Positions
- Associate Professor
-
Pediatrics-Neurology
Baylor College of Medicine
Houston, TX US
Addresses
- Jan and Duncan Neurological Research Institute (Office)
-
Suite 1225
Houston, TX 77030
United States
Phone: (832) 824-3976
annea@bcm.edu
- Texas Children's Hospital, Clinical Care Center (Clinic)
-
6701 Fannin St
Ste 1250
Houston, TX 77030
United States
Phone: (832) 822-1750
Professional Interests
- Signal transduction mechanisms in epilepsy
- Potassium channels
- MAPK
Websites
Selected Publications
- Anderson AE, Hrachovy RA, Antalffy BA, Armstrong DL, Swann JW "A chronic focal epilepsy with mossy fiber sprouting follows recurrent seizures induced by intrahippocampal tetanus toxin injection in infant rats.." Neuroscience. 1999;92(1):73-82. Pubmed PMID: 10392831
- Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ, Trimmer JS "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.." J. Biol. Chem.. 2003 Sep 19;278(38):36445-54. Pubmed PMID: 12829703
- Bernard C, Anderson A, Becker A, Poolos NP, Beck H, Johnston D "Acquired dendritic channelopathy in temporal lobe epilepsy.." Science. 2004 Jul 23;305(5683):532-5. Pubmed PMID: 15273397
- Lugo JN, Barnwell LF, Ren Y, Lee WL, Johnston LD, Kim R, Hrachovy RA, Sweatt JD, Anderson AE "Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticus.." J. Neurochem.. 2008 Aug;106(4):1929-40. Pubmed PMID: 18513371
- Bealer SL, Little JG, Metcalf CS, Brewster AL, Anderson AE "Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus.." Epilepsy Res.. 2010 Sep;91(1):66-73. Pubmed PMID: 20650612
- Varga AW, Yuan LL, Anderson AE, Schrader LA, Wu GY, Gatchel JR, Johnston D, Sweatt JD "Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents.." J. Neurosci.. 2004 Apr 7;24(14):3643-54. Pubmed PMID: 15071113
- Anderson A, Oviedo M, Adcock LM, Yamashita Y, Louis PT, Goddard-Finegold J "Cytochrome oxidase is decreased in piglet hippocampus following hypoxia-ischemia.." Metab Brain Dis. 1997 Mar;12(1):61-8. Pubmed PMID: 9101538
- Harbour DV, Anderson AE, Farrington J, Wassef A, Smith E, Meyer MJ "Decreased mononuclear leukocyte TSH responsiveness in patients with major depressive disorder." Biol. Psychiatry. 1988;23(8):797-806.
- Kazdoba TM, Sunnen CN, Crowell B, Lee GH, Anderson AE, D'Arcangelo G "Development and characterization of NEX-Pten, a novel forebrain excitatory neuron-specific knockout mouse." Dev. Neurosci.. 2012;34(41308):198-209. Pubmed PMID: 22572802
- Miller CL, Landry SH, Smith KE, Wildin SR, Anderson AE, Swank PR "Developmental change in the neuropsychological functioning of very low birth weight infants." Child Neuropsychol.. 1995;1:224-36.
- Marcelin B, Lugo JN, Brewster AL, Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram TZ, Anderson AE, Becker A, Esclapez M, Bernard C "Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites." J. Biol. Chem.. 2012 May 18;287(21):17656-61. Pubmed PMID: 22511771
- Schrader LA, Birnbaum SG, Nadin BM, Ren Y, Bui D, Anderson AE, Sweatt JD "ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit.." Am. J. Physiol., Cell Physiol.. 2006 Mar;290(3):C852-61. Pubmed PMID: 16251476
- Krueger DA, Wilfong AA, Holland-Bouley K, Anderson AE, Agricola K, Tudor C, Mays M, Lopez CM, Kim MO, Franz DN "Everolimus treatment of refractory epilepsy in tuberous sclerosis complex." Ann. Neurol. 2013;74(5):679-87.
- Staley KJ, Anderson AE "Hyperactive interneurons impair learning in a neurofibromatosis model.." Nat. Neurosci.. 2009 Jan;12(1):8-10. Pubmed PMID: 19107143
- Anderson AE, Hrachovy RA, Swann JW "Increased susceptibility to tetanus toxin-induced seizures in immature rats.." Epilepsy Res.. 1997 Mar;26(3):433-42. Pubmed PMID: 9127724
- Sunnen CN, Brewster AL, Lugo JN, Vanegas F, Turcios E, Mukhi S, Parghi D, D'Arcangelo G, Anderson AE "Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice.." Epilepsia. 2011 Nov;52(11):2065-75. Pubmed PMID: 21973019
- Varga AW, Anderson AE, Adams JP, Vogel H, Sweatt JD "Input-specific immunolocalization of differentially phosphorylated Kv4.2 in the mouse brain.." Learn. Mem.. 2000;7(5):321-32. Pubmed PMID: 11040264
- Rashid S, Lee I, Anderson AE, Hrachovy RA, Swann JW "Insights into the tetanus toxin model of early-onset epilepsy from long-term video monitoring during anticonvulsant therapy.." Brain Res. Dev. Brain Res.. 1999 Dec 10;118(41276):221-5. Pubmed PMID: 10611523
- Smith KE, Denson SE, Swank PR, Miller-Loncar CL, Anderson AE, Landry SH "Is severity of respiratory disease associated with differences in neurodevelopmental patterns in preterm infants?." Dev. Neuropsych.. 1998;16(1):59-77.
- Lubin FD, Johnston LD, Sweatt JD, Anderson AE "Kainate mediates nuclear factor-kappa B activation in hippocampus via phosphatidylinositol-3 kinase and extracellular signal-regulated protein kinase.." Neuroscience. 2005;133(4):969-81. Pubmed PMID: 15916859
- Schrader LA, Ren Y, Cheng F, Bui D, Sweatt JD, Anderson AE "Kv4.2 is a locus for PKC and ERK/MAPK cross-talk.." Biochem. J.. 2009 Feb 1;417(3):705-15. Pubmed PMID: 18795890
- Barnwell LF, Lugo JN, Lee WL, Willis SE, Gertz SJ, Hrachovy RA, Anderson AE "Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation.." Epilepsia. 2009 Jul;50(7):1741-51. Pubmed PMID: 19453702
- Lugo JN, Brewster AL, Spencer CM, Anderson AE "Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits.." Learn. Mem.. 2012;19(5):182-9. Pubmed PMID: 22505720
- Anderson AE, Adams JP, Qian Y, Cook RG, Pfaffinger PJ, Sweatt JD "Kv4.2 phosphorylation by cyclic AMP-dependent protein kinase.." J. Biol. Chem.. 2000 Feb 25;275(8):5337-46. Pubmed PMID: 10681507
- Dineley KT, Weeber EJ, Atkins C, Adams JP, Anderson AE, Sweatt JD "Leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination.." J. Neurochem.. 2001 May;77(4):961-71. Pubmed PMID: 11359861
- Heilstedt HA, Burgess DL, Anderson AE, Chedrawi A, Tharp B, Lee O, Kashork CD, Starkey DE, Wu YQ, Noebels JL, Shaffer LG, Shapira SK "Loss of the potassium channel beta-subunit gene, KCNAB2, is associated with epilepsy in patients with 1p36 deletion syndrome.." Epilepsia. 2001 Sep;42(9):1103-11. Pubmed PMID: 11580756
- Anderson A, Swank P, Wildin S, Landry S, Smith K "Modeling analysis of change in neurologic abnormalities in children born prematurely: a novel approach.." J. Child Neurol.. 1999 Aug;14(8):502-8. Pubmed PMID: 10456759
- Lubin FD, Ren Y, Xu X, Anderson AE "Nuclear factor-kappa B regulates seizure threshold and gene transcription following convulsant stimulation.." J. Neurochem.. 2007 Nov;103(4):1381-95. Pubmed PMID: 17727632
- Schrader LA, Anderson AE, Mayne A, Pfaffinger PJ, Sweatt JD "PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex.." J. Neurosci.. 2002 Dec 1;22(23):10123-33. Pubmed PMID: 12451113
- Wildin SR, Anderson AE, Woodside M, Swank P, Smith K, Denson S, Landry S "Prediction of 12-month neurodevelopmental outcome from a 6-month neurologic examination in premature infants." Clin. Pediatr.. 1995;34(6):290-9.
- Jung S, Jones TD, Lugo JN, Sheerin AH, Miller JW, D'Ambrosio R, Anderson AE, Poolos NP "Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy.." J. Neurosci.. 2007 Nov 21;27(47):13012-21. Pubmed PMID: 18032674
- Brewster AL, Lugo JN, Patil VV, Lee WL, Qian Y, Vanegas F, Anderson AE "Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.." PLoS ONE. 2013;8(3):e57808. Pubmed PMID: 23536771
- Ljungberg MC, Sunnen CN, Lugo JN, Anderson AE, D'Arcangelo G "Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia.." Dis Model Mech. 2009;2(2):389-98. Pubmed PMID: 19470613
- Hawasli AH, Koovakkattu D, Hayashi K, Anderson AE, Powell CM, Sinton CM, Bibb JA, Cooper DC "Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5.." PLoS ONE. 2009;4(6):e5808. Pubmed PMID: 19529798
- Misonou H, Mohapatra DP, Park EW, Leung V, Zhen D, Misonou K, Anderson AE, Trimmer JS "Regulation of ion channel localization and phosphorylation by neuronal activity.." Nat. Neurosci.. 2004 Jul;7(7):711-8. Pubmed PMID: 15195093
- Ren Y, Barnwell LF, Alexander JC, Lubin FD, Adelman JP, Pfaffinger PJ, Schrader LA, Anderson AE "Regulation of surface localization of the small conductance Ca2+-activated potassium channel, Sk2, through direct phosphorylation by cAMP-dependent protein kinase.." J. Biol. Chem.. 2006 Apr 28;281(17):11769-79. Pubmed PMID: 16513649
- Shah MM, Anderson AE, Leung V, Lin X, Johnston D "Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons.." Neuron. 2004 Oct 28;44(3):495-508. Pubmed PMID: 15504329
- Anderson AE, Wildin SR, Woodside M, Swank PR, Smith KE, Denson SE, Miller CL, Butler IJ, Landry SH "Severity of medical and neurologic complications as a determinant of neurodevelopmental outcome at 6 and 12 months in very low birth weight infants.." J. Child Neurol.. 1996 May;11(3):215-9. Pubmed PMID: 8734026
- Birnbaum SG, Varga AW, Yuan LL, Anderson AE, Sweatt JD, Schrader LA "Structure and function of Kv4-family transient potassium channels.." Physiol. Rev.. 2004 Jul;84(3):803-33. Pubmed PMID: 15269337
- Adams JP, Anderson AE, Varga AW, Dineley KT, Cook RG, Pfaffinger PJ, Sweatt JD "The A-type potassium channel Kv4.2 is a substrate for the mitogen-activated protein kinase ERK.." J. Neurochem.. 2000 Dec;75(6):2277-87. Pubmed PMID: 11080179
- Schrader LA, Anderson AE, Varga AW, Levy M, Sweatt JD "The other half of Hebb: K+ channels and the regulation of neuronal excitability in the hippocampus.." Mol. Neurobiol.. 2002 Feb;25(1):51-66. Pubmed PMID: 11890457
Funding
- SLEEP MODULATION OF EPILEPTIC ACTIVITY IN IMMATURE BRAIN - #K08NS001836 (04/01/1996 - 03/31/2001) NIH/NINDS
- THE MAPK CASCADE IN EPILEPSY - #K02NS002231 (09/30/2000 - 08/31/2005) NIH/NINDS
- Ion Channel Remodeling in Epilepsy - #R01NS039943 (05/01/2004 - 04/30/2012) NIH/NINDS
- ION CHANNEL REGULATION OF EXCITABILITY IN IMMATURE BRAIN - #R01NS049427 (12/05/2005 - 11/30/2011) NIH/NINDS
- Signaling pathway dysregulation in epilepsy - #R01NS081053 (09/01/2013 - 08/30/2017) NIH/NINDS
- Everolimus (RAD001) Therapy of Epilepsy in Patients with Tuberous - #NA (01/01/2011 - 12/12/2012) Novartis
- Sponsored by Novartis to enroll 20 children (10 at each center)
- Gene Expression Profiles of Normal and Abnormal Neurons in Cortical Dysplasia - #NA
- $50,000.00 (07/01/2007 - 06/30/2011) Vivian L Smith Foundation
- Evaluation of Novel Therapeutics and Seizure/EEG - #FIRE Initiative (Integrative Res (05/01/2013 - 04/30/2014) Foundation for Angelman Syndrome Therapeutics (FAST)
- Activity-dependent Ion Channel Regulation: A Candidate Mechanism in Developmental Epilepsy - #NA (10/01/2005 - 09/30/2007) Partnership for Pediatric Epilepsy Research/Epilepsy Foundation
- Generation and characterization of mouse models of cortical dysplasia - #Subcontract with Rutgers Univers (02/01/2008 - 12/31/2010) Citizens United for a Research in Epilepsy (CURE)
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