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Genetic Labs

Houston, Texas

Genetic Laboratory
Medical Genetics Laboratories
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Medical Genetics Test Details

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PIK3CA Mutation Analysis - Tumor
Test Information: Indication for Study:

Identification of mutations in exons 9 and 20 of the PIK3CA gene.
Test Details
Test Code: 9036
Test Includes: Sequence Analysis of exons 9 & 20 of the PIK3CA gene.

Special Notes: This test can also be performed on FFPE samples (#9035).

Germline mutation analysis is required if novel mutations are detected. Please see detailed requirements under test code (#9037).

PIK3CA is commonly mutated and thereby activated in various human cancers, including colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, breast cancer, cervical cancer, and adenocarcinoma of lung. The most common mutations of PIK3CA are in exon 9 and exon 20. These mutations render tumor cells resistance to some anti-cancer therapies.

Technical Limitations:

This test is designed to detect mutations in exons 9 and 20 of the PIK3CA gene only. The limit of the test is approximately 20 mutated cells in 100 total cells (20%).

Results of this test must always be interpreted in the context of relevant clinical and pathological data, and should not be used alone for a diagnosis of malignancy.

Useful Publications:
- KRAS, BRAF, PIK3CA, and PTEN Mutations: Implications for Targeted Therapies in Metastatic Colorectal Cancer
- FGFR3, HRAS, KRAS, NRAS and PIK3CA Mutations in Bladder Cancer and Their Potential as Biomarkers for Surveillance and Therapy
Technical Information
Methodology: Sequence analysis is performed in both forward and reverse directions of exons 9 and 20 of the PIK3CA gene
Gene Name: PIK3CA
Protein Name: Phosphatidylinositol 3-Kinase, Catalytic, Alpha
Sample & Shipping Information
Test Requisition: Tumor Analysis
Specimen Type: Fresh Frozen Tissue
Requirements: 150 mg (0.5-2.0 cm3) Fresh tissue snap frozen at -20C. Store at -20C.
Shipping Conditions: Ship on minimum of 10 lbs. of dry ice in an insulated container by overnight courier.



Turn Around Time: 14 days
Billing Information
List Price: *For Insurance or Institutional Prices, please call.
CPT Codes: 81479x1


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