Changyi Johnny Chen, M.D., Ph.D.
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Changyi Johnny Chen, M.D., Ph.D.
Professor and Director, Basic Science and Translational Labs
Phone
Phone
Positions
- Professor and Director, Basic Science and Translational Labs
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Baylor College of Medicine
- Molecular Surgery Endowed Chair
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Baylor College of Medicine
- Professor of Molecular and Cellular Biology
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Baylor College of Medicine
- Editor-in-Chief
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Patient Preference and Adherence
Addresses
- Alkek Building for Biomedical Research (Lab)
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One Baylor Plaza
R413
Houston, TX 77021
United States
Education
- MS from The University of Texas at El Paso
- 01/1991 - El Paso, TX United States
- MD from Southeast University School of Medicine
- 01/1982 - Nanjing, China, People's Rep
- Residency at Southeast University School of Medicine - Zhong-Da Hospital
- 01/1987 - Nanjing, China, People's Rep
- PhD from Georgia Institute of Technology
- 01/1996 - Atlanta, GA United States
Honors & Awards
- 2018 Hans-Peter Krayenbuehl Memorial Award
- International Academy of Cardiology
- Inaugural Senior Member
- National Academy of Inventors (NAI)
Professional Interests
- Pancreatic cancer
- Hyperuricemia and uric acid-lowering drug discoveries
- LGA-PEI based nanotechnology drug delivery systems
- Pancreatic cancer
- ACE2 inhibitors and drug discoveries
- Endothelial dysfunction and vascular disease
- Angiogenesis
- Atherosclerosis
- Cardiovascular disease
- Endothelial nitric oxide synthase
- Hemodynamics
- Vascular tissue engineering
- Oxidative stress and antioxidants
Professional Statement
Dr. Chen's laboratory is actively conducting several basic science and translational research projects that are highly relevant to clinical cardiovascular disease and pancreatic cancer. Cardiovascular risk factors and their molecular mechanisms in cardiovascular disease:We are investigating the effects and the molecular mechanisms of several cardiovascular risk factors, including HIV protease inhibitors, the adipokine resistin, soluble CD40L, and uric acid, on biochemical pathways associated with endothelial cell functions. Some of the biochemical pathways under investigation are the endothelial nitric oxide synthase system, the oxidative stress system, and signal transduction pathways. We are carrying on these investigations using several experimental models, such as myographies, organ cultures, mouse models, human tissue samples, and different types of endothelial cells. Based on the molecular mechanisms we uncover, we develop effective therapeutic strategies to treat endothelial dysfunction and atherosclerosis. Endothelial cell differentiation and angiogenesis:
We are studying the role played by and the molecular mechanisms of hemodynamic factors and several novel molecules on endothelial cells differentiated from embryonic stem cells and from bone marrow-derived stem cells. We are identifying key regulatory genes that trigger endothelial cell differentiation and promote stable angiogenesis. These findings can potentially be applied to the design of novel therapeutic strategies to treat ischemic tissues using genetically engineered endothelial cells. In addition, these studies may provide useful information to genetically engineer novel tissues for vascular grafts. Pancreatic cancer:
We have been heavily involved in pancreatic cancer research programs for many years. We have several projects focusing on the role and on the mechanisms of several genes, such as microRNA 196a (miR-196a), X-inactive specific transcript (XIST), and Jude-2 in pancreatic cancer. Our comprehensive studies analyze human cancer specimens, clinical outcomes, established cell lines, a nude mouse model, and a genetically engineered mouse model of pancreatic cancer called the KPC model. We are developing LGA-PEI-based nanotechnology for molecular imaging and for specific drug and gene delivery, which has great potential clinical applications, such as molecular diagnostics and targeted therapies. Drug discoveries:
We have been actively involved in drug discovery programs through high throughput screen libraries, focusing on novel xanthine oxidase (XO) inhibitors, which have potential clinical applications for the treatment of hyperuricemia-associated diseases. Recently, we also discover novel ACE2 inhibitors, which may have potential clinical application for the prevention or treatment of COVID-19 or other ACE2 related diseases.
