Medical Genetics Test Details
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|Bile Acids Panel-Plasma|
|Test Information:||Bile acids are physiological detergents that generate bile flow and facilitate intestinal absorption and transport of lipids, nutrients, and vitamins. Bile acids are formed in the liver from cholesterol and are stored and concentrated in the gall bladder and released into the intestine after feeding. Bile acids serve to emulsify fat and promote proper digestion. Approximately 90% of bile acids are absorbed in the intestine and taken up by hepatocytes for re-excretion into bile. Bile acids aid in fat absorption and modulate cholesterol levels. Measurement of bile acid concentrations is a good indicator of hepatobiliary function, but it is not specific for the type of underlying liver disease or for diseases that secondarily affect the liver.
Indications for Testing:
Intrahepatic cholestasis of pregnancy (ICP)
Reduced functional hepatic mass
Congenital and acquired vascular shunts
The concentration of bile acids in the serum is elevated in patients with many structural liver diseases due to the inability of the liver to extract bile acids efficiently from portal blood. An elevated fasting level, due to impaired hepatic clearance, is a sensitive indicator of liver disease. Following meals, serum bile acid levels have been shown to increase only slightly in normal persons but markedly in patients with various liver diseases, including cirrhosis, hepatitis, cholestasis, portal-vein thrombosis, Budd-Chiari syndrome, cholangitis, Wilson's disease, and hemochromatosis. Bile acid levels may be altered even when other liver function tests are normal and may serve as a sensitive and specific indicator of liver disease.
Metabolic liver diseases such as Gilbert disease, Crigler-Najjar syndrome, or Dubin-Johnson syndrome do not cause elevated bile acid concentrations. Bile acid levels will not be increased in patients with intestinal malabsorption.
Chenodeoxycholic acid - CDCA
Cholic acid - CA, chenodiol
Deoxycholic acid - DCA
Glycocholic acid - GCA
Glycochenodeoxycholic acid - GCDCA
Glycodeoxycholic acid - GDCA
Lithocholic acid - LCA
Taurochenodeoxycholic acid - TCDCA
Tarocholic acid - TCA
Taurodeoxycholic acid - TDCA
Tauroursodeoxycholic acid - TUDCA
Ursodeoxycholic acid - UDCA, ursodiol
7a-hydroxy-4-cholestan-3-one - C4, HCO
|Sample & Shipping Information|
|Requirements:||Whole blood drawn in an EDTA (purple-top) tube and separate as soon as possible. Send 1-2 cc of plasma. Store the specimen frozen at 20C. Specimen may be stored frozen for up to 7 days.
|Shipping Conditions:||Ship frozen overnight in an insulated container.
|Turn Around Time:||14 days|
|List Price:||*For Insurance or Institutional Prices, please call.|