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Genetic Labs

Houston, Texas

Genetic Laboratory
Medical Genetics Laboratories
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Medical Genetics Test Details

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Oncology FISH Analysis - ROS1 Rearrangement
Test Information: Indication for Study:

Identification of ROS1-associated rearrangements. The presence of ROS1-associated rearrangement may confer an improved response to ALK-targeted therapy.
Test Details
Test Code: 8781
Special Notes: For FFPE Specimens:
Specimens subject to this FISH testing should be fixed in 10% neutral buffered formalin for at least 6 hours and no longer than 48 hours. The volume of formalin should be at least 10 times the volume of the specimen. Decalcification solutions with strong acids should not be used. Specimens fixed for less than 6 or longer than 48 hours may show false negative results.

Technical Limitations:

Results of this test must always be interpreted in the context of relevant clinical and pathological data, and should not be used alone for a diagnosis of malignancy.

For additional information on our FISH probes and the frequency and prognostic significance of specific chromosomal abnormalities, please visit the Cancer Fish Probes List.
Technical Information
Methodology: Fluorescent in Situ Hybridization (FISH) Analysis
Gene Name: ROS1
Protein Name: ROS1
Sample & Shipping Information
Test Requisition: Tumor Analysis
Specimen Type: FFPE - Slide(s)
Requirements: 3 to 5 unstained 5um FFPE slides containing adequate amounts of tumor to be analyzed with areas of tumor marked. Please include a copy of corresponding surgical pathology report.

Transport Temperature: Ship at ambient temperature (18-25C/64-77F). Protect paraffin tissue from excessive heat. Ship in cooled container during summer months.

Unacceptable Conditions: No tumor in tissue. Frozen specimens and specimens fixed/processed in alternative fixatives.

Stability: Ambient: Indefinitely; Refrigerated: Acceptable.
Shipping Conditions: Ship at ambient temperature (18-25C/64-77F) in an insulated container by overnight courier. Do not heat or freeze.


Specimen Type: FFPE - Tumor Block
Requirements: Paraffin-embedded, formalin-fixed tissue block containing adequate amounts of tumor to be analyzed with areas of tumor marked. Please include a copy of corresponding surgical pathology report.

Transport Temperature: sent at ambient temperature (18-25C/64-77F). Protect paraffin tissue from excessive heat. Ship in cooled container during summer months.

Unacceptable Conditions: No tumor in tissue. Frozen specimens and specimens fixed/processed in alternative fixatives.

Stability: Ambient: Indefinitely; Refrigerated: Acceptable.
Shipping Conditions: Ship at ambient temperature (18-25C/64-77F) in an insulated container by overnight courier. Do not heat or freeze.


Turn Around Time: 5 - 7 days
Billing Information
List Price: *For Insurance or Institutional Prices, please call.
CPT Codes: 88271x2, 88275x1, 88291x1


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