Martin M. Matzuk, M.D., Ph.D.
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Positions
- Department Chair
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Pathology & Immunology
Baylor College of Medicine
- Stuart A. Wallace Chair, Robert L. Moody, Sr. Chair, and Professor
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Pathology & Immunology
Baylor College of Medicine
- Director
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Center for Drug Discovery
Baylor College of Medicine
- Deputy Director
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Clinical Chemistry
Ben Taub Hospital
- Professor
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Molecular and Human Genetics
Baylor College of Medicine
- Professor
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Biochemistry and Molecular Pharmacology
Baylor College of Medicine
- Professor
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Molecular & Cellular Biology
Baylor College of Medicine
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Education
- BA from University Of Chicago (with Honors)
- 06/1982 - Chicago, IL United States
- PhD from Washington University School of Medicine
- 12/1989 - St. Louis, MO United States
- MD from Washington University School Of Medicine
- 12/1989 - St. Louis, Missouri United States
- Postdoctoral Fellowship at Baylor College Of Medicine
- 06/1993 - Houston, Texas United States
- Residency at Hospital of the University Of Pennsylvania
- 04/1991 - Philadelphia, PA United States
Honors & Awards
- Member of the National Academy of Sciences
- 04/2014
- Member of The Academy of Medicine, Engineering, and Science of Texas (TAMEST)
- 04/2014
- Fellow of the National Academy of Inventors
- 12/2016
- Inaugural Hill Prize in Medicine
- Lyda Hill Philanthropies and TAMEST (02/2024)
- Carl G. Hartman Award
- Society for the Study of Reproduction (07/2022)
- Inaugural Distinguished Fellow
- Society for the Study of Reproduction (07/2021)
- NIH MERIT Award
- National Institute of Child Health and Human Development (05/2001 - 04/2011)
- Distinguished Alumnus Award
- Baylor College of Medicine (03/2019)
- Trainee Mentoring Award
- The Society for the Study of Reproduction (07/2015)
- 5th Int’l Fundacion IVI Award for Best Basic Research Record in Reproductive Medicine
- 04/2013
- The Roy O. Greep Award
- The Endocrine Society (06/2010)
- Pfizer Outstanding Investigator Award
- American Society for Investigative Pathology (04/2002)
- The HypoCCS Award
- Eli Lilly (11/1999)
- The Inaugural Ernst Knobil Lecture
- University of Pittsburgh (10/1998)
- The Richard E. Weitzman Memorial Award
- The Endocrine Society (06/1996)
- The Michael E. DeBakey, M.D., Excellence in Research Award
- Baylor College of Medicine (11/1995)
- Experimental Pathologist-in-Training Award
- American Society for Investigative Pathology (04/1993)
- John R. Rainey, M.D. Research Award
- Texas Society of Pathology (02/1993)
- Dr. Philip Needleman Prize for Excellence in Pharmacology Research
- Washington University School of Medicine (05/1990)
Professional Interests
- Chemical biology and drug discovery
- Mammalian reproduction, endometriosis, germ cell biology, infertility, and contraception
- TGF-beta and cell signaling networks in female reproduction
Professional Statement
