Positions
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
- Associate Professor
-
Biochemistry and Molecular Pharmacology
Baylor College of Medicine
Houston, Texas USA
Addresses
- BCM-Alkek Graduate School (Office)
-
Room: BCMN-N520.03
Houston, TX 77030
United States
Education
- Post-Doctoral Fellowship at The Scripps Research Institute
- La Jolla, California USA
- NMR Spectroscopy
- PhD from University of Texas Medical Branch
- Galveston, Texas USA
- Structural Biology and Biophysical Chemistry
- BS from University of the Philippines-Diliman
- Quezon City, Philippines
- Molecular Biology & Biotechnology
Honors & Awards
- Leukemia and Lymphoma Society Special Fellow
- James W. McLaughlin Postdoctoral Fellow
- Sealy Center for Structural Biology Pre-Doctoral Fellow
Professional Interests
- NMR Spectroscopy
- Stem Cell Biology
- Intrinsically Disordered Proteins
- Protein Structure and Function
- Post-Translational Modifications
Websites
Selected Publications
- Ferreon ACM*, Ferreon JC*, Wright PE, and Deniz, AA [*co-first authors] "Modulation of Allostery by Protein Intrinsic Disorder.." Nature. 2013;498(7454):390-4. Pubmed PMID: 23783631
- Arai M, Ferreon JC, and Wright PE "Quantitative analysis of multisite protein ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP.." J Am Chem Soc. 2012;134(8):3792-803. Pubmed PMID: 22280219
- Lee CW*, Ferreon JC*, Ferreon ACM, Arai M, and Wright PE [*co-first authors] "Graded enhancement of p53 binding to CBP/p300 by multisite phosphorylation.." Proc Natl Acad Sci USA. 2010;107(45):19290-5. Pubmed PMID: 20962272
- Ferreon JC, Martinez-Yamout MA, Dyson HJ, and Wright PE "Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein.." Proc Natl Acad Sci USA. 2009;106(32):13260-5. Pubmed PMID: 19651603
- Ferreon AC, Moran CR, Ferreon JC, and Deniz AA "Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson’s disease.." Angew Chem Int Ed Engl. 2010;49(20):3469-72. Pubmed PMID: 20544898
- Manson A, Whitten ST, Ferreon JC, Fox RO, and Hilser VJ "Characterizing the role of ensemble modulation in mutation-induced changes in binding affinity.." J Am Chem Soc. 2009;131(19):6785-93. Pubmed PMID: 19397330
- Ferreon JC, Lee CW, Arai M, Martinez-Yamout MA, Dyson HJ, and Wright PE "Cooperative regulation of p53 by modulation of ternary complex formation with CBP and HDM2.." Proc Natl Acad Sci USA. 2009;106(16):6591-6. Pubmed PMID: 19357310
- Whitten ST, Ferreon JC, Hamburger JB, and Hilser VJ "Calorimetric Determination of the Thermodynamics of Polyproline II (PII) Helix Formation." In the Unfolded States of Protein In Unfolded. 2008;
- Ferreon ACM, Ferreon JC, Bolen DW, and Rösgen J "Protein phase diagrams II: nonideal behavior of biochemical reactions in the presence of osmolytes.." Biophys J. 2007;92(1):245-56. Pubmed PMID: 17028144
- Ferreon JC, Ferreon ACM, Li K, and Lemon SM "Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease.." J Biol Chem. 2005;280(21):20483-92. Pubmed PMID: 15767257
- Li K, Foy E, Ferreon JC, Nakamura M, Ferreon ACM, Ikeda M, Ray SC, Gale Jr. M, and Lemon SM "Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF.." Proc Natl Acad Sci USA. 2005;102(8):2992-7. Pubmed PMID: 15710891
- Ferreon JC, Hamburger JB, Whitten ST, and Hilser VJ "An experimental strategy to evaluate the thermodynamic stability of highly dynamic binding sites in proteins using hydrogen exchange.." J Am Chem Soc. 2004;126(40):12774-5. Pubmed PMID: 15469262
- Hamburger JB, Ferreon JC, Whitten ST, and Hilser VJ "Thermodynamic mechanism and consequences of the polyproline II (PII) structural bias in the denatured states of proteins.." Biochemistry. 2004;43(30):9790-9. Pubmed PMID: 15274633
- Ferreon JC and Hilser VJ "Thermodynamics of binding to SH3 domains: the energetic impact of polyproline II (PII) helix formation.." Biochemistry. 2004;43(24):7787-97. Pubmed PMID: 15196021
- Ferguson MR, Fan X, Mukherjee M, Luo J, Khan R, Ferreon JC, Hilser VJ, Shope RE, and Fox RO "Directed discovery of bivalent peptide ligands to an SH3 domain.." Protein Sci. 2004;13(3):626-32. Pubmed PMID: 14978303
- Ferreon JC, Volk DE, Luxon BA, Gorenstein DG, and Hilser VJ "Solution structure, dynamics and thermodynamics of the native state ensemble of the SEM-5 C-terminal SH3 domain.." Biochemistry. 2003;42(19):5582-91. Pubmed PMID: 12741814
- Ferreon JC and Hilser VJ "Ligand-induced changes in dynamics in the RT loop of the C-terminal SH3 domain of SEM-5 indicate cooperative conformational coupling.." Protein Sci. 2003;12(5):982-996. Pubmed PMID: 12717021
- Ferreon JC and Hilser VJ "The effect of the polyproline II (PPII) conformation on the denatured state entropy.." Protein Sci. 2003;12(3):447-457. Pubmed PMID: 12592015
- Tabbada KA, Magno MM, Delfin FC, Calacal GC, Tan M, C-Ferreon J, Halos SC, and De Ungria MCA "Allele Frequencies of Eight Short Tandem Repeat Loci in Three Visayas Regional Populations of the Philippines.." J Forensic Sci. 2002;47(6):1397-8. Pubmed PMID: 12455671
- Soman KV, Midoro-Horiuti T, Ferreon JC, Goldblum RM, Brooks EG, Kurosky A, Braun W, and Schein C "Homology modeling and characterization of IgE binding epitopes of mountain cedar allergen Jun a 3.." Biophys J. 2000;79(3):1601-9. Pubmed PMID: 10969020
- Halos SC, Chu JY, Ferreon ACM, and Magno MM "Philippine population database at nine microsatellite loci for forensic and paternity applications.." Forensic Sci Int. 1999;101(1):27-32. Pubmed PMID: 10376334
- Halos SC, Fortuno ES 3rd, Ferreon AC, Chu JY, Miranda J, Harada S, and Benecke M "Allele frequency distributions of the polymorphic STR loci HUMVWA, HUMFES, HUMF13A01 and the VNTR D1S80 in a Filipino population from Metro Manila.." Int J Legal Med. 1998;111(4):224-6. Pubmed PMID: 9646171
Memberships
- Biophysical Society
- Protein Society
Languages
Tagalog
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