March 4 – 8, 2019
Yosemite Valley Lodge
9006 Yosemite Lodge Dr.
Yosemite National Park, CA 95389
For the past five decades, the Jasper's Basic Mechanisms of the Epilepsies (BME) Workshops has provided a unique opportunity for basic research scientists in epilepsy to assess where the field of epilepsy has been, what it has accomplished, and where it should go. The last meeting was held in 2009, and it is once again time to stimulate a new intellectual ferment in understanding the genetic, molecular, cellular, and systems mechanisms of the epilepsies.
These workshops have led to the publication of four editions of the leading textbook in the field, Jasper's Basic Mechanisms of the Epilepsies. We are now planning the fifth BME Workshops, which will include over 70 leading expert investigators participating in 14 workshops and poster sessions held over four days in the early spring of 2019. Five senior editors are responsible for the organization and editing of the textbook, assisted by 10 associate editors.
The Workshops not only address fundamental epilepsy research but also emphasize the translation of new knowledge of epilepsy disease mechanisms into new strategies for epilepsy treatment.
Organizers
Organizers and Chief Editors
| Jeffrey Noebels, M.D., Ph.D. Baylor College of Medicine |
| Massimo Avoli, M.D., Ph.D. Montreal Neurological Institute, McGill University and Sapienza University of Rome |
| Michael A. Rogawski, M.D., Ph.D. University of California, Davis |
| Annamaria Vezzani, Ph.D. Mario Negri Institute for Pharmacological Research |
| Antonio V. Delgado-Escueta, M.D. University of California, Los Angeles and | ||
Emeritus Organizers and Editors
Richard Olsen, Ph.D.
Roger J. Porter, M.D.
Wilkie A. Wilson, Ph.D.
Editorial Advisory Board
Christophe Bernard, Ph.D.
Marseille, France
Marco de Curtis, M.D.
Milan, Italy
Peyman Golshani, M.D., Ph.D.
Los Angeles, Calif., USA
David Henshall, Ph.D.
Dublin, Ireland
Carolyn Houser, Ph.D.
Los Angeles, Calif., USA
Arnold Kriegstein, M.D., Ph.D.
San Francisco, Calif., USA
Wolfgang Löscher, D.V.M.
Hannover, Germany
Berge Minassian, M.D., Ph.D.
Dallas, Texas, USA
Elsa Rossignol, M.D., Ph.D.
Montreal, Canada
Helen Scharfman, Ph.D.
New York, NY, USA
H. S. White, Ph.D.
Seattle, Wash., USA
William Theodore, M.D.
NIH, Bethesda, Md., USA
Scientific Program
Monday, March 4, 2019
2:00 p.m.
Registration Open
5:00
Welcome and aims of the Jasper's Workshops
Editors
5:15
Welcome from the Sponsors
Vicky Whittemore
Neuronal Network Pathology
Chair and Discussion Leader: David A. Prince
5:30
PDS: The First Basic Mechanism of Focal Epilepsy
Massimo Avoli
5:50
The Emergence of Epilepsy Genes as Targets for Treatment
Jeffrey Noebels
6:10
Hippocampal Network Alterations in Temporal Lobe Epilepsy: New Views and Challenges
Carolyn Houser
6:30
Neuropathological Perspective of Focal Cortical Dysplasias and Generalized Epilepsy
Harvey Sarnat
6:50
Focal Cortical Malformations: mTOR and More
Peter Crino
7:10
Dinner: Buffet and Drinks
Tuesday, March 5, 2019
6:30 a.m.
Breakfast Buffet
Workshop A — Focal Seizures
Chair and Discussion Leader: Jeanne Paz
8:00
Low-Voltage Fast Activity at the Onset of Focal Seizures
Marco de Curtis
8:20
High-Frequency Oscillations in Rodent Model of Mesial Temporal Lobe Epilepsy
Maxime Levesque
8:40
Dynamics of Spontaneous Seizures in Experimental Models In Vitro and In Vivo
John Jefferys
9:00
Connexins, Pannexins and Epilepsy
Peter Carlen
9:20
A Classification of Seizures based on Dynamics
Christophe Bernard
9:40
Cytokine-Mediated Inhibition of Astrocyte Gap Junction Coupling as a Cause of Temporal Lobe Epilepsy
Christian Steinhauser
10:00
Open Floor Discussion
10:20
Break: Coffee and Snacks
Workshop B — Generalized Seizures
Chairs and Discussion Leaders: Marco de Curtis and Christophe Bernard
10:40
Firing Dynamics of Cortical and Thalamic Neuronal Assemblies during Absence Seizures
Vincenzo Crunelli
11:00
Cortical PV+ Interneuron Dysfunction in the Pathogenesis of Absence Epilepsy
Atul Maheshwari
11:20
Novel Role of the Thalamus in Dravet Syndrome
Jeanne Paz
11:40
Open Floor Discussion
Noon
The CURE Mission and Research Portfolio
Laura Lubbers
12:30 p.m.
