William Harris Hudson
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William Harris Hudson
Assistant Professor
Positions
- Assistant Professor
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Mol & Cell Biology
Baylor College of Medicine
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Addresses
- BCM Michael DeBakey Center (Lab)
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Room M512E
Houston, TX 77030
United States
Education
- BS from Georgia Institute of Technology
- Atlanta, GA
- PhD from Emory University
- Atlanta, GA
Professional Interests
- Cancer immunology
- Viral immunology
- Immunotherapy
- T cell biology
- Bioinformatics
Professional Statement
T cells are responsible for destroying tumors and cells infected with intracellular pathogens such as viruses and bacteria. Unfortunately T cell responses are not always optimal, leading to chronic infections and the growth of tumors. My research focuses on understanding the causes of T cell dysfunction in order to develop new immunotherapies for cancer and other diseases.Selected Publications
- Sudmeier LJ, Hoang KB, Nduom EK, Wieland A, Neill SG, Schniederjan MJ, Ramalingam SS, Olson JJ, Ahmed R, Hudson WH "Distinct phenotypic states and spatial distribution of CD8+ T cell clonotypes in human brain metastases." Cell Reports Medicine. 2022; Pubmed PMID: 35584630
- Hudson WH, Prokhnevska N, Gensheimer J, Akondy R, McGuire DJ, Ahmed R, Kissick HT. "Expression of novel long noncoding RNAs defines virus-specific effector and memory CD8+ T cells." Nature Communications. 2019; Pubmed PMID: 30643116
- Hudson WH, Gensheimer J, Hashimoto M, Wieland A, Valanparambil RM, Li P, Lin J-X, Konieczny BT, Im SJ, Leonard WJ, Kissick HT, Ahmed R. "Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection." Immunity. 2019; Pubmed PMID: 31810882
Funding
- CPRIT Recruitment of First-Time, Tenure-Track Faculty Members - #RR220069 (09/01/2022 - 08/31/2025) Cancer Prevention and Research Institute of Texas
- NIH Pathway to Independence Award - #K99AI153736 (08/17/2020 - 07/31/2024) Grant funding from National Institutes of Health
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