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Genetic Labs

Houston, Texas

Genetic Laboratory
Medical Genetics Laboratories
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Medical Genetics Test Details

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Chromosomal Microarray Analysis - HR
Test Details
Test Code: 8655
Special Notes: Chromosomal Microarray Analysis - High Resolution (CMA-HR) utilizes array-based comparative genomic hybridization (aCGH) with approximately 180,000 oligos covering the whole genome at the average resolution of 30Kb, 1,714 genes with all exons covered, 700 microRNAs, and the entire mitochondrial genome. Genomic DNA from the test sample and a control sample are differentially labeled with fluorescent dyes and hybridized to the oligos. Results are analyzed using quantitative imaging methods and analytical software to assist in identifying each targeted-DNA sequence as loss of copy number (deletion), gain of copy number (duplication) or normal copy number. This technology has been validated in our laboratory on many patients with known microdeletions/duplications and other unbalanced karyotypes detected by traditional cytogenetic methods. CMA is limited to detection of gain or loss of genomic material. It will not detect low level mosaicism, balanced translocations, inversions, or point mutations that may be responsible for the clinical phenotype.

We require that the referring center consult with our laboratory genetic counselors prior to submitting Product of Conception (POC) or Autopsy specimens. Please call 1-800-411-4363. If fetal demise occurred more than 48-72 hours prior to retrieval of tissue and delivery to lab, fetal tissue is unlikely to grow. In case of prior fetal demise, placenta is most likely to grow.

For information regarding CMA parental studies, please review the following document titled CMA Parental Studies Policy.
Technical Information
Methodology: Microarray
Sample & Shipping Information
Test Requisition: Cytogenetics
Specimen Type: Blood
Requirements: Draw blood in both Sodium Heparin (green-top) tube(s) and an EDTA (purple-top) tube(s) and send 3-5 cc (Adults/Children) or 1-2 cc (Infant< 2 years).
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze. Sample must arrive within 48 hrs.

Specimen Type: Product of Conception/Autopsy <12 weeks gestation - Identifiable Fetal Parts
Requirements: Collect 5 cubic millimeters of sample in a separate sterile container with RPMI media. In the absence of RPMI media, place sample in a sterile container with a small amount of sterile saline. Never place samples in formalin or other fixative.
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze. Sample must arrive within 48 hrs.

Specimen Type: Product of Conception/Autopsy <12 weeks gestation - Placenta
Requirements: Collect 10 cubic millimeters Placenta from fetal side near the site of cord insertion. Place sample in a separate sterile container with RPMI media. In the absence of RPMI media, place sample in a sterile container with a small amount of sterile saline. Never place samples in formalin or other fixative.
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze. Sample must arrive within 48 hrs.

Specimen Type: Product of Conception/Autopsy >12 weeks gestation - Lung or Kidney
Requirements: Collect 5 cubic millimeters of Lung or Kidney. Place sample in a separate sterile container with RPMI media. In the absence of RPMI media, place sample in a sterile container with a small amount of sterile saline. Never place samples in formalin or other fixative.
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze. Sample must arrive within 48 hrs.

Specimen Type: Product of Conception/Autopsy >12 weeks gestation - Placenta
Requirements: Collect 10 cubic millimeters Placenta from fetal side near the site of cord insertion. Place sample in a separate sterile container with RPMI media. In the absence of RPMI media, place sample in a sterile container with a small amount of sterile saline. Never place samples in formalin or other fixative.
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze. Sample must arrive within 48 hrs.

Specimen Type: Product of Conception/Autopsy >12 weeks gestation - Skin
Requirements: Collect 5 cubic millimeters of Skin from a central location (eg. Buttock or Upper Thigh) rather than from a distal location (eg. Foot) to enhance cell viability. Place sample in a separate sterile container with RPMI media. In the absence of RPMI media, place sample in a sterile container with a small amount of sterile saline. Never place samples in formalin or other fixative.
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze. Sample must arrive within 48 hrs.

Specimen Type: Product of Conception/Autopsy >12 weeks gestation - Unclotted Cord or Cardiac Blood
Requirements: Draw blood in both Sodium Heparin (green-top) tube(s) and an EDTA (purple-top) tube(s) and send 3-5 cc (Adults/Children) or 1-2 cc (Infant< 2 years).
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze. Sample must arrive within 48 hrs.

Specimen Type: Skin Biopsy
Requirements: Collect 5 cubic millimeters of Skin from a central location (eg. Buttock or Upper Thigh) rather than from a distal location (eg. Foot) to enhance cell viability. Place sample in a separate sterile container with RPMI media. In the absence of RPMI media, place sample in a sterile container with a small amount of sterile saline. Never place samples in formalin or other fixative.
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze. Sample must arrive within 48 hrs.

Turn Around Time: 14 days
Billing Information
List Price: $1,800.00 *Institutional discounts may apply, please call.
CPT Codes: 81228x1


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