Websites
eNOS Signal Pathways
Baylor College of Medicine graduate starts Speratum CR to bring his own discovery to cancer patients
Videos
eNOS Signaling Pathways
Selected Publications
- Mohiuddin I, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C "Nitrotyrosine and chlorotyrosine: clinical significance and biological functions in the vascular system.." J. Surg. Res.. 2006 Jun 15;133(2):143-9. Pubmed PMID: 16360172
- Conklin BS, Zhong DS, Zhao W, Lin PH, Chen C "Shear stress regulates occludin and VEGF expression in porcine arterial endothelial cells.." J. Surg. Res.. 2002 Jan;102(1):13-21. Pubmed PMID: 11792146
- Yan S, Li M, Chai H, Yang H, Lin PH, Yao Q, Chen C "TNF-alpha decreases expression of somatostatin, somatostatin receptors, and cortistatin in human coronary endothelial cells.." J. Surg. Res.. 2005 Feb;123(2):294-301. Pubmed PMID: 15680393
- Li M, Fisher WE, Kim HJ, Wang X, Brunicardi CF, Chen C, Yao Q "Somatostatin, somatostatin receptors, and pancreatic cancer.." World J Surg. 2005 Mar;29(3):293-6. Pubmed PMID: 15706439
- Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C "Review: application of stem cells for vascular tissue engineering.." Tissue Eng..;11(41527):1535-52. Pubmed PMID: 16259608
- Li M, Yang H, Chai H, Fisher WE, Wang X, Brunicardi FC, Yao Q, Chen C "Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors.." Cancer. 2004 Nov 15;101(10):2341-50. Pubmed PMID: 15476280
- Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen CJ "Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease.." Med. Sci. Monit.. 2004 Aug;10(8):RA187-92. Pubmed PMID: 15278009
- Wang XP, Yazawa K, Templeton NS, Yang J, Liu S, Li Z, Li M, Yao Q, Chen C, Brunicardi FC "Intravenous delivery of liposome-mediated nonviral DNA is less toxic than intraperitoneal delivery in mice.." World J Surg. 2005 Mar;29(3):339-43. Pubmed PMID: 15706434
- Lin PH, Martin L, Matsuura JH, Wellons E, Bush RL, Terramani TT, Chen C, Lumsden AB "Intraaortic stabilization of the AneuRx stent-graft system: a useful adjunct to minimize device migration.." Cardiovasc Intervent Radiol.;26(1):73-5. Pubmed PMID: 12491021
- Cesarman E, Moore PS, Rao PH, Inghirami G, Knowles DM, Chang Y "In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences.." Blood. 1995 Oct 1;86(7):2708-14. Pubmed PMID: 7670109
- Rodriguez E, Rao PH, Ladanyi M, Altorki N, Albino AP, Kelsen DP, Jhanwar SC, Chaganti RS "11p13-15 is a specific region of chromosomal rearrangement in gastric and esophageal adenocarcinomas.." Cancer Res.. 1990 Oct 1;50(19):6410-6. Pubmed PMID: 2400998
- Lin PH, Bush RL, Chaikof EL, Chen C, Conklin B, Terramani TT, Brinkman WT, Lumsden AB "A prospective evaluation of hypogastric artery embolization in endovascular aortoiliac aneurysm repair.." J. Vasc. Surg.. 2002 Sep;36(3):500-6. Pubmed PMID: 12218973
- Lin PH, Bush RL, Yao Q, Lam R, Paladugu R, Zhou W, Chen C, Lumsden AB "Abdominal aortic surgery in patients with human immunodeficiency virus infection.." Am. J. Surg.. 2004 Dec;188(6):690-7. Pubmed PMID: 15619485
