachin ZT, Duong DM, Gearing M, et al. TBK1 interacts with tau and enhances neurodegeneration in tauopathy. J Biol Chem. 2021;296:100760. PMID: 33965374.

0     

Alfradique-Dunham I, Al-Ouran R, von Coelln R, Blauwendraat C, Hill E, Luo L, et al. Genome-wide association study meta-analysis for Parkinson disease motor subtypes. Neurol Genet. 2021;7(2):e557. PMID: 33987465.

0     

Bailey M, Shulman LM, Ryan D, Ouyang B, Shulman JM, Buchman AS, et al. Frequency of parkinsonism and Parkinson disease in African Americans in the Chicago community. J Gerontol A Biol Sci Med Sci. 2021;76(7):1340-5. PMID: 33631006.

0     

Guo Q, Dammer EB, Zhou M, Kundinger SR, Gearing M, Lah JJ, et al. Targeted quantification of detergent-insoluble RNA-binding proteins in human brain reveals stage and disease specific co-aggregation in Alzheimer's disease. Front Mol Neurosci. 2021;14:623659. PMID: 33815056.

0     

Hill EJ, Mangleburg CG, Alfradique-Dunham I, Ripperger B, Stillwell A, Saade H, et al. Quantitative mobility measures complement the MDS-UPDRS for characterization of Parkinson's disease heterogeneity. Parkinsonism Relat Disord. 2021;84:105-11. PMID: 33607526.

0     

Petyuk VA, Yu L, Olson HM, Yu F, Clair G, Qian WJ, et al. Proteomic profiling of the substantia nigra to identify determinants of Lewy body pathology and dopaminergic neuronal loss. J Proteome Res. 2021;20(5):2266-82. PMID: 33900085.

0     

Salazar JL, Yang SA, Lin YQ, Li-Kroeger D, Marcogliese PC, Deal SL, et al. TM2D genes regulate Notch signaling and neuronal function in Drosophila. PLoS Genet. 2021;17(12):e1009962. PMID: 34905536.

52

Blauwendraat C, Reed X, Krohn L, Heilbron K, Bandres-Ciga S, Tan M, et al. Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia. Brain. 2020;143(1):234-48. PMID: 31755958.

0     

Chung HL, Wangler MF, Marcogliese PC, Jo J, Ravenscroft TA, Zuo Z, et al. Loss- or gain-of-function mutations in ACOX1 cause axonal loss via different mechanisms. Neuron. 2020;106(4):589-606 e6. PMID: 32169171.

0     

Das P, Salazar JL, Li-Kroeger D, Yamamoto S, Nakamura M, Sasamura T, et al. Maternal almondex, a neurogenic gene, is required for proper subcellular Notch distribution in early Drosophila embryogenesis. Dev Growth Differ. 2020;62(1):80-93. PMID: 31782145.

0     

Johnson ECB, Dammer EB, Duong DM, Ping L, Zhou M, Yin L, et al. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nat Med. 2020;26(5):769-80. PMID: 32284590.

0     

Mangleburg CG, Wu T, Yalamanchili HK, Guo C, Hsieh YC, Duong DM, et al. Integrated analysis of the aging brain transcriptome and proteome in tauopathy. Mol Neurodegener. 2020;15(1):56. PMID: 32993812.

0     

Robak LA, Du R, Yuan B, Gu S, Alfradique-Dunham I, Kondapalli V, et al. Integrated sequencing and array comparative genomic hybridization in familial Parkinson disease. Neurol Genet. 2020;6(5):e498. PMID: 32802956.

0     

Wan YW, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, et al. Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models. Cell Rep. 2020;32(2):107908. PMID: 32668255.

0     

Yao T, Sweeney E, Nagorski J, Shulman JM, Allen GI. Quantifying cognitive resilience in Alzheimer's Disease: The Alzheimer's Disease Cognitive Resilience Score. PLoS One. 2020;15(11):e0241707. PMID: 33152028.

