Kyle P. Eagen, Ph.D.
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Kyle P. Eagen, Ph.D.
Assistant Professor and CPRIT Scholar in Cancer Research
Positions
- Assistant Professor and CPRIT Scholar in Cancer Research
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Department of Molecular and Cellular Biology
Center for Precision Environmental Health
Baylor College of Medicine
Houston, Texas United States
- Member
-
Stem Cells and Regenerative Medicine Center (STaR)
Baylor College of Medicine
Houston, Texas United States
- Member
-
Center for Cell and Gene Therapy (CAGT)
Baylor College of Medicine
Houston, Texas United States
- Member
-
Therapeutic Innovation Center (THINC)
Baylor College of Medicine
Houston, Texas United States
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
- Faculty Member
-
Graduate Program in Cancer & Cell Biology
Graduate Program in Genetics & Genomics
Baylor College of Medicine
Houston, Texas United States
Addresses
- Baylor College of Medicine (Office)
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Michael E. DeBakey Center M512F
One Baylor Plaza, BCM130
Houston, TX 77030
United States
Phone: (713) 798-3560
kyle.eagen@bcm.edu
- Baylor College of Medicine (Lab)
-
Michael E. DeBakey Center M513
One Baylor Plaza, BCM130
Houston, TX 77009
United States
Phone: (713) 798-6082
Education
- PhD from Stanford University
- 01/2017 - Stanford, California United States
- Biophysics
- BS from Cornell University
- 05/2008 - Ithaca, New York United States
- Biological Sciences
Honors & Awards
- NIH Director's Early Independence Award
- National Institutes of Health
- CPRIT Scholar in Cancer Research
- Cancer Prevention and Research Institute of Texas
- Distinguished Scientist Award
- The Sontag Foundation
Professional Interests
- Genomics and computational biology
- Nuclear organization
- Epigenetics and chromatin
- Chromosome biology
- Cancer biology and therapeutics
- Stem cells and developmental biology
Professional Statement
The folding and compaction of DNA in nuclei and chromosomes has fascinated biologists for over a century. Active and inactive genes are located in different regions of the nucleus indicating that the spatial organization of DNA influences proper gene regulation. Various and intricate chromosome 3D folding patterns have been described, but the molecular basis of how these folding patterns arise has not been fully realized. In particular, the spatial segregation of loci into distinct regions, or compartments, of the nucleus impacts diverse areas of biology from aging and cancer to hematopoiesis and olfaction. Additionally, aberrant chromosome compartmentalization in a variety of diseases, including cancer, pathogenically rewires gene expression programs. Defining the pathophysiology of and therapeutically intervening in these diseases will come from molecular insights into how chromosomes are organized within nuclear compartments.The Eagen Lab combines concepts and approaches from biochemistry with methods and analytical tools from cell biology, molecular biology, pharmacology, genomics, and computational biology to determine the molecular basis of how chromosomes are folded in three dimensions and compartmentalized within nuclei. Our long-term goal is to reveal fundamental principles underlying how the folding of chromosomes within nuclear compartments impacts biological function. This will enable new insights into human disease processes and will serve as a basis for developing pharmacological intervention of aberrant chromatin 3D structure as a novel therapeutic approach for disease treatment.
Websites
Selected Publications
- Rosencrance CD, Ammouri HA, Yu Q, Ge T, Rendleman EJ, Marshal SA, Eagen KP "Chromatin Hyperacetylation Impacts Chromosome Folding by Forming a Nuclear Subcompartment." Mol Cell. 2020 Apr 2;78(1):112-126. Pubmed PMID: 32243828
- Ge T, Rosencrance CD, Eagen KP "Contact Mapping to Unravel Chromosome Folding." Trends Biochem Sci. 2019 Dec 1;44(12):1089-1090. Pubmed PMID: 31677956
- Eagen KP "Principles of Chromosome Architecture Revealed by Hi-C." Trends Biochem Sci. 2018 Jun 1;43(6):469-478. Pubmed PMID: 29685368
- Eagen KP, Hartl TA, Kornberg RD "Stable Chromosome Condensation Revealed by Chromosome Conformation Capture." Cell. 2015 Nov 5;163(4):934-946. Pubmed PMID: 26544940
- Eagen KP*, Lieberman Aiden E, Kornberg RD* "Polycomb-mediated chromatin loops revealed by a subkilobase-resolution chromatin interaction map." Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8764-8769. Pubmed PMID: 28765367
- Eagen KP "BET proteins loop and compartmentalize the 3D genome." Nat Genet. 2022 Apr 11;54(4):370-371. Pubmed PMID: 35410382
- Huang Y, Durall RT...Eagen KP, French CA "EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes." Cancer Res. 2023 Dec 1;83:3956-3973. Pubmed PMID: 37747726
Funding
- Recruitment of First-Time, Tenure-Track Faculty Members - #RR210082 Grant funding from Cancer Prevention & Research Institute of Texas
- Chromatin Structure as a Therapeutic Vulnerability in Cancer
- R Accelerated Award - #22-25794 Grant funding from Alex’s Lemonade Stand Foundation for Childhood Cancer
- GENOME ORIGAMI: Refolding Aberrant Chromosome 3D Structure for Treating NUT Carcinoma
- Distinguished Scientist Award Grant funding from The Sontag Foundation
- Transcriptional Regulation and Drug Sensitivity Through Chromosome 3D Structure Rewiring by a Brain Tumor Fusion Oncoprotein
- U01 Award - #U01CA294062 Grant funding from National Cancer Institute
- Overcoming Limitations of BET Inhibition in NUT Carcinoma
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