- Mu H, Ohashi R, Yan S, Chai H, Yang H, Lin P, Yao Q, Chen C "Adipokine resistin promotes in vitro angiogenesis of human endothelial cells.." Cardiovasc. Res.. 2006 Apr 1;70(1):146-57. Pubmed PMID: 16515776
- Lin PH, Surowiec SM, Conklin B, Bush RL, Chen C, Chaikof EL, Lumsden AB "An endovascular model of carotid stenosis for the evaluation of thrombolysis and angioplasty.." J. Endovasc. Ther.. 2000 Dec;7(6):486-93. Pubmed PMID: 11194820
- Lin PH, Bush RL, Nguyen L, Guerrero MA, Chen C, Lumsden AB "Anastomotic strategies to improve hemodialysis access patency--a review.." Vasc Endovascular Surg.;39(2):135-42. Pubmed PMID: 15806274
- Verma RS, Pulivarthi RH "Balanced chromosomal translocations and mental illness.." J Ment Defic Res. 1991 Dec;35:548-50. Pubmed PMID: 1800754
- Chen C, Li J, Mattar SG, Pierce GF, Aukerman L, Hanson SR, Lumsden AB "Boundary layer infusion of basic fibroblast growth factor accelerates intimal hyperplasia in endarterectomized canine artery.." J. Surg. Res.. 1997 May;69(2):300-6. Pubmed PMID: 9224397
- Chen C, Hanson SR, Keefer LK, Saavedra JE, Davies KM, Hutsell TC, Hughes JD, Ku DN, Lumsden AB "Boundary layer infusion of nitric oxide reduces early smooth muscle cell proliferation in the endarterectomized canine artery.." J. Surg. Res.. 1997 Jan;67(1):26-32. Pubmed PMID: 9070177
- Nan B, Yang H, Yan S, Lin PH, Lumsden AB, Yao Q, Chen C "C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells.." Surgery. 2005 Aug;138(2):212-22. Pubmed PMID: 16153429
- Ohashi R, Mu H, Yao Q, Chen C "Cellular and molecular mechanisms of atherosclerosis with mouse models.." Trends Cardiovasc. Med.. 2004 Jul;14(5):187-90. Pubmed PMID: 15261890
- Mu H, Ohashi R, Lin P, Yao Q, Chen C "Cellular and molecular mechanisms of coronary vessel development.." Vasc Med. 2005 Feb;10(1):37-44. Pubmed PMID: 15920999
- Li M, Li W, Kim HJ, Yao Q, Chen C, Fisher WE "Characterization of somatostatin receptor expression in human pancreatic cancer using real-time RT-PCR.." J. Surg. Res.. 2004 Jun 15;119(2):130-7. Pubmed PMID: 15145694
- Wu H, Yao Q, Lumsden A, Chen C "Characterization of two populations of human coronary artery endothelial cells(1).." J. Surg. Res.. 2004 May 1;118(1):38-44. Pubmed PMID: 15093715
- Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C "Clinical use and molecular mechanisms of action of extract of Ginkgo biloba leaves in cardiovascular diseases.." Cardiovasc Drug Rev. 2004;22(4):309-19. Pubmed PMID: 15592576
- Ye BH, Rao PH, Chaganti RS, Dalla-Favera R "Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma.." Cancer Res.. 1993 Jun 15;53(12):2732-5. Pubmed PMID: 8504412
- Sreekantaiah C, Rao PH, Xu L, Sacks PG, Schantz SP, Chaganti RS "Consistent chromosomal losses in head and neck squamous cell carcinoma cell lines.." Genes Chromosomes Cancer. 1994 Sep;11(1):29-39. Pubmed PMID: 7529044
- Liao D, Wang X, Lin PH, Yao Q, Chen CJ "Covalent linkage of heparin provides a stable anti-coagulation surface of decellularized porcine arteries.." J. Cell. Mol. Med.. 2009 Aug;13(8):2736-43. Pubmed PMID: 19040421
- Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C "Curcumin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine coronary arteries.." J. Am. Coll. Surg.. 2005 Jun;200(6):820-30. Pubmed PMID: 15922191