0     

Ye H, Ojelade SA, Li-Kroeger D, Zuo Z, Wang L, Li Y, et al. Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain. elife. 2020;9:. PMID: 32286230.

3

Al-Ouran R, Wan YW, Mangleburg CG, Lee TV, Allison K, Shulman JM, et al. A portal to visualize transcriptome profiles in mouse models of neurological disorders. Genes (Basel). 2019;10(10):. PMID: 31561642.

109

Blauwendraat C, Heilbron K, Vallerga CL, Bandres-Ciga S, von Coelln R, Pihlstrom L, et al. Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and alpha-synuclein mechanisms. Mov Disord. 2019;34(6):866-75. PMID: 30957308.

31

Buchman AS, Yu L, Wilson RS, Leurgans SE, Nag S, Shulman JM, et al. Progressive parkinsonism in older adults is related to the burden of mixed brain pathologies. Neurology. 2019;92(16):e1821-30. PMID: 30894446.

43

Hsieh YC, Guo C, Yalamanchili HK, Abreha M, Al-Ouran R, Li Y, et al. Tau-mediated disruption of the spliceosome triggers cryptic RNA splicing and neurodegeneration in Alzheimer's disease. Cell Rep. 2019;29(2):301-16 e10. PMID: 31597093.

363

Nalls MA, Blauwendraat C, Vallerga CL, Heilbron K, Bandres-Ciga S, Chang D, et al. Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: A meta-analysis of genome-wide association studies. Lancet Neurol. 2019;18(12):1091-102. PMID: 31701892.

12

Ojelade SA, Lee TV, Giagtzoglou N, Yu L, Ugur B, Li Y, et al. cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis. Cell Rep. 2019;28(7):1799-813 e5. PMID: 31412248.

55

Satizabal CL, Adams HHH, Hibar DP, White CC, Knol MJ, Stein JL, et al. Genetic architecture of subcortical brain structures in 38,851 individuals. Nat Genet. 2019;51(11):1624-36. PMID: 31636452.

9

von Coelln R, Dawe RJ, Leurgans SE, Curran TA, Truty T, Yu L, et al. Quantitative mobility metrics from a wearable sensor predict incident parkinsonism in older adults. Parkinsonism Relat Disord. 2019;65:190-6. PMID: 31272924.

0     

Wang J, Rousseau J, Kim E, Ehresmann S, Cheng YT, Duraine L, et al. Loss of oxidation resistance 1, OXR1, is associated with an autosomal-recessive neurological disease with cerebellar atrophy and lysosomal dysfunction. Am J Hum Genet. 2019;105(6):1237-53. PMID: 31785787.

23

Ysselstein D, Shulman JM, Krainc D. Emerging links between pediatric lysosomal storage diseases and adult parkinsonism. Mov Disord. 2019;34(5):614-24. PMID: 30726573.

20

Chibnik LB, White CC, Mukherjee S, Raj T, Yu L, Larson EB, et al. Susceptibility to neurofibrillary tangles: Role of the PTPRD locus and limited pleiotropy with other neuropathologies. Mol Psychiatry. 2018;23(6):1521-9. PMID: 28322283.

91

Guo C, Jeong HH, Hsieh YC, Klein HU, Bennett DA, De Jager PL, et al. Tau activates transposable elements in Alzheimer's disease. Cell Rep. 2018;23(10):2874-80. PMID: 29874575.

28

Jeong HH, Yalamanchili HK, Guo C, Shulman JM, Liu Z. An ultra-fast and scalable quantification pipeline for transposable elements from next generation sequencing data. Pac Symp Biocomput. 2018;23:168-79. PMID: 29218879.

0     

Lee PT, Zirin J, Kanca O, Lin WW, Schulze KL, Li-Kroeger D, et al. A gene-specific T2A-GAL4 library for Drosophila. elife. 2018;7:. PMID: 29565247.

0     

Li-Kroeger D, Kanca O, Lee PT, Cowan S, Lee MT, Jaiswal M, et al. An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila. elife. 2018;7:. PMID: 30091705.

