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Genetic Labs

Houston, Texas

Genetic Laboratory
Baylor Genetics Laboratories
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Medical Genetics Test Details

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The American Medical Association (AMA) Current Procedural Terminology (CPT) codes and Healthcare Common Procedure Coding System (HCPCS) codes listed, are provided for informational purposes only. The codes reflect our interpretation of CPT/HCPCS coding requirements based upon AMA guidelines published annually. CPT/HCPCS codes are provided only as guidance to assist clients with billing. Baylor Genetics strongly recommends that clients confirm CPT/HCPCS codes with their Medicare Administrative Contractor (MAC) or other payer being billed, as requirements may differ. CPT coding is the sole responsibility of the billing party. Baylor Genetics assumes no responsibility for billing errors due to reliance on the CPT codes listed. Please direct any questions regarding CPT coding to the payer being billed.

High Risk Hereditary Colorectal Cancer Panel
Test Information: Confirmation of Clinical Diagnosis, Differential Diagnosis

The High Risk Hereditary Colorectal Cancer Panel uses next-generation sequencing and deletion/duplication analysis to simultaneously analyze selected genes associated with an increased risk for a wide range of cancers. Approximately 5 to 10% of all colorectal cancers are believed to be hereditary. In general, this test is used when a patient's medical history and family history findings strongly suggest that there is an underlying genetic etiology of colorectal cancer.
Test Details
Test Code: 23204
Special Notes: Twelve genes involved in high risk hereditary colorectal cancer are analyzed by the newly developed and clinically validated approach of Massively Parallel Sequencing (MPS) using Next Generation Sequence (NGS) technology. The genes analyzed by this panel are tabulated below. Sequencing of these genes is also available using the associated individual test codes.


All coding exons of these 12 genes and at least 20 base pairs of flanking intronic sequences are analyzed. All exonic variants and intronic variants within 20 bp of the exon/intron boundary will be reported. Sequence analysis will not detect genomic structural rearrangements (e.g. heterozygous deletions, duplications, and inversions), large heterozygous insertion mutations (e.g. ALU mediated insertion), and mutations within the promoter or deep intronic regions. Mutations and novel variants detected by NGS are confirmed by Sanger sequencing.

The panel also includes gross copy number analyses of these genes by MLPA and/or aCGH. Certain exons with no known gross deletion/duplication mutations, or certain genes/exons with highly homologous sequences in the genome may not be evaluated by this copy number analysis.

A Hereditary Colorectal/Gastrointestinal Cancer Panel (Test code: 22804) is also available, which is more comprehensive and includes 22 genes associated with colorectal/gastrointestinal cancer.

*Only copy analysis for this gene will be reported since there are no known sequencing variations associated with cancer in this gene.
Technical Information
Methodology: Targeted Capture followed by Massively Parallel Sequencing, Multiplex Ligation-dependent Probe Amplification (MLPA), and/or Array CGH Analysis (aCGH).
Sample & Shipping Information
Test Requisition: Hereditary Cancer
Specimen Type: Blood
Requirements: Draw blood in an EDTA (purple-top) tube(s) and send 3-5 cc (Adults/Children).
Shipping Conditions: Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze. Sample must arrive within 72 hrs.

Specimen Type: Buccal Swab
Requirements: Collected with ORAcollectDx(OCD-100) self-collection kit (provided by Baylor Genetics with instructions). It is highly recommended that the sample be collected by a healthcare professional.
Shipping Conditions: Ship at room temperature in an insulated container by overnight carrier. Do not heat or freeze. Sample must arrive within 72 hours.

Turn Around Time: 14 days
Billing Information
List Price: *For Insurance or Institutional Prices, please call.
CPT Codes: 81292x1, 81295x1, 81298x1, 81317x1

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