- Ramaswami G, Chai H, Yao Q, Lin PH, Lumsden AB, Chen C "Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries.." J. Vasc. Surg.. 2004 Dec;40(6):1216-22. Pubmed PMID: 15622377
- Rodriguez E, Rao PH, Reuter V "Cytogenetic analysis of a juvenile granulosa cell tumor.." Cancer Genet. Cytogenet.. 1992 Jul 15;61(2):207-9. Pubmed PMID: 1638506
- Rao PH, Mathew S, Kelsen DP, Chaganti RS "Cytogenetics of gastric and esophageal adenocarcinomas. 3q deletion as a possible primary chromosomal change.." Cancer Genet. Cytogenet.. 1995 Jun;81(2):139-43. Pubmed PMID: 7621410
- Chen C, Li J, Micko CJ, Pierce GF, Cunningham MR, Lumsden AB "Cytotoxic effects of basic FGF and heparin binding EGF conjugated with cytotoxin saporin on vascular cell cultures.." J. Surg. Res.. 1998 Feb 15;75(1):35-41. Pubmed PMID: 9614854
- Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C "Defensins and cathelicidins: neutrophil peptides with roles in inflammation, hyperlipidemia and atherosclerosis.." J. Cell. Mol. Med..;9(1):41343. Pubmed PMID: 15784160
- Gaidano G, Hauptschein RS, Parsa NZ, Offit K, Rao PH, Lenoir G, Knowles DM, Chaganti RS, Dalla-Favera R "Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lymphoma.." Blood. 1992 Oct 1;80(7):1781-7. Pubmed PMID: 1356511
- Li M, Wang H, Li F, Fisher WE, Chen C, Yao Q "Effect of cyclophilin A on gene expression in human pancreatic cancer cells.." Am. J. Surg.. 2005 Nov;190(5):739-45. Pubmed PMID: 16226951
- Safaya R, Chai H, Kougias P, Lin P, Lumsden A, Yao Q, Chen C "Effect of lysophosphatidylcholine on vasomotor functions of porcine coronary arteries.." J. Surg. Res.. 2005 Jun 15;126(2):182-8. Pubmed PMID: 15919417
- Chai H, Yang H, Yan S, Li M, Lin PH, Lumsden AB, Yao Q, Chen C "Effects of 5 HIV protease inhibitors on vasomotor function and superoxide anion production in porcine coronary arteries.." J. Acquir. Immune Defic. Syndr.. 2005 Sep 1;40(1):41617. Pubmed PMID: 16123675
- Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C "Effects of adipocyte-derived cytokines on endothelial functions: implication of vascular disease.." J. Surg. Res.. 2005 Jun 1;126(1):121-9. Pubmed PMID: 15916985
- Yang H, Li M, Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C "Effects of cyclophilin A on cell proliferation and gene expressions in human vascular smooth muscle cells and endothelial cells.." J. Surg. Res.. 2005 Feb;123(2):312-9. Pubmed PMID: 15680395
- Fu W, Chai H, Yao Q, Chen C "Effects of HIV protease inhibitor ritonavir on vasomotor function and endothelial nitric oxide synthase expression.." J. Acquir. Immune Defic. Syndr.. 2005 Jun 1;39(2):152-8. Pubmed PMID: 15905730
- Ohashi R, Yan S, Mu H, Chai H, Yao Q, Lin PH, Chen C "Effects of homocysteine and ginsenoside Rb1 on endothelial proliferation and superoxide anion production.." J. Surg. Res.. 2006 Jun 15;133(2):89-94. Pubmed PMID: 16271366
- Chen C, Halkos ME, Surowiec SM, Conklin BS, Lin PH, Lumsden AB "Effects of homocysteine on smooth muscle cell proliferation in both cell culture and artery perfusion culture models.." J. Surg. Res.. 2000 Jan;88(1):26-33. Pubmed PMID: 10644463
