Medical Genetics Test Details

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KIT Mutations, Melanoma
Test Information:	Predicts response to tyrosine kinase inhibitor (TKI) therapy. Detects activating mutations in KIT and PDGFRA.
Test Details
Test Code:	9103
Special Notes:	Samples received will be tested by ARUP.
Technical Information
Methodology:	Polymerase Chain Reaction/Sequencing of exons 9, 11, 13, and 17 of the KIT gene and exons 12, 14, 18 of the PDGFRA gene
Gene Name:	KIT and PDGFRA
Protein Name:	KIT: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog PDGFRA: platelet-derived growth factor receptor alpha

Sample & Shipping Information
Test Requisition:	Tumor Analysis
Specimen Type:	FFPE - Slide(s)
Requirements:	5 unstained 5um FFPE slides (Min: 4 slides) containing adequate amounts of tumor to be analyzed. Please include a copy of corresponding surgical pathology report.
Shipping Conditions:	Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months. Unacceptable Conditions: Less than 50 percent tumor. Specimens fixed/processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives. Decalcified specimens. Stability: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Specimen Type:	FFPE - Tumor Block
Requirements:	Paraffin-embedded, formalin-fixed (10 percent neutral buffered formalin) tissue block containing adequate amounts of tumor to be analyzed. Please include a copy of corresponding surgical pathology report.
Shipping Conditions:	Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months. Unacceptable Conditions: Less than 50 percent tumor. Specimens fixed/processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives. Decalcified specimens. Stability: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Billing Information
Turn Around Time:	10-12 days
List Price:	*For Insurance or Institutional Prices, please call.
CPT Codes:	88381 x 1, 81272 x 1, 81314 x 1