Everyone on Their Own for Lunch, Afternoon Recreational Activity
Breakout Parallel Sessions on the 5th Edition of Jasper's BME Book
3:30
Book Section I: Seizures, Networks, and Systems
Led by M. Avoli, C. Bernard, and M. de Curtis
3:30
Book Section II: Epileptogenesis
Led by A. Vezzani and H. Scharfman
Workshop C — Epileptogenesis: Models and Mechanisms
Chair and Discussion Leader: Ray Dingledine
4:30
Artificial Intelligence-Guided Phenotyping in Epilepsy
Ivan Soltesz
4:50
Mossy Cells and Epileptogenesis
Helen Scharfman
5:10
Adenosine for Epilepsy Prevention
Detlev Boison
5:30
TrkB-Shc Signaling Protects Against Hippocampal Injury Following Status Epilepticus
James O. McNamara
5:50
Blood Brain Barrier-Induced Aberrant TGF-β Signaling in Epileptogenesis
Daniela Kaufer
6:10
Initiation of an Epileptogenic Cascade by Focal Neuronal Lesions
Steve Danzer
6:30
Open Floor Discussion
Poster Session
7:00
Poster Session and Dinner: Buffet with Drinks
Workshop D — Epileptogenesis Biomarkers
Chair and Discussion Leaders: Matthias Koepp and William Theodore
8:30
Microvascular Pathology in Seizures and Epileptogenesis: A Mechanism-Driven Biomarker and New Target for Treatment?
Alon Friedman
8:50
Machine-Learning Approach to Discover Novel Biomarkers of Posttraumatic Epilepsy
Asla Pitkanen
9:10
Cerebrospinal Fluid and Blood Micrornas as Biomarkers of Epilepsy
Michele Simonato
9:30
Open Floor Discussion
9:50
Adjourn
Wednesday, March 6, 2019
6:30 a.m.
Breakfast Buffet
Genes and Network Development
Chair and Discussion Leader: Jeffrey Noebels
8:00
Gene Interactome Analysis to Understand Complex Molecular Traits in Epilepsy
Katja Kobow
8:20
Molecular Taxonomy of Epilepsy, a Framework to Target Underlying Disease Biology
Stephanie Dedeurwaerdere
Workshop E — Membrane Excitability and Synaptic Mechanisms
Chair and Discussion Leader: Lori Isom
8:40
Voltage-gated Sodium Channel Gene SCN2A and Neurological Diseases
Kazuhiro Yamakawa
9:00
Potassium Channel Gain of Function in Epilepsy: an Unresolved Paradox
Anastassios Tzingounis
9:20
Mechanisms of
Elsa Rossignol
9:40
Break: Coffee and Snacks
10:00
GABA(A) Receptors in Epilepsy: Recent Advances in Genetics, Subtype Pharmacology, Plasticity, Brain Circuitry, and Structure-Function
Richard Olsen
10:20
TBD
Patrick Cossette
10:40
Open Floor Discussion
Workshop F — Migration and Malformation
Chair and Discussion Leader: Bernard Lakaye
11:00
Maf Transcription Factors in the Generation and Function of Cortical Interneurons
John Rubenstein
11:20
Neurodevelopmental Origins of Human Focal Cortical Dysplasia
Lakshmi Subramanian
11:40
Understanding the Mechanisms of Epilepsy in mTOR-Dependent Cortical Malformation
Angelique Bordey
Noon
Role of Brain Somatic Mutations in Genes of the GATOR1-mTOR Pathway in Focal Cortical Dysplasia
Stephanie Baulac
12:20 p.m.