9

Pandey A, Li-Kroeger D, Sethi MK, Lee TV, Buettner FF, Bakker H, et al. Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila Notch signaling. Glycobiology. 2018;28(11):849-59. PMID: 30169771.

17

Rousseaux MWC, Vazquez-Velez GE, Al-Ramahi I, Jeong HH, Bajic A, Revelli JP, et al. A druggable genome screen identifies modifiers of alpha-synuclein levels via a tiered cross-species validation approach. J Neurosci. 2018;38(43):9286-301. PMID: 30249792.

0     

Shulman JM. Reply: Lysosomal storage disorder gene variants in multiple system atrophy. Brain. 2018;141(7):e54. PMID: 29741598.

50

Blauwendraat C, Faghri F, Pihlstrom L, Geiger JT, Elbaz A, Lesage S, et al. NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases. Neurobiol Aging. 2017;57:247 e9-247 e13. PMID: 28602509.

18

Giri A, Mok KY, Jansen I, Sharma M, Tesson C, Mangone G, et al. Lack of evidence for a role of genetic variation in TMEM230 in the risk for Parkinson's disease in the Caucasian population. Neurobiol Aging. 2017;50:167 e11-167 e13. PMID: 27818000.

57

Jansen IE, Ye H, Heetveld S, Lechler MC, Michels H, Seinstra RI, et al. Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biol. 2017;18(1):22. PMID: 28137300.

20

Lee TV*, Pandey A*, Jafar-Nejad H. Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila. PLoS Genet. 2017;13(4):e1006723. PMID: 28394891.

173

Robak LA, Jansen IE, van Rooij J, Uitterlinden AG, Kraaij R, Jankovic J, et al. Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease. Brain. 2017;140(12):3191-203. PMID: 29140481.

12

Rousseaux MWC, Shulman JM, Jankovic J. Progress toward an integrated understanding of Parkinson's disease. F1000Res. 2017;6:1121. PMID: 28751973.

0     

Wang G, Gutzwiller L, Li-Kroeger D, Gebelein B. A Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes. PLoS Genet. 2017;13(7):e1006910. PMID: 28715417.

25

Wangler MF, Hu Y, Shulman JM. Drosophila and genome-wide association studies: a review and resource for the functional dissection of human complex traits. Dis Model Mech. 2017;10(2):77-88. PMID: 28151408.

0     

Wong CO, Gregory S, Hu H, Chao Y, Sepulveda VE, He Y, et al. Lysosomal degradation is required for sustained phagocytosis of bacteria by macrophages. Cell Host Microbe. 2017;21(6):719-30 e6. PMID: 28579255.

68

Ali YO, Allen HM, Yu L, Li-Kroeger D, Bakhshizadehmahmoudi D, Hatcher A, et al. NMNAT2:HSP90 complex mediates proteostasis in proteinopathies. PLoS Biol. 2016;14(6):e1002472. PMID: 27254664.

41

Buchman AS, Leurgans SE, Yu L, Wilson RS, Lim AS, James BD, et al. Incident parkinsonism in older adults without Parkinson disease. Neurology. 2016;87(10):1036-44. PMID: 27488597.

40

Buchman AS, Wilson RS, Shulman JM, Leurgans SE, Schneider JA, Bennett DA. Parkinsonism in older adults and its association with adverse health outcomes and neuropathology. J Gerontol A Biol Sci Med Sci. 2016;71(4):549-56. PMID: 26362440.

37

Chouhan AK, Guo C, Hsieh YC, Ye H, Senturk M, Zuo Z, et al. Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease. Acta Neuropathol Commun. 2016;4(1):62. PMID: 27338814.

45

Farlow JL, Robak LA, Hetrick K, Bowling K, Boerwinkle E, Coban-Akdemir ZH, et al. Whole-exome sequencing in familial Parkinson disease. JAMA Neurol. 2016;73(1):68-75. PMID: 26595808.

