Medical Genetics Test Details
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|Chromosomal Microarray Analysis - HR|
Product of Conception(POC) tests should be requested using the Cytogenetics - Products of Conception Requisition
Chromosomal Microarray Analysis - High Resolution (CMA-HR) utilizes array-based comparative genomic hybridization (aCGH) with approximately 180,000 oligos covering the whole genome at the average resolution of 30Kb, 1,714 genes with all exons covered, 700 microRNAs, and the entire mitochondrial genome. Genomic DNA from the test sample and a control sample are differentially labeled with fluorescent dyes and hybridized to the oligos. Results are analyzed using quantitative imaging methods and analytical software to assist in identifying each targeted-DNA sequence as loss of copy number (deletion), gain of copy number (duplication) or normal copy number. This technology has been validated in our laboratory on many patients with known microdeletions/duplications and other unbalanced karyotypes detected by traditional cytogenetic methods. CMA is limited to detection of gain or loss of genomic material. It will not detect low level mosaicism, balanced translocations, inversions, or point mutations that may be responsible for the clinical phenotype.
For information regarding CMA parental studies, please review the following document titled CMA Parental Studies Policy.
|Sample & Shipping Information|
|Requirements:||Draw blood in both Sodium Heparin (green-top) tube(s) and an EDTA (purple-top) tube(s) and send 3-5 cc (Adults/Children) or 1-2 cc (Infant< 2 years).|
|Shipping Conditions:||Ship at room temperature in an insulated container by overnight courier. Do not heat or freeze. Sample must arrive within 72 hrs.
|Turn Around Time:||14 days|
|List Price:||$1,800.00 *Institutional discounts may apply, please call.|