Positions
- Professor
-
Huffington Center On Aging
Baylor College of Medicine
Houston, TX US
- Associate Director
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Genetics and Genomics Graduate Program
Baylor College of Medicine
- Professor
-
Molecular and Human Genetics
Baylor College of Medicine
- Robert C. Fyfe Endowed Chair on Aging
-
Baylor College of Medicine
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
- Investigator
-
Howard Hughes Medical Institute
Education
- Post-Doctoral Fellowship at Massachusetts General Hospital Harvard Medical School
- 09/2010 - Boston, MA United States
- PhD from University Of Rochester
- 10/2005 - Rochester, New York United States
- BS from Peking University
- 07/2001 - Beijing, China
Honors & Awards
- Early Career Life Scientist Award of the American Society for Cell Biology
- Edith and Peter O’Donnell Award in Medicine
- Glenn Award for Research in Biological Mechanisms of Aging
- NIH Director’s Pioneer Award
- Howard Hughes Medical Institute Faculty Scholars Award
- Marc Dresden Excellence in Graduate Education Award
- Gibco Emerging Leader Prizes of the American Society for Cell Biology
- Ellison Medical Foundation New Scholar Award
- Michael E. DeBakey M.D. Excellence in Research Award
- AAAS Fellow
- American Association for the Advancement of Science. (11/2019)
Professional Interests
- Systemic studies of endocrine and metabolic signaling in promoting healthy aging
Professional Statement
Our research goals are to advance our knowledge on the fundamental mechanisms of somatic aging, lipid metabolism and reproductive senescence. These intertwined biological processes exert profound influence on human health, and are the major risk factors for various chronic and degenerative diseases. Our laboratory has been studying the molecular mechanisms governing these key biological processes and their complex interrelationship, by harnessing the power of functional genomics in Caenorhabditis elegans with metabolomics/lipodomics, chemical engineering and optical biophysics.Our research has uncovered a lysosome-to-nucleus retrograde lipid messenger pathway, provided in-depth biochemical mechanisms for its action and demonstrated its novel roles in regulating longevity. We have also discovered a previously unknown communication mode between bacteria and host mitochondria, deciphered bacteria-derived metabolites mediating this ancient dialogue and their signaling mechanisms and determined their vital effects on host’s lipid metabolism and longevity. In addition, our work provides evidence that volatile metabolites signal through specific olfactory neuroendocrine nexus to shape reproductive and metabolic strategies. Technically, we have developed and applied hyperspectral and isotope-labeling-coupled stimulated Raman scattering (SRS) microscopy systems for investigating in vivo spatiotemporal dynamics of metabolite molecules and its previously unknown association with metabolic pathologies. Based on SRS microscopy, we have assembled high-throughput platforms for both forward and reverse genetic screens, leading to the discovery of new regulatory mechanisms of lipid metabolism.
Ongoing projects in my laboratory include: (1) investigating the systemic role of lipid signaling in the regulation of longevity; (2) studying the mechanistic link governing the signaling crosstalk between bacteria and host mitochondria; (3) characterizing the cellular and molecular mechanism regulating reproductive homeostasis during aging; (4) analyzing lipid dynamics using quantitative SRS label-free imaging.
Websites
Selected Publications
- Ramachandran PV, Savini M, Folick AK, Hu K, Masand R, Graham BH, Wang MC "Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity.." Dev Cell.. 2019;48:685-696.e5..
- Bing, H., Sivaramakrishnan, P., Lin, C.J., Neve, I.A.A, Sowa, J.N., He, J., Tay, L.W.R., Sizovs, A., Du, G., Wang, J., Herman, C., Wang, M.C. "Microbial genetic composition tunes host longevity." Cell. 2017 Jun;169(7):1249-62. Pubmed PMID: 28622510
- Lin, C., Wang, M.C. "Microbial Metabolites Regulate Host Lipid Metabolism through NR5A-Hedgehog signaling." Nat Cell Biol. 2017 May;19(5):550-7. Pubmed PMID: 28436966
- Yu Y, Mutlu AS, Liu H, Wang MC "High-throughput screens using photo-highlighting discover BMP signaling in mitochondrial lipid oxidation.." Nat Commun.. 2017;8:865.
- Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC "Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.." Science. 2015;347:83-6.
- Sowa JN, Mutlu AS, Xia F, Wang MC "Olfaction Modulates Reproductive Plasticity through Neuroendocrine Signaling in Caenorhabditis elegans.." Curr Biol. 2015 Aug 12;25:2284-9. Pubmed PMID: 26279229
- Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC "Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans." Science. 2015 Jan 2;347(6217):83-6. Pubmed PMID: 25554789
- Fu D, Yu Y, Folick A, Currie E, Farese RV Jr, Tsai TH, Xie XS, Wang MC "In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy." J Am Chem Soc. 2014 Jun 18;136(24):8820-8. Pubmed PMID: 24869754
- Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G "Gene pathways that delay Caenorhabditis elegans reproductive senescence.." PLoS Genet. 2014 Dec 4;10:e1004752. Pubmed PMID: 25474471
- Wei L, Yu Y, Shen Y, Wang MC, Min W. "Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy." Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11226-31. Pubmed PMID: 23798434
- Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS. "RNAi screening for fat regulatory genes with SRS microscopy." Nat Methods. 2011 Feb;8(2):135-8. Pubmed PMID: 21240281
Memberships
- American Society for Cell Biology
- Genetics Society of America
- Society for Developmental Biology
- American Aging Association
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