32

Hales CM, Dammer EB, Deng Q, Duong DM, Gearing M, Troncoso JC, et al. Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression. Proteomics. 2016;16(23):3042-53. PMID: 27718298.

71

Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, et al. GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Mol Psychiatry. 2016;21(2):189-97. PMID: 25869804.

23

Jakobsdottir J, van der Lee SJ, Bis JC, Chouraki V, Li-Kroeger D, Yamamoto S, et al. Rare functional variant in TM2D3 is associated with late-onset Alzheimer's disease. PLoS Genet. 2016;12(10):e1006327. PMID: 27764101.

7

Lee TV*, Kamber Kaya HE*, Simin R, Baehrecke EH, Bergmann A. The initiator caspase Dronc is subject of enhanced autophagy upon proteasome impairment in Drosophila. Cell Death Differ. 2016;23(9):1555-64. PMID: 27104928.

54

Muller SH, Girard SL, Hopfner F, Merner ND, Bourassa CV, Lorenz D, et al. Genome-wide association study in essential tremor identifies three new loci. Brain. 2016;139(Pt 12):3163-9. PMID: 27797806.

55

Servian-Morilla E, Takeuchi H, Lee TV, Clarimon J, Mavillard F, Area-Gomez E, et al. A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss. EMBO Mol Med. 2016;8(11):1289-309. PMID: 27807076.

14

Valenca GT, Srivastava GP, Oliveira-Filho J, White CC, Yu L, Schneider JA, et al. The role of MAPT haplotype H2 and isoform 1N/4R in parkinsonism of older adults. PLoS One. 2016;11(7):e0157452. PMID: 27458716.

44

Debette S, Ibrahim Verbaas CA, Bressler J, Schuur M, Smith A, Bis JC, et al. Genome-wide studies of verbal declarative memory in nondemented older people: The Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Biol Psychiatry. 2015;77(8):749-63. PMID: 25648963.

10

Shulman JM. Drosophila and experimental neurology in the post-genomic era. Exp Neurol. 2015;274(Pt A):4-13. PMID: 25814441.

8

Buchman AS, Yu L, Wilson RS, Shulman JM, Boyle PA, Bennett DA. Harm avoidance is associated with progression of parkinsonism in community-dwelling older adults: A prospective cohort study. BMC Geriatr. 2014;14:54. PMID: 24754876.

82

Haelterman NA, Yoon WH, Sandoval H, Jaiswal M, Shulman JM, Bellen HJ. A mitocentric view of Parkinson's disease. Annu Rev Neurosci. 2014;37:137-59. PMID: 24821430.

25

Haltom AR*, Lee TV*, Harvey BM, Leonardi J, Chen YJ, Hong Y, et al. The protein O-glucosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in Drosophila. PLoS Genet. 2014;10(11):e1004795. PMID: 25412384.

57

LeBon L, Lee TV, Sprinzak D, Jafar-Nejad H, Elowitz MB. Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states. elife. 2014;3:e02950. PMID: 25255098.

64

Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, et al. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. Alzheimers Dement. 2014;10(1):45-52. PMID: 23535033.

96

Shulman JM, Imboywa S, Giagtzoglou N, Powers MP, Hu Y, Devenport D, et al. Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Hum Mol Genet. 2014;23(4):870-7. PMID: 24067533.

31

Shulman JM, Yu L, Buchman AS, Evans DA, Schneider JA, Bennett DA, et al. Association of Parkinson disease risk loci with mild parkinsonian signs in older persons. JAMA Neurol. 2014;71(4):429-35. PMID: 24514572.

0     

Ali YO, Li-Kroeger D, Bellen HJ, Zhai RG, Lu HC. NMNATs, evolutionarily conserved neuronal maintenance factors. Trends Neurosci. 2013;36(11):632-40. PMID: 23968695.

