Chad William Johnston, Ph.D.
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Chad William Johnston, Ph.D.
Faculty
Positions
- Faculty
-
Pharmacology & Chemical Biology; Molecular Virology & Microbiology
Baylor College of Medicine
Education
- Postdoctoral Fellowship at Massachusetts Institute of Technology
- 05/2021 - Cambridge, Massachusetts United States
- Synthetic Biology
- PhD from McMaster University
- 04/2016 - Hamilton, Ontario Canada
- Biochemistry
- BSc from McMaster University
- 04/2016 - Hamilton, Ontario Canada
- Biochemistry
Professional Interests
- Chemical Biology
- Microbial Natural Products
- Directed Evolution
- Synthetic Biology
- Antibiotic Discovery
- LCMS
Websites
Selected Publications
- Johnston CW*, Wyatt MA*, Li X, Ibrahim A, Shuster J, Southam G, Magarvey NA. "Gold biomineralization by a metallophore from a gold-associated microbe." Nat Chem Biol.. 2013;9 Pubmed PMID: 23377039
- Skinnider MA*, Johnston CW*, Edgar RE, Dejong CA, Merwin NJ, Rees PN, Magarvey NA. "Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining." Proc Natl Acad Sci U S A.. 2016;113 Pubmed PMID: 27698135
- Yang L*, Ibrahim A*, Johnston CW*, Skinnider MA, Ma B, Magarvey NA. "Exploration of nonribosomal peptide families with an automated informatic search algorithm." Chem Biol.. 2015;22 Pubmed PMID: 26364933
- Johnston CW, Badran AH, Collins JJ. "Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway." Nat Commun.. 2020;11 Pubmed PMID: 32826900
- Skinnider MA, Johnston CW, Gunabalasingam M, Merwin NJ, Kieliszek AM, MacLellan RJ, Li H, Ranieri MRM, Webster ALH, Cao MPT, Pfeifle A, Spencer N, To QH, Wallace DP, Dejong CA, Magarvey NA. "Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences." Nat Commun.. 2020;11 Pubmed PMID: 33247171
- Johnston CW, Skinnider MA, Dejong CA, Rees PN, Chen GM, Walker CG, French S, Brown ED, Bérdy J, Liu DY, Magarvey NA. "Assembly and clustering of natural antibiotics guides target identification." Nat Chem Biol.. 2016;12 Pubmed PMID: 26829473
- Johnston CW*, Skinnider MA*, Wyatt MA, Li X, Ranieri MR, Yang L, Zechel DL, Ma B, Magarvey NA. "An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products." Nat Commun.. 2015;6 Pubmed PMID: 26412281
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