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Genetic Labs

Houston, Texas

Genetic Laboratory
Medical Genetics Laboratories
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Medical Genetics Test Details

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Warfarin Sensitivity Genotyping
Test Information: Evaluating genetic factors affecting drug metabolism for patients coumadin (Warfarin).

This analysis tests for seven genetic variations in the CYP2C9 and VKORC1 genes.

Reasons for Referral:
1. Patients starting initial treatment with Warfarin.
2. Patients already treated with Warfarin who are experiencing difficulty in achieving therapeutic INR
3. The results of this test can be used in available algorithms to determine appropriate Warfarin dosing (example www. Warfarindosing.org)
Test Details
Test Code: 6880
Test Includes: Variant alleles tested:

CYP2C9:

2 (c.430C>T, p.R144C): Decreased activity
3 (c.1075A>C, p.I359L): Decreased activity
4 (c.1076T>C): Decreased activity
5 (c.1080C>G, p.D360E): Decreased activity
6 (c.808delA): No activity
11 (c.1003C>T, p.R335W): Decreased activity

VKORC1:
1639G>A: Decreased activity


Special Notes: Limitations:
1. Not all variants with known impact on enzyme expression and activity are tested in this assay.
2. Non-genetic factors, variations in the other genes involving the drug metabolism or drug interactions are not measured by this assay.
3. Rare genetic alterations at primer binding sites may result in diagnostic errors.
Technical Information
Methodology: This analysis incorporates DNA amplification by multiplex PCR, allele specific primer extension, microarray hybridization and Fluorescence signal detection.
Gene Name: CYP2C9, VKORC1
References Values or Ranges: Analytical Sensitivity and Specificity: Greater than 99%
Sample & Shipping Information
Test Requisition: Molecular Diagnostics
Specimen Type: Blood
Requirements: Draw blood in an EDTA (purple-top) tube(s) and send 3 cc (Adults)
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze.

Turn Around Time: 7 days
Billing Information
List Price: *For Insurance or Institutional Prices, please call.
CPT Codes: 81227x1, 81355x1


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