25

Chou SH, Shulman JM, Keenan BT, Secor EA, Buchman AS, Schneider J, et al. Genetic susceptibility for ischemic infarction and arteriolosclerosis based on neuropathologic evaluations. Cerebrovasc Dis. 2013;36(3):181-8. PMID: 24135527.

215

Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, et al. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. 2013;78(2):256-68. PMID: 23562540.

120

Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, et al. A genome-wide association study of depressive symptoms. Biol Psychiatry. 2013;73(7):667-78. PMID: 23290196.

66

Lee TV, Sethi MK, Leonardi J, Rana NA, Buettner FF, Haltiwanger RS, et al. Negative regulation of notch signaling by xylose. PLoS Genet. 2013;9(6):e1003547. PMID: 23754965.

110

Shulman JM, Chen K, Keenan BT, Chibnik LB, Fleisher A, Thiyyagura P, et al. Genetic susceptibility for Alzheimer disease neuritic plaque pathology. JAMA Neurol. 2013;70(9):1150-7. PMID: 23836404.

2

Shulman JM. Structural variation and the expanding genomic architecture of Parkinson disease. JAMA Neurol. 2013;70(11):1355-6. PMID: 24018918.

0     

Talebagha S, Rizk C, Elawabdeh N, Abramowsky CR, Shehata BM. Usefulness of OCT4/3 immunostain in pediatric malignant germ cell tumors. Fetal Pediatr Pathol. 2013;32(2):82-7. PMID: 22506928.

66

Biffi A, Shulman JM, Jagiella JM, Cortellini L, Ayres AM, Schwab K, et al. Genetic variation at CR1 increases risk of cerebral amyloid angiopathy. Neurology. 2012;78(5):334-41. PMID: 22262751.

168

Bis JC, DeCarli C, Smith AV, van der Lijn F, Crivello F, Fornage M, et al. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat Genet. 2012;44(5):545-51. PMID: 22504421.

34

Buchman AS, Nag S, Shulman JM, Lim AS, VanderHorst VG, Leurgans SE, et al. Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease. Mov Disord. 2012;27(13):1625-31. PMID: 23038629.

141

Buchman AS, Shulman JM, Nag S, Leurgans SE, Arnold SE, Morris MC, et al. Nigral pathology and parkinsonian signs in elders without Parkinson disease. Ann Neurol. 2012;71(2):258-66. PMID: 22367997.

91

De Jager PL, Shulman JM, Chibnik LB, Keenan BT, Raj T, Wilson RS, et al. A genome-wide scan for common variants affecting the rate of age-related cognitive decline. Neurobiol Aging. 2012;33(5):1017 e1-15. PMID: 22054870.

64

Keenan BT, Shulman JM, Chibnik LB, Raj T, Tran D, Sabuncu MR, et al. A coding variant in CR1 interacts with APOE-epsilon4 to influence cognitive decline. Hum Mol Genet. 2012;21(10):2377-88. PMID: 22343410.

0     

Li-Kroeger D, Cook TA, Gebelein B. Integration of an abdominal Hox complex with Pax2 yields cell-specific EGF secretion from Drosophila sensory precursor cells. Development. 2012;139(9):1611-9. PMID: 22438572.

30

Lim AS, Chang AM, Shulman JM, Raj T, Chibnik LB, Cain SW, et al. A common polymorphism near PER1 and the timing of human behavioral rhythms. Ann Neurol. 2012;72(3):324-34. PMID: 23034908.

53

Raj T, Shulman JM, Keenan BT, Chibnik LB, Evans DA, Bennett DA, et al. Alzheimer disease susceptibility loci: Evidence for a protein network under natural selection. Am J Hum Genet. 2012;90(4):720-6. PMID: 22482808.

0     

Shulman JM, Schneider JA. Molecular mechanisms of cortical degeneration in Parkinson disease. Neurology. 2012;79(17):1750-1. PMID: 23019261.

22

Yu L, Shulman JM, Chibnik L, Leurgans S, Schneider JA, De Jager PL, et al. The CETP I405V polymorphism is associated with an increased risk of Alzheimer's disease. Aging Cell. 2012;11(2):228-33. PMID: 22122979.