- Yan S, Chai H, Wang H, Yang H, Nan B, Yao Q, Chen C "Effects of lysophosphatidylcholine on monolayer cell permeability of human coronary artery endothelial cells.." Surgery. 2005 Sep;138(3):464-73. Pubmed PMID: 16213900
- Cox MW, Fu W, Chai H, Paladugu R, Lin PH, Lumsden AB, Yao Q, Chen C "Effects of progesterone and estrogen on endothelial dysfunction in porcine coronary arteries.." J. Surg. Res.. 2005 Mar;124(1):104-11. Pubmed PMID: 15734487
- Nan B, Lin P, Lumsden AB, Yao Q, Chen C "Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells.." Thromb. Res.. 2005;115(5):417-26. Pubmed PMID: 15733976
- Ofenloch JC, Chen C, Hughes JD, Lumsden AB "Endoscopic venous valve transplantation with a valve-stent device.." Ann Vasc Surg. 1997 Jan;11(1):62-7. Pubmed PMID: 9061141
- Bush RL, Lin PH, Reddy PP, Chen C, Weiss VJ, Guinn G, Lumsden AB "Epidural analgesia in patients with chronic obstructive pulmonary disease undergoing transperitoneal abdominal aortic aneurysmorraphy--a multi-institutional analysis.." Cardiovasc Surg. 2003 Jun;11(3):179-84. Pubmed PMID: 12704325
- Spencer TA, Chai H, Fu W, Ramaswami G, Cox MW, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C "Estrogen blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries(1,2).." J. Surg. Res.. 2004 May 1;118(1):83-90. Pubmed PMID: 15093721
- Lin PH, Surowiec SM, Conklin B, Chen C, Bush R, Weiss VJ, Lumsden AB "Evaluation of thrombolysis and angioplasty in a porcine iliac artery thrombosis model: application of endovascular stent-graft-induced thrombosis.." J Vasc Interv Radiol. 2000 Jun;11(6):785-91. Pubmed PMID: 10877428
- Lin PH, Chen C, Surowiec SM, Conklin B, Bush RL, Lumsden AB "Evaluation of thrombolysis in a porcine model of chronic deep venous thrombosis: an endovascular model.." J. Vasc. Surg.. 2001 Mar;33(3):621-7. Pubmed PMID: 11241136
- Yang H, Li M, Chai H, Yan S, Zhang R, Yao Q, Chen C "Expression and regulation of neuropilins and VEGF receptors by TNF-alpha in human endothelial cells.." J. Surg. Res.. 2004 Dec;122(2):249-55. Pubmed PMID: 15555625
- Rodriguez JA, Li M, Yao Q, Chen C, Fisher WE "Gene overexpression in pancreatic adenocarcinoma: diagnostic and therapeutic implications.." World J Surg. 2005 Mar;29(3):297-305. Pubmed PMID: 15696394
- Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C "Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries.." J. Vasc. Surg.. 2005 May;41(5):861-8. Pubmed PMID: 15886672
- Lin PH, Chronos NA, Marijianowski MM, Chen C, Bush RL, Conklin B, Lumsden AB, Hanson SR "Heparin-coated balloon-expandable stent reduces intimal hyperplasia in the iliac artery in baboons.." J Vasc Interv Radiol. 2003 May;14(5):603-11. Pubmed PMID: 12761314
- Yao Q, Compans RW, Chen C "HIV envelope proteins differentially utilize CXCR4 and CCR5 coreceptors for induction of apoptosis.." Virology. 2001 Jun 20;285(1):128-37. Pubmed PMID: 11414813
- Conklin BS, Fu W, Lin PH, Lumsden AB, Yao Q, Chen C "HIV protease inhibitor ritonavir decreases endothelium-dependent vasorelaxation and increases superoxide in porcine arteries.." Cardiovasc. Res.. 2004 Jul 1;63(1):168-75. Pubmed PMID: 15194474