Open Floor Discussion
12:40
Everyone on Their Own for Lunch, Afternoon Recreational Activity
Breakout Parallel Sessions on the 5th Edition of Jasper's BME Book
2:30
Book Section III: Genes and Network Development
Led by J. Noebels, A. Delgado-Escueta, and E. Rossignol
Workshop G — Towards a Cure in Progressive Myoclonic Epilepsy
Chair and Discussion Leaders: Antonio V. Delgado-Escueta, Berge Minassian, and Jose M. Serratosa
3:30
Overview of Advances in Progressive Myoclonus Epilepsies Including Intraventricular Cerliponase Alfa for CLN2
Berge Minassian
3:50
Early and Late Treatment with Etformin in Lafora Disease Mice
Jose M. Serratosa
4:10
Targeting Pathogenic Lafora Bodies in Lafora Disease Using an Antibody-Enzyme Fusion
Matt Gentry
4:30
Antisense Oligonucleotides in SMA,Lafora Disease and Other Epilepsies
Tamar Grossman
4:50
Progress in Progressive Myoclonus-Epilepsy
Berge Minassian
5:10
Electrographic Features of Nodding Syndrome, a Novel Tau-Associated Epileptic Encephalopathy
Rajarshi Mazumder
5:30
Open Floor Discussion
Poster Session
6:00
Poster Session and Dinner: Buffet with Drinks
Workshop H — Monogenic Comorbidities
Chair and Discussion Leader: Helen Scharfman
8:00
Reduced Synaptic Connectivity and Disrupted Oscillatory Population Dynamics in the Medial Prefrontal Cortex of the CNTNAP2 Mouse Model of Autism
Peyman Golshani
8:20
Network Abnormalities and Interneuron Dysfunction in Alzheimer's Disease
Jorge Palop
8:40
On Measuring and Manipulating in Mice with MTLE
Vaishnav Krishnan
9:00
Single Gene Mechanisms for SUDEP Risk
Jeffrey Noebels
9:20
Open Floor Discussion
9:40
Adjourn
Thursday, March 7, 2019
6:30 a.m.
Breakfast Buffet
Workshop I — Preventing and Stopping Seizures
Chair and Discussion Leader: Claude Wasterlain
8:00
Overview
Michael Rogawski
8:20
Status Epilepticus: Role of Synaptic Potentiation
Jaideep Kapur
8:40
GABA Signaling: Pathologies and Therapies
Kevin Staley
9:00
Multi-Targeted Drug Combinations for Antiepileptogenesis
Wolfgang Loescher
9:20
TBD
Pierandrea Muglia
9:40
Open Floor Discussion
10:00
Break: Coffee and Snacks
Workshop J — Gene Guided and Targeted Therapies
Chair and Discussion Leader: Merab Kokaia
10:20
Gene Therapy for Refractory Epilepsy
Dimitri Kullman
10:40
The Role of Gain- and Loss-of-Function Ionotropic Glutamate Receptor Variants in Epilepsy
Steve Traynelis
11:00
Epileptogenic Channelopathies Guide Design of XEN901, a Selective Inhibitor of NaV1.6
Charlie Cohen
11:20
KCNQ2-Related Epilepsy: Variant Spectrum and Prospects for Precision Therapy
Ed Cooper
11:40
Antisense Oligonucleotides in the Treatment of Rare Monogenic Disease
Paul Goldberg
Noon
Targeted Augmentation of Nuclear Gene Output (TANGO) in SCN1A Dravet Syndrome
Lori Isom
12:20 p.m.
Open Floor Discussion
12:40
Everyone on Their Own for Lunch
Workshop K — New Models and Therapeutic Strategies
Chair and Discussion Leader: Michael Rogawski
2:00
Animal Models of Therapy Resistant Epilepsy
H. Steve White
2:20
Anti-Inflammatory Strategies for Disease-Modifications
Annamaria Vezzani
2:40
Treatment of Febrile Status Epilepticus: Past, Present and Future
Tallie Z. Baram
3:00
Dynamic Interaction of Transhemispheric Networks in Ictogenesis and Its Inhibition by Gene Therapies
Merab Kokaia
3:20
Mechanisms of Ketogenic Diet Action
Jong Rho
3:40
Prophylaxis of Epileptogenesis: Recalibrating the Excitatory-Inhibitory Synaptic Balance
David A. Prince
4:00
Open Floor Discussion
Breakout Session on the 4th Edition of Jasper's BME Book
4:30
Book Section IV: Epilepsy Therapeutics
Led by M. Rogawski, H. S. White, and W. Löscher
Summary of Breakout Sessions on the 5th Edition of Jasper's BME Book
5:15
Book Section I: Seizures, Networks, and Systems
Presented by M. Avoli
Book Section II: Epileptogenesis
Presented by A. Vezzani and H. Scharfman
Book Section III: Genes and Developing Networks
Presented by J. Noebels and A. Delgado-Escueta
Book Section IV: Epilepsy Therapeutics
Presented by M. Rogawski
7:00
Summation of Workshops and Research Priorities 2020-2030
8:00
Closing Reception and Dinner
Friday, March 8, 2019
Morning
Departures