0     

Charlton-Perkins M, Whitaker SL, Fei Y, Xie B, Li-Kroeger D, Gebelein B, et al. Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling. Neural Dev. 2011;6:20. PMID: 21539742.

121

Chibnik LB, Shulman JM, Leurgans SE, Schneider JA, Wilson RS, Tran D, et al. CR1 is associated with amyloid plaque burden and age-related cognitive decline. Ann Neurol. 2011;69(3):560-9. PMID: 21391232.

34

Lee TV*, Fan Y*, Wang S, Srivastava M, Broemer M, Meier P, et al. Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation. PLoS Genet. 2011;7(9):e1002261. PMID: 21909282.

60

Shulman JM, Chipendo P, Chibnik LB, Aubin C, Tran D, Keenan BT, et al. Functional screening of Alzheimer pathology genome-wide association signals in Drosophila. Am J Hum Genet. 2011;88(2):232-8. PMID: 21295279.

502

Shulman JM, De Jager PL, Feany MB. Parkinson's disease: Genetics and pathogenesis. Annu Rev Pathol. 2011;6:193-222. PMID: 21034221.

255

Treusch S, Hamamichi S, Goodman JL, Matlack KE, Chung CY, Baru V, et al. Functional links between Abeta toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science. 2011;334(6060):1241-5. PMID: 22033521.

181

Corneveaux JJ, Myers AJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, et al. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Hum Mol Genet. 2010;19(16):3295-301. PMID: 20534741.

55

Fan Y, Lee TV, Xu D, Chen Z, Lamblin AF, Steller H, et al. Dual roles of Drosophila p53 in cell death and cell differentiation. Cell Death Differ. 2010;17(6):912-21. PMID: 19960025.

10

Lee TV, Takeuchi H, Jafar-Nejad H. Regulation of notch signaling via O-glucosylation insights from Drosophila studies. Methods Enzymol. 2010;480:375-98. PMID: 20816218.

34

Shulman JM, Chibnik LB, Aubin C, Schneider JA, Bennett DA, De Jager PL. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. PLoS One. 2010;5(6):e11244. PMID: 20574532.

0     

 

Shulman JM. Incidence and risk for dementia in Parkinson disease. Journal Watch: Neurology. 2010;12(4):28.

0     

Witt LM, Gutzwiller LM, Gresser AL, Li-Kroeger D, Cook TA, Gebelein B. Atonal, senseless, and Abdominal-A regulate rhomboid enhancer activity in abdominal sensory organ precursors. Dev Biol. 2010;344(2):1060-70. PMID: 20478292.

14

Xia Z, Chibnik LB, Glanz BI, Liguori M, Shulman JM, Tran D, et al. A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis. PLoS One. 2010;5(11):e14169. PMID: 21152065.

34

Shulman JM, De Jager PL. Evidence for a common pathway linking neurodegenerative diseases. Nat Genet. 2009;41(12):1261-2. PMID: 19935760.

83

Xu D, Woodfield SE, Lee TV, Fan Y, Antonio C, Bergmann A. Genetic control of programmed cell death (apoptosis) in Drosophila. Fly (Austin). 2009;3(1):78-90. PMID: 19182545.

0     

Alcalay RN, Shulman JM, Plotkin SR. Ramsay Hunt syndrome in a patient with metastatic lung cancer to brain. J Neurooncol. 2008;86(1):55-6. PMID: 17634859.

95

Ditzel M, Broemer M, Tenev T, Bolduc C, Lee TV, Rigbolt KT, et al. Inactivation of effector caspases through nondegradative polyubiquitylation. Mol Cell. 2008;32(4):540-53. PMID: 19026784.

49

Lee TV, Ding T, Chen Z, Rajendran V, Scherr H, Lackey M, et al. The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously. Development. 2008;135(1):43-52. PMID: 18045837.

0     

Li-Kroeger D, Witt LM, Grimes HL, Cook TA, Gebelein B. Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS. Dev Cell. 2008;15(2):298-308. PMID: 18694568.

84

Steinhilb ML, Dias-Santagata D, Mulkearns EE, Shulman JM, Biernat J, Mandelkow EM, et al. S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila. J Neurosci Res. 2007;85(6):1271-8. PMID: 17335084.

209

Khurana V, Lu Y, Steinhilb ML, Oldham S, Shulman JM, Feany MB. TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr Biol. 2006;16(3):230-41. PMID: 16461276.

58

Cashio P, Lee TV, Bergmann A. Genetic control of programmed cell death in Drosophila melanogaster. Semin Cell Dev Biol. 2005;16(2):225-35. PMID: 15797833.

0     

 

Shulman JM. Wing of fly, tail of rodent, scale of fish, and pinch of yeast: cooking up the ultimate animal model in movement disorders. Moving Along. 2005;7(1):1.

22

Werz C, Lee TV, Lee PL, Lackey M, Bolduc C, Stein DS, et al. Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila. Development. 2005;132(24):5343-52. PMID: 16280349.

0     

Polak M, Kroeger DE, Cartwright IL, Ponce deLeon C. Genotype-specific responses of fluctuating asymmetry and of preadult survival to the effects of lead and temperature stress in Drosophila melanogaster. Environ Pollut. 2004;127(1):145-55. PMID: 14554005.

0     

Shulman JM. Surgical lessons from Shakespeare. Curr Surg. 2004;61(1):96-7. PMID: 14972180.

123

Doerflinger H, Benton R, Shulman JM, St Johnston D. The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium. Development. 2003;130(17):3965-75. PMID: 12874119.

192

Shulman JM, Feany MB. Genetic modifiers of tauopathy in Drosophila. Genetics. 2003;165(3):1233-42. PMID: 14668378.

80

Shulman JM, Shulman LM, Weiner WJ, Feany MB. From fruit fly to bedside: Translating lessons from Drosophila models of neurodegenerative disease. Curr Opin Neurol. 2003;16(4):443-9. PMID: 12869801.

328

Tree DR, Shulman JM, Rousset R, Scott MP, Gubb D, Axelrod JD. Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Cell. 2002;109(3):371-81. PMID: 12015986.

88

Huynh JR, Shulman JM, Benton R, St Johnston D. PAR-1 is required for the maintenance of oocyte fate in Drosophila. Development. 2001;128(7):1201-9. PMID: 11245586.

662

Wittmann CW, Wszolek MF, Shulman JM, Salvaterra PM, Lewis J, Hutton M, et al. Tauopathy in Drosophila: Neurodegeneration without neurofibrillary tangles. Science. 2001;293(5530):711-4. PMID: 11408621.

0     

Lee TV, Anderson BW, Peoples GE, Castilleja A, Murray JL, Gershenson DM, et al. Identification of activated tumor antigen-reactive CD8+ cells in healthy individuals. Oncol Rep. 2000;7(3):455-66. PMID: 10767352.

243

Shulman JM, Benton R, St Johnston D. The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole. Cell. 2000;101(4):377-88. PMID: 10830165.

28

Shulman JM, St Johnston D. Pattern formation in single cells. Trends Cell Biol. 1999;9(12):M60-4. PMID: 10611685.

522

Axelrod JD, Miller JR, Shulman JM, Moon RT, Perrimon N. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev. 1998;12(16):2610-22. PMID: 9716412.

159

Shulman JM, Perrimon N, Axelrod JD. Frizzled signaling and the developmental control of cell polarity. Trends Genet. 1998;14(11):452-8. PMID: 9825673.

0     

 

Uetz GW, Hieber CS, Jakob EM, Wilcox RS, Kroeger DE, McCrate A, et al. Behavior of colonial orb weaving spiders during a solar eclipse. Ethology. 1994;96:24-32.