- Paladugu R, Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C "Hiv Tat protein causes endothelial dysfunction in porcine coronary arteries.." J. Vasc. Surg.. 2003 Sep;38(3):549-55; discuss. Pubmed PMID: 12947275
- Ren Z, Yao Q, Chen C "HIV-1 envelope glycoprotein 120 increases intercellular adhesion molecule-1 expression by human endothelial cells.." Lab. Invest.. 2002 Mar;82(3):245-55. Pubmed PMID: 11896203
- Chen C, Conklin BS, Ren Z, Zhong DS "Homocysteine decreases endothelium-dependent vasorelaxation in porcine arteries.." J. Surg. Res.. 2002 Jan;102(1):22-30. Pubmed PMID: 11792147
- Mitra AB, Rao PH, Pratap M "i(5p) and del(6q) are nonrandom abnormalities in carcinoma cervix uteri. Cytogenetics of two newly developed cell lines.." Cancer Genet. Cytogenet.. 1994 Aug;76(1):56-8. Pubmed PMID: 8076353
- Lin PH, Bush RL, Milas M, Terramani TT, Dodson TF, Chen C, Chaikof EL, Lumsden AB "Impact of an endovascular program on the operative experience of abdominal aortic aneurysm in vascular fellowship and general surgery residency.." Am. J. Surg.. 2003 Aug;186(2):189-93. Pubmed PMID: 12885616
- Morsy AH, Kulbaski M, Chen C, Isiklar H, Lumsden AB "Incidence and characteristics of patients with hand ischemia after a hemodialysis access procedure.." J. Surg. Res.. 1998 Jan;74(1):41496. Pubmed PMID: 9536965
- Rao PH, Mathew S, Lauwers G, Rodriguez E, Kelsen DP, Chaganti RS "Interphase cytogenetics of gastric and esophageal adenocarcinomas.." Diagn. Mol. Pathol.. 1993 Dec;2(4):264-8. Pubmed PMID: 8118604
- Chen C, Surowiec SM, Morsy AH, Ma M "Intraperitoneal infusion of homocysteine increases intimal hyperplasia in balloon-injured rat carotid arteries.." Atherosclerosis. 2002 Jan;160(1):103-14. Pubmed PMID: 11755927
- Lin PH, Bush RL, Conklin BS, Chen C, Weiss VJ, Chaikof EL, Lumsden AB "Late complication of aortoiliac stent placement- atheroembolization of the lower extremities.." J. Surg. Res.. 2002 Apr;103(2):153-9. Pubmed PMID: 11922729
- Ladanyl M, Heinemann FS, Huvos AG, Rao PH, Chen QG, Jhanwar SC "Neural differentiation in small round cell tumors of bone and soft tissue with the translocation t(11;22)(q24;q12): an immunohistochemical study of 11 cases.." Hum. Pathol.. 1990 Dec;21(12):1245-51. Pubmed PMID: 2174403
- Lumsden AB, Chen C, Coyle KA, Ofenloch JC, Wang JH, Yasuda HK, Hanson SR "Nonporous silicone polymer coating of expanded polytetrafluoroethylene grafts reduces graft neointimal hyperplasia in dog and baboon models.." J. Vasc. Surg.. 1996 Nov;24(5):825-33. Pubmed PMID: 8918330
- Hughes JD, Chen C, Mattar SG, Someren A, Noe B, Suwyn CR, Lumsden AB "Normothermic renal artery perfusion: a comparison of perfusates.." Ann Vasc Surg. 1996 Mar;10(2):123-30. Pubmed PMID: 8733863
- Chen C, Mattar SG, Lumsden AB "Oral administration of L-arginine reduces intimal hyperplasia in balloon-injured rat carotid arteries.." J. Surg. Res.. 1999 Mar;82(1):17-23. Pubmed PMID: 10068520
- Yao Q, Kuhlmann FM, Eller R, Compans RW, Chen C "Production and characterization of simian--human immunodeficiency virus-like particles.." AIDS Res. Hum. Retroviruses. 2000 Feb 10;16(3):227-36. Pubmed PMID: 10710211
- Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C "Red wine prevents homocysteine-induced endothelial dysfunction in porcine coronary arteries.." J. Surg. Res.. 2003 Nov;115(1):82-91. Pubmed PMID: 14572777
- Houldsworth J, Mathew S, Rao PH, Dyomina K, Louie DC, Parsa N, Offit K, Chaganti RS "REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma.." Blood. 1996 Jan 1;87(1):25-9. Pubmed PMID: 8547649
- Chen C, Ofenloch JC, Yianni YP, Hanson SR, Lumsden AB "Phosphorylcholine coating of ePTFE reduces platelet deposition and neointimal hyperplasia in arteriovenous grafts.." J. Surg. Res.. 1998 Jul 1;77(2):119-25. Pubmed PMID: 9733597
- Hughes JD, Mattar SG, Chen C, Someren A, Noe B, Suwyn CR, Lumsden AB "Renal artery perfusion modifies ischemia/reperfusion injury.." J. Surg. Res.. 1996 Feb 1;60(2):321-6. Pubmed PMID: 8598662
- Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C "Roles of cyclophilins in cancers and other organ systems.." World J Surg. 2005 Mar;29(3):276-80. Pubmed PMID: 15706440
- Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C "Roles of hemodynamic forces in vascular cell differentiation.." Ann Biomed Eng. 2005 Jun;33(6):772-9. Pubmed PMID: 16078617
- Chen C, Li M, Chai H, Yang H, Fisher WE, Yao Q "Roles of neuropilins in neuronal development, angiogenesis, and cancers.." World J Surg. 2005 Mar;29(3):271-5. Pubmed PMID: 15696396
- Chen C, Li M, Yang H, Chai H, Fisher W, Yao Q "Roles of thymosins in cancers and other organ systems.." World J Surg. 2005 Mar;29(3):264-70. Pubmed PMID: 15706436
- Zhang R, Li M, Chen C, Yao Q "SHIV virus-like particles bind and activate human dendritic cells.." Vaccine. 2004 Nov 25;23(2):139-47. Pubmed PMID: 15531030
- Lin PH, Dodson TF, Bush RL, Weiss VJ, Conklin BS, Chen C, Chaikof EL, Lumsden AB "Surgical intervention for complications caused by femoral artery catheterization in pediatric patients.." J. Vasc. Surg.. 2001 Dec;34(6):1071-8. Pubmed PMID: 11743563
- Chen C, Ku DN, Kikeri D, Lumsden AB "Tenascin: a potential role in human arteriovenous PTFE graft failure.." J. Surg. Res.. 1996 Feb 1;60(2):409-16. Pubmed PMID: 8598678
- Lin PH, Kulbaski MJ, Terramani TT, Bush RL, Brinkman WT, Chen C, Conklin B, Lumsden AB "The regained referral ground and clinical practice of vena cava filter placement in vascular surgery.." Am Surg. 2002 Oct;68(10):865-70. Pubmed PMID: 12412712
- Chen C, Hughes JD, Mattar SG, Ku DN, Lumsden AB "Time-course study of intimal hyperplasia in the endarterectomized canine artery.." J. Surg. Res.. 1997 Jan;67(1):106-12. Pubmed PMID: 9070191
- Nanus DM, Lynch SA, Rao PH, Anderson SM, Jhanwar SC, Albino AP "Transformation of human kidney proximal tubule cells by a src-containing retrovirus.." Oncogene. 1991 Nov;6(11):2105-11. Pubmed PMID: 1945415
- Doan LX, Li M, Chen C, Yao Q "Virus-like particles as HIV-1 vaccines.." Rev. Med. Virol..;15(2):75-88. Pubmed PMID: 15484204
- Lin PH, Bush RL, Chen C, Lumsden AB "What is new in the preoperative evaluation of arteriovenous access operation?." Semin Vasc Surg. 2004 Mar;17(1):57-63. Pubmed PMID: 15011181
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