I am a reproductive biologist, a clinical pathologist, Director of Baylor College of Medicine’s Center for Drug Discovery, Deputy Director of the Clinical Chemistry laboratory at Ben Taub Hospital, and Chair of the Department of Pathology & Immunology. As a faculty member at Baylor during the last 30 years, I have directly mentored over 50 students, postdoctoral fellows, and medical fellows, including 13 underrepresented minority trainees, and I was the recipient of the 2015 Trainee Mentoring Award from the Society for the Study of Reproduction. My 16 Ph.D. students have averaged over 9 papers as part of their training in my laboratory, and my trainees have received multiple honors and moved on to research and leadership positions in academia and the biotech industry. I have been a member of the National Advisory Child Health and Human Development Council, am discipline chair of the National Academy of Sciences Animal Genetics and Physiology Section (Section 61), chaired the NIH CMIR study section and the Burroughs Wellcome Fund CABS and CAMS review panels, and was a member of the Board of Reviewing Editors at Science. I have published more than 400 papers (including over 25 papers in Cell, Nature, and Science journals), generated >200 mouse models, lectured at >180 symposia in 27 countries, and have been supported continuously by the NIH since 1991. I am an inventor on 13 patents for my biomedical research discoveries, including ELONVA, a long-acting follicle stimulating hormone biologic that I helped to develop. As shown on this page, I have multiple additional honors from the Society for the Study of Reproduction (2002 SSR Research Award, 2021 Fellow of the SSR, and 2022 Carl G. Hartman Award) as well as the Endocrine Society (The Richard E. Weitzman Memorial Award and The Roy O. Greep Award), received the IVI Foundation’s 5th International Award for Best Basic Research Record in Reproductive Medicine, and was awarded a prestigious NIH MERIT award. For my career contributions to reproductive medicine, drug discovery, TGFβ family signaling, and ovarian cancer, I was elected to the National Academy of Sciences and the Texas Academy of Medicine, Engineering, Science, and Technology (TAMEST) in 2014 and as a Fellow in the National Academy of Inventors in 2016, and I received the inaugural Hill Prize in Medicine from TAMEST in 2024 for drug development research in endometriosis.Research in my laboratory is focused on 1) using functional genomics to investigate essential fertility pathways, reproductive tract cancers, and TGFβ superfamily signaling in mammals, and 2) applying chemical biology approaches to develop lead compounds for endometriosis, contraception, cancer, and debilitating diseases. My collaborative group has created hundreds of unique transgenic mouse models to study fertility, development, and ovarian cancer and to decipher the crosstalk of TGFβ family, hormonal, and small RNA signaling pathways in normal and diseased reproductive tissues and their roles during pregnancy. Based on Google Scholar, my h-index is 125, and more than 20 papers have been cited over 600 times. I was the first to show that a secreted protein (inhibin) could function as a tumor suppressor in vivo, demonstrate that an oocyte-secreted protein (GDF9) could regulate somatic cell function and fertility in vivo, uncover a small molecule (JQ1) that specifically targets male germ cells to induce a reversible contraceptive effect, and uncover a epididymis-specific protease, ovochymase 2, that is required for sperm maturation. To rapidly and cost-effectively develop lead compounds in academia, we established a DNA-Encoded Chemistry Technology (DEC-Tec) platform; our team has synthesized >70 DNA-encoded chemical libraries containing >7 billion diverse small molecules, has innovated in developing a novel bioinformatic analysis pipeline and DNA-compatible chemical reactions for producing unprecedented libraries, and has screened these libraries to uncover low nanomolar drug-like inhibitors and novel chemical matter.
Websites
Selected Publications
- Modukuri, RK, Monsivais, D, Li, F, Palaniappan, M, Bohren, KM, Tan, Z, Ku, AF, Wang, Y, Madasu, C, Li, JY, Tang, S, Miklossy, G, Palmer, SS, Young, DW, and Matzuk, MM "Discovery of highly potent and BMPR2-selective kinase inhibitors using DNA-encoded chemical library screening." Journal of Medicinal Chemistry. 2023;66:2143-2160. Pubmed PMID: 35622893
- Kiyozumi, D., Noda, T., Yamaguchi, R., Tobita, T., Matsumura, T., Shimada, K., Kodani, M., Kohda, T., Fujihara, Y., Ozawa, M., Yu, Z., Miklossy, G., Bohren, K., Horie, M., Okabe, M., Matzuk, M.M., and Ikawa, M. "NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility." Science. 2020 Jun;368:1132-1135. Pubmed PMID: 32499443
- Dawadi, S., Simmons, N., Miklossy, G., Bohren, K.M., Faver, J.C., Ucisik, M.N., Nyshadham, P., Yu, Z., and Matzuk, M.M. "Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library." Proc Natl Acad Sci USA. 2020 Jul;117(29):16782-16789. Pubmed PMID: 32641511
- Peng J, Li Q, Wigglesworth K, Rangarajan A, Kattamuri C, Peterson RT, Eppig JJ, Thompson TB, Matzuk MM "Growth differentiation factor 9: bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions." Proc. Natl. Acad. Sci. U.S.A.. 2013;110(8):E776-85. Pubmed PMID: 23382188
- Matzuk MM, McKeown MR, Filippakopoulos P, Li Q, Ma L, Agno JE, Lemieux ME, Picaud S, Yu RN, Qi J, Knapp S, Bradner JE "Small-molecule inhibition of BRDT for male contraception." Cell. 2012 Aug 17;150(4):673-84. Pubmed PMID: 22901802
- Matzuk MM and Lamb DJ "The biology of infertility: research advances and clinical challenges.." Nature Medicine. 2008 Nov;14(11):1197-1213. Pubmed PMID: 18989307
- Greenbaum MP, Yan W, Wu MH, Lin YN, Agno JE, Sharma M, Braun RE, Rajkovic A, Matzuk MM "TEX14 is essential for intercellular bridges and fertility in male mice." Proc. Natl. Acad. Sci. U.S.A.. 2006 Mar 28;103(13):4982-7. Pubmed PMID: 16549803
- Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM "NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression.." Science. 2004 Aug 20;305(5687):1157-9. Pubmed PMID: 15326356
- Burns KH, Viveiros MM, Ren Y, Wang P, DeMayo FJ, Frail DE, Eppig JJ, Matzuk MM "Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos." Science. 2003 Apr 25;300(5619):633-6. Pubmed PMID: 12714744
- Wu X, Viveiros MM, Eppig JJ, Bai Y, Fitzpatrick SL, Matzuk MM "Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition.." Nat. Genet.. 2003 Feb;33(2):187-91. Pubmed PMID: 12539046
- Matzuk MM, Burns KH, Viveiros MM, Eppig JJ "Intercellular communication in the mammalian ovary: oocytes carry the conversation.." Science. 2002 Jun 21;296(5576):2178-80. Pubmed PMID: 12077402
- Shou W, Aghdasi B, Armstrong DL, Guo Q, Bao S, Charng MJ, Mathews LM, Schneider MD, Hamilton SL, and Matzuk MM "Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12." Nature. 1998 Jan 29;391(6666):489-92. Pubmed PMID: 9461216
- Kumar TR, Wang Y, Lu N, and Matzuk MM "Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility." Nature Genetics. 1997 Feb;15(2):201-204. Pubmed PMID: 9020850
- Dong J, Albertini DF, Nishimori K, Kumar TR, Lu N, Matzuk MM "Growth differentiation factor-9 is required during early ovarian folliculogenesis." Nature. 1996 Oct 10;383(6600):531-5. Pubmed PMID: 8849725
- Matzuk MM, Kumar TR, Vassalli A, Bickenbach JR, Roop DR, Jaenisch R, Bradley A "Functional analysis of activins during mammalian development." Nature. 1995 Mar 23;374(6520):354-6. Pubmed PMID: 7885473
- Matzuk MM, Kumar TR, Bradley A "Different phenotypes for mice deficient in either activins or activin receptor type II." Nature. 1995 Mar 23;374(6520):356-60. Pubmed PMID: 7885474
- Matzuk MM, Lu N, Vogel H, Sellheyer K, Roop DR, Bradley A "Multiple defects and perinatal death in mice deficient in follistatin." Nature. 1995 Mar 23;374(6520):360-3. Pubmed PMID: 7885475
- Matzuk MM, Finegold MJ, Su JG, Hsueh AJ, and Bradley A "Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice.." Nature. 1992;360(6402):313-319. Pubmed PMID: 1448148
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