Molecular & Cellular Biology
New receptors: old drugs and new ideas
David D. Moore, Ph.D., received the award for his research on the functions of new members of the nuclear hormone receptor superfamily. This superfamily includes the well-known steroid and thyroid hormone receptors, along with a number of other proteins whose function was not known. Over the last several years Dr. Moore's work has identified compounds that regulate the activity of several of the newer members of this family and elucidated their function. These studies have revealed that one of these new receptors, called CAR, functions in a chemical defense response that protects the body from potentially toxic foreign compounds, and may also be involved in the management of endogenous toxic products. Dr. Moore has also characterized the functions of two other receptors, FXR and SHP, in cholesterol metabolism and identified a natural product that lowers LDL cholesterol levels as a specific FXR antagonist.
Dr. Moore’s nomination was based on the following publications:
Wei P, Zhang J, Egan-Hafley M, Liang S, Moore DD. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature. 2000 Oct 19;407(6806):920-3.
Wang L, Lee YK, Bundman D, Han Y, Thevananther S, Kim CS, Chua SS, Wei P, Heyman RA, Karin M, Moore DD. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell. 2002 Jun;2(6):721-31.
Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, Moore DD. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science. 2002 May 31;296(5573):1703-6.