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Genetic Labs

Houston, Texas

Genetic Laboratory
Medical Genetics Laboratories
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Medical Genetics Test Details

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AKT1 Mutation Analysis - Tumor
Test Information: Confirmation of Clinical Diagnosis, Indication for Study:

Identification of mutations in codon 17 of the AKT gene.
Test Details
Test Code: 9026
Special Notes: This test can also be performed on FFPE samples (#9025).

AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is a central member of possibly the most frequently activated proliferation and survival pathway in cancer. A somatic mutation in AKT1 (E17K) has been detected in breast, colorectal, lungand ovarian cancers. The E17K change results in constitutive AKT1 activation and decreases the sensitivity to an allosteric kinase inhibitor. The purpose of this test is to determine the mutation status of AKT1 in tumors which can be used to predict patient response to certain certain theraputic regimens.

Technical Limitations:

The sensitivity of detection is approximately 5-10 mutated cells per 100 total cells in the sample (5-10%).

Results of this test must always be interpreted in the context of relevant clinical and pathological data, and should not be used alone for a diagnosis of malignancy.

Useful Publications:
- AKT1(E17K) in Human Solid Tumours.
Technical Information
Methodology: Pyrosequencing
Gene Name: AKT1
Protein Name: v-akt murine thymoma viral oncogene homolog 1
Sample & Shipping Information
Test Requisition: Tumor Analysis
Specimen Type: Fresh Frozen Tissue
Requirements: 150 mg (0.5-2.0 cm3) Fresh tissue snap frozen at -20C. Store at -20C.
Shipping Conditions: Ship on minimum of 10 lbs. of dry ice in an insulated container by overnight courier.

Turn Around Time: 14 days
Billing Information
List Price: $450.00 *Institutional discounts may apply, please call.
CPT Codes: 81479x1

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