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Genetic Labs

Houston, Texas

Genetic Laboratory
Baylor Genetics Laboratories
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Medical Genetics Test Details

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The American Medical Association (AMA) Current Procedural Terminology (CPT) codes and Healthcare Common Procedure Coding System (HCPCS) codes listed, are provided for informational purposes only. The codes reflect our interpretation of CPT/HCPCS coding requirements based upon AMA guidelines published annually. CPT/HCPCS codes are provided only as guidance to assist clients with billing. Baylor Genetics strongly recommends that clients confirm CPT/HCPCS codes with their Medicare Administrative Contractor (MAC) or other payer being billed, as requirements may differ. CPT coding is the sole responsibility of the billing party. Baylor Genetics assumes no responsibility for billing errors due to reliance on the CPT codes listed. Please direct any questions regarding CPT coding to the payer being billed.


Common Hereditary Cancer Panel
Test Information: The Common Hereditary Cancer Panel analyzes 43 genes by the clinically validated approach of Massively Parallel Sequencing (MPS) using Next-Generation Sequence (NGS) technology to analyze selected genes associated with an increased risk for various cancers. The genes analyzed by this panel can be found in the ?Gene Name? section. Sequencing of these genes is also available using the associated individual test codes.

The panel can be used for confirmation of clinical diagnosis and differential diagnosis.
Test Details
Test Code: 24001
Special Notes: For copy number analysis, single/multiple exon deletions or consecutive exon duplications can be detected at >97% (95% CI, 75.8-100%, N=12) analytical sensitivity. Note, NGS-based copy number variation (CNV) analysis can be impacted by sample quality, characteristics of targeted regions (GC content, presence of homologous sequences, etc.) and other technical variations. Read depth analyses that are either uninformative or unsupportive of a copy number change do not exclude large deletions or duplications.

Thus, targeted oligonucleotide array CGH analysis (test code 2001 for a single locus and 2003 for multiple loci included in this panel) may be warranted if intragenic deletions/duplications are suspected. Samples not meeting the quality control requirement for NGS CNV analysis are also recommended for additional testing using alternative methodologies. In addition, multiplex ligation-dependent probe amplification (MLPA) and/or array comparative genomic hybridization (aCGH), performed on a targeted oligonucleotide array CGH (PanelArr), may be used to assess or confirm copy number changes involving gene(s) in this panel. Certain genes or exons in some genes (e.g., PMS2, CHEK2, etc.) with highly homologous sequences in the genome will not be evaluated for copy number variations by the above analyses. Findings are reported according to human genome build hg19. This assay will not detect balanced translocations, inversions, low level mosaicism, uniparental disomy, and imprinting defects.

Genes (except for ENG and PMS1) included in the Hereditary Breast/Ovarian/Endometrial Cancer Panel, Hereditary High-Risk Colorectal Cancer, Hereditary Pancreatic Cancer, Hereditary Prostate Cancer, and Hereditary Colorectal/Gastrointestinal Cancer Panel are included in the Common Hereditary Cancer Panel.
Technical Information
Methodology: Targeted Capture followed by Massively Parallel Sequencing. Multiplex Ligation-dependent Probe Amplification (MLPA), Array CGH analysis (aCGH), and/or Sanger sequencing may be used for confirmation.
Gene Name: APC, ATM, AXIN2, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, GALNT12, GREM1, HOXB13, MEN1, MITF, MLH1, MLH3, MRE11, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, PTEN, RAD50, RAD51C, RAD51D, RNF43, RPS20, SMAD4, STK11, TP53, VHL
Sample & Shipping Information
Test Requisition: Hereditary Cancer
Specimen Type: Blood
Requirements: Draw blood in an EDTA (purple-top) tube(s) and send 3-5 cc (children/adults).
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze. Sample must arrive within 72 hrs.

Specimen Type: Buccal Swab
Requirements: Collected with ORAcollectDx(OCD-100) self-collection kit (provided by Baylor Genetics with instructions). It is highly recommended that the sample be collected by a healthcare professional.
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze. Sample must arrive within 72 hrs.

Specimen Type: Purified DNA
Requirements: Send at least 20ug of purified DNA (minimal concentration of 50ng/uL; A260/A280 of ~1.7).
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze.

Specimen Type: Saliva
Requirements: Collect with Oragene DNA Self-Collection Kit
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze.

Turn Around Time: 21-28 days
Billing Information
List Price: *For Insurance or Institutional Prices, please call.
CPT Codes: 81432x1, 81433x1


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