H. Courtney Hodges, Ph.D.
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H. Courtney Hodges, Ph.D.
Associate Professor
Positions
- Associate Professor
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Department of Molecular and Cellular Biology
Center for Precision Environmental Health
Baylor College of Medicine
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
- Adjunct Faculty
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Department of Bioengineering
Rice University
- Faculty Member
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Graduate Program in Genetics and Genomics
- Faculty Member
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Graduate Program in Cancer and Cell Biology
Addresses
- One Baylor Plaza, BCM 229 (Office)
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Alkek Building N1317
Houston, TX 77030
United States
chodges@bcm.edu
- One Baylor Plaza, BCM 229 (Lab)
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Alkek Building N1302
Houston, TX 77030
United States
http://www.hodgeslab.org/
Education
- Postdoctoral Fellowship at Stanford University School of Medicine
- Stanford, California United States
- PhD from U.C. Berkeley
- Berkeley, California United States
Honors & Awards
- V Scholar Award
- The V Foundation
- Medical Research Award
- Gabrielle's Angel Foundation for Cancer Research
- CPRIT Faculty Scholar
- Cancer Prevention & Research Institute of Texas
Professional Interests
- Epigenomics
- Translational biology
- Chromatin and epigenetics
- Cancer biology
Professional Statement
Research in the Hodges lab focuses on mechanisms of transcription and epigenetic function in human disease. We use interdisciplinary approaches, including epigenomics, live-cell imaging, and chemical biology to understand chromatin regulatory systems in various settings. Our research is especially focused on new technologies, including single-cell and other quantitative methods.Websites
Selected Publications
- Chambers C, Cermakova K, Chan YS, Kurtz K, Wohlan K, Lewis AH, Wang C, Pham A, Dejmek M, Sala M, Loeza Cabrera M, Aguilar R, Nencka R, Lacorazza D, Rau RE, Hodges HC "SWI/SNF blockade disrupts PU.1-directed enhancer programs in normal hematopoietic cells and acute myeloid leukemia." Cancer Res. 2023 Jan 20; Pubmed PMID: 36662812
- Cermakova K, Demeulemeester J, Lux V, Nedomova M, Goldman SR, Smith EA, Srb P, Hexnerova R, Fabry M, Madlikova M, Horejsi M, De Rijck J, Debyser Z, Adelman K, Hodges* HC, Veverka* V "A ubiquitous disordered protein interaction module orchestrates transcription elongation." Science. 2021 Nov 26;374(6571):1113-1121. Pubmed PMID: 34822292
- Hodges* HC, Stanton* BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR "Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers." Nat Struct Mol Biol. 2018;25(1):61-72. Pubmed PMID: 29323272
- Hodges* C, Bintu* L, Lubkowska L, Kashlev M, Bustamante C "Nucleosomal fluctuations govern the transcription dynamics of RNA polymerase II." Science. 2009;325(5940):626-628. Pubmed PMID: 19644123
- Hathaway NA, Bell O, Hodges C, Miller EL, Neel DS, Crabtree GR "Dynamics and memory of heterochromatin in living cells." Cell. 2012;149(7):1447-1460. Pubmed PMID: 22704655
- Kadoch C, Hargreaves DC, Hodges C, Elias L, Ho L, Ranish J, Crabtree GR "Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy." Nat Genet. 2013;45(6):592-601. Pubmed PMID: 23644491
- Stanton* BZ, Hodges* C, Calarco JP, Braun SM, Ku WL, Kadoch C, Zhao K, Crabtree GR "Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin." Nat Genet. 2017;49(2):282-288. Pubmed PMID: 27941795
- Hodges C, Crabtree GR "Dynamics of inherently bounded histone modification domains." Proc Natl Acad Sci USA. 2012;109(33):13296-13301. Pubmed PMID: 22847427
- Hodges C, Kirkland JG, Crabtree GR "The many roles of BAF (mSWI/SNF) and PBAF complexes in cancer." Cold Spring Harb Perspect Med. 2016;6(8):a026930. Pubmed PMID: 27413115
- Wen JD, Lancaster L, Hodges C, Zeri AC, Yoshimura SH, Noller HF, Bustamante C, Tinoco I "Following translation by single ribosomes one codon at a time." Nature. 2008;452(7187):598-603. Pubmed PMID: 18327250
- Sharma S, Cermakova K, De Rijck J, Demeulemeester J, Fabry M, El Ashkar S, Van Belle S, Lepsik M, Tesina P, Duchoslav V, Novak P, Hubalek M, Srb P, Christ F, Rezacova P, Hodges HC, Debyser Z, Veverka V "Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation." Proc Natl Acad Sci USA. 2018;115(30):E7053-E7062. Pubmed PMID: 29997176
- Cermakova K, Hodges HC "Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation." Molecules. 2018;23(8):E1958. Pubmed PMID: 30082609
- England JP, Hao Y, Bai L, Glick V, Hodges HC, Taylor SS, Maillard RA "Switching of the folding-energy landscape governs the allosteric activation of protein kinase A." Proc Natl Acad Sci USA. 2018;115(32):E7478-E7485. Pubmed PMID: 30038016
Languages
English, Spanish
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