Sandeep Krishna Agarwal, M.D., Ph.D.
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Positions
- Associate Professor
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Medicine
Immunology, Allergy & Rheumatology
Baylor College of Medicine
Addresses
- Baylor College of Medicine Medical Center, McNair Campus (Clinic)
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7200 Cambridge St., 8th Floor, Suite 8A
Houston, TX 77030
United States
Phone: (713) 798-3390
Education
- Clinical Fellowship at Brigham And Women's Hospital, Harvard Medical School
- Boston, Massachusetts United States
- Rheumatology
- Postdoctoral Fellowship at Brigham And Women's Hospital, Harvard Medical School
- 01/2007 - Boston, Massachusetts United States
- MD from The University of Texas Health Science Center at Houston Medical School
- Houston, TX United States
- PhD from The University of Texas Health Science Center at Houston Graduate School for Biomedical Sciences
- Houston, TX United States
- Immunology
- Residency at Brigham and Women's Hospital/ Harvard Medical School
- Boston, Massachusetts United States
- Internal Medicine
- Internship at Brigham and Women's Hospital/Harvard Medical School
- Boston, United States
- Internal Medicine
- BA from University Of Texas At Austin
- Austin, TX United States
- Microbiology
Certifications
- Rheumatology
- American Board of Internal Medicine
Professional Interests
- Clinical : Diagnosis and management of autoimmune diseases including rheumatoid arthritis, systemic sclerosis/scleroderma, systemic lupus erythematosus, psoriatic arthritis, ankylosing spondylitis, polymyalgia rheumatica, vasculitis
- Research :To understand the complex cellular and molecular interactions that lead to autoimmune diseases and tissue fibrosis with the goal of identifying novel therapeutic targets.
- Systemic sclerosis
- Autoimmune mediated lung fibrosis
Professional Statement
Dr. Sandeep Agarwal is a physician scientist and board certified rheumatologist with an independent research program at Baylor College of Medicine. He has served various administrative and leadership roles in the past and is currently the Program Director of the Rheumatology Fellowship Program, Rheumatology Subspeciality Director at Ben Taub Hospital and Rheumatology Service Line Director at Baylor St Lukes Medical Center - TMC.His clinical interests are largely in autoimmune and arthritic diseases (including rheumatoid arthritis, systemic sclerosis/scleroderma, systemic lupus erythematosus, and vasculitis. Dr. Agarwal has a specific interest in autoimmune diseases that involve fibrosis of the skin, lungs and other internal organs and as well as systemic lupus erythematosus, which are also the focus of his laboratory research.
Dr. Agarwal’s laboratory is studying the mechanisms that underlie the development of autoimmune and fibrotic disease, including systemic sclerosis/scleroderma, rheumatoid arthritis, and idiopathic pulmonary fibrosis. His laboratory is interested in the cells that mediate the fibrotic process, in particularly the interactions between fibroblasts and macrophages. Ultimately, Dr. Agarwal and his laboratory seek to understand the complex cellular and molecular interactions that lead to tissue fibrosis with the goal of identifying novel therapeutic targets of patients with these diseases.
1. His laboratory has identified increased expression of cadherin-11 in patients with scleroderma and idiopathic pulmonary fibrosis and demonstrated that cadherin-11 is a critical mediator of lung and skin fibrosis in mouse models. His laboratory has determined that cadherin-11 is an important regulator of fibroblasts, alveolar epithelial cells and macrophages. His laboratory has continues to utilize mouse models, cellular and molecular immunology techniques and samples from patients to determine how cadherin-11 is regulating the development of fibrosis. He is currently working to translate these research findings into the care of patients with autoimmune fibrotic diseases.
2. Dr. Agarwal's laboratory has identified a number of other candidate molecules, including osteopontin and STAT3, involved in autoimmunity and fibrosis, and has active projects on the regulation of skin and lung fibrosis by STAT3 using mouse models and cellular immunology.
3. Dr. Agarwal's laboratory has expanded its interest in autoimmune disease to systemic lupus erythematosus. His laboratory has bee studying candidate molecules such as cadherin-11 in the development of lupus in mouse models. Furthermore, he is collaborating with Dr. Sebasian Bruera, also at Baylor College of Medicine, to build a lupus cohort, with patients from diverse social and ethnic backgrounds, to better understand the development of lupus in patients and clinic outcomes, in order to translate his basic science studies into patient care.
Websites
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