Eveline Barbieri
Picture
Eveline Barbieri
Associate Professor
Positions
- Associate Professor
-
Pediatrics
Hematology/Oncology
Baylor College of Medicine
Houston, TX US
- Faculty Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
- Faculty Member
-
Graduate Program in Cancer and Cell Biology
Baylor College of Medicine
Houston, Texas United States
Addresses
- 1102 Bates Street (Lab)
-
Feigin Center
TXFC-C75003
Houston, TX 77030
United States
Phone: (832) 824-4747
barbieri@bcm.edu
Education
- PhD from University of Bologna
- 04/2010 - Bologna, Italy
- Oncology and Experimental Pathology
- MD from University of Bologna
- 09/2005 - Bologna, Italy
- Pediatrics- Hematology Oncology
- MD from University of Bologna
- 03/1999 - Bologna, Italy
Honors & Awards
- American Cancer Society Scholar
- ACS
- St. Baldrick's Scholar
- St. Baldrick's Foundation
- Hyundai Hope on Wheels Scholar
- Hyundai Hope on Wheels
- Young Investigator Award
- Department of Pediatrics
- High Impact Publication Award (senior author)
- Department of Pediatrics
Professional Interests
- Neuroblastoma
- Cancer Metabolism
- Developmental Therapeutics
- Tumor Microenvironment and Immunometabolism
Professional Statement
My research goals and interests lie at the intersection between the study of the molecular mechanisms driving neuroblastoma oncogenesis, tumor metabolism, and translational oncology. Amplification of the MYCN oncogene is the most common genetic aberration in high-risk neuroblastoma and is associated with poor prognosis and chemoresistance. The long-term goal of my laboratory is to elucidate the MYCN-dependent pathways that serve as targets for neuroblastoma treatment. Toward this goal, my focus is to understand how MYCN drives undifferentiated, chemorefractory, and metabolically distinct tumors and develop novel approaches to intervention for high-risk MYCN-amplified disease.Websites
Selected Publications
- Tao L, Moreno-Smith M, Ibarra-García-Padilla R, Milazzo G, Drolet NA, Hernandez BE, Oh YS, Patel I, Kim JJ, Zorman B, Patel T, Kamal AHM, Zhao Y, Hicks J, Vasudevan SA, Putluri N, Coarfa C, Sumazin P, Perini G, Parchem RJ, Uribe RA, Barbieri E. "CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming.." Adv Sci (Weinh). 2021; Pubmed PMID: 34365742
- Tao L, Mohammad MA, Milazzo G, Moreno-Smith M, Patel TD, Zorman B, Badachhape A, Hernandez BE, Wolf AB, Zeng Z, Foster JH, Aloisi S, Sumazin P, Zu Y, Hicks J, Ghaghada KB, Putluri N, Perini G, Coarfa C, Barbieri E. "MYCN-driven Fatty Acid Uptake is a Metabolic Vulnerability in Neuroblastoma.." Nat Commun.. 2022; Pubmed PMID: 35764645
- Moreno-Smith M, Milazzo G, Tao L, Fekry B, Zhu B, Mohammad MA, Di Giacomo S, Borkar R, Reddy KRK, Capasso M, Vasudevan SA, Sumazin P, Hicks J, Putluri N, Perini G, Eckel-Mahan K, Burris TP, Barbieri E. "Restoration of the molecular clock is tumor suppressive in neuroblastoma.." Nat Commun.. 2021; Pubmed PMID: 34183658
- Myrthala Moreno-Smith, Anna Lakoma, Zaowen Chen, Ling Tao...and Eveline Barbieri "p53 Nongenotoxic Activation and mTORC1 Inhibition Lead to Effective Combination for Neuroblastoma Therapy." Clin Cancer Res. 2017; Pubmed PMID: 28821555
Languages
Italian
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