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Genetic Labs

Houston, Texas

Genetic Laboratory
Baylor Genetics Laboratories
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Medical Genetics Test Details

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The American Medical Association (AMA) Current Procedural Terminology (CPT) codes and Healthcare Common Procedure Coding System (HCPCS) codes listed, are provided for informational purposes only. The codes reflect our interpretation of CPT/HCPCS coding requirements based upon AMA guidelines published annually. CPT/HCPCS codes are provided only as guidance to assist clients with billing. Baylor Genetics strongly recommends that clients confirm CPT/HCPCS codes with their Medicare Administrative Contractor (MAC) or other payer being billed, as requirements may differ. CPT coding is the sole responsibility of the billing party. Baylor Genetics assumes no responsibility for billing errors due to reliance on the CPT codes listed. Please direct any questions regarding CPT coding to the payer being billed.

FISH Analysis - Angelman Syndrome Panel
Test Information: Confirmation of Clinical Diagnosis, FISH may also be indicated when methylation studies have shown only an unmethylated contribution to further characterize the cause of Angelman syndrome in these patients.
Test Details
Test Code: 8459
Special Notes: The genetic basis of AS is heterogeneous. The majority of AS patients (80-84%) with the following types of genetic alterations will exhibit abnormal DNA methylation pattern showing only the paternally inherited allele using the methylation sensitive SNRPN probe (#6006). : 1) A deletion of the maternally contributed 15q11-q13 chromosome (~70% of AS patients; 2) Paternal uniparental disomy (UPD) (~3-5% of AS patients); and 3) An abnormality in the imprinting process which causes nonexpression of maternal genes in the AS critical region (~7-9% of AS patients). Patients with positive methylation results should have additional testing to delineate the specific mutation : microarray testing (#8655) to assess deletions/duplications and/or UPD 15 studies. For AS patients with normal methylation results, approximately 5-8% carry a point mutation in the UBE3A gene (#6007) . The other ~10-15% of AS patients have an unknown molecular etiology.
Technical Information
Methodology: Fluorescent in Situ Hybridization (FISH) Analysis
Gene Name: UBE3A
Protein Name: Ubiquitin-Protein Ligase E3A
Sample & Shipping Information
Test Requisition: Cytogenetics
Specimen Type: Blood
Requirements: Draw blood in a Sodium Heparin (green-top) tube(s) and send 3-5 cc (Adults/Children) or 1-2 cc (Infant< 2 years).
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Specimen should arrive in the laboratory within 48 hrs of collection. Do not heat or freeze.

Turn Around Time: 14 days
Billing Information
List Price: *For Insurance or Institutional Prices, please call.
CPT Codes: 88230x1, 88271x3, 88273x1, 88291x1

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