Andy Groves, Ph.D.
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Positions
- Professor and Vivian L. Smith Endowed Chair in Neuroscience
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Departments of Neuroscience and Molecular and Human Genetics
Baylor College of Medicine
- Director
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Graduate Program in Development, Disease Models and Therapeutics
Baylor College of Medicine
Education
- PhD from Ludwig Institute for Cancer Research, University College London
- 01/1992 - London, United Kingdom
- Post-Doctoral Fellowship at California Institute of Technology
- 01/1999 - Pasadena, California United States
- MA from University of Cambridge
- 01/1991 - Cambridge, United Kingdom
Professional Interests
- The development, evolution, and regeneration of the inner ear
Professional Statement
Research in our lab spans the development of the inner ear from its earliest beginnings as a piece of embryonic ectoderm to the development of the highly patterned organ of Corti in the cochlea. We are also interested using our understanding of developmental processes to address why the sensory tissue of the cochlea fails to regenerate after damage and to identify genes involved in hereditary deafness.We have an ongoing collaboration with Shinya Yamamoto's lab at Baylor in which we are trying to use the fruit fly, Drosophila, to identify new mutations in genes that affect hearing. We are also working with Huda Zoghbi's lab to identify targets of transcription factors that promote the differentiation of sensory hair cells. Finally, we also work on some aspects of craniofacial development, prompted by the discovery of the Foxi3 transcription factor, a Forkhead gene that plays crucial roles in the development of the inner ear and the branchial arch region and which causes canine ectodermal dysplasia in three breeds of hairless dogs.
Websites
Selected Publications
- Tao L, Yu H, Llamas J, Trecek T, Wang X, Stojanova Z, Groves AK Segil N "Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration.." Dev Cell.. 2021;56:1–15.
- Gnedeva K, Wang X, McGovern MM, Barton M, Tao L, (...), Groves AK, Warchol M, Segil N "Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal.." Proc Natl Acad Sci U S A.. 2020;117:13552-13561.
- Brown RM 2nd, Nelson JC, Zhang H, Kiernan AE, Groves AK "Notch-mediated lateral induction is necessary to maintain vestibular prosensory identity during inner ear development." Dev Biol. 2020;462:74-84.
- Jen HI, Hill MC, Tao L, Sheng K, Cao W, Zhang H, Yu HV, Llamas J, Zong C, Martin JF, Segil N, Groves AK "Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1.." Elife. 2019;8:pii: e44328.
- Xie WR, Jen HI, Seymour ML, Yeh SY, Pereira FA, Groves AK, Klisch TJ, Zoghbi HY "An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment.." J Neurosci.. 2017;37:8583-8594.
- Basch ML, Brown RM, Jen HI, Semerci F, Depreux F, Edlund RK, Zhang H, Norton CR, Gridley T, Cole SE, Doetzlhofer A, Maletic-Savatic M, Segil N, Groves AK "Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.." Elife. 2016;5:pii: e19921..
- Li T, Giagtzoglou N, Eberl DF, Jaiswal SN, Cai T, Godt D, Groves AK, Bellen HJ "The E3 ligase Ubr3 regulates Usher syndrome and MYH9-related disorder proteins in the auditory organs of Drosophila and mammals.." ELife. 2016;5:pii: e15258.
- Birol O, Ohyama T, Edlund RK, Drakou K, Georgiades P, Groves AK "The mouse Foxi3 transcription factor is necessary for the development of posterior placodes.." Dev Biol.. 2016;409:139-151.
- Shirokova V, Biggs LC, Jussila M, Ohyama T, Groves AK, Mikkola ML "Foxi3 deficiency compromises hair follicle stem cell specification and activation.." Stem Cells. 2016;34:1896-1908.
- Cai T, Jen HI, Kang H, Klisch TJ, Zoghbi HY, Groves AK "Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor." J Neurosci. 2015 Apr 8;35:5870-83. Pubmed PMID: 25855195
- Maass JC, Gu R, Basch ML, Waldhaus J, Lopez EM, Xia A, Oghalai JS, Heller S, Groves AK "Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea." Front Cell Neurosci.. 2015 Mar 31;9:110. Pubmed PMID: 25873862
- Yang L, O'Neill P, Martin K, Maass JC, Vassilev V, Ladher R, Groves AK "Analysis of FGF-Dependent and FGF-Independent Pathways in Otic Placode Induction.." PLoS ONE. 2013;8(1):e55011. Pubmed PMID: 23355906
- Ohyama T, Basch ML, Mishina Y, Lyons KM, Segil N, Groves AK "BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea.." J. Neurosci.. 2010 Nov 10;30(45):15044-51. Pubmed PMID: 21068310
- Basch ML, Ohyama T, Segil N, Groves AK "Canonical Notch Signaling Is Not Necessary for Prosensory Induction in the Mouse Cochlea: Insights from a Conditional Mutant of RBPj{kappa}.." J. Neurosci.. 2011 Jun 1;31(22):8046-58. Pubmed PMID: 21632926
- Martin K, Groves AK "Competence of cranial ectoderm to respond to Fgf signaling suggests a two-step model of otic placode induction.." Development. 2006 Mar;133(5):877-87. Pubmed PMID: 16452090
- Cai T, Seymour ML, Zhang H, Pereira FA, Groves AK "Conditional deletion of atoh1 reveals distinct critical periods for survival and function of hair cells in the organ of corti.." J. Neurosci.. 2013 Jun 12;33(24):10110-22. Pubmed PMID: 23761906
- Raft S, Koundakjian EJ, Quinones H, Jayasena CS, Goodrich LV, Johnson JE, Segil N, Groves AK "Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development.." Development. 2007 Dec;134(24):4405-15. Pubmed PMID: 18039969
- White PM, Stone JS, Groves AK, Segil N "EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals.." Dev. Biol.. 2012 Mar 1;363(1):191-200. Pubmed PMID: 22230616
- Khatri SB, Groves AK "Expression of the Foxi2 and Foxi3 transcription factors during development of chicken sensory placodes and pharyngeal arches.." Gene Expr. Patterns. 2013 Jan;13(41276):38-42. Pubmed PMID: 23124078
- Edlund RK, Ohyama T, Kantarci H, Riley BB, Groves AK "Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers." Dev Biol. 2014 Jun 1;390(1):1-13. Pubmed PMID: 24650709
- Khatri SB, Edlund RK, Groves AK "Foxi3 is necessary for the induction of the chick otic placode in response to FGF signaling." Dev Biol. 2014 Jul 15;391(2):158-69. Pubmed PMID: 24780628
- Doetzlhofer A, Basch ML, Ohyama T, Gessler M, Groves AK, Segil N "Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti.." Dev. Cell. 2009 Jan;16(1):58-69. Pubmed PMID: 19154718
- White PM, Doetzlhofer A, Lee YS, Groves AK, Segil N "Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells.." Nature. 2006 Jun 22;441(7096):984-7. Pubmed PMID: 16791196
- Jayasena CS, Ohyama T, Segil N, Groves AK "Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode.." Development. 2008 Jul;135(13):2251-61. Pubmed PMID: 18495817
- Groves AK, Fekete DM "Shaping sound in space: the regulation of inner ear patterning.." Development. 2012 Jan;139(2):245-57. Pubmed PMID: 22186725
- Groves AK "The challenge of hair cell regeneration.." Exp. Biol. Med. (Maywood). 2010 Apr 1;235(4):434-46. Pubmed PMID: 20407075
- Jarman AP, Groves AK "The role of Atonal transcription factors in the development of mechanosensitive cells.." Semin. Cell Dev. Biol.. 2013 May;24(5):438-47. Pubmed PMID: 23548731
- Ohyama T, Mohamed OA, Taketo MM, Dufort D, Groves AK "Wnt signals mediate a fate decision between otic placode and epidermis.." Development. 2006 Mar;133(5):865-75. Pubmed PMID: 16452098
- Mao K, Borel C, Ansar M, {...] Cox TC, Groves AK, Lupski JR, Zhang Q, Zhang YB, Antonarakis SE "FOXI3 pathogenic variants cause one form of craniofacial microsomia.." Nature Communications. 2023;14:2026. Pubmed PMID: 37041148
- Iyer, A., Hosamani, I., Nguyen, J.D., Cai, T., Singh, S., Beyer, L.A., Zhang, H., Jen, H.-I, Yousaf, R., Birol, O., Sun, J., Ray, R.S., Raphael, Y., Segil, N. and Groves, A.K. "Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals.." eLife.;11:e79712. Pubmed PMID: 36445327
- McGovern, M.M., Hartman, B.H., Thawani, A., Maunsell, H.R., Zhang, H., Yousaf, R., Heller, S., Stone, J.S. and Groves, A.K. "Fbxo2CreERT2 is expressed in the cochlear duct and vestibular organs in the mouse inner ear.." ;428:108686. Pubmed PMID: 36587458
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