Research

Publications

Master
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Selected Publications Supported by the GEM Core

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2018

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Baharan Fekry, Aleix Ribas-Latre, Corrine Baumgartner, Jonathan R. Deans, Christopher Kwok, Pooja Patel, Loning Fu, Rebecca Berdeaux, Kai Sun, Mikhail G. Kolonin, Sidney H. Wang, Seung-Hee Yoo, Frances M. Sladek and Kristin Eckel-Mahan. Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma. Nat Commun. 2018 Oct 19;9(1):4349. PMID: 30341289; PMCID: PMC6195513.

Dasgupta, S., Rajapakshe, K., Zhu, B., Nikolai, B. C., Yi, P., Putluri, N., Choi, J.M., Jung, S.Y., Coarfa, C., Westbrook, T.F., Zhang, X.H.-F., Foulds, C.E., Tsai, S.Y., Tsai, M.-J. and O’Malley, B.W. Glycolytic enzyme PFKFB4 directly activates oncogenic coactivator SRC-3 to drive breast tumorigenesis and metastasis. Nature556: 249-254 (2018). PMID: 29615789. PMCID: PMC5895503

Lanza DG, Gaspero A, Zheng P, Lorenzo I, Liao L, Zheng P, Wang Y, Deng Y, Cheng C, Zhang C,Seavitt JR, DeMayo FJ, Xu J, Dickinson ME, Beaudet AL, and Heaney JD. Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles. BMC Biology 2018; 16:69. PMC6011517

Ayush T. Raman, Amy E. Pohodich, Ying-Wooi Wan, Hari Krishna Yalamanchili, William E. Lowry, Huda Y. Zoghbi & Zhandong Liu (2018) Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations. Nat Commun.2018 Aug 13;9(1):3225. PMID: 30104565 PMCID: PMC6089998

Tan Q, Brunetti L, Rousseaux MWC, Lu HC, Wan YW, Revelli JP, Liu Z, Goodell MA, Zoghbi HY (2018) Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma. Proc Natl Acad Sci U S A.2018 Feb 13;115(7):E1511-1519. PMID: 29382756 PMCID: PMC5816173

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2017

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Sreekumar A, Toneff MJ, Toh E, Roarty K, Creighton CJ, Belka GK, Lee DK, Xu J, Chodosh LA, Richards JS, Rosen JM. WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis. Dev Cell. 2017 Nov 20;43(4):436- 448.e6. doi: 10.1016/j.devcel.2017.10.007. Epub 2017 Nov 2. PMID:29103953.

Lei Y, Zhang X, Su J, Jeong M, Gundry MC, Huang YH, Zhou Y, Li W, Goodell MA. Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein. Nat Commun. 2017 Jul 11;8:16026. doi: 10.1038/ncomms16026. PMID: 28695892, PMCID: PMC5508226.

Zhao, F., Franco, H.L., Tsai, M.-J., Tsai, S.Y. and Yao, H.H.-C. Elimination of the male reproductive tract in the female embryo is mediated by action of COUP-TFII. Science 357: 717-720 (2017) PMID: 28818950; PMCID: PMC5713893..

Mercedes Barzi, Francis P. Pankowicz, Barry Zorman, Xing Liu, Xavier Legras, Diane Yang, Malgorzata Borowiak, Beatrice Bissig- Choisat, Pavel Sumazin, Feng Li & Karl-Dimiter Bissig (2017). A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism. Nature Communications, PMID:28659616.

Meehan TF, Conte N, West DB, Jacobsen JO, Mason J, Warren J, Chen CK, Tudose I, Relac M, Matthews P, Karp N, Santos L, Fiegel T, Ring N, Westerberg H, Greenaway S, Sneddon D, Morgan H, Codner GF, Stewart ME, Brown J, Horner N; International Mouse Phenotyping Consortium, Haendel M, Washington N, Mungall CJ, Reynolds CL, Gallegos J, Gailus-Durner V, Sorg T, Pavlovic G, Bower LR, Moore M, Morse I, Gao X, Tocchini-Valentini GP, Obata Y, Cho SY, Seong JK, Seavitt J, Beaudet AL, Dickinson ME, Herault Y, Wurst W, de Angelis MH, Lloyd KCK, Flenniken AM, Nutter LMJ, Newbigging S, McKerlie C, Justice MJ, Murray SA, Svenson KL, Braun RE, White JK, Bradley A, Flicek P, Wells S, Skarnes WC, Adams DJ, Parkinson H, Mallon AM, Brown SDM, Smedley D.(2017), Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nat Genet. 2017 Aug;49(8):1231-1238